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RESEARCH
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Michael Phelps, Ph.D.
Contact Information:
Work Phone Number:
310-825-6539
Mailing Address:
Mail Code: 173517 Los Angeles, CA 90095 UNITED STATES
Work Address:
Office 23-138 CHS, 10833 Le Conte Ave. Los Angeles, CA 90095 UNITED STATES
Chair,
DOE Funded Faculty
Biomedical Physics IDP
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Director,
Crump Institute for Molecular Imaging
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Chair,
Molecular & Medical Pharmacology
Institute for Molecular Medicine
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Director,
Institute for Molecular Medicine |
Norton Simon Professor,
Molecular & Medical Pharmacology
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Professor,
Biomathematics
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Member,
ACCESS Program: Dept. of Molecular & Medical Pharmacology
Cancer Molecular Imaging
Internal Advisory Board
NanoBiotechnology and Biomaterials
Brain Research Institute
CTSI
California NanoSystems Institute
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Faculty,
Cellular and Molecular Pathology PhD Program
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Investigator,
Center for Translational Technologies
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A Short Biography:
Michael Phelps, the Norton Simon Professor and Chair of the UCLA Department of Molecular and Medical Pharmacology, has been on the faculty of the University of California since 1976. He is actively engaged in medical research, educational programs and multimedia technologies at UCLA. Dr. Phelps uniquely holds six academic positions at UCLA. In addition to serving as the Departmental Chairman and holding an endowed professorship, he is also the Director of the Crump Institute for Molecular Imaging, Professor of Biomathematics, the Director of the Institute for Molecular Medicine and the Chief of Nuclear Medicine.
He has received numerous awards, among them, the 1992 Pasarow Foundation Award, the 1987 Rosenthal Foundation Award of the American College of Physicians, the George Von Hevesy Prize (won twice) from the Von Hevesy Foundation in Zurich (Von Hevesy won the Nobel Prize in Chemistry), the 1984 Sarah L. Poiley Memorial Award from the New York Academy of Sciences, the 1984 Ernest O. Lawrence Presidential Award, the 1983 Paul Aebersold Award from the Society of Nuclear Medicine, chaired the 1983 Nobel Symposium, elected to the Institute of Medicine of the National Academy of Sciences in 1985, Enrico Fermi Presidential Award, 1998, elected to the National Academy of Sciences in 1999.
Dr. Phelps is the original inventor of PET (Positron Emission Tomography). PET is a molecular imaging technique that provides in vivo images of biological processes, blood flow, metabolism, cell communication systems, drug interactions and gene expression. PET is used in research to study the biological basis of normal organ function and the biological basis of disease. It is also routinely used as a clinical service in the early detection, characterization and evaluation of the therapeutic responses in cancer, neurological disorders and cardiovascular disease.
He has published over 520 scientific papers and books.
Awards and Honors:
President Clinton
Enrico Fermi Presidential Award
General Motors Cancer Research Foundation
Kettering Prize
Institute of Medicine
Elected
National Academy of Sciences
Elected
Detailed Biography:
Michael Phelps, the Norton Simon Professor and Chair of the UCLA Department of Molecular and Medical Pharmacology, has been on the faculty of the University of California since 1976. He is actively engaged in medical research, educational programs and multimedia technologies at UCLA. In addition to serving as the Departmental Chairman and holding an endowed professorship, he is also the Director of the Crump Institute for Molecular Imaging, and Professor of Biomathematics.
He has received numerous awards, among them, the 1992 Pasarow Foundation Award, the 1987 Rosenthal Foundation Award of the American College of Physicians, the George Von Hevesy Prize (won twice) from the Von Hevesy Foundation in Zurich (Von Hevesy won the Nobel Prize in Chemistry), the 1984 Sarah L. Poiley Memorial Award from the New York Academy of Sciences, the 1984 Ernest O. Lawrence Presidential Award, the 1983 Paul Aebersold Award from the Society of Nuclear Medicine, chaired the 1983 Nobel Symposium, elected to the Institute of Medicine of the National Academy of Sciences in 1985, Enrico Fermi Presidential Award, 1998, elected to the National Academy of Sciences in 1999.
Dr. Phelps is the original inventor of PET (Positron Emission Tomography). PET is a molecular imaging technique that provides in vivo images of biological processes, blood flow, metabolism, cell communication systems, drug interactions and gene expression. PET is used in research to study the biological basis of normal organ function and the biological basis of disease. It is also routinely used as a clinical service in the early detection, characterization and evaluation of the therapeutic responses in cancer, neurological disorders and cardiovascular disease.
He has published 720 peer-reviewed scientific articles and four textbooks.
Walter MA, Benz MR, Hildebrandt IJ, Laing RE, Hartung V, Damoiseaux RD, Bockisch A, Phelps ME, Czernin J, Weber WA Metabolic imaging allows early prediction of response to vandetanib.
J Nucl Med.
2011;
52(2):
231-40.
Sun J, Masterman-Smith MD, Graham NA, Jiao J, Mottahedeh J, Laks DR, Ohashi M, DeJesus J, Kamei K, Lee KB, Wang H, Yu ZT, Lu YT, Hou S, Li K, Liu M, Zhang N, Wang S, Angenieux B, Panosyan E, Samuels ER, Park J, Williams D, Konkankit V, Nathanson D, van Dam RM, Phelps ME, Wu H, Liau LM, Mischel PS, Lazareff JA, Kornblum HI, Yong WH, Graeber TG, Tseng HR A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens.
Cancer Res.
2010;
70(15):
6128-38.
Benz MR, Dry SM, Eilber FC, Allen-Auerbach MS, Tap WD, Elashoff D, Phelps ME, Czernin J Correlation between glycolytic phenotype and tumor grade in soft-tissue sarcomas by 18F-FDG PET.
J Nucl Med.
2010;
51(8):
1174-81.
Fueger BJ, Czernin J, Cloughesy T, Silverman DH, Geist CL, Walter MA, Schiepers C, Nghiemphu P, Lai A, Phelps ME, Chen W Correlation of 6-18F-fluoro-L-dopa PET uptake with proliferation and tumor grade in newly diagnosed and recurrent gliomas.
J Nucl Med.
2010;
51(10):
1532-8.
Phelps ME, Barrio JR Correlation of brain amyloid with "aerobic glycolysis": A question of assumptions?.
PNAS USA.
2010;
107(41):
17459-60.
Brewer S, Nair-Gill E, Wei B, Chen L, Li X, Riedinger M, Campbell DO, Wiltzius S, Satyamurthy N, Phelps ME, Radu C, Witte ON, Braun J Epithelial uptake of [18F]1-(2'-deoxy-2'-arabinofuranosyl) cytosine indicates intestinal inflammation in mice.
Gastroenterology.
2010;
138(4):
1266-75.
Benz MR, Czernin J, Tap WD, Eckardt JJ, Seeger LL, Allen-Auerbach MS, Dry SM, Phelps ME, Weber WA, Eilber FC FDG-PET/CT Imaging Predicts Histopathologic Treatment Responses after Neoadjuvant Therapy in Adult Primary Bone Sarcomas.
Sarcoma.
2010;
2010:
.
Schwarzenberg J, Radu CG, Benz M, Fueger B, Tran AQ, Phelps ME, Witte ON, Satyamurthy N, Czernin J, Schiepers C Human biodistribution and radiation dosimetry of novel PET probes targeting the deoxyribonucleoside salvage pathway.
Eur J Nucl Med Mol Imaging.
2010;
38(4):
711-21.
Fang C, Wang Y, Vu NT, Lin WY, Hsieh YT, Rubbi L, Phelps ME, Müschen M, Kim YM, Chatziioannou AF, Tseng HR, Graeber TG Integrated microfluidic and imaging platform for a kinase activity radioassay to analyze minute patient cancer samples.
Cancer Res.
2010;
70(21):
8299-308.
Schiepers C, Dahlbom M, Chen W, Cloughesy T, Czernin J, Phelps ME, Huang SC Kinetics of 3'-deoxy-3'-18F-fluorothymidine during treatment monitoring of recurrent high-grade glioma.
J Nucl Med.
2010;
51(5):
720-7.
Shu CJ, Campbell DO, Lee JT, Tran AQ, Wengrod JC, Witte ON, Phelps ME, Satyamurthy N, Czernin J, Radu CG Novel PET probes specific for deoxycytidine kinase.
J Nucl Med.
2010;
51(7):
1092-8.
Benz MR, Czernin J, Dry SM, Tap WD, Allen-Auerbach MS, Elashoff D, Phelps ME, Weber WA, Eilber FC Quantitative F18-fluorodeoxyglucose positron emission tomography accurately characterizes peripheral nerve sheath tumors as malignant or benign.
Cancer.
2010;
116(2):
451-8.
Toy G, Austin WR, Liao HI, CHeng D, Sing A, Campbell DO, Ishikawa TO, Lehmann LW, Satyamurthy N, Phelps ME, Herschman HR, Czernin J, Witte ON, Radu CG Requirement for deoxycytidine kinase in T and B lymphocyte development.
Proc Natl Acad Sci.
2010;
107(12):
5551-6.
Walter MA, Hildebrandt IJ, Hacke K, Kesner AL, Kelly O, Lawson GW, Phelps ME, Czernin J, Weber WA, Schiestl RH Small-animal PET/CT for monitoring the development and response to chemotherapy of thymic lymphoma in Trp53-/- mice.
J Nucl Med.
2010;
21(8):
1285-92.
Fueger BJ, Yeom K, Czernin J, Sayre JW, Phelps ME, Allen-Auerbach MS Comparison of CT, PET, and PET/CT for staging of patients with indolent non-Hodgkin's lymphoma.
Mol Imaging Biol.
2009;
11(4):
269-74.
Ercoli LM, Siddarth P, Kepe V, Miller KJ, Huang SC, Cole GM, Lavretsky H, Bookheimer SY, Kim J, Phelps ME, Barrio JR, Small GW Differential FDDNP PET patterns in nondemented middle-aged and older adult.
Am J Geriatr Psychiatry.
2009;
17(5):
397-406.
Benz MR, Czernin J, Allen-Auerbach MS, Tap WD, Dry SM, Elashoff D, Chow K, Evilevitch V, Eckardt JJ, Phelps ME, Weber WA, Eilber FC FDG-PET/CT imaging predicts histopathologic treatment resopnses after the initial cycle of neoadjuvant chemotherapy in high-grade soft-tissue sarcomas.
Clin Cancer Res.
2009;
15(8):
2856-2863.
Laing RE, Walter MA, Campbell DO, Herschman HR, Satyamurthy N, Phelps ME, Czernin J, Witte ON, Radu CG Noninvasive prediction of tumor responses to gemcitabine using positron emission tomography.
P Natl Acad Sci.
2009;
106(8):
2847-2852.
Burton JB, Johnson M, Sato M, Boon S, Koh S, Mulholland DJ, Stout D, Chatziioannou AF, Phelps ME, Wu L, Wu L Adenovirus Mediated Gene Expression Imaging to Directly Detect Sentinel Lymph Node Metastasis of Prostate Cancer.
Nat Medicine.
2008;
14(8):
882-888.
Radu CG, Shu CJ, Nair-Gill E, Shelly SM, Barrio JR, Satyamurthy N, Phelps ME, Witte ON Molecular imaging of lymphoid organs and immune activation using positron emission tomography with a new 18F-labeled 2'-deoxycytidine analog.
Nat Medicine.
2008;
14(7):
783-788.
Benz MR, Evilevitch V, Allen-Auerbach MS, Eilber FC, Phelps ME, Czernin J, Weber WA Treatment monitoring by 18F-FDG PET/CT in patients with sarcomas: interobserver variability of quantitative parameters in treatment-induced changes in histopathologically responding and nonresponding tumors.
J Nucl Med.
2008;
49(7):
1038-1046.
Radu CG, Shu CJ, Shelly SM, Phelps ME, Witte ON Positron emission tomography with computed tomography imaging of neuroinflammation in experimental autoimmune encephalomyelitis.
PNAS.
2007;
104(6):
1937-1942.
Su H, Bodenstein C, Dumont RA, Seimbille Y, Dubinett S, Phelps ME, Herschman H, Czernin J, Weber W Monitoring Tumor Glucose Utilization by Positron Emission Tomography for the Prediction of Treatment Response to Epidermal Growth Factor Receptor Kinase Inhibitors.
Clin Cancer Res.
2006;
12(19):
5659-5667.
Lu Y, Dang H, Middleton B, Zhang Z, Washburn L, Stout DB, Campbell-Thompson M, Atkinson MA, Phelps M, Gambhir SS, Tian J, Kaufman DL Noninvasive imaging of islet grafts using positron-emission tomography.
Proc Nat Acad Sci.
2006;
103(30):
11294-11299.
Small GW, Kepe V, Ercoli LM, Siddarth P, Bookheimer SY, Miller KJ, Lavretsky H, Burggren AC, Cole GM, Vinters HV, Thompson PM, Huang SC, Satyamurthy N, Phelps ME, Barrio JR PET of Brain Amyloid and Tau in Mild Cognitive Impairment.
New Engl J Med.
2006;
355(25):
2652-2663.
Lee C-C, Sui G, Elizarov A, Shu CJ, Shin Y-S, Dooley AN, Huang J, Daridon A, Wyatt P, Stout D, Kolb HC, Witte ON, Satyamurthy N, Heath JR, Phelps ME, Quake SR, Tseng HR Multistep Synthesis of a Radiolabeled Imaging Probe Using Integrated Microfluidics.
Science.
2005;
310(5755):
1793-1796.
Hood L, Heath JR, Phelps ME, Lin B Systems Biology and New Technologies Enable Predictive and Preventative Medicine.
Science.
2004;
306(5696):
640-643.
Filmont JE, Czernin J, Yap C, Silverman DH, Quon A, Phelps ME, Emmanouilides C Value of F-18 Fluorodeoxyglucose Positron Emission Tomography for Predicting the Clinical Outcome of Patients With Aggressive Lymphoma Prior to and After Autologous Stem-Cell Transplantation.
Chest.
2003;
124(2):
608-613.
Liang Q, Nguyen K, Satyamurthy N, Barrio JR, Phelps ME, Gambhir SS, Herschman HR Monitoring adenoviral DNA delivery, using a mutant herpes simplex virus type 1 thymidine kinase gene as a PET reporter gene.
Gene Ther.
2002;
9(24):
1659-1666.
Seltzer MA, Yap C, Silverman DH, Meta J, Schiepers C, Phelps ME, Sayre J, Ariannejad M, Gambhir SS, Rao J, Valk PE, Czernin J The impact of positron emission tomography on the management of patients with lung cancer: the referring physician's perspective.
J Nucl Med.
2002;
43(6):
752-756.
Silverman DH, Small GW, Chang C, Lu CS, Kung de Auburto M, Chen W, Czernin J, Rapoport SI, Pietrini P, Alexander GE, Schapiro MB, Jagust WJ, Hoffman J, Welsh-Bohmer K, Alavi A, Clark CM, Salmon E, deLeon M, Mielke R, Cummings J, Kowell A, Gambhir SS, Hoh CK, Phelps ME Positron emission tomography in evaluation of dementia: regional brain metabolism and long term outcome.
J Amer Med Assoc
2001;
286:
2120-2127.
Phelps ME Positron emission tomography provides molecular imaging of biological processes.
Proc Nat Acad Sci
2000;
97:
9226-9233.
Guerrero TM, Hoffman EJ, Dahlbom M, Cutler PD, Hawkins RA, Phelps ME Characterization of a whole body imaging technique for PET.
IEEE
1990;
37:
676-680.
Chugani HT, Phelps ME Maturational changes in cerebral function in human infants determined by 18FDG positron emission tomography.
Science
1986;
231:
840-843.
Phelps ME, Kuhl DE, Mazziotta JC Metabolic mapping of the brain's response to visual stimulation: studies in man.
Science (cover article)
1981;
211:
1445-1448.
Phelps ME, Huang SC, Hoffman EJ, Selin CE, Kuhl DE Tomographic measurement of local cerebral glucose metabolic rate in man with (18F) fluorodeoxyglucose:Validation of method.
Ann Neurol
1979;
6:
371-388.
Phelps ME, Hoffman EJ, Huang SC, Kuhl DE ECAT: A new computerized tomographic imaging system for positron-emitting radiopharmaceuticals.
J Nucl Med
1978;
19:
635-647.
Phelps ME, Hoffman EJ, Mullani NA, Higgins CS, Ter-Pogossian MM Design considerations for a positron emission transaxial tomograph (PETT III).
IEEE Nucl Sci
1976;
NS-23:
516-522.
Phelps ME, Hoffman EJ, Mullani NA, Ter-Pogossian MM Application of annihilation coincidence detection to transaxial reconstruction tomography.
J Nucl Med
1975;
16:
210-224.
Keng Pei Yuin, Chen Supin, Ding Huijiang, Sadeghi Saman, Shah Gaurav J, Dooraghi Alex, Phelps Michael E, Satyamurthy Nagichettiar, Chatziioannou Arion F, Kim Chang-Jin Cj, van Dam R Michael Micro-chemical synthesis of molecular probes on an electronic
microfluidic device..
Proceedings of the National Academy of Sciences of the United States of America.
2012;
109(3):
690-5.
Weber Wolfgang A, Czernin Johannes, Phelps Michael E, Herschman Harvey R Technology Insight: novel imaging of molecular targets is an emerging
area crucial to the development of targeted drugs..
Nature clinical practice. Oncology.
2008;
5(1):
44-54.
Kepe Vladimir, Barrio Jorge R, Huang Sung-Cheng, Ercoli Linda, Siddarth Prabha, Shoghi-Jadid Kooresh, Cole Gregory M, Satyamurthy Nagichettiar, Cummings Jeffrey L, Small Gary W, Phelps Michael E Serotonin 1A receptors in the living brain of Alzheimer's disease
patients..
Proceedings of the National Academy of Sciences of the United States of America.
2006;
103(3):
702-7.
Mazziotta J C, Phelps M E, Pahl J J, Huang S C, Baxter L R, Riege W H, Hoffman J M, Kuhl D E, Lanto A B, Wapenski J A Reduced cerebral glucose metabolism in asymptomatic subjects at risk
for Huntington's disease..
The New England journal of medicine.
1987;
316(7):
357-62.
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