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Fax Number:

(310) 825-8685

Work Phone Number:

(310) 825-8002

Work Address:

5-357C Gonda / AV-628 CHS
CAMPUS -176620
Los Angeles, CA 90095
UNITED STATES Office
Gonda Center
Los Angeles, CA 90095
UNITED STATES

Work Email Address:

janet@mednet.ucla.edu

Website:

Home Page.

Detailed Biography:

Janet Sinsheimer is a Professor in the Departments of Human Genetics, Biomathematics and Biostatistics at UCLA. She has a PhD in Biomathematics (UCLA), an MA in Biochemistry (Brandeis) and an ScB in Chemistry (Brown U). Dr. Sinsheimer's research is focused on developing mathematical models of evolution and genetics. Her research program involves the development and application of statistical methodology for mapping complex trait and disease genes. Most recently, her group have been working on statistical methods for detecting disease genes acting through maternal-fetal genotype incompatibility and models to disentangle maternal genetic effects from environment. She has also developed methods for realistic inference of evolutionary relationships in a Bayesian context and applied these methods to HIV evolution. Her research in HIV evolution has been geared towards understanding the mechanisms by which HIV evades the immune system.

J.J. Zhou, K. Lange, J.C. Papp, J.S. Sinsheimer A heterozygote-homozygote test of Hardy-Weinberg equilibrium. European Journal of Human Genetics 2009; .

J. Sinsheimer Statistical genetic approaches for mapping ophthalmic trait and disease genes. Am J Ophthalmol. 2009; 148: 183-5.

M.E. Sehl, L.R. Langer, J.C. Papp, L. Kwan, J.L. Seldon, G. Arellano, J. Reiss, E.F. Reed, S. Dandekar, Y. Korin, J.S. Sinsheimer, Z. F. Zhang, P.A. Ganz Associations between single nucleotide polymorphisms in double-stranded DNA repair pathway genes and familial breast cancer. Clinical Cancer Research 2009; 15: 2192-203.

C.S.G. Palmer, E. Mallery, J.A. Turunen, H.J. Hsieh, L. Peltonen, J. Lonnqvist, J.A. Woodward, J.S. Sinsheimer Effect of Rhesus D incompatibility on schizophrenia depends on offspring sex.. Schizophrenia Research 2008; 104: 135-45.

L.E. Bauman, J.S. Sinsheimer, E.M. Sobel, K. Lange Mixed effects models for quantitative trait Loci mapping with inbred strains. Genetics 2008; 180: 1743-1761.

G. Nikolova, H. Lee, S. Berkovitz, S. Nelson, J. Sinsheimer, E. Vilain, L.. Rodriguez. Sequence variant in the laminin gamma 1 (LAMC1) gene associated with familial pelvic organ prolapse.. Human Genetics 2007; 120: 847-856.

H.-J. Hsieh, C.G. S. Palmer, S. Harney, H.-W. Chen, L. Bauman, M. A. Brown, J.S. Sinsheimer. Using the MFG Test to Assess Non-Inherited Maternal HLA-DRB1 Antigen Coding Alleles as Rheumatoid Arthritis Risk Factors. BMC Proceedings 2007; 1(1): .

S. Kim, Y. Kim, T. Liang, J.S. Sinsheimer, S.A. Cho A high throughput method of cloning and sequencing HIV-1 integration sites.. Journal of Virology 2006; 80: 11313-21.

H.-J. Hsieh, C.G.S. Palmer, J.S. Sinsheimer Allowing for missing data at highly polymorphic genes when testing for maternal, offspring and maternal-fetal genotype incompatibility effects. Human Heredity. 2006; 62: 165-174.
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C.G.S. Palmer, H-J. Hsieh, E.F. Reed, J. Lonnqvist, L. Peltonen, J.A. Woodward, J.S. Sinsheimer. HLA-B maternal-fetal genotype matching increases risk of schizophrenia. . American Journal of Human Genetics. 2006; 79: 710-715.
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S. Minassian, C. G. S. Palmer, J. A. Turunen, T. Paunio, J. Lonnqvist, L. Peltonen, J. A. Woodward, J. S. Sinsheimer Incorporating Serotypes into Family Based Association Studies using the MFG Test. Annals of Human Genetic. 2006; 70: 541-553.
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H-J. Hsieh, C.G.S. Palmer, S.Harney, J. L. Newton, P. Wordsworth, M.A. Brown, J.S. Sinsheimer The v-MFG test: Investigating maternal, offspring, and maternal-fetal genetic incompatibility effects on disease and viability. Genetic Epidemiology. 2006; 30(4): 333.
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S. L. Minassian, C. G. S. Palmer, J. S. Sinsheimer An exact maternal-fetal genotype incompatibility (MFG) test. Genetic Epidemiology. 2005; 28: 83-95.
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K. Lange, J. S. Sinsheimer, E. Sobel Association Testing with Mendel. Genetic Epidemiology. 2005; 29: 36-50.
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L. Bauman, L. Almasy, J. Blangero, R. Duggirala, J. S. Sinsheimer, K. Lange Fishing for Pleiotropic QTLs in a Polygenic Sea. Ann Hum Gen . 2005; 69: 590-611.
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M. A. Suchard, R. E. Weiss, J. S. Sinsheimer Models for estimating Bayes factors with applications to phylogeny and tests of monophyly. Biometrics. 2005; 61: 665-673.
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Kraft P, Palmer CGS, Woodward JA, Turunen JA, Minassian S, Paunio T, Lonnqvist J, Peltonen L, Sinsheimer JS RHD Maternal-fetal genotype incompatibility and schizophrenia: extending the MFG test to include multiple siblings and birth order . European Journal of Human Genetics 2004; 12: 192-198.

Dorman KS, Sinsheimer JS, Lange K In the Garden of Branching Processes. SIAM Reviews 2004; 46: 202-229.

Lange K, Sinsheimer JS The pedigree trimming problem.. Human heredity. . 2004; 58(2): 108-11.

Sinsheimer JS, Suchard MA, Dorman KS, Fang F, Weiss RE Are you my mother? Bayesian phylogenetic inference of recombination among putative parental strains. Appl Bioinformatics. 2003; 2(3): 131-44.

Dorman KS, Kaplan AH, Sinsheimer JS Bootstrap confidence levels for HIV-1 recombinants.. Journal of Molecular Evolution 2002; 54: 200-209.

Palmer CGS, Turunen J, Sinsheimer JS, Minassian S, Paunio T, Lonnqvist J, Peltonen L, Woodward JA Maternal-fetal genotype incompatibility: evidence that the RHD locus increases susceptibility to schizophrenia.. American Journal of Human Genetics 2002; 71: 1312-1319.

Sinsheimer JS, McKenzie CA, Keavney B, Lange K SNPs and snails and puppy dog tails: analysis of SNP haplotype data using the gamete competition model.. Annals of Human Genetics 2001; 65: 483-490 .

Minassian SL, Palmer CG, Sinsheimer JS An exact maternal-fetal genotype incompatibility (MFG) test.. Genetic epidemiology. . 2005; 28(1): 83-95.

Mar R, Pajukanta P, Allayee H, Groenendijk M, Dallinga-Thie G, Krauss RM, Sinsheimer JS, Cantor RM, de Bruin TW, Lusis AJ Association of the APOLIPOPROTEIN A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemia.. Circulation research. . 2004; 94(7): 993-9.

Pajukanta P, Lilja HE, Sinsheimer JS, Cantor RM, Lusis AJ, Gentile M, Duan XJ, Soro-Paavonen A, Naukkarinen J, Saarela J, Laakso M, Ehnholm C, Taskinen MR, Peltonen L Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1).. Nature genetics. . 2004; 36(4): 371-6.