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Shaping the Future

Christopher Lee

Contact Information:

Fax Number:

(310) 206-7286

Lab Number:

1 (310) 794-4026

Work Phone Number:

1 (310) 825-7374

Laboratory Address:

Paul Boyer Hall 609

Work Address:

Paul Boyer Hall 601A

Work Email Address:



Professor, Chemistry and Biochemistry

Biochemistry, Molecular Biology

Member, Bioinformatics GPB Home Area

Graduate Program in Biochemistry and Molecular Biology

Molecular Biology Institute

Researcher, Biochemistry

Biophysics and Structural Biology

Proteomics and Bioinformatics

A Short Biography:

Professor Lee received a B.A. summa cum laude in Biochemistry and Molecular Biology in 1988 from Harvard College, and a Ph.D. in Structural Biology from Stanford University in 1993. He co-founded Molecular Applications Group with Michael Levitt in 1993, and served as Vice-President for Research until 1998. After completing a postdoctoral fellowship in the Department of Chemistry at Stanford, he joined the UCLA faculty in 1998.

Prof. Lee accepts graduate students through the Biochemistry and Molecular Biology (BMB) Graduate Program and the UCLA ACCESS Ph.D. Program.

Awards and Honors:

Searle Scholar Award
Camille and Henry Dreyfus New Faculty Award
Harvard Detur Prize
Phi Beta Kappa Junior Twelve
UCLA Seaborg Award
UCLA Apple Workgroup Cluster for Bioinformatics Award
MIT Technology Review TR100 Award
Camille and Henry Dreyfus Teacher-Scholar Award
Harvard's Thomas Hoopes Prize for Undergraduate Thesis Research
American Cancer Society Postdoctoral Fellowship
Howard Hughes Medical Institute Predoctoral Fellowship

Detailed Biography:

Prof. Lee has been a Faculty member in the Department of Chemistry and Biochemistry since 1998. His training provided an unusual combination of experimental cell biology, biophysics, and algorithm development, which he has has applied at UCLA to bioinformatics analysis of genome evolution. He has led efforts to establish a bioinformatics Ph.D. program at UCLA. He has served on the Board of Scientific Counselors, NIH National Center for Biotechnology Information, and serves on the editorial board of Biology Direct . His current research focuses on alternative splicing and its role in genome evolution.

Selected Publications:

Lee Christopher Open peer review by a selected-papers network. Frontiers in computational neuroscience. 2012; 6(12): 1.
Lu Hongchao, Lin Lan, Sato Seiko, Xing Yi, Lee Christopher J Predicting functional alternative splicing by measuring RNA selection pressure from multigenome alignments. PLoS computational biology. 2009; 5(12): e1000608.
Wang Qi, Barr Ian, Guo Feng, Lee Christopher Evidence of a novel RNA secondary structure in the coding region of HIV-1 pol gene. RNA (New York, N.Y.). 2008; 14(12): 2478-88.
Roy Meenakshi, Kim Namshin, Xing Yi, Lee Christopher The effect of intron length on exon creation ratios during the evolution of mammalian genomes. RNA (New York, N.Y.). 2008; 14(11): 2261-73.
Parker Douglass Stott, Hsiao Ruey-Lung, Xing Yi, Resch Alissa M, Lee Christopher J Solving the problem of Trans-Genomic Query with alignment tables. IEEE/ACM transactions on computational biology and bioinformatics / IEEE, ACM. 2008; 5(3): 432-47.
Kim Namshin, Lee Christopher Bioinformatics detection of alternative splicing. Methods Mol. Biol. 2008; 452(1): 179-97.
Wang Qi, Lee Christopher Distinguishing functional amino acid covariation from background linkage disequilibrium in HIV protease and reverse transcriptase. PLoS ONE. 2007; 2(8): e814.
Kim Namshin, Lee Christopher QPRIMER: a quick web-based application for designing conserved PCR primers from multigenome alignments. Bioinformatics. 2007; 23(17): 2331-3.
Kim Namshin, Lee Christopher Three-Dimensional Phylogeny Explorer: distinguishing paralogs, lateral transfer, and violation of . BMC Bioinformatics. 2007; 8(3): 213.
Alekseyenko Alexander V, Lee Christopher J Nested Containment List (NCList): a new algorithm for accelerating interval query of genome alignment and interval databases. Bioinformatics. 2007; 23(11): 1386-93.
Alekseyenko Alexander V, Kim Namshin, Lee Christopher J Global analysis of exon creation versus loss and the role of alternative splicing in 17 vertebrate genomes. RNA. 2007; 13(5): 661-70.
Xing Yi, Lee Christopher Relating alternative splicing to proteome complexity and genome evolution. Adv. Exp. Med. Biol. 2007; 623(2): 36-49.
Kim Namshin, Alekseyenko Alexander V, Roy Meenakshi, Lee Christopher The ASAP II database: analysis and comparative genomics of alternative splicing in 15 animal species. Nucleic Acids Res. 2007; 35(Database issue): D93-8.
Pan Calvin, Kim Joseph, Chen Lamei, Wang Qi, Lee Christopher The HIV positive selection mutation database. Nucleic Acids Res. 2007; 35(Database issue): D371-5.
Xing Yi, Lee Christopher Alternative splicing and RNA selection pressure--evolutionary consequences for eukaryotic genomes. Nat. Rev. Genet. 2006; 7(7): 499-509.
Xing Yi, Yu Tianwei, Wu Ying Nian, Roy Meenakshi, Kim Joseph, Lee Christopher An expectation-maximization algorithm for probabilistic reconstructions of full-length isoforms from splice graphs. Nucleic Acids Res. 2006; 34(10): 3150-60.
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