Janet Sinsheimer, Ph.D.


Work Titles
UCLA Professor, Biostatistics Professor, Human Genetics Professor and Interim Chair, Biomathematics Faculty, BWF-IT-MD Faculty, Center for Metabolic Disease Prevention
Education:
Degrees:
Ph.D.

Contact Information:

Work Email Address:

janets@mednet.ucla.edu


Website:

Biostatistics

Fax Number:

(310) 825-8685

Work Phone Number:

(310) 825-8002

Work Address:

5-357C Gonda / 5213 LSB
Los Angeles, CA 90095

Office
Gonda Center
Los Angeles, CA 90095


Detailed Biography:

Janet Sinsheimer is a Professor in the Departments of Human Genetics, Biomathematics and Biostatistics at UCLA. She is the Interim Chair of the Department of Biomathematics. She has a PhD in Biomathematics (UCLA), an MA in Biochemistry (Brandeis) and an ScB in Chemistry (Brown U). Dr. Sinsheimer's research is focused on developing mathematical models of evolution and genetics. Her research program involves the development and application of statistical methodology for mapping complex trait and disease genes. Most recently, her group have been working on statistical methods for detecting disease genes acting through maternal-fetal genotype incompatibility and models to disentangle maternal genetic effects from environment. She has also developed methods for realistic inference of evolutionary relationships in a Bayesian context and applied these methods to HIV evolution. Her research in HIV evolution has been geared towards understanding the mechanisms by which HIV evades the immune system.

Publications:

Palmer Christina G S, Boudreault Patrick, Baldwin Erin E, Fox Michelle, Deignan Joshua L, Kobayashi Yoko, Sininger Yvonne, Grody Wayne, Sinsheimer Janet S   Deaf genetic testing and psychological well-being in deaf adults Journal of genetic counseling, 2013; 22(4): 492-507.
Lee Pei-Chen, Rhodes Shannon L, Sinsheimer Janet S, Bronstein Jeff, Ritz Beate   Functional paraoxonase 1 variants modify the risk of Parkinson's disease due to organophosphate exposure Environment international, 2013; 56(12): 42-7.
Lange Kenneth, Papp Jeanette C, Sinsheimer Janet S, Sripracha Ram, Zhou Hua, Sobel Eric M   Mendel: the Swiss army knife of genetic analysis programs Bioinformatics (Oxford, England), 2013; 29(12): 1568-70.
Weissglas-Volkov Daphna, Aguilar-Salinas Carlos A, Nikkola Elina, Deere Kerry A, Cruz-Bautista Ivette, Arellano-Campos Olimpia, Muñoz-Hernandez Linda Liliana, Gomez-Munguia Lizeth, Ordoñez-Sánchez Maria Luisa, Reddy Prasad M V Linga, Lusis Aldons J, Matikainen Niina, Taskinen Marja-Riitta, Riba Laura, Cantor Rita M, Sinsheimer Janet S, Tusie-Luna Teresa, Pajukanta Päivi   Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci Journal of medical genetics, 2013; 50(5): 298-308.
Cybis Gabriela B, Sinsheimer Janet S, Lemey Philippe, Suchard Marc A   Graph hierarchies for phylogeography Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2013; 368(1614): 20120206.
Anastasopoulos Eleftherios, Kakoulidou Anastasia, Coleman Anne L, Sinsheimer Janet S, Wilson M Roy, Yu Fei, Salonikiou Aggeliki, Koskosas Archimidis, Pappas Theofanis, Founti Panayiota, Lambropoulos Alexandros, Topouzis Fotis   Association of sequence variation in the CX3CR1 gene with geographic atrophy age-related macular degeneration in a Greek population Current eye research, 2012; 37(12): 1148-55.
Reddy M V Prasad Linga, Iatan Iulia, Weissglas-Volkov Daphna, Nikkola Elina, Haas Blake E, Juvonen Miina, Ruel Isabelle, Ruel Miina Juvonen Isabelle, Sinsheimer Janet S, Genest Jacques, Pajukanta Päivi   Exome sequencing identifies 2 rare variants for low high-density lipoprotein cholesterol in an extended family Circulation. Cardiovascular genetics, 2012; 5(5): 538-46.
Tom Jennifer A, Sinsheimer Janet S, Suchard Marc A   Does history repeat itself? Wavelets and the phylodynamics of influenza A Molecular biology and evolution, 2012; 29(5): 1367-77.
Deere Kerry A, Grether Gregory F, Sun Aida, Sinsheimer Janet S   Female mate preference explains countergradient variation in the sexual coloration of guppies (Poecilia reticulata) Proceedings. Biological sciences / The Royal Society, 2012; 279(1734): 1684-90.
Baldwin Erin E, Boudreault Patrick, Fox Michelle, Sinsheimer Janet S, Palmer Christina G S   Effect of pre-test genetic counseling for deaf adults on knowledge of genetic testing Journal of genetic counseling, 2012; 21(2): 256-72.
Riley Lindsay, Zhou Hua, Lange Kenneth, Sinsheimer Janet S, Sehl Mary E   Determining duration of HER2-targeted therapy using stem cell extinction models PloS one, 2012; 7(12): e46613.
Levine Andrew J, Sinsheimer Janet S, Bilder Robert, Shapshak Paul, Singer Elyse J   Functional polymorphisms in dopamine-related genes: effect on neurocognitive functioning in HIV+ adults Journal of clinical and experimental neuropsychology, 2012; 34(1): 78-91.
Zhou Jin J, Ghazalpour Anatole, Sobel Eric M, Sinsheimer Janet S, Lange Kenneth   Quantitative trait Loci association mapping by imputation of strain origins in multifounder crosses Genetics, 2012; 190(2): 459-73.
Sinsheimer Janet S, Little Roderick J A, Lake James A   Rooting gene trees without outgroups: EP rooting Genome biology and evolution, 2012; 4(8): 709-19.
Sehl Mary, Zhou Hua, Sinsheimer Janet S, Lange Kenneth L   Extinction models for cancer stem cell therapy Mathematical biosciences, 2011; 234(2): 132-46.
Sinsheimer Janet   "Statistics 101"--a primer for the genetics of complex human disease Cold Spring Harbor protocols, 2011; 2011(10): 1190-9.
Weissglas-Volkov Daphna, Calkin Anna C, Tusie-Luna Teresa, Sinsheimer Janet S, Zelcer Noam, Riba Laura, Tino Ana Maria Vargas, Ordoñez-Sánchez Maria Luisa, Cruz-Bautista Ivette, Aguilar-Salinas Carlos A, Tontonoz Peter, Pajukanta Päivi   The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans The Journal of clinical investigation, 2011; 121(8): 3062-71.
Ghazalpour Anatole, Bennett Brian, Petyuk Vladislav A, Orozco Luz, Hagopian Raffi, Mungrue Imran N, Farber Charles R, Sinsheimer Janet, Kang Hyun M, Furlotte Nicholas, Park Christopher C, Wen Ping-Zi, Brewer Heather, Weitz Karl, Camp David G, Pan Calvin, Yordanova Roumyana, Neuhaus Isaac, Tilford Charles, Siemers Nathan, Gargalovic Peter, Eskin Eleazar, Kirchgessner Todd, Smith Desmond J, Smith Richard D, Lusis Aldons J   Comparative analysis of proteome and transcriptome variation in mouse PLoS genetics, 2011; 7(6): e1001393.
Suwanwela Jaijam, Lee Jaehoon, Lin Audrey, Ucer T Cemal, Devlin Hugh, Sinsheimer Janet, Garrett Neal R, Nishimura Ichiro   A genetic association study of single nucleotide polymorphisms in FGFR1OP2/wit3.0 and long-term atrophy of edentulous mandible PloS one, 2011; 6(1): e16204.
Childs Erica J, Sobel Eric M, Palmer Christina G S, Sinsheimer Janet S   Detection of intergenerational genetic effects with application to HLA-B matching as a risk factor for schizophrenia Human heredity, 2011; 72(3): 161-72.
Bocklandt Sven, Lin Wen, Sehl Mary E, Sánchez Francisco J, Sinsheimer Janet S, Horvath Steve, Vilain Eric   Epigenetic predictor of age PloS one, 2011; 6(6): e14821.
Rhodes Shannon L, Sinsheimer Janet S, Bordelon Yvette, Bronstein Jeff M, Ritz Beate   Replication of GWAS associations for GAK and MAPT in Parkinson's disease Annals of human genetics, 2011; 75(2): 195-200.
Zhou Hua, Sehl Mary E, Sinsheimer Janet S, Lange Kenneth   Association screening of common and rare genetic variants by penalized regression Bioinformatics (Oxford, England), 2010; 26(19): 2375-82.
Boudreault Patrick, Baldwin Erin E, Fox Michelle, Dutton Loriel, Tullis Leeelle, Linden Joyce, Kobayashi Yoko, Zhou Jin, Sinsheimer Janet S, Sininger Yvonne, Grody Wayne W, Palmer Christina G S   Deaf adults' reasons for genetic testing depend on cultural affiliation: results from a prospective, longitudinal genetic counseling and testing study Journal of deaf studies and deaf education, 2010; 15(3): 209-27.
van Nas Atila, Ingram-Drake Leslie, Sinsheimer Janet S, Wang Susanna S, Schadt Eric E, Drake Thomas, Lusis Aldons J   Expression quantitative trait loci: replication, tissue- and sex-specificity in mice Genetics, 2010; 185(3): 1059-68.
Childs Erica J, Palmer Christina G S, Lange Kenneth, Sinsheimer Janet S   Modeling maternal-offspring gene-gene interactions: the extended-MFG test Genetic epidemiology, 2010; 34(5): 512-21.
Weissglas-Volkov Daphna, Plaisier Christopher L, Huertas-Vazquez Adriana, Cruz-Bautista Ivette, Riaño-Barros Daniela, Herrera-Hernandez Miguel, Riba Laura, Cantor Rita M, Sinsheimer Janet S, Aguilar-Salinas Carlos A, Tusie-Luna Teresa, Pajukanta Päivi   Identification of two common variants contributing to serum apolipoprotein B levels in Mexicans Arteriosclerosis, thrombosis, and vascular biology, 2010; 30(2): 353-9.
Weissglas-Volkov Daphna, Aguilar-Salinas Carlos A, Sinsheimer Janet S, Riba Laura, Huertas-Vazquez Adriana, Ordoñez-Sánchez Maria L, Rodriguez-Guillen Rosario, Cantor Rita M, Tusie-Luna Teresa, Pajukanta Päivi   Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples Circulation. Cardiovascular genetics, 2010; 3(1): 31-8.
Sinsheimer Janet S, Elston Robert C, Fu Wenjiang J   Gene-gene interaction in maternal and perinatal research Journal of biomedicine & biotechnology, 2010; 2010(1): .
Cantor Rita M, Lange Kenneth, Sinsheimer Janet S   Prioritizing GWAS results: A review of statistical methods and recommendations for their application American journal of human genetics, 2010; 86(1): 6-22.
Sehl Mary E, Sinsheimer Janet S, Zhou Hua, Lange Kenneth L   Differential destruction of stem cells: implications for targeted cancer stem cell therapy Cancer research, 2009; 69(24): 9481-9.
Bonneaud Camille, Sinsheimer Janet S, Richard Murielle, Chastel Olivier, Sorci Gabriele   Mhc polymorphisms fail to explain the heritability of phytohaemagglutinin-induced skin swelling in a wild passerine Biology letters, 2009; 5(6): 784-7.
Zhou Jin J, Lange Kenneth, Papp Jeanette C, Sinsheimer Janet S   A heterozygote-homozygote test of Hardy-Weinberg equilibrium European journal of human genetics : EJHG, 2009; 17(11): 1495-500.
Levine Andrew J, Singer Elyse J, Sinsheimer Janet S, Hinkin Charles H, Papp Jeanette, Dandekar Sugandha, Giovanelli Allison, Shapshak Paul   CCL3 genotype and current depression increase risk of HIV-associated dementia Neurobehavioral HIV medicine, 2009; 1(11): 1-7.
Meex Steven J R, Weissglas-Volkov Daphna, van der Kallen Carla J H, Thuerauf Donna J, van Greevenbroek Marleen M J, Schalkwijk Casper G, Stehouwer Coen D A, Feskens Edith J M, Heldens Lonneke, Ayoubi Torik A, Hofker Marten H, Wouters Bradly G, Vlietinck Robert, Sinsheimer Janet S, Taskinen Marja-Riitta, Kuusisto Johanna, Laakso Markku, de Bruin Tjerk W A, Pajukanta Päivi, Glembotski Christopher C   The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels Arteriosclerosis, thrombosis, and vascular biology, 2009; 29(9): 1322-7.
Sinsheimer Janet   Statistical genetic approaches for mapping ophthalmic trait and disease genes American journal of ophthalmology, 2009; 148(2): 183-5.
J.J. Zhou, K. Lange, J.C. Papp, J.S. Sinsheimer   A heterozygote-homozygote test of Hardy-Weinberg equilibrium, European Journal of Human Genetics, 2009; .
J. Sinsheimer   Statistical genetic approaches for mapping ophthalmic trait and disease genes, Am J Ophthalmol, 2009; 148: 183-5.
M.E. Sehl, L.R. Langer, J.C. Papp, L. Kwan, J.L. Seldon, G. Arellano, J. Reiss, E.F. Reed, S. Dandekar, Y. Korin, J.S. Sinsheimer, Z. F. Zhang, P.A. Ganz   Associations between single nucleotide polymorphisms in double-stranded DNA repair pathway genes and familial breast cancer, Clinical Cancer Research, 2009; 15: 2192-203.
Sehl Mary E, Langer Lucy R, Papp Jeanette C, Kwan Lorna, Seldon Joyce L, Arellano Geovanni, Reiss Jean, Reed Elaine F, Dandekar Sugandha, Korin Yael, Sinsheimer Janet S, Zhang Zuo-Feng, Ganz Patricia A   Associations between single nucleotide polymorphisms in double-stranded DNA repair pathway genes and familial breast cancer Clinical cancer research : an official journal of the American Association for Cancer Research, 2009; 15(6): 2192-203.
Plaisier Christopher L, Kyttälä Mira, Weissglas-Volkov Daphna, Sinsheimer Janet S, Huertas-Vazquez Adriana, Riba Laura, Ramírez-Jiménez Salvador, de Bruin Tjerk W A, Tusié-Luna Teresa, Aouizerat Bradley E, Pullinger Clive R, Malloy Mary J, Kane John P, Cruz-Bautista Ivette, Herrera Miguel F, Aguilar-Salinas Carlos, Kuusisto Johanna, Laakso Markku, Taskinen Marja-Riitta, van der Kallen Carla J H, Pajukanta Päivi   Galanin preproprotein is associated with elevated plasma triglycerides Arteriosclerosis, thrombosis, and vascular biology, 2009; 29(1): 147-52.
Crandall Carolyn J, Sehl Mary E, Crawford Sybil L, Gold Ellen B, Habel Laurel A, Butler Lesley M, Sowers Maryfran R, Greendale Gail A, Sinsheimer Janet S   Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women Breast cancer research : BCR, 2009; 11(4): R51.
Bauman Lara E, Sinsheimer Janet S, Sobel Eric M, Lange Kenneth   Mixed effects models for quantitative trait loci mapping with inbred strains Genetics, 2008; 180(3): 1743-61.
Palmer Christina G S, Mallery Erin, Turunen Joni A, Hsieh Hsin-Ju, Peltonen Leena, Lonnqvist Jouko, Woodward J Arthur, Sinsheimer Janet S   Effect of Rhesus D incompatibility on schizophrenia depends on offspring sex Schizophrenia research, 2008; 104(1-3): 135-45.
C.S.G. Palmer, E. Mallery, J.A. Turunen, H.J. Hsieh, L. Peltonen, J. Lonnqvist, J.A. Woodward, J.S. Sinsheimer   Effect of Rhesus D incompatibility on schizophrenia depends on offspring sex, Schizophrenia Research, 2008; 104: 135-45.
L.E. Bauman, J.S. Sinsheimer, E.M. Sobel, K. Lange   Mixed effects models for quantitative trait Loci mapping with inbred strains, Genetics, 2008; 180: 1743-1761.
Seitzman Robin L, Mahajan Vinit B, Mangione Carol, Cauley Jane A, Ensrud Kristine E, Stone Katie L, Cummings Steven R, Hochberg Marc C, Hillier Teresa A, Sinsheimer Janet S, Yu Fei, Coleman Anne L, Coleman Anne L   Estrogen receptor alpha and matrix metalloproteinase 2 polymorphisms and age-related maculopathy in older women American journal of epidemiology, 2008; 167(10): 1217-25.
Nikolova Ganka, Sinsheimer Janet S, Eicher Eva M, Vilain Eric   The chromosome 11 region from strain 129 provides protection from sex reversal in XYPOS mice Genetics, 2008; 179(1): 419-27.
Lee Yuan-Chin Amy, Morgenstern Hal, Greenland Sander, Tashkin Donald P, Papp Jeanette, Sinsheimer Janet, Cao Wei, Hashibe Mia, You Nai-Chieh Y, Mao Jenny T, Cozen Wendy, Mack Thomas M, Zhang Zuo-Feng   A case-control study of the association of the polymorphisms and haplotypes of DNA ligase I with lung and upper-aerodigestive-tract cancers International journal of cancer. Journal international du cancer, 2008; 122(7): 1630-8.
Sinsheimer Janet S, Plaisier Christopher L, Huertas-Vazquez Adriana, Aguilar-Salinas Carlos, Tusie-Luna Teresa, Pajukanta Päivi, Lange Kenneth   Estimating ethnic admixture from pedigree data The American Journal of Human Genetics, 2008; 82(3): 748-55.

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