Katrina Dipple, M.D., Ph.D.

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Work Titles
CTSI Professor, Genetics Member, CTSI Member, Workforce Development
UCLA Professor, Pediatrics Professor, Pediatric Craniofacial Clinic Professor, Pediatric Genetics
Education:
Degrees:
M.D., Indiana University School of Medicine, Indianapolis, IN, 1987 - 1995
Ph.D., Indiana University School of Medicine, Indianapolis, IN, 1987 - 1995
B.S., Indiana University, Bloomington, IN, 1983 - 1987
Fellowship:
1998 - 2001 Cedars-Sinai Medical Center
Internship:
1995 - 1996 UCLA School of Medicine
Academic Experience:
1998 - 2000 University of California, Los Angeles, Genetics
Residency:
1995 - 1998 University of California, Los Angeles
Certifications:
Certifications:
2002 American Board of Medical Genetics
1998 American Board of Pediatrics

Contact Information:

Work Email Address:

www.uclahealth.org/KatrinaDipple


Website:

http://people.healthsciences.ucla.edu/institution/personnel?personnel_id=9226
Web-Profile

Lab Number:

310-825-7967

Work Phone Number:

310-206-6581

310-825-1997

310-825-5904

Mailing Address:

Research Lab
695 Charles E. Young Drive South
Los Angeles, CA 90095


Work Address:

Office
Gonda 5506B


Detailed Biography:

Katrina M. Dipple, MD, PhD has always been interested in biochemistry and medicine. She has a BS in Biochemistry from Indiana University in Bloomington. During her undergraduate education she became interested in genetics and decided to go to graduate school. Dr. Dipple did a combined MD/PhD degree at Indiana University School of Medicine. Her PhD is in biochemistry and molecular biology. After finishing graduate school, she came to UCLA for a pediatric residency and postdoctoral fellowship in Genetics. Her career has focused on combining basic research and clinical work. Since joining the faculty, her work has focused on understanding the complexity of genetic disorders including the role of fat metabolism in type 2 diabetes mellitus.

Publications:

A selected list of publications:

Amarillo Ina E, Dipple Katrina M, Quintero-Rivera Fabiola   Familial Microdeletion of 17q24.3 Upstream of SOX9 Is Associated With Isolated Pierre Robin Sequence Due to Position Effect American journal of medical genetics. Part A, 2013; 161(5): 1167-72.
Peredo Jane, Quintero-Rivera Fabiola, Bradley James P, Tu Marinda, Dipple Katrina M   Cleft Lip and Palate in a Patient with 5q35.2-q35.3 Microdeletion: The Importance of Chromosomal Microarray Testing in the Craniofacial Clinic The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2012; 161(5): .
Wightman Patrick J, Jackson George R, Dipple Katrina M   Glycerol hypersensitivity in a Drosophila model for glycerol kinase deficiency is affected by mutations in eye pigmentation genes PloS one, 2012; 7(3): e31779.
Kohannim Omid, Peredo Jane, Dipple Katrina M, Quintero-Rivera Fabiola   Clinical findings associated with a de novo partial trisomy 10p11.22p15.3 and monosomy 7p22.3 detected by chromosomal microarray analysis Case reports in genetics, 2011; 2011(3): 131768.
Kosuga Motomichi, Henderson-MacLennan Nicole K, Zhang Yao-Hua, Huang Bing-Ling, Dipple Katrina M, McCabe Edward R B   Glycerol homeostasis and metabolism in glycerol kinase carrier mice Molecular genetics and metabolism, 2011; 103(3): 297-9.
Gallant Natalie M, Baldwin Erin, Salamon Noriko, Dipple Katrina M, Quintero-Rivera Fabiola   Pontocerebellar hypoplasia in association with de novo 19p13.11p13.12 microdeletion American journal of medical genetics. Part A, 2011; 155A(11): 2871-8.
Dean Jason T, Rizk Matthew L, Tan Yikun, Dipple Katrina M, Liao James C   Ensemble modeling of hepatic fatty acid metabolism with a synthetic glyoxylate shunt Biophysical journal, 2010; 98(8): 1385-95.
Sriram Ganesh, Parr Lilly S, Rahib Lola, Liao James C, Dipple Katrina M   Moonlighting function of glycerol kinase causes systems-level changes in rat hepatoma cells Metabolic engineering, 2010; 12(4): 332-40.
Ortube Maria Carolina, Dipple Katrina, Setoguchi Yoshio, Kawamoto Henry K, Demer Joseph L   Ocular manifestations of oblique facial clefts The Journal of craniofacial surgery, 2010; 21(5): 1630-1.
MacLennan Nicole K, Dong Jun, Aten Jason E, Horvath Steve, Rahib Lola, Ornelas Loren, Dipple Katrina M, McCabe Edward R B   Weighted gene co-expression network analysis identifies biomarkers in glycerol kinase deficient mice Molecular genetics and metabolism, 2010; 98(1-2): 203-14.
Sakamoto Kathleen M, Dipple Katrina M   Becoming a woman physician scientist Academic medicine : journal of the Association of American Medical Colleges, 2009; 84(7): 817.
Dean Jason T, Tran Linh, Beaven Simon, Tontonoz Peter, Reue Karen, Dipple Katrina M, Liao James C   Resistance to diet-induced obesity in mice with synthetic glyoxylate shunt Cell metabolism, 2009; 9(6): 525-36.
Rahib Lola, Sriram Ganesh, Harada Melissa K, Liao James C, Dipple Katrina M   Transcriptomic and network component analysis of glycerol kinase in skeletal muscle using a mouse model of glycerol kinase deficiency Molecular genetics and metabolism, 2009; 96(3): 106-12.
Yang Xia, Deignan Joshua L, Qi Hongxiu, Zhu Jun, Qian Su, Zhong Judy, Torosyan Gevork, Majid Sana, Falkard Brie, Kleinhanz Robert R, Karlsson Jenny, Castellani Lawrence W, Mumick Sheena, Wang Kai, Xie Tao, Coon Michael, Zhang Chunsheng, Estrada-Smith Daria, Farber Charles R, Wang Susanna S, van Nas Atila, Ghazalpour Anatole, Zhang Bin, Macneil Douglas J, Lamb John R, Dipple Katrina M, Reitman Marc L, Mehrabian Margarete, Lum Pek Y, Schadt Eric E, Lusis Aldons J, Drake Thomas A   Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks Nature genetics, 2009; 41(4): 415-23.
Sriram Ganesh, Rahib Lola, He Jian-Sen, Campos Allison E, Parr Lilly S, Liao James C, Dipple Katrina M   Global metabolic effects of glycerol kinase overexpression in rat hepatoma cells Molecular genetics and metabolism, 2008; 93(2): 145-59.
Blackwell Jennifer, Katika Kamal M, Pilon Laurent, Dipple Katrina M, Levin Seymour R, Nouvong Aksone   In vivo time-resolved autofluorescence measurements to test for glycation of human skin Journal of biomedical optics, 2008; 13(1): 014004.
Rahib Lola, MacLennan Nicole K, Horvath Steve, Liao James C, Dipple Katrina M   Glycerol kinase deficiency alters expression of genes involved in lipid metabolism, carbohydrate metabolism, and insulin signaling European journal of human genetics : EJHG, 2007; 15(6): 646-57.
Zhang, Y. H. Huang, B. L. Jialal, I. Northrup, H. McCabe, E. R. Dipple, K. M.   Asymptomatic isolated human glycerol kinase deficiency associated with splice-site mutations and nonsense-mediated decay of mutant RNA Pediatr Res, 2006; 59(4 Pt 1): 590-2.
Zhang Yao-Hua, Huang Bing-Ling, Jialal Ishwarlal, Northrup Hope, McCabe Edward R B, Dipple Katrina M   Asymptomatic isolated human glycerol kinase deficiency associated with splice-site mutations and nonsense-mediated decay of mutant RNA Pediatric research, 2006; 59(4 Pt 1): 590-2.
MacLennan Nicole K, Rahib Lola, Shin Cynthia, Fang Zixing, Horvath Steve, Dean Jason, Liao James C, McCabe Edward R B, Dipple Katrina M   Targeted disruption of glycerol kinase gene in mice: expression analysis in liver shows alterations in network partners related to glycerol kinase activity Human molecular genetics, 2006; 15(3): 405-15.
MacLennan, N. K. Rahib, L. Shin, C. Fang, Z. Horvath, S. Dean, J. Liao, J. C. McCabe, E. R. Dipple, K. M.   Targeted disruption of glycerol kinase gene in mice: expression analysis in liver shows alterations in network partners related to glycerol kinase activity Hum Mol Genet, 2006; 15(3): 405-15.
Crombez, E. A. Dipple, K. M. Schimmenti, L. A. Rao, N.   Duplication of the Down syndrome critical region does not predict facial phenotype in a baby with a ring chromosome 21 Clin Dysmorphol, 2005; 14(4): 183-7.
Crombez Eric A, Dipple Katrina M, Schimmenti Lisa A, Rao Nagesh   Duplication of the Down syndrome critical region does not predict facial phenotype in a baby with a ring chromosome 21 Clinical dysmorphology, 2005; 14(4): 183-7.
Kuwada, N. Nagano, K. MacLennan, N. Havens, J. Kumar, M. Dipple, K. M. McCabe, E. R.   Gene therapy for murine glycerol kinase deficiency: importance of murine ortholog Biochem Biophys Res Commun, 2005; 335(1): 247-55.
Ohira, R.H., Dipple, K.M., Zhang, Y.-H., and McCabe, E.R.B.   Human and murine glycerol kinase: Influence of exon 18 alternative splicing on function. Biochem. Biophys, Research Comm, 2005; 331: 239-246.
Ohira Riki H, Dipple Katrina M, Zhang Yao-Hua, McCabe Edward R B   Human and murine glycerol kinase: influence of exon 18 alternative splicing on function Biochemical and biophysical research communications, 2005; 331(1): 239-46.
Sriram, G. Martinez, J. A. McCabe, E. R. Liao, J. C. Dipple, K. M.   Single-gene disorders: what role could moonlighting enzymes play? Am J Hum Genet, 2005; 76(6): 911-24.
Sriram Ganesh, Martinez Julian A, McCabe Edward R B, Liao James C, Dipple Katrina M   Single-gene disorders: what role could moonlighting enzymes play? American journal of human genetics, 2005; 76(6): 911-24.
Sriram, G Martinez, JA McCabe, ER Liao, JC Dipple, KM   Single-gene disorders: what role could moonlighting enzymes play? American journal of human genetics. , 2005; 76(6): 911-24.
Zhang Yao-Hua, Huang Bing-Ling, Niakan Kathy K, McCabe Linda L, McCabe Edward R B, Dipple Katrina M   IL1RAPL1 is associated with mental retardation in patients with complex glycerol kinase deficiency who have deletions extending telomeric of DAX1 Human mutation, 2004; 24(3): 273.
Zhang, YH Huang, BL Niakan, KK McCabe, LL McCabe, ER Dipple, KM   IL1RAPL1 is associated with mental retardation in patients with complex glycerol kinase deficiency who have deletions extending telomeric of DAX1 Human mutation. , 2004; 24(3): 273.
Stepanian Sevan V, Huyn Steven T, McCabe Edward R B, Dipple Katrina M   Characterization of the human glycerol kinase promoter: identification of a functional HNF-4alpha binding site and evidence for transcriptional activation Molecular genetics and metabolism, 2003; 80(4): 412-8.
Stepanian, SV Huyn, ST McCabe, ER Dipple, KM   Characterization of the human glycerol kinase promoter: identification of a functional HNF-4alpha binding site and evidence for transcriptional activation Molecular genetics and metabolism. , 2003; 80(4): 412-8.
Cederbaum, S. D. Koo-McCoy, S. Tein, I. Hsu, B. Y. Ganguly, A. Vilain, E. Dipple, K. Cvitanovic-Sojat, L. Stanley, C.   Carnitine membrane transporter deficiency: a long-term follow up and OCTN2 mutation in the first documented case of primary carnitine deficiency Mol Genet Metab, 2002; 77(3): 195-201.
Cederbaum Stephen D, Koo-McCoy Samantha, Tein Ingrid, Hsu Betty Y L, Ganguly Arupa, Vilain Eric, Dipple Katrina, Cvitanovic-Sojat Ljerka, Stanley Charles   Carnitine membrane transporter deficiency: a long-term follow up and OCTN2 mutation in the first documented case of primary carnitine deficiency Molecular genetics and metabolism, 2002; 77(3): 195-201.
Ohira, R. Zhang, Y. H. Guo, W. Dipple, K. Shih, S. L. Doerr, J. Huang, B. L. Fu, L. J. Abu-Khalil, A. Geschwind, D. McCabe, E. R.   Human ARX gene: genomic characterization and expression Mol Genet Metab, 2002; 77(1-2): 179-88.
Dipple, K. M. Phelan, J. K. McCabe, E. R.   Consequences of complexity within biological networks: robustness and health, or vulnerability and disease Mol Genet Metab, 2001; 74(1-2): 45-50.
Dipple, KM Zhang, YH Huang, BL McCabe, LL Dallongeville, J Inokuchi, T Kimura, M Marx, HJ Roederer, GO Shih, V Yamaguchi, S Yoshida, I McCabe, ER   Glycerol kinase deficiency: evidence for complexity in a single gene disorder Human genetics. , 2001; 109(1): 55-62.
Zhang, Y Dipple, KM Vilain, E Huang, BL Finlayson, G Therrell, BL Worley, K Deininger, P McCabe, ER   AluY insertion (IVS4-52ins316alu) in the glycerol kinase gene from an individual with benign glycerol kinase deficiency Human mutation. , 2000; 15(4): 316-23.
Dipple, KM McCabe, ER   Modifier genes convert "simple" Mendelian disorders to complex traits Molecular genetics and metabolism. , 2000; 71(1-2): 43-50.
Pinaire, J. Chou, W. Y. Stewart, M. Dipple, K. Crabb, D.   Activity of the human aldehyde dehydrogenase 2 promoter is influenced by the balance between activation by hepatocyte nuclear factor 4 and repression by perosixome proliferator activated receptor delta, chicken ovalbumin upstream promoter-transcription factor, and apolipoprotein regulatory protein-1 Adv Exp Med Biol, 1999; 463: 115-21.
Stewart, M. J. Dipple, K. M. Estonius, M. Nakshatri, H. Everett, L. M. Crabb, D. W.   Binding and activation of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4 Biochim Biophys Acta, 1998; 1399(2-3): 181-6.
Dipple, K. M.   The resident's column Pediatr Ann, 1997; 26(9): 523-4.
Stewart, M. J. Dipple, K. M. Stewart, T. R. Crabb, D. W.   The role of nuclear factor NF-Y/CP1 in the transcriptional regulation of the human aldehyde dehydrogenase 2-encoding gene Gene, 1996; 173(2): 155-61.
Stewart, M. J. Malek, K. Xiao, Q. Dipple, K. M. Crabb, D. W.   The novel aldehyde dehydrogenase gene, ALDH5, encodes an active aldehyde dehydrogenase enzyme Biochem Biophys Res Commun, 1995; 211(1): 144-51.
Dipple, K. M. Stewart, M. J. Crabb, D. W.   Tissue-specific expression and preliminary functional analysis of the 5' flanking regions of the human mitochondrial aldehyde dehydrogenase (ALDH2) gene Adv Exp Med Biol, 1995; 372: 123-30.
Crabb, D. W. Dipple, K. M. Thomasson, H. R.   Alcohol sensitivity, alcohol metabolism, risk of alcoholism, and the role of alcohol and aldehyde dehydrogenase genotypes J Lab Clin Med, 1993; 122(3): 234-40.
Dipple, K. M. Qulali, M. Ross, R. A. Crabb, D. W.   Effects of thyroxine on the expression of alcohol dehydrogenase in rat liver and kidney Hepatology, 1993; 17(4): 701-6.
Qulali, M. Dipple, K. M. Crabb, D. W.   Modulation of hepatic and renal alcohol dehydrogenase activity and mRNA by steroid hormones in vivo Adv Exp Med Biol, 1993; 328: 581-9.
Dipple, K. M. Crabb, D. W.   The mitochondrial aldehyde dehydrogenase gene resides in an HTF island but is expressed in a tissue-specific manner Biochem Biophys Res Commun, 1993; 193(1): 420-7.
Crabb, D. W. Qulali, M. Dipple, K. M.   Endocrine regulation and methylation patterns of rat class I alcohol dehydrogenase in liver and kidney Adv Exp Med Biol, 1991; 284: 277-84.
Crabb, D. W. Stein, P. M. Dipple, K. M. Hittle, J. B. Sidhu, R. Qulali, M. Zhang, K. Edenberg, H. J.   Structure and expression of the rat class I alcohol dehydrogenase gene Genomics, 1989; 5(4): 906-14.

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