Publications:
A selected list of publications:
Simonato Michele, Bennett Jean, Boulis Nicholas M, Castro Maria G, Fink David J, Goins William F, Gray Steven J, Lowenstein Pedro R, Vandenberghe Luk H, Wilson Thomas J, Wolfe John H, Glorioso Joseph C
Progress in gene therapy for neurological disorders
Nature reviews. Neurology,
2013; 9(5):
277-91.
Puntel Mariana, A K M Ghulam Muhammad, Farrokhi Catherine, Vanderveen Nathan, Paran Christopher, Appelhans Ashley, Kroeger Kurt M, Salem Alireza, Lacayo Liliana, Pechnick Robert N, Kelson Kyle R, Kaur Sukhpreet, Kennedy Sean, Palmer Donna, Ng Philip, Liu Chunyan, Krasinkiewicz Johnny, Lowenstein Pedro R, Castro Maria G
Safety profile, efficacy, and biodistribution of a bicistronic
high-capacity adenovirus vector encoding a combined immunostimulation
and cytotoxic gene therapy as a prelude to a phase I clinical trial
for glioblastoma
Toxicology and applied pharmacology,
2013; 268(3):
318-30.
Sanderson Nicholas Stephen Rennie, Puntel Mariana, Kroeger Kurt M, Bondale Niyati S, Swerdlow Mark, Iranmanesh Niloufar, Yagita Hideo, Ibrahim Ahmed, Castro Maria G, Lowenstein Pedro R
Cytotoxic immunological synapses do not restrict the action of
interferon-γ to antigenic target cells
Proceedings of the National Academy of Sciences of the United States of America,
2012; 109(20):
7835-40.
Mineharu Yohei, Muhammad A K M Ghulam, Yagiz Kader, Candolfi Marianela, Kroeger Kurt M, Xiong Weidong, Puntel Mariana, Liu Chunyan, Levy Eva, Lugo Claudia, Kocharian Adrina, Allison James P, Curran Michael A, Lowenstein Pedro R, Castro Maria G
Gene therapy-mediated reprogramming tumor infiltrating T cells using
IL-2 and inhibiting NF-κB signaling improves the efficacy of
immunotherapy in a brain cancer model
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics,
2012; 9(4):
827-43.
Zirger Jeffrey M, Puntel Mariana, Bergeron Josee, Wibowo Mia, Moridzadeh Rameen, Bondale Niyati, Barcia Carlos, Kroeger Kurt M, Liu Chunyan, Castro Maria G, Lowenstein Pedro R
Immune-mediated loss of transgene expression from virally transduced
brain cells is irreversible, mediated by IFNγ, perforin, and TNFα,
and due to the elimination of transduced cells
Molecular therapy : the journal of the American Society of Gene Therapy,
2012; 20(4):
808-19.
Candolfi Marianela, King Gwendalyn D, Yagiz Kader, Curtin James F, Mineharu Yohei, Muhammad A K M Ghulam, Foulad David, Kroeger Kurt M, Barnett Nick, Josien Regis, Lowenstein Pedro R, Castro Maria G
Plasmacytoid dendritic cells in the tumor microenvironment: immune
targets for glioma therapeutics
Neoplasia (New York, N.Y.),
2012; 14(8):
757-70.
Castro Maria, Xiong Weidong, Puntel Mariana, Farrokhi Catherine, Kroeger Kurt M, Pechnick Robert N, Ng Philip, Lowenstein Pedro, Ghulam Muhammad Akm, Salem Alireza, Lacayo Liliana, Kelson Kyle R, Palmer Donna J, Liu Chungyan, Appelhans Ashley
Safety Profile of Gutless Adenovirus Vectors Delivered into the Normal
Brain Parenchyma: Implications for a Glioma Phase I Clinical Trial
Human gene therapy methods,
2012; 268(3):
.
Muhammad A K M Ghulam, Xiong Weidong, Puntel Mariana, Farrokhi Catherine, Kroeger Kurt M, Salem Alireza, Lacayo Liliana, Pechnick Robert N, Kelson Kyle R, Palmer Donna, Ng Philip, Liu Chunyan, Lowenstein Pedro R, Castro Maria G
Safety profile of gutless adenovirus vectors delivered into the normal
brain parenchyma: implications for a glioma phase 1 clinical trial
Human gene therapy methods,
2012; 23(4):
271-84.
Candolfi Marianela, Curtin James F, Yagiz Kader, Assi Hikmat, Wibowo Mia K, Alzadeh Gabrielle E, Foulad David, Muhammad A K M G, Salehi Sofia, Keech Naomi, Puntel Mariana, Liu Chunyan, Sanderson Nicholas R, Kroeger Kurt M, Dunn Robert, Martins Gislaine, Lowenstein Pedro R, Castro Maria G
B cells are critical to T-cell-mediated antitumor immunity induced by
a combined immune-stimulatory/conditionally cytotoxic therapy for
glioblastoma
Neoplasia (New York, N.Y.),
2011; 13(10):
947-60.
King Gwendalyn D, Muhammad A K M Ghulam, Larocque Daniel, Kelson Kyle R, Xiong Weidong, Liu Chunyan, Sanderson Nicholas S R, Kroeger Kurt M, Castro Maria G, Lowenstein Pedro R
Combined Flt3L/TK gene therapy induces immunological surveillance
which mediates an immune response against a surrogate brain tumor
neoantigen
Molecular therapy : the journal of the American Society of Gene Therapy,
2011; 19(10):
1793-801.
Castro Maria G, Candolfi Marianela, Kroeger Kurt, King Gwendalyn D, Curtin James F, Yagiz Kader, Mineharu Yohei, Assi Hikmat, Wibowo Mia, Ghulam Muhammad A K M, Foulad David, Puntel Mariana, Lowenstein Pedro R
Gene therapy and targeted toxins for glioma
Current gene therapy,
2011; 11(3):
155-80.
Puntel Mariana, Barrett Robert, Sanderson Nicholas S R, Kroeger Kurt M, Bondale Niyati, Wibowo Mia, Kennedy Sean, Liu Chunyan, Castro Maria G, Lowenstein Pedro R
Identification and visualization of CD8+ T cell mediated IFN-γ
signaling in target cells during an antiviral immune response in the
brain
PloS one,
2011; 6(8):
e23523.
Candolfi Marianela, Kroeger Kurt M, Xiong Weidong, Liu Chunyan, Puntel Mariana, Yagiz Kader, Muhammad Akm Ghulam, Mineharu Yohei, Foulad David, Wibowo Mia, Assi Hikmat, Baker Gregory J, Lowenstein Pedro R, Castro Maria G
Targeted toxins for glioblastoma multiforme: pre-clinical studies and
clinical implementation
Anti-cancer agents in medicinal chemistry,
2011; 11(8):
729-38.
Puntel Mariana, Muhammad A K M G, Candolfi Marianela, Salem Alireza, Yagiz Kader, Farrokhi Catherine, Kroeger Kurt M, Xiong Weidong, Curtin James F, Liu Chunyan, Bondale Niyati S, Lerner Jonathan, Pechnick Robert N, Palmer Donna, Ng Philip, Lowenstein Pedro R, Castro Maria G
A novel bicistronic high-capacity gutless adenovirus vector that
drives constitutive expression of herpes simplex virus type 1
thymidine kinase and tet-inducible expression of Flt3L for glioma
therapeutics
Journal of virology,
2010; 84(12):
6007-17.
Pluhar G Elizabeth, Grogan Patrick T, Seiler Charlie, Goulart Michelle, Santacruz Karen S, Carlson Cathy, Chen Wei, Olin Mike R, Lowenstein Pedro R, Castro Maria G, Haines Stephen J, Ohlfest John R
Anti-tumor immune response correlates with neurological symptoms in a
dog with spontaneous astrocytoma treated by gene and vaccine therapy
Vaccine,
2010; 28(19):
3371-8.
Larocque Daniel, Sanderson Nicholas S R, Bergeron Josée, Curtin James F, Girton Joe, Wibowo Mia, Bondale Niyati, Kroeger Kurt M, Yang Jieping, Lacayo Liliana M, Reyes Kevin C, Farrokhi Catherine, Pechnick Robert N, Castro Maria G, Lowenstein Pedro R
Exogenous fms-like tyrosine kinase 3 ligand overrides brain immune
privilege and facilitates recognition of a neo-antigen without causing
autoimmune neuropathology
Proceedings of the National Academy of Sciences of the United States of America,
2010; 107(32):
14443-8.
Kroeger Kurt M, Muhammad A K M Ghulam, Baker Gregory J, Assi Hikmat, Wibowo Mia K, Xiong Weidong, Yagiz Kader, Candolfi Marianela, Lowenstein Pedro R, Castro Maria G
Gene therapy and virotherapy: novel therapeutic approaches for brain
tumors
Discovery medicine,
2010; 10(53):
293-304.
Candolfi Marianela, Xiong Weidong, Yagiz Kader, Liu Chunyan, Muhammad A K M G, Puntel Mariana, Foulad David, Zadmehr Ali, Ahlzadeh Gabrielle E, Kroeger Kurt M, Tesarfreund Matthew, Lee Sharon, Debinski Waldemar, Sareen Dhruv, Svendsen Clive N, Rodriguez Ron, Lowenstein Pedro R, Castro Maria G
Gene therapy-mediated delivery of targeted cytotoxins for glioma
therapeutics
Proceedings of the National Academy of Sciences of the United States of America,
2010; 107(46):
20021-6.
Puntel Mariana, Kroeger Kurt M, Sanderson Nicholas S R, Thomas Clare E, Castro Maria G, Lowenstein Pedro R
Gene transfer into rat brain using adenoviral vectors
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.],
2010; Chapter 4(19):
Unit 4.24.
Xiong Weidong, Candolfi Marianela, Liu Chunyan, Muhammad A K M Ghulam, Yagiz Kader, Puntel Mariana, Moore Peter F, Avalos Julie, Young John D, Khan Dorothy, Donelson Randy, Pluhar G Elizabeth, Ohlfest John R, Wawrowsky Kolja, Lowenstein Pedro R, Castro Maria G
Human Flt3L generates dendritic cells from canine peripheral blood
precursors: implications for a dog glioma clinical trial
PloS one,
2010; 5(6):
e11074.
Vit Jean-Philippe, Ohara Peter T, Sundberg Christopher, Rubi Blanca, Maechler Pierre, Liu Chunyan, Puntel Mariana, Lowenstein Pedro, Castro Maria, Jasmin Luc
Adenovector GAD65 gene delivery into the rat trigeminal ganglion
produces orofacial analgesia
Molecular pain,
2009; 5(5):
42.
Ghulam Muhammad A K M, Candolfi Marianela, King Gwendalyn D, Yagiz Kader, Foulad David, Mineharu Yohei, Kroeger Kurt M, Treuer Katherine A, Nichols W Stephen, Sanderson Nicholas S, Yang Jieping, Khayznikov Maksim, Van Rooijen Nico, Lowenstein Pedro R, Castro Maria G
Antiglioma immunological memory in response to conditional
cytotoxic/immune-stimulatory gene therapy: humoral and cellular
immunity lead to tumor regression
Clinical cancer research : an official journal of the American Association for Cancer Research,
2009; 15(19):
6113-27.
Curtin James F, Liu Naiyou, Candolfi Marianela, Xiong Weidong, Assi Hikmat, Yagiz Kader, Edwards Matthew R, Michelsen Kathrin S, Kroeger Kurt M, Liu Chunyan, Muhammad A K M Ghulam, Clark Mary C, Arditi Moshe, Comin-Anduix Begonya, Ribas Antoni, Lowenstein Pedro R, Castro Maria G
HMGB1 mediates endogenous TLR2 activation and brain tumor regression
PLoS medicine,
2009; 6(1):
e10.
Candolfi Marianela, Yagiz Kader, Foulad David, Alzadeh Gabrielle E, Tesarfreund Matthew, Muhammad A K M Ghulam, Puntel Mariana, Kroeger Kurt M, Liu Chunyan, Lee Sharon, Curtin James F, King Gwendalyn D, Lerner Jonathan, Sato Katsuaki, Mineharu Yohei, Xiong Weidong, Lowenstein Pedro R, Castro Maria G
Release of HMGB1 in response to proapoptotic glioma killing
strategies: efficacy and neurotoxicity
Clinical cancer research : an official journal of the American Association for Cancer Research,
2009; 15(13):
4401-14.
Barcia Carlos, Gomez Aurora, de Pablos Vicente, Fernández-Villalba Emiliano, Liu Chunyan, Kroeger Kurt M, MartÃn Javier, Barreiro Andrés Fernández, Castro Maria G, Lowenstein Pedro R, Herrero Maria-Trinidad
CD20, CD3, and CD40 ligand microclusters segregate three-dimensionally
in vivo at B-cell-T-cell immunological synapses after viral immunity
in primate brain
Journal of virology,
2008; 82(20):
9978-93.
King Gwendalyn D, Muhammad A K M Ghulam, Curtin James F, Barcia Carlos, Puntel Mariana, Liu Chunyan, Honig Sarah B, Candolfi Marianela, Mondkar Sonali, Lowenstein Pedro R, Castro Maria G
Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic
glioblastoma model
Neuro-oncology,
2008; 10(1):
19-31.
King Gwendalyn D, Kroeger Kurt M, Bresee Catherine J, Candolfi Marianela, Liu Chunyan, Manalo Charlene M, Muhammad A K M Ghulam, Pechnick Robert N, Lowenstein Pedro R, Castro Maria G
Flt3L in combination with HSV1-TK-mediated gene therapy reverses brain
tumor-induced behavioral deficits
Molecular therapy : the journal of the American Society of Gene Therapy,
2008; 16(4):
682-90.
Schubert Manfred, Breakefield Xandra, Federoff Howard, Frederickson Robert M, Lowenstein Pedro R
Gene delivery to the nervous system
Molecular therapy : the journal of the American Society of Gene Therapy,
2008; 16(4):
640-6.
King Gwendalyn D, Muhammad A K M Ghulam, Xiong Weidong, Kroeger Kurt M, Puntel Mariana, Larocque Daniel, Palmer Donna, Ng Philip, Lowenstein Pedro R, Castro Maria G
High-capacity adenovirus vector-mediated anti-glioma gene therapy in
the presence of systemic antiadenovirus immunity
Journal of virology,
2008; 82(9):
4680-4.
Xiong Weidong, Candolfi Marianela, Kroeger Kurt M, Puntel Mariana, Mondkar Sonali, Larocque Daniel, Liu Chunyan, Curtin James F, Palmer Donna, Ng Philip, Lowenstein Pedro R, Castro Maria G
Immunization against the transgene but not the TetON switch reduces
expression from gutless adenoviral vectors in the brain
Molecular therapy : the journal of the American Society of Gene Therapy,
2008; 16(2):
343-51.
Barcia C, Wawrowsky K, Barrett RJ, Liu C, Castro MG, Lowenstein PR.
In Vivo Polarization of IFN-{gamma} at Kupfer and Non-Kupfer Immunological Synapses during the Clearance of Virally Infected Brain Cells,
Journal of Immunology,
2008; 3(180):
1344-1352.
Download
Curtin James F, Candolfi Marianela, Puntel Mariana, Xiong Weidong, Muhammad A K M, Kroeger Kurt, Mondkar Sonali, Liu Chunyan, Bondale Niyati, Lowenstein Pedro R, Castro Maria G
Regulated expression of adenoviral vectors-based gene therapies:
therapeutic expression of toxins and immune-modulators
Methods in molecular biology (Clifton, N.J.),
2008; 434(1):
239-66.
Curtin F.James , Marianela Candolfi, Weidong Xiong, Pedro R. Lowenstein, and Maria G. Castro
Turning the gene tap off; implications of regulating gene expression for cancer therapeutics,
Mol Cancer Ther,
2008; 3(7):
.
Download
Candolfi Marianela, Kroeger Kurt M, Pluhar G Elizabeth, Bergeron Josee, Puntel Mariana, Curtin James F, McNiel Elizabeth A, Freese Andrew B, Ohlfest John R, Moore Peter, Lowenstein Pedro R, Castro Maria G
Adenoviral-mediated gene transfer into the canine brain in vivo
Neurosurgery,
2007; 60(1):
167-77; discussion 178.
Candolfi Marianela, Curtin James F, Nichols W Stephen, Muhammad Akm G, King Gwendalyn D, Pluhar G Elizabeth, McNiel Elizabeth A, Ohlfest John R, Freese Andrew B, Moore Peter F, Lerner Jonathan, Lowenstein Pedro R, Castro Maria G
Intracranial glioblastoma models in preclinical neuro-oncology:
neuropathological characterization and tumor progression
Journal of neuro-oncology,
2007; 85(2):
133-48.
Barcia C, Jimenez-Dalmaroni M, Kroeger KM, Puntel M, Rapaport AJ, Larocque D, King GD, Johnson SA, Liu C, Xiong W, Candolfi M, Mondkar S, Ng P, Palmer D, Castro MG, Lowenstein PR.
One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications,
Molecular Therapy,
2007; 12(15):
2154-63.
Download
Barcia Carlos, Jimenez-Dalmaroni Maximiliano, Kroeger Kurt M, Puntel Mariana, Rapaport Alison J, Larocque Daniel, King Gwendalyn D, Johnson Stephen A, Liu Chunyan, Xiong Weidong, Candolfi Marianela, Mondkar Sonali, Ng Philip, Palmer Donna, Castro Maria G, Lowenstein Pedro R
One-year expression from high-capacity adenoviral vectors in the
brains of animals with pre-existing anti-adenoviral immunity: clinical
implications
Molecular therapy : the journal of the American Society of Gene Therapy,
2007; 15(12):
2154-63.
Candolfi Marianela, Pluhar G Elizabeth, Kroeger Kurt, Puntel Mariana, Curtin James, Barcia Carlos, Muhammad A K M Ghulam, Xiong Weidong, Liu Chunyan, Mondkar Sonali, Kuoy William, Kang Terry, McNeil Elizabeth A, Freese Andrew B, Ohlfest John R, Moore Peter, Palmer Donna, Ng Phillip, Young John D, Lowenstein Pedro R, Castro Maria G
Optimization of adenoviral vector-mediated transgene expression in the
canine brain in vivo, and in canine glioma cells in vitro
Neuro-oncology,
2007; 9(3):
245-58.
Candolfi Marianela, Curtin James F, Xiong Wei-Dong, Kroeger Kurt M, Liu Chunyan, Rentsendorj Altan, Agadjanian Hasmik, Medina-Kauwe Lali, Palmer Donna, Ng Philip, Lowenstein Pedro R, Castro Maria G
Effective high-capacity gutless adenoviral vectors mediate transgene
expression in human glioma cells
Molecular therapy : the journal of the American Society of Gene Therapy,
2006; 14(3):
371-81.
Curtin JF, King GD, Barcia C, Liu C, Hubert FX, Guillonneau C, Josien R, Anegon I, Lowenstein PR, Castro MG.
Fms-like tyrosine kinase 3 ligand recruits plasmacytoid dendritic cells to the brain
Journal of Immunology,
2006; 6(176):
3566-77.
Download
Curtin James F, King Gwendalyn D, Barcia Carlos, Liu Chunyan, Hubert François X, Guillonneau Carole, Josien Régis, Anegon Ignacio, Lowenstein Pedro R, Castro Maria G
Fms-like tyrosine kinase 3 ligand recruits plasmacytoid dendritic
cells to the brain
Journal of immunology (Baltimore, Md. : 1950),
2006; 176(6):
3566-77.
Barcia C, Thomas CE, Curtin JF, King GD, Wawrowsky K, Candolfi M, Xiong WD, Liu C, Kroeger K, Boyer O, Kupiec-Weglinski J, Klatzmann D, Castro MG, Lowenstein PR.
In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain
Journal of Experimental Medicine,
2006; 9(203):
2095-107.
Download
Barcia Carlos, Thomas Clare E, Curtin James F, King Gwendalyn D, Wawrowsky Kolja, Candolfi Marianela, Xiong Wei-Dong, Liu Chunyan, Kroeger Kurt, Boyer Olivier, Kupiec-Weglinski Jerzy, Klatzmann David, Castro Maria G, Lowenstein Pedro R
In vivo mature immunological synapses forming SMACs mediate clearance
of virally infected astrocytes from the brain
The Journal of experimental medicine,
2006; 203(9):
2095-107.
Zirger Jeffrey M, Barcia Carlos, Liu Chunyan, Puntel Mariana, Mitchell Ngan, Campbell Iain, Castro Maria, Lowenstein Pedro R
Rapid upregulation of interferon-regulated and chemokine mRNAs upon
injection of 108 international units, but not lower doses, of
adenoviral vectors into the brain
Journal of virology,
2006; 80(11):
5655-9.
Zirger JM, Barcia C, Liu C, Puntel M, Mitchell N, Campbell I, Castro M, Lowenstein PR.
Rapid upregulation of interferon-regulated and chemokine mRNAs upon injection of 108 international units, but not lower doses, of adenoviral vectors into the brain
Journal of Virology,
2006; 11(80):
5655-9.
Download
Xiong Weidong, Goverdhana Shyam, Sciascia Sandra A, Candolfi Marianela, Zirger Jeffrey M, Barcia Carlos, Curtin James F, King Gwendalyn D, Jaita Gabriela, Liu Chunyan, Kroeger Kurt, Agadjanian Hasmik, Medina-Kauwe Lali, Palmer Donna, Ng Philip, Lowenstein Pedro R, Castro Maria G
Regulatable gutless adenovirus vectors sustain inducible transgene
expression in the brain in the presence of an immune response against
adenoviruses
Journal of virology,
2006; 80(1):
27-37.
Ali Sumia, King Gwendalyn D, Curtin James F, Candolfi Marianela, Xiong Weidong, Liu Chunyan, Puntel Mariana, Cheng Queng, Prieto Jesus, Ribas Antoni, Kupiec-Weglinski Jerzy, van Rooijen Nico, Lassmann Hans, Lowenstein Pedro R, Castro Maria G
Combined immunostimulation and conditional cytotoxic gene therapy
provide long-term survival in a large glioma model
Cancer research,
2005; 65(16):
7194-204.
Ali S, King GD, Curtin JF, Candolfi M, Xiong W, Liu C, Puntel M, Cheng Q, Prieto J, Ribas A, Kupiec-Weglinski J, van Rooijen N, Lassmann H, Lowenstein PR, Castro MG.
Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model
Cancer Research,
2005; 16(65):
7194-204.
Download
Domingo E, Pariente N, Airaksinen A, Gonzalez-Lopez C, Sierra S, Herrera M, Grande-Perez A, Lowenstein PR, Manrubia SC, Lazaro E, Escarmis C.
Foot-and-mouth disease virus evolution: exploring pathways towards virus extinction
Current Topic Microbiology and Immunology,
2005; 288:
149-73.
Ali Sumia, Curtin James F, Zirger Jeffrey M, Xiong Weidong, King Gwendalyn D, Barcia Carlos, Liu Chunyan, Puntel Mariana, Goverdhana Shyam, Lowenstein Pedro R, Castro Maria G
Inflammatory and anti-glioma effects of an adenovirus expressing human
soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L): treatment with
hsFlt3L inhibits intracranial glioma progression
Molecular therapy : the journal of the American Society of Gene Therapy,
2004; 10(6):
1071-84.
Kingston Paul A, Sinha Sanjay, Appleby Clare E, David Anne, Verakis Thomas, Castro Maria G, Lowenstein Pedro R, Heagerty Anthony M
Adenovirus-mediated gene transfer of transforming growth factor-beta3,
but not transforming growth factor-beta1, inhibits constrictive
remodeling and reduces luminal loss after coronary angioplasty
Circulation,
2003; 108(22):
2819-25.
Solly Sounkary K, Trajcevski Stephane, Frisén Charlotte, Holzer Georg W, Nelson Elisabeth, Clerc Béatrice, Abordo-Adesida Evelyn, Castro Maria, Lowenstein Pedro, Klatzmann David
Replicative retroviral vectors for cancer gene therapy
Cancer gene therapy,
2003; 10(1):
30-9.
Guillot Cécile, Guillonneau Carole, Mathieu Patrick, Gerdes Christian A, Ménoret Séverine, Braudeau Cécile, Tesson Laurent, Renaudin Karine, Castro Maria G, Löwenstein Pedro R, Anegon Ignacio
Prolonged blockade of CD40-CD40 ligand interactions by gene transfer
of CD40Ig results in long-term heart allograft survival and
donor-specific hyporesponsiveness, but does not prevent chronic
rejection
Journal of immunology (Baltimore, Md. : 1950),
2002; 168(4):
1600-9.
Dewey RA, Morrissey G, Cowsill CM, Stone D, Bolognani F, Dodd NJ, Southgate TD, Klatzmann D, Lassmann H, Castro MG, Lowenstein PR.
Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials
Nat Med. ,
1999; 5(11):
1256-63.
Download