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Shaping the Future
RESEARCH

Karen Reue, Ph.D.

Contact Information:

Fax Number:

(310) 794-5446

Lab Number:

(310) 267-2752

Office Phone Number:

(310) 794-5631

Laboratory Address:

Laboratory
Department of Human Genetics
Gonda Building, 6th floor
UCLA
Los Angeles, CA 90095
UNITED STATES

Mailing Address:

Mailing Address
Department of Human Genetics
David Geffen School of Medicine at UCLA
695 Charles E. Young Drive South
Los Angeles, CA 90095
UNITED STATES

Office Address:

Office
Department of Human Genetics
Gonda Building, 6th floor
Los Angeles, CA 90095
UNITED STATES

Email Address:

reuek@ucla.edu

Professor, Human Genetics

Member, Genetics & Genomics GPB Home Area

Molecular, Cellular & Integrative Physiology GPB Home Area

Faculty, Molecular Biology IDP


Detailed Biography:

Research Interest:

Genes underlying disorders in lipid and glucose metabolism

We are interested in identifying genes that underlie abnormalities in lipid and glucose metabolism using the mouse as a model. Much of our recent work has focused on the fatty liver dystrophy (fld) mutation, which results in lipodystrophy (lack of fat tissue), insulin resistance, and increased susceptibility to atherosclerosis. Using a positional cloning approach, we identified the fld mutation in a novel gene that we named Lipin. We are studying the role of lipin in fat tissue development and metabolic disorders in several models, including engineered mouse strains, cultured cells, human adipose tissue, and invertebrate organisms. A second positional cloning project that is underway is aimed at isolating a gene mutation that confers resistance to hypercholesterolemia and atherosclerosis. We are also pleased to be a member of the BayGenomics consortium that is performing analysis of gene function in the mouse on a large scale using gene-trap technology.

Selected Publications:

Villanueva Claudio J, Vergnes Laurent, Wang Jiexin, Drew Brian G, Hong Cynthia, Tu Yiping, Hu Yan, Peng Xu, Xu Feng, Saez Enrique, Wroblewski Kevin, Hevener Andrea L, Reue Karen, Fong Loren G, Young Stephen G, Tontonoz Peter Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs. Cell metabolism. 2013; 17(3): 423-35.
Williams Kevin J, Argus Joseph P, Zhu Yue, Wilks Moses Q, Marbois Beth N, York Autumn G, Kidani Yoko, Pourzia Alexandra L, Akhavan David, Lisiero Dominique N, Komisopoulou Evangelia, Henkin Amy H, Soto Horacio, Chamberlain Brian T, Vergnes Laurent, Jung Michael E, Torres Jorge Z, Liau Linda M, Christofk Heather R, Prins Robert M, Mischel Paul S, Reue Karen, Graeber Thomas G, Bensinger Steven J An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity. Cancer research. 2013; 73(9): 2850-62.
Arnold Arthur P, Chen Xuqi, Link Jenny C, Itoh Yuichiro, Reue Karen Cell-autonomous sex determination outside of the gonad. Developmental dynamics : an official publication of the American Association of Anatomists. 2013; 242(4): 371-9.
Vergnes Laurent, Lee Jessica M, Chin Robert G, Auwerx Johan, Reue Karen Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels. Cell metabolism. 2013; 17(6): 916-28.
Csaki Lauren S, Dwyer Jennifer R, Fong Loren G, Tontonoz Peter, Young Stephen G, Reue Karen Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling. Progress in lipid research. 2013; 52(3): 305-16.
Link Jenny C, Chen Xuqi, Arnold Arthur P, Reue Karen Metabolic impact of sex chromosomes. Adipocyte. 2013; 2(2): 74-9.
Martin Lisa J, Lau Edward, Singh Harpreet, Vergnes Laurent, Tarling Elizabeth J, Mehrabian Margarete, Mungrue Imran, Xiao Sheila, Shih Diana, Castellani Lawrence, Ping Peipei, Reue Karen, Stefani Enrico, Drake Thomas A, Bostrom Kristina, Lusis Aldons J Response to Pomozi et al's research commentary. Circulation research. 2013; 112(11): e152-3.
Kidani Yoko, Elsaesser Heidi, Hock M Benjamin, Vergnes Laurent, Williams Kevin J, Argus Joseph P, Marbois Beth N, Komisopoulou Evangelia, Wilson Elizabeth B, Osborne Timothy F, Graeber Thomas G, Reue Karen, Brooks David G, Bensinger Steven J Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity. Nature immunology. 2013; 14(5): 489-99.
Chen Xuqi, Williams-Burris Shayna M, McClusky Rebecca, Ngun Tuck C, Ghahramani Negar, Barseghyan Hayk, Reue Karen, Vilain Eric, Arnold Arthur P The Sex Chromosome Trisomy mouse model of XXY and XYY: metabolism and motor performance. Biology of sex differences. 2013; 4(1): 15.
Chen Xuqi, McClusky Rebecca, Itoh Yuichiro, Reue Karen, Arnold Arthur P X and Y chromosome complement influence adiposity and metabolism in mice. Endocrinology. 2013; 154(3): 1092-104.
Martin Lisa J, Lau Edward, Singh Harpreet, Vergnes Laurent, Tarling Elizabeth J, Mehrabian Margarete, Mungrue Imran, Xiao Sheila, Shih Diana, Castellani Lawrence, Ping Peipei, Reue Karen, Stefani Enrico, Drake Thomas A, Bostrom Kristina, Lusis Aldons J ABCC6 localizes to the mitochondria-associated membrane. Circulation research. 2012; 111(5): 516-20.
Zhang Li, Reue Karen, Fong Loren G, Young Stephen G, Tontonoz Peter Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis. Arteriosclerosis, thrombosis, and vascular biology. 2012; 32(11): 2541-6.
Ghazalpour Anatole, Rau Christoph D, Farber Charles R, Bennett Brian J, Orozco Luz D, van Nas Atila, Pan Calvin, Allayee Hooman, Beaven Simon W, Civelek Mete, Davis Richard C, Drake Thomas A, Friedman Rick A, Furlotte Nick, Hui Simon T, Jentsch J David, Kostem Emrah, Kang Hyun Min, Kang Eun Yong, Joo Jong Wha, Korshunov Vyacheslav A, Laughlin Rick E, Martin Lisa J, Ohmen Jeffrey D, Parks Brian W, Pellegrini Matteo, Reue Karen, Smith Desmond J, Tetradis Sotirios, Wang Jessica, Wang Yibin, Weiss James N, Kirchgessner Todd, Gargalovic Peter S, Eskin Eleazar, Lusis Aldons J, LeBoeuf Renée C Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mammalian genome : official journal of the International Mammalian Genome Society. 2012; 23(9-10): 680-92.
Zhang Peixiang, Takeuchi Kazuharu, Csaki Lauren S, Reue Karen Lipin-1 phosphatidic phosphatase activity modulates phosphatidate levels to promote peroxisome proliferator-activated receptor γ (PPARγ) gene expression during adipogenesis. The Journal of biological chemistry. 2012; 287(5): 3485-94.
Dwyer Jennifer R, Donkor Jimmy, Zhang Peixiang, Csaki Lauren S, Vergnes Laurent, Lee Jessica M, Dewald Jay, Brindley David N, Atti Elisa, Tetradis Sotirios, Yoshinaga Yuko, De Jong Pieter J, Fong Loren G, Young Stephen G, Reue Karen Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum. Proceedings of the National Academy of Sciences of the United States of America. 2012; 109(37): E2486-95.
Han Sungwon, Bahmanyar Shirin, Zhang Peixiang, Grishin Nick, Oegema Karen, Crooke Roseann, Graham Mark, Reue Karen, Dixon Jack E, Goodman Joel M Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway. The Journal of biological chemistry. 2012; 287(5): 3123-37.
Weinstein Michael M, Goulbourne Christopher N, Davies Brandon S J, Tu Yiping, Barnes Richard H, Watkins Steven M, Davis Ryan, Reue Karen, Tontonoz Peter, Beigneux Anne P, Fong Loren G, Young Stephen G Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice. Arteriosclerosis, thrombosis, and vascular biology. 2012; 32(2): 230-5.
Chao Lily C, Wroblewski Kevin, Ilkayeva Olga R, Stevens Robert D, Bain James, Meyer Gretchen A, Schenk Simon, Martinez Leonel, Vergnes Laurent, Narkar Vihang A, Drew Brian G, Hong Cynthia, Boyadjian Rima, Hevener Andrea L, Evans Ronald M, Reue Karen, Spencer Melissa J, Newgard Christopher B, Tontonoz Peter Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization. Journal of lipid research. 2012; 53(12): 2610-9.
Chen Xuqi, McClusky Rebecca, Chen Jenny, Beaven Simon W, Tontonoz Peter, Arnold Arthur P, Reue Karen The number of x chromosomes causes sex differences in adiposity in mice. PLoS genetics. 2012; 8(5): e1002709.
Williams Lisa K, Csaki Lauren S, Cantor Rita M, Reue Karen, Lawson Greg W Ulcerative dermatitis in C57BL/6 mice exhibits an oxidative stress response consistent with normal wound healing. Comparative medicine. 2012; 62(3): 166-71.
Reue Karen A thematic review series: lipid droplet storage and metabolism: from yeast to man. Journal of lipid research. 2011; 52(11): 1865-8.
Coffinier Catherine, Jung Hea-Jin, Nobumori Chika, Chang Sandy, Tu Yiping, Barnes Richard H, Yoshinaga Yuko, de Jong Pieter J, Vergnes Laurent, Reue Karen, Fong Loren G, Young Stephen G Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons. Molecular biology of the cell. 2011; 22(23): 4683-93.
Young Stephen G, Davies Brandon S J, Voss Constance V, Gin Peter, Weinstein Michael M, Tontonoz Peter, Reue Karen, Bensadoun André, Fong Loren G, Beigneux Anne P GPIHBP1, an endothelial cell transporter for lipoprotein lipase. Journal of lipid research. 2011; 52(11): 1869-84.
Vergnes Laurent, Chin Robert, Young Stephen G, Reue Karen Heart-type fatty acid-binding protein is essential for efficient brown adipose tissue fatty acid oxidation and cold tolerance. The Journal of biological chemistry. 2011; 286(1): 380-90.
Vlashi Erina, Lagadec Chann, Vergnes Laurent, Matsutani Tomoo, Masui Kenta, Poulou Maria, Popescu Ruxandra, Della Donna Lorenza, Evers Patrick, Dekmezian Carmen, Reue Karen, Christofk Heather, Mischel Paul S, Pajonk Frank Metabolic state of glioma stem cells and nontumorigenic cells. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(38): 16062-7.
Barajas Berenice, Che Nam, Yin Fen, Rowshanrad Amir, Orozco Luz D, Gong Ke Wei, Wang Xuping, Castellani Lawrence W, Reue Karen, Lusis Aldons J, Araujo Jesus A NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protection. Arteriosclerosis, thrombosis, and vascular biology. 2011; 31(1): 58-66.
Devarajan Asokan, Bourquard Noam, Hama Susan, Navab Mohamad, Grijalva Victor R, Morvardi Susan, Clarke Catherine F, Vergnes Laurent, Reue Karen, Teiber John F, Reddy Srinivasa T Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis. Antioxidants & redox signaling. 2011; 14(3): 341-51.
Zhang Jin, Khvorostov Ivan, Hong Jason S, Oktay Yavuz, Vergnes Laurent, Nuebel Esther, Wahjudi Paulin N, Setoguchi Kiyoko, Wang Geng, Do Anna, Jung Hea-Jin, McCaffery J Michael, Kurland Irwin J, Reue Karen, Lee Wai-Nang P, Koehler Carla M, Teitell Michael A UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells. The EMBO journal. 2011; 30(24): 4860-73.
Weinstein Michael M, Tu Yiping, Beigneux Anne P, Davies Brandon S J, Gin Peter, Voss Constance, Walzem Rosemary L, Reue Karen, Tontonoz Peter, Bensadoun André, Fong Loren G, Young Stephen G Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice. Arteriosclerosis, thrombosis, and vascular biology. 2010; 30(11): 2106-13.
Pterfy M, Harris TE, Fujita N, Reue K Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes. J Biol Chem 2010; Epub ahead of print Dec 2, 2009: .
Péterfy Miklós, Harris Thurl E, Fujita Naoya, Reue Karen Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes. The Journal of biological chemistry. 2010; 285(6): 3857-64.
Csaki Lauren S, Reue Karen Lipins: multifunctional lipid metabolism proteins. Annual review of nutrition. 2010; 30(11): 257-72.
Donkor J, Zhang P, Wong S, O?Loughlin L, Kok B, Dewald J, Brindley DN, Reue K A conserved serine residue is required for the phosphatidate phosphatase activity but not coactivator functions of lipin-1 and lipin-2. J Biol Chem 2009; 284: 29968-29978.
Donkor Jimmy, Zhang Peixiang, Wong Samantha, O'Loughlin Lauren, Dewald Jay, Kok Bernard P C, Brindley David N, Reue Karen A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2. The Journal of biological chemistry. 2009; 284(43): 29968-78.
Phan J, Hickey M, Zhang P, Chesselet M, Reue K Adipose tissue dysfunction tracks disease progression in two Huntington?s disease mouse models. Hum Mol Genet 2009; 18: 1006-1016.
Phan Jack, Hickey Miriam A, Zhang Peixiang, Chesselet Marie-Francoise, Reue Karen Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models. Human molecular genetics. 2009; 18(6): 1006-16.
Takeuchi K, Reue K Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis. Am J Physiol Endocrinol Metab 2009; 296: E1195-209.
Takeuchi Kazuharu, Reue Karen Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis. American journal of physiology. Endocrinology and metabolism. 2009; 296(6): E1195-209.
Hegele RA, Reue K Hoofbeats, zebras, and insights into insulin resistance. J Clin Invest 2009; 119: 249-251.
Hegele Robert A, Reue Karen Hoofbeats, zebras, and insights into insulin resistance. The Journal of clinical investigation. 2009; 119(2): 249-51.
Chao LC, Wroblewski K, Zhang A, Pei L, Vergnes L, Ilkayeva OR, Ding S, Reue K, Watt MJ, Newgard CB, Pilch PF, Hevener AL, Tontonoz P Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77. Diabetes 2009; 58: 2788-2796.
Chao Lily C, Wroblewski Kevin, Zhang Zidong, Pei Liming, Vergnes Laurent, Ilkayeva Olga R, Ding Shi Ying, Reue Karen, Watt Matthew J, Newgard Christopher B, Pilch Paul F, Hevener Andrea L, Tontonoz Peter Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77. Diabetes. 2009; 58(12): 2788-96.
Reue K, Dwyer J Lipin proteins and metabolic homeostasis. J Lipid Res 2009; 50: Suppl: S109-114.
Reue Karen, Dwyer Jennifer R Lipin proteins and metabolic homeostasis. Journal of lipid research. 2009; 50 Suppl(3): S109-14.
Brindley DN, Pilquil C, Sariahmetoglu M, Reue K Phosphatidate degradation: Phosphatidate phosphatases (lipins) and lipid phosphate phosphatases. Biochim Biophys Acta 2009; 1791: 956-961.
Brindley David N, Pilquil Carlos, Sariahmetoglu Meltem, Reue Karen Phosphatidate degradation: phosphatidate phosphatases (lipins) and lipid phosphate phosphatases. Biochimica et biophysica acta. 2009; 1791(9): 956-61.
Dean JT, Tran L, Beaven S, Tontonoz P, Reue K, Dipple KM, Liao JC Resistance to diet-induced obesity in mice with synthetic glyoxylate shunt. Cell Metab 2009; 9: 525-536.
Dean Jason T, Tran Linh, Beaven Simon, Tontonoz Peter, Reue Karen, Dipple Katrina M, Liao James C Resistance to diet-induced obesity in mice with synthetic glyoxylate shunt. Cell metabolism. 2009; 9(6): 525-36.
Bou Khalil M, Sundaram M, Zhang HY, Links PH, Raven JF, Manmontri B, Sariahmetoglu M, Tran K, Reue K, Brindley DN, Yao Z The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic very low density lipoproteins. J Lipid Res 2009; 50: 47-58.
Bou Khalil Maroun, Sundaram Meenakshi, Zhang Hong-Yu, Links Philip H, Raven Jennifer F, Manmontri Boripont, Sariahmetoglu Meltem, Tran Khai, Reue Karen, Brindley David N, Yao Zemin The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic VLDL. Journal of lipid research. 2009; 50(1): 47-58.
Reue Karen The lipin family: mutations and metabolism. Current opinion in lipidology. 2009; 20(3): 165-70.
Reue K The lipin protein family: mutations and metabolism. Curr Opin Lipidol 2009; 20: 165-170.
Donkor J, Sparks LM, Xie H, Smith SR, Reue K Adipose tissue lipin-1 expression is correlated with PPAR? gene expression and insulin sensitivity in healthy young men. J Clin Endocrinol Metab 2008; 93: 233-239.
Donkor Jimmy, Sparks Lauren M, Xie Hui, Smith Steven R, Reue Karen Adipose tissue lipin-1 expression is correlated with peroxisome proliferator-activated receptor alpha gene expression and insulin sensitivity in healthy young men. The Journal of clinical endocrinology and metabolism. 2008; 93(1): 233-9.
Manmontri B, Sariahmetoglu M, Donkor J, Bou Khalil M, Yao Z, Reue K, Lehner R, Brindley DN Glucocorticoids and cAMP selectively increase hepatic lipin-1 expression and insulin acts antagonistically. J Lipid Res 2008; 49: 1056-1067.
Manmontri Boripont, Sariahmetoglu Meltem, Donkor Jimmy, Bou Khalil Maroun, Sundaram Meenakshi, Yao Zemin, Reue Karen, Lehner Richard, Brindley David N Glucocorticoids and cyclic AMP selectively increase hepatic lipin-1 expression, and insulin acts antagonistically. Journal of lipid research. 2008; 49(5): 1056-67.
Nagle CA, Vergnes L, Dejong H, Wang S, Lewin TM, Reue K, Coleman RA Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6?/? mice. J Lipid Res 2008; 49: 823-831.
Nagle Cynthia A, Vergnes Laurent, Dejong Hendrik, Wang Shuli, Lewin Tal M, Reue Karen, Coleman Rosalind A Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6-/- mice. Journal of lipid research. 2008; 49(4): 823-31.
Lusis AJ, Attie AD, Reue K Metabolic Syndrome: from epidemiology to gene networks. Nat Rev Genet 2008; 9: 819-830.
Lusis Aldons J, Attie Alan D, Reue Karen Metabolic syndrome: from epidemiology to systems biology. Nature reviews. Genetics. 2008; 9(11): 819-30.
Reue K, Brindley DN Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism. J Lipid Res 2008; 49: 2493-2503.
Zhang P, O?Loughlin L, Brindley, DN, Reue K Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis. J Lipid Res 2008; 49: 1519-1528.
Zhang Peixiang, O'Loughlin Lauren, Brindley David N, Reue Karen Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis. Journal of lipid research. 2008; 49(7): 1519-28.
Reue K, Zhang P The lipin protein family: dual roles in lipid biosynthesis and gene expression. FEBS Lett 2008; 582: 90-96.
Reue Karen, Zhang Peixiang The lipin protein family: dual roles in lipid biosynthesis and gene expression. FEBS letters. 2008; 582(1): 90-6.
Reue Karen, Brindley David N Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism. Journal of lipid research. 2008; 49(12): 2493-503.
Ji J, Lee RT, Vergnes L, Fong LG, Stewart CL, Reue K, Young SG, Zhang Q, Shanahan CM, Lammerding J Cell nuclei spin in the absence of lamin B1. J Biol Chem 2007; 282: 20015-20026.
Ji Julie Y, Lee Richard T, Vergnes Laurent, Fong Loren G, Stewart Colin L, Reue Karen, Young Stephen G, Zhang Qiuping, Shanahan Catherine M, Lammerding Jan Cell nuclei spin in the absence of lamin b1. The Journal of biological chemistry. 2007; 282(27): 20015-26.
Reue K, Donkor J Genetic factors in type 2 diabetes: all in the (lipin) family. Diabetes 2007; 56: 2842-2843.
Reue Karen, Donkor Jimmy Genetic factors in type 2 diabetes: all in the (lipin) family. Diabetes. 2007; 56(12): 2842-3.
Pterfy M, Ben-Zeev O, Mao HZ, Weissglas-Volkov D. Aouizerat BE, Pullinger CR, Frost PH, Kane JP, Malloy MJ, Reue K, Pajukanta P, Doolittle MH Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia. Nat Genet 2007; 39: 1483-1487.
Péterfy Miklós, Ben-Zeev Osnat, Mao Hui Z, Weissglas-Volkov Daphna, Aouizerat Bradley E, Pullinger Clive R, Frost Philip H, Kane John P, Malloy Mary J, Reue Karen, Pajukanta Päivi, Doolittle Mark H Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia. Nature genetics. 2007; 39(12): 1483-7.
Reue Karen The role of lipin 1 in adipogenesis and lipid metabolism. Novartis Foundation symposium. 2007; 286(6): 58-68; discussion 68-71, 162-3, 196-203.
Waki Hironori, Park Kye Won, Mitro Nico, Pei Liming, Damoiseaux Robert, Wilpitz Damien C, Reue Karen, Saez Enrique, Tontonoz Peter The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression. Cell metabolism. 2007; 5(5): 357-70.
Donkor J, Sariahmetoglu M, Dewald J, Brindley DN, Reue K Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns. J Biol Chem 2007; 282: 3450-3457.
Donkor Jimmy, Sariahmetoglu Meltem, Dewald Jay, Brindley David N, Reue Karen Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns. The Journal of biological chemistry. 2007; 282(6): 3450-7.
Lindegaard, B., Larsen, L.F., Hansen, A.-B.E., Gerstoft, J., Pedersen, B.K., Reue, K Adipose tissue lipin expression levels distinguish HIV patients with and without lipodystrophy. Int. J. Obes 2006; 31: 449-456.
Vergnes L Beigneux AP Davis R Watkins SM Young SG Reue K Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity. J Lipid Res 2006; 47: 745-754.
Vergnes Laurent, Beigneux Anne P, Davis Ryan, Watkins Steven M, Young Stephen G, Reue Karen Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity. Journal of lipid research. 2006; 47(4): 745-54.
Beigneux AP Vernes L Qiao X Quatela S Davis R Watkins SM Coleman RA Walzem RL Philips M Reue K Young, SG Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium. J Lipid Res 2006; 47: 734-744.
Beigneux Anne P, Vergnes Laurent, Qiao Xin, Quatela Steven, Davis Ryan, Watkins Steven M, Coleman Rosalind A, Walzem Rosemary L, Philips Mark, Reue Karen, Young Stephen G Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium. Journal of lipid research. 2006; 47(4): 734-44.
Reue Karen, Vergnes Laurent Approaches to lipid metabolism gene identification and characterization in the postgenomic era. Journal of lipid research. 2006; 47(9): 1891-907.
Suviolahti E Reue K Cantor RM Phan J Gentile M Naukkarinen J Soro-Paavonen A Oksanen L Kaprio J Rissanen A Salomaa V Kontula K Taskinen MR Pajukanta P Peltonen L. Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism. Hum Mol Genet 2006; 15: 377-386.
Suviolahti Elina, Reue Karen, Cantor Rita M, Phan Jack, Gentile Massimiliano, Naukkarinen Jussi, Soro-Paavonen Aino, Oksanen Laura, Kaprio Jaakko, Rissanen Aila, Salomaa Veikko, Kontula Kimmo, Taskinen Marja-Riitta, Pajukanta Päivi, Peltonen Leena Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism. Human molecular genetics. 2006; 15(3): 377-86.
Lammerding J Fong L Ji JY Reue K Stewart CL Young SG Lee RT Lamins A and C but not lamin B1 regulate nuclear mechanics. J. Biol. Chem 2006; 281: 25768-25780.
Lammerding Jan, Fong Loren G, Ji Julie Y, Reue Karen, Stewart Colin L, Young Stephen G, Lee Richard T Lamins A and C but not lamin B1 regulate nuclear mechanics. The Journal of biological chemistry. 2006; 281(35): 25768-80.
Xu J Lee WN Phan J Saad MF Reue K Kurland IJ Lipin deficiency impairs diurnal metabolic fuel switching. Diabetes 2006; 55: 3429-3438.
Xu Jun, Lee W N Paul, Phan Jack, Saad Mohammed F, Reue Karen, Kurland Irwin J Lipin deficiency impairs diurnal metabolic fuel switching. Diabetes. 2006; 55(12): 3429-38.
Yao-Borengasser A Rasouli N Varma V Miles LM Phanavanh B Starks TN Phan J Spencer HJ 3rd McGehee RE Jr Reue K Kern PA Lipin expression is attenuated in adipose tissue of insulin-resistant human subjects and increases with peroxisome proliferator-activated receptor gamma activation. Diabetes 2006; 55: 2811-2818.
Yao-Borengasser Aiwei, Rasouli Neda, Varma Vijayalakshmi, Miles Leslie M, Phanavanh Bounleut, Starks Tasha N, Phan Jack, Spencer Horace J, McGehee Robert E, Reue Karen, Kern Philip A Lipin expression is attenuated in adipose tissue of insulin-resistant human subjects and increases with peroxisome proliferator-activated receptor gamma activation. Diabetes. 2006; 55(10): 2811-8.
Reue K Phan J Metabolic consequences of lipodystrophy in mouse models. Curr. Opin. Clin. Nutr. Metab. Care 2006; 9: 436-441.
Reue Karen, Phan Jack Metabolic consequences of lipodystrophy in mouse models. Current opinion in clinical nutrition and metabolic care. 2006; 9(4): 436-41.
Reue K, Vergnes L Systems biology approaches to metabolic and cardiovascular disorders. Approaches to lipid metabolism gene identification and characterization in the post-genomic era. J Lipid Res 2006; 47: 1891-1907.
Peterfy, M. Phan, J. Reue, K. Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization and role in adipogenesis. J. Biol. Chem 2005; 280: 32883-32889.
Péterfy Miklós, Phan Jack, Reue Karen Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis. The Journal of biological chemistry. 2005; 280(38): 32883-9.
Phan, J Peterfy, M Reue, K Biphasic expression of lipin suggests dual roles in adipocyte development. Drug news & perspectives. . 2005; 18(1): 5-11.
Phan Jack, Peterfy Miklos, Reue Karen Biphasic expression of lipin suggests dual roles in adipocyte development. Drug news & perspectives. 2005; 18(1): 5-11.
Phan, J Reue, K Lipin, a lipodystrophy and obesity gene. Cell metabolism. . 2005; 1(1): 73-83.
Phan Jack, Reue Karen Lipin, a lipodystrophy and obesity gene. Cell metabolism. 2005; 1(1): 73-83.
Fong, LG Ng, JK Meta, M Coté, N Yang, SH Stewart, CL Sullivan, T Burghardt, A Majumdar, S Reue, K Bergo, MO Young, SG Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. . 2004; 101(52): 18111-6.
Fong Loren G, Ng Jennifer K, Meta Margarita, Coté Nathan, Yang Shao H, Stewart Colin L, Sullivan Terry, Burghardt Andrew, Majumdar Sharmila, Reue Karen, Bergo Martin O, Young Stephen G Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 2004; 101(52): 18111-6.
Vergnes, L., Peterfy, M., Bergo, M., Young, S.G., Reue, K. Lamin B1 is required for mouse development and nuclear integrity. Proc. Natl. Acad. Sci. USA 2004; 101: 10428-10433.
Vergnes Laurent, Péterfy Miklós, Bergo Martin O, Young Stephen G, Reue Karen Lamin B1 is required for mouse development and nuclear integrity. Proceedings of the National Academy of Sciences of the United States of America. 2004; 101(28): 10428-33.
Phan, J., Peterfy, M., Reue, K. Lipin expression preceding PPAR-gamma is critical for adipogenesis in vivo and in vitro. J. Biol. Chem 2004; 279: 29558-29564.
Phan Jack, Péterfy Miklós, Reue Karen Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro. The Journal of biological chemistry. 2004; 279(28): 29558-64.
Vergnes Laurent, Phan Jack, Stolz Andrew, Reue Karen A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13. Journal of lipid research. 2003; 44(3): 503-11.
Vergnes, L Phan, J Stolz, A Reue, K A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13. Journal of lipid research. . 2003; 44(3): 503-11.
Vergnes, L Phan, J Strauss, M Tafuri, S Reue, K Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression. The Journal of biological chemistry. . 2003; 278(44): 42774-84.
Vergnes Laurent, Phan Jack, Strauss Merav, Tafuri Sherrie, Reue Karen Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression. The Journal of biological chemistry. 2003; 278(44): 42774-84.
Phan, J Pesaran, T Davis, RC Reue, K The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism. The Journal of biological chemistry. 2002; 277(1): 469-77.
Phan Jack, Pesaran Tina, Davis Richard C, Reue Karen The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism. The Journal of biological chemistry. 2002; 277(1): 469-77.
Reue, K Glueck, SB Accumulating evidence for differences during preadipocyte development: Focus on "Differential gene expression in white and brown preadipocytes". Physiological genomics. . 2001; 7(1): 1-2.
Karlsson, M Reue, K Xia, YR Lusis, AJ Langin, D Tornqvist, H Holm, C Exon-intron organization and chromosomal localization of the mouse monoglyceride lipase gene. Gene. . 2001; 272(1-2): 11-8.
Kast, HR Nguyen, CM Sinal, CJ Jones, SA Laffitte, BA Reue, K Gonzalez, FJ Willson, TM Edwards, PA Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids. Molecular endocrinology (Baltimore, Md.) . 2001; 15(10): 1720-8.
Peterfy, M., Phan, J., Xu, P., Reue, K. Lipodystrophy in the fld mouse results from mutation in a novel nuclear protein, lipin. Nature Genetics 2001; 27: 121-124.
Mouzeyan, A., Choi, J., Allayee, H., Sinsheimer, J., Phan, J., Castellani, L.W., Reue, K., Lusis, A.J., Davis, R.C. A gene conferring resistance to diet-induced hypercholesterolemia and atherosclerosis on mouse chromosome 2. J. Lipid Res. 2000; 41: 573-582.
Reue, K Xu, P Wang, XP Slavin, BG Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene. Journal of lipid research. . 2000; 41(7): 1067-76.
Harte, R.A., Hulten, L.M., Lindmark, H., Reue, K., Schotz, M.C., Khoo, J., Rosenfeld, M.E. Low level expression of hormone-sensitive lipase in arterial macrophage-derived foam cells: potential explanation for low rates of cholesteryl ester hydrolysis. Atherosclerosis 2000; 149: 343-350.
Phan, J., Reue, K., Peterfy, M. MS-IRS: PCR: A simple method for the isolation of microsatellites. BioTechniques 2000; 28: 18-20.
Reue, K., Peterfy, M. Mouse models of lipodystrophy. Curr. Atherosclerosis Reports 2000; 2: 390-396.
Klingenspor, M Xu, P Cohen, RD Welch, C Reue, K Altered gene expression pattern in the fatty liver dystrophy mouse reveals impaired insulin-mediated cytoskeleton dynamics. The Journal of biological chemistry. . 1999; 274(33): 23078-84.
Escary, JL Choy, HA Reue, K Wang, XP Castellani, LW Glass, CK Lusis, AJ Schotz, MC Paradoxical effect on atherosclerosis of hormone-sensitive lipase overexpression in macrophages. Journal of lipid research. . 1999; 40(3): 397-404.
Oswell, GM Doolittle, MH Reue, K Preparation of YAC end fragments from the whitehead/MIT mouse YAC library pRML vectors. BioTechniques. . 1999; 26(3): 396-8, 400, 402.
Escary, JL Choy, HA Reue, K Schotz, MC Hormone-sensitive lipase overexpression increases cholesteryl ester hydrolysis in macrophage foam cells. Arteriosclerosis, thrombosis, and vascular biology. . 1998; 18(6): 991-8.
Rehnmark, S Giometti, CS Slavin, BG Doolittle, MH Reue, K The fatty liver dystrophy mutant mouse: microvesicular steatosis associated with altered expression levels of peroxisome proliferator-regulated proteins. Journal of lipid research. . 1998; 39(11): 2209-17.
Reue, K mRNA quantitation techniques: considerations for experimental design and application. The Journal of nutrition. . 1998; 128(11): 2038-44.
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