Christopher Lee

A Short Biography:

Professor Lee received a B.A. summa cum laude in Biochemistry and Molecular Biology in 1988 from Harvard College, and a Ph.D. in Structural Biology from Stanford University in 1993. He co-founded Molecular Applications Group with Michael Levitt in 1993, and served as Vice-President for Research until 1998. After completing a postdoctoral fellowship in the Department of Chemistry at Stanford, he joined the UCLA faculty in 1998.

Prof. Lee accepts graduate students through the Biochemistry and Molecular Biology (BMB) Graduate Program and the UCLA ACCESS Ph.D. Program.

Work Titles and Affiliation
UCLA Professor, Chemistry and Biochemistry
Howard Hughes Medical Institute, Predoctoral Fellowship
American Cancer Society, Postdoctoral Fellowship
Honors and Awards:
Camille and Henry Dreyfus Teacher-Scholar Award
Searle Scholar Award
Camille and Henry Dreyfus New Faculty Award
UCLA, Seaborg Award
Harvard, Detur Prize
UCLA, Apple Workgroup Cluster for Bioinformatics Award
Harvard's Thomas Hoopes Prize for Undergraduate Thesis Research
MIT, Technology Review TR100 Award
Phi Beta Kappa Junior Twelve

Contact Information:

Work Email Address:



Fax Number:

(310) 206-7286

Lab Number:

1 (310) 794-4026

Work Phone Number:

1 (310) 825-7374

Laboratory Address:

Paul Boyer Hall 609

Work Address:

Paul Boyer Hall 601A

Detailed Biography:

Prof. Lee has been a Faculty member in the Department of Chemistry and Biochemistry since 1998. His training provided an unusual combination of experimental cell biology, biophysics, and algorithm development, which he has has applied at UCLA to bioinformatics analysis of genome evolution. He has led efforts to establish a bioinformatics Ph.D. program at UCLA. He has served on the Board of Scientific Counselors, NIH National Center for Biotechnology Information, and serves on the editorial board of Biology Direct . His current research focuses on alternative splicing and its role in genome evolution.


Lee Christopher   Open peer review by a selected-papers network Frontiers in computational neuroscience, 2012; 6(12): 1.
Lu Hongchao, Lin Lan, Sato Seiko, Xing Yi, Lee Christopher J   Predicting functional alternative splicing by measuring RNA selection pressure from multigenome alignments PLoS computational biology, 2009; 5(12): e1000608.
Wang Qi, Barr Ian, Guo Feng, Lee Christopher   Evidence of a novel RNA secondary structure in the coding region of HIV-1 pol gene RNA (New York, N.Y.), 2008; 14(12): 2478-88.
Roy Meenakshi, Kim Namshin, Xing Yi, Lee Christopher   The effect of intron length on exon creation ratios during the evolution of mammalian genomes RNA (New York, N.Y.), 2008; 14(11): 2261-73.
Parker Douglass Stott, Hsiao Ruey-Lung, Xing Yi, Resch Alissa M, Lee Christopher J   Solving the problem of Trans-Genomic Query with alignment tables IEEE/ACM transactions on computational biology and bioinformatics / IEEE, ACM, 2008; 5(3): 432-47.
Kim Namshin, Lee Christopher   Bioinformatics detection of alternative splicing Methods Mol. Biol, 2008; 452(1): 179-97.
Kim Namshin, Lee Christopher   QPRIMER: a quick web-based application for designing conserved PCR primers from multigenome alignments Bioinformatics, 2007; 23(17): 2331-3.
Kim Namshin, Lee Christopher   Three-Dimensional Phylogeny Explorer: distinguishing paralogs, lateral transfer, and violation of BMC Bioinformatics, 2007; 8(3): 213.
Alekseyenko Alexander V, Lee Christopher J   Nested Containment List (NCList): a new algorithm for accelerating interval query of genome alignment and interval databases Bioinformatics, 2007; 23(11): 1386-93.
Alekseyenko Alexander V, Kim Namshin, Lee Christopher J   Global analysis of exon creation versus loss and the role of alternative splicing in 17 vertebrate genomes RNA, 2007; 13(5): 661-70.
Xing Yi, Lee Christopher   Relating alternative splicing to proteome complexity and genome evolution Adv. Exp. Med. Biol, 2007; 623(2): 36-49.
Kim Namshin, Alekseyenko Alexander V, Roy Meenakshi, Lee Christopher   The ASAP II database: analysis and comparative genomics of alternative splicing in 15 animal species Nucleic Acids Res, 2007; 35(Database issue): D93-8.
Pan Calvin, Kim Joseph, Chen Lamei, Wang Qi, Lee Christopher   The HIV positive selection mutation database Nucleic Acids Res, 2007; 35(Database issue): D371-5.
Xing Yi, Lee Christopher   Alternative splicing and RNA selection pressure--evolutionary consequences for eukaryotic genomes Nat. Rev. Genet, 2006; 7(7): 499-509.
Xing Yi, Yu Tianwei, Wu Ying Nian, Roy Meenakshi, Kim Joseph, Lee Christopher   An expectation-maximization algorithm for probabilistic reconstructions of full-length isoforms from splice graphs Nucleic Acids Res, 2006; 34(10): 3150-60.

MeSH Terms:

What is MeSH?

Medical Subject Headings

We have integrated Faculty Profiles with the U.S. National Library of Medicine's MeSH terms. For every publication added to a profile, we pull its MeSH terms and display it here. This enhancement allows you to search for research themes of our faculty members.

Click on any of the terms below to see additional researchers with similar keywords.

MeSH is:

  • an acronym for Medical Subject Headings.
  • the U.S. National Library of Medicine's controlled vocabulary (thesaurus).
  • a vocabulary that gives uniformity and consistency to the indexing and cataloging of biomedical literature.
  • a distinctive feature of MEDLINE.
  • arranged in a hierarchical manner called the MeSH Tree Structures.
  • updated annually.

MeSH Vocabulary includes four types of terms:

  • Headings
  • Subheadings
  • Supplementary Concept Records
  • Publication Characteristics (or Types)

Over 26,000 MeSH headings (also called "main headings" or "descriptors" represents concepts found in the biomedical literature

Subheadings - (also called qualifiers) are attached to MeSH headings to describe a specific aspect of a concept.

Supplementary Concept Records are over 200,000 terms in a separate thesaurus from the Medical Subject Headings. These are primarily substance terms, but also include some protocols and rare desease terms. These terms are updated weekly.

Publication Characteristics or (Publication Types) describe the type of publication being indexed; i.e., what the item is, not what the article is about.

Information from U.S. National Library of Medicine.

Algorithms Alternative Splicing Animals Base Sequence Chromosome Mapping Computational Biology Computer Simulation Conserved Sequence Databases, Genetic Databases, Nucleic Acid Evolution, Molecular Exons Expressed Sequence Tags Genome Genomics HIV Protease HIV-1 Humans Internet Introns Mice Models, Genetic Molecular Sequence Data Oligonucleotide Array Sequence Analysis RNA RNA Splice Sites Reverse Transcriptase Polymerase Chain Reaction Selection, Genetic Sequence Alignment Sequence Analysis, DNA Software User-Computer Interface

Does this profile need updating? Contact Us