Jonathan Jahr, M.D.

A Short Biography:

Dr. Jahr has been at the forefront the conduct of definitive preclinical and clinical studies involving the application of hemoglobin based oxygen carriers in the treatment of hemorrhage and orthopedic surgery. He is the world’s foremost expert in the use of advanced diagnostic techniques in the study of the impact of volumizing fluids and HBOCs on coagulapathy, and related thrombin and platelet function. He has served as principal investigator in Phase I trials of Alliance Corporations’ Perflubon™, Phase II trials of Hemosol’s Hemolink™, and Phase II and Phase III trials of Biopure’s HemoPure™ product. Dr. Jahr has previously studied OxyVita®’s impact on coagulapathy in ex vivo studies and reported his findings in the Journal of Cardiothoracic and Vascular Anesthesia, Vol 22:1, 34-39 (February, 2008). Throughout his extraordinary professional career, Dr. Jahr has been interested in the use of resuscitative fluids, blood transfusions, and intervention in the treatment of severe trauma, and the clinical efficacy of the use of blood substitutes, including perfluorocarbon technologies and hemoglobin based oxygen carriers to reduce the need for blood transfusions in clinical practice. He has been the principal investigator in over 30 clinical trials, has published over 150 studies, abstracts, review articles and case studies. He has served on the editorial review boards of Anesthesiology Review, American Journal of Anesthesiology, American Journal of Therapeutics, Journal of Cardiovascular Pharmacology and Therapeutics, Journal of Clinical Anesthesiology, Critical Care Medicine, American Journal of Physiology: Hear and Circulatory Physiology, Hematological, Anesthesiology, British Journal of Anesthesiology, and Vascular Pharmacology, and regularly lectures on issues regarding anesthesiology, oxygen therapeutics, and the management of blood products in surgical operations. Dr. Jahr received his undergraduate degree in Biology from Hamilton College, Clinton, NY Cum Laude, and with Honors, and his medical degree from New York Medical College, Valhalla, NY.

Work Titles
UCLA Physician, Jules Stein Eye Institute Operating Rooms Service Physician, Main Operating Room Service Professor of Clinical Anesthesiology Step V, Anesthesiology
M.D., New York Medical College, 1985
1985 - 1986 St. Vincent's Hospital and Medical Center of NY
1989 - 1989 Allegheny General Hospital
1988 - 1988 Children's Hospital of Pittsburgh
1986 - 1988 University of Pittsburgh School of Medicine
1991 American Board of Anesthesiology
Certification Type:
2011 - 2012 UCLA Anderson School of Management, Graduate, Executive Education in Management

Contact Information:

Mailing Address:

UCLA Department of Anesthesiology
757 Westwood Plaza Suite 3325
Los Angeles, CA 90095

Detailed Biography:

As a practicing Anesthesiologist, providing care personally, and supervising Anesthesiology Residents and Nurse Anesthetists, I have first-hand knowledge and experience in dealing with devastating traumatic hemorrhagic shock (THMS). With poor survival due to inadequate current resuscitation fluid used in the field, a more effective solution is required for improving outcome. As Interim Chair of Anesthesiology for the past 23 years and Trauma Clinical Trials Research Director at a traditionally underserved minority institution for two years, I witnessed how disparities in healthcare lead to worse outcomes in trauma. For the past 23 years, in basic science, translational and clinical models/trials, I have devoted my energy to understanding the pathophysiology, pharmacology and management of THS with over 100 peer reviewed publications, especially with regard attention to oxygen carriers, and specifically to the coagulopathic effects of these products. Notably, recently I led a Phase III clinical trial of a leading HBOC product which resulted in a publication, which is considered as one of the key publications in the field (Jahr et al., 2008). This work while presenting an Invited Plenary Lecture at the XII International Symposium on Blood Substitutes, Parma, Italy, entitled: “Clinical and Translational Advances in Blood Substitutes--One Investigator’s Perspective”, I proposed a Consortium approach for new development of blood substitute science. My expertise, extensive experience, and leadership roles in the resuscitation fluid research has enabled me to guide this form a Consortium of world class thought leaders and researchers in this area, and based on the goals of the consortium, to transition from oxygen carriers, to study the therapeutic potential provide outstanding science in a transformational area of multifunctional resuscitation fluids, (specifically a Small volume Multifunctional Emergency Resuscitation Fluid (: SMERF) consisting of a plasma expander, an oxygen carrier, coagulation factors and other beneficial mediators as a potential universal resuscitation fluid for field treatment of THS. Potential bias due to conflict-of-interest issues for industry sponsored investigators has been well recognized. Therefore, to conduct objective evaluations, SMERF must be studied without the influence of component manufacturers of the components (oxygen carrier, coagulation factors, fluids, other beneficial mediators) and be able to be reported in an unbiased way; the independence of consortium investigators will allow objective assessment of candidate SMERFs. Further, the safety and efficacy of candidate SMERFs will be evaluated by blinding of test materials and adoption of randomized study designs, similar to clinical trials (but uncommon in basic/translational research) The development of a model that includes blinded testing of the candidate SMERF products, amongst the 4 sites with well-established stellar scientific models and publications in this exact area, to vet these products and evaluate safety and efficacy in translational models is unparalleled. This project and call provide an outstanding platform on which to create, develop, and study this novel SMERF, so that a final product will emerge that can be vetted and approved by the Food and Drug Administration (FDA) for an IND Investigational New Drug (IND) Application, leading into FDA sponsored guided human Phase I through III trials, and eventual approval for human use. Consultant scientists from the FDA and the UCLA Director of Clinical and Translational Science Institute (CTSI) will participate in all critical decision points during the conduct of the grant. The potential for this fluid is truly revolutionary and if successful, will transform the field of resuscitation medicinal and allow for survival of trauma victims. The potential for this fluid is truly revolutionary and if successful, will transform the field of resuscitation medicine and allow for improved survival of trauma victims. My recent training in Executive Leadership at the UCLA Anderson School of Management will enable me to leverage the knowledge and abilities gained, to conduct the science and administration of this transformational grant in an exemplary manner. In summary, I have the expertise, experience and leadership to lead and manage the proposed research project to a successful solution.


A selected list of publications:

Carlson K A, Jahr J S   A historical overview and update on pulse oximetry Anesthesiology review, ; 20(5): 173-81.
Cheung ATW, Jahr JS, Duong PL, Driessen B, Gunther RA   A quantitative study on microvascular changes in hypovolemia and resuscitation, The microcirculation and vascular biology, ; 165-168.
Mackenzie Colin F, Pitman Arkadiy N, Hodgson R Eric, Sussman Martin J, Levien Lewis J, Jahr Jonathan S, Greenburg A Gerson   Are Hemoglobin-Based Oxygen Carriers Being Withheld Because of Regulatory Requirement for Equivalence to Packed Red Blood Cells? American journal of therapeutics, ; 22(4): e115-21.
Jahr Jonathan S, Nesargi Susmita B, Lewis Kenneth, Johnson Calvin   Blood substitutes and oxygen therapeutics: an overview and current status American journal of therapeutics, ; 9(5): 437-43.
Lurie Fedor, Jahr Jonathan S, Driessen Bernd   Changes in circulating blood and plasma volume after hemoglobin-based oxygen carrier infusion and additional infusion of colloid solutions American journal of therapeutics, ; 9(5): 425-30.
Jahr Jonathan S, Liu Hong, Albert Olga K, Gull Amy, Moallempour Mojgan, Lim Jennifer, Gosselin Robert   Does HBOC-201 (Hemopure) affect platelet function in orthopedic surgery: a single-site analysis from a multicenter study American journal of therapeutics, ; 17(2): 140-7.
Weeks David L, Jahr Jonathan S, Lim Jennifer C, Butch Anthony W, Driessen Bernd   Does Hextend impair coagulation compared to 6% hetastarch? An ex vivo thromboelastography study American journal of therapeutics, ; 15(3): 225-30.
Jahr Jonathan S, Lurie Fedor, Gosselin Robert, Lin Jonathan S, Wong Luchin, Owings John T, Larkin Edward   Effects of hemoglobin glutamer-250 (bovine) (HBOC-201, Hemopure) on coagulation testing American journal of therapeutics, ; 9(5): 431-6.
Sinatra Raymond S, Boice Judith A, Loeys Tom L, Ko Amy T, Kashuba Maureen M, Jahr Jonathan S, Rhondeau Steven, Singla Neil, Cavanaugh Paul F, Reicin Alise S, Reicin Alise S   Evaluation of the effect of perioperative rofecoxib treatment on pain control and clinical outcomes in patients recovering from gynecologic abdominal surgery: a randomized, double-blind, placebo-controlled clinical study Regional anesthesia and pain medicine, ; 31(2): 134-42.
Singla Neil K, Hale Martin E, Davis Jeffrey C, Bekker Alex, Gimbel Joseph, Jahr Jonathan, Royal Mike A, Ang Robert Y, Viscusi Eugene R   IV acetaminophen: Efficacy of a single dose for postoperative pain after hip arthroplasty: subset data analysis of 2 unpublished randomized clinical trials American journal of therapeutics, ; 22(1): 2-10.
Arciaga Peregrina L, Windokun Adejare, Jahr Jonathan S, Tetzlaff John, Steen Stephen   Impact of a Didactic Lecture on Professionalism in Increasing Knowledge Amongst Faculty and Residents in an Academic Department The journal of education in perioperative medicine : JEPM, ; 10(1): E047.
Jahr Jonathan S, Lurie Fedor, Bezdikian Vatche, Driessen Bernd, Gunther Robert A   Measuring circulating blood volume using infused hemoglobin-based oxygen carrier (oxyglobin) as an indicator: verification in a canine hypovolemia model American journal of therapeutics, ; 15(2): 98-101.
Ren Wendy H P, Jahr Jonathan S   Reversal of neuromuscular block with a selective relaxant-binding agent: sugammadex American journal of therapeutics, ; 16(4): 295-9.
Springer D K, Jahr J S   The laryngeal mask airway. Safety, efficacy, and current use The American journal of anesthesiology, ; 22(2): 65-9.
Jahr J S, Keller T, Williams M D, Liukkonen J R, Anwar M, Paxtor C G, Greene M, Gitlin M C   To reverse or not to reverse: an evaluation of reversal of mivacurium chloride in women undergoing outpatient gynecological procedures American journal of therapeutics, ; 4(9-10): 315-22.
Jahr Jonathan S, Lurie Fedor, Driessen Bernd, Tang Zuping, Louie Richard F, Kost Gerald   Validation of oxygen saturation measurements in a canine model of hemoglobin-based oxygen carrier infusion American journal of therapeutics, ; 10(1): 21-8.
Nguyen-Lee J, Moreland N, Sadoughi A, Borna R, Salehi A, Jahr JS edited by Dr. G. Murphy   Sugammadex: Clinical Pharmacodynamics and Pharmacokinetics, Current Anesthesiology Reports, 2018; 8(2): .
Borna RM, Jahr JS, Kmiecik S, Mancuso K, Kaye AP   Pharmacology of Octreotide: Clinical Implications for Anesthesiologists and Associated Risks Anesthesiology Clinics, 2017; 35(2): 327-339.
Chung M, Mayer L, Nourmand H, You M, Jahr JS, edited by Kaye AD, Kaye AM, Urman RD   Blood, Blood Products, and Substitutes, Chapter 26: Essentials of Pharmacology for Anesthesia, Pain Medicine, and Critical Care, 2015; 421-432.
Jahr JS, Chung M, Anvarhosseini A, Kim HW, edited by HW Kim and AG Greenberg. Edited by HW Kim and AG Greenberg.   Chapter 34: Hemoglobin-based Oxygen Carrier Mediated Coagulopathy, Hemoglobin-based oxygen carriers as red blood cell substitutes and oxygen therapeutics, 2013; 647-664.
Kim HW, Jahr JS, Mozzarelli A, Sakai H, edited by HW Kim and AG Greenberg. Edited by HW Kim and AG Greenberg   Chapter: International Consortium for Development of Hemoglobin-based Oxygen Carriers, Oxygen Therapeutics and Multifunctional Resuscitation Fluids- A White Paper, Hemoglobin-based oxygen carriers as red blood cell substitutes and oxygen therapeutics, 2013; 737-746.
Jahr JS, Zimmerman D, edited by Nina Singh-Radcliff and Anita Gupta   Blood Substitutes, The 5-Minute Anesthesia Consult, 2012; 132-133.
Jahr JS, Sadighi Akha A, Doherty L, Li A, Kim HW, edited by Andrea Mozzarelli and Stefano Bettati   Chapter 22: Hemoglobin-based Oxygen Carriers: History, Limits, Brief Summary of the State of the Art, Including Clinical Trials, Chemistry and Biochemistry of Oxygen Therapeutics: from Transfusion to Artificial Blood, First Edition, 2011; .
Kim HW, Mozzarelli A, Sakai H, Jahr JS, edited by Andrea Mozzarelli and Stefano Bettati   Chapter 29: Academia - Industry Collaboration in Blood Substitute Development - Issues, Case Histories and a Proposal, Chemistry and Biochemistry of Oxygen Therapeutics: from Transfusion to Artificial Blood, First Edition, 2011; .
Eds: Sinatra RS, Jahr JS, and Watkins-Pitchford M.   The Essence of Analgesics and Analgesia, , 2011; .
Lee VK, Jahr JS, edited by Sinatra, Jahr, and Pitchford   IV Acetaminophen (IV-Paracetamol), The Essence of Analgesics and Analgesia, 2010; .
Jahr JS and Lee VK, edited by Kaye AD and Fleisher LA   Intravenous Acetaminophen, Perioperative Pharmacology, an Issue of Anesthesiology Clinics, 2010; .
Jahr JS, Lee VK, edited by Sinatra, Jahr, and Pitchford   Nonselective Nonsteroidal Anti-Inflammatory Drugs, COX-2 Inhibitors, and Acetaminophen, The Essence of Analgesics and Analgesia, 2010; .
Sadighi Akha A, Rosa J, Jahr JS, Li A, Kiai K, edited by Kaye AD, and Fleisher LA,   Sugammadex: Cyclodextrins, Development of Selective Binding Agents, Pharmacology, Clinical Development, and Future Directions, Perioperative Pharmacology, an Issue of Anesthesiology Clinics, 2010; .
Jahr JS, Donkor KN, Sinatra RS, edited by Sinatra R, deLeon-Cassola O, Ginsberg B and Viscusi ER   Non-Selective Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Cyclooxygenase-2 Inhibitors (COX-2Is), and Acetaminophen in Acute Perioperative Pain: Analgesic efficacy, opiate-sparing effects, and adverse effects, Acute Pain Management, 2nd ed, 2009; .
Jahr JS, Driessen B, Gunther RA, Lurie F, Lim JC, Cheung ATW   Translational Advances in Second and Third Generation Hemoglobin Based Oxygen Carriers: One Research Team’s Perspective, Artificial Blood , 2009; .
Jahr JS, Moallempour M, Ellis JE   Transfusion update--triggers, targets, and will we ever have a blood substitute?, Current Reviews in Clinical Anesthesia, 2008; .
Cheung Anthony T W, To Patricia L Duong, Chan Danielle M, Ramanujam Sahana, Barbosa Michelle A, Chen Peter C Y, Driessen Bernd, Jahr Jonathan S, Gunther Robert A   Comparison of treatment modalities for hemorrhagic shock Artificial cells, blood substitutes, and immobilization biotechnology, 2007; 35(2): 173-90.
Cheung Anthony T, Duong Patricia L, Driessen Bernd, Chen Peter C, Jahr Jonathan S, Gunther Robert A   Systemic function, oxygenation and microvascular correlation during treatment of hemorrhagic shock with blood substitutes Clinical hemorheology and microcirculation, 2006; 34(1-2): 325-34.
  Proceedings of the 23rd European Conference on Microcirculation, , 2005; 81-86.
Jahr Jonathan S., Driessen Bernd, Lurie Fedor, Tang Zuping, Louie Richard F., Kost Gerald   Oxygen saturation measurements in canine blood containing hemoglobin glutamer-200 (Bovine): in vitro validation of the NOVA CO-Oximeter Veterinary clinical pathology, 2001; 30(1): 39-45.
Jahr JS.    Acute normovolemic hemodilution: a wise choice or just extra work?,  American Journal of Anesthesiology, 2001; 27(2): 76.
Jahr J S, Lurie F, Gosselin R, Lin J S, Wong L, Larkin E   Effects of a hemoglobin-based oxygen carrier (HBOC-201) on coagulation testing Clinical laboratory science : journal of the American Society for Medical Technology, 2000; 13(4): 210-4.
Jahr J S, Lurie F, Driessen B, Tang Z, Louie R F, Kullar R, Kost G   Validation of oxygen saturation measurements in a canine model of hemoglobin based oxygen carrier (HBOC) infusion Clinical laboratory science : journal of the American Society for Medical Technology, 2000; 13(2): 173-9.
Gray J, Jahr JS, Schneider P   Carcinoid Syndrome and the Anesthetic Use of Octreotide: A Review, American Journal of Anesthesiology , 1999; .
Barrons RW, Jahr JS   Aprotinin and antifibrinolytics in cardiopulmonary bypass bleeding, Seminars in Anesthesia, Perioperative Medicine and Pain, 1998; 17(3): 224-238.
Lian T S, Bellan J A, Jahr J S, Holton R H, Nossaman B D, Kadowitz P J   Vasodilator responses to desmopressin and its diluent, chlorobutanol, in the hindquarters vascular bed of the cat Journal of medicine, 1996; 27(1-2): 73-87.
Jahr J S, Kaye A D, Kang B, Feng C J, Nossaman B D   Analysis of aprotinin on the mean arterial pressure, carotid artery blood flow, and hindlimb vascular resistance in the live rat, and pulmonary vascular resistance in the isolated perfused rat lung Journal of medicine, 1995; 26(1-2): 31-42.
Jahr J S, Kang B, Kaye A D, Paxtor C, Feng C J, Nossaman B D   Analysis of responses to vancomycin in carotid blood flow in the male rat Journal of medicine, 1995; 26(3-4): 175-81.
Jahr JS, Hester Z, Davis J, Liukkonen J, Ramadhyani U   Comparison of two sites for non-invasive blood pressure monitoring, American Journal of Anesthesiology, 1995; 22(1): 32-36.
Carlson KA, Jahr JS   An update on pulse oximetry: limitations and future directions, Anesthesiology Review, 1994; .
Jahr J S, Montalvo H M, Holton R, Liukkonen J   Does ketorolac tromethamine, a new analgesic, decrease postoperative recovery time, narcotic requirements, nausea and/or vomiting, and unscheduled hospital admissions: a retrospective analysis Acta anaesthesiologica Belgica, 1993; 44(4): 141-7.
Jahr JS, Texidor M, Kelley D, Kuchta K   Nausea or vomiting after propofol for outpatient lithotripsy, Anesthesiology Review, 1991; 18(6): 23-26.
Jahr Jonathan S, Bergese Sergio D, Sheth Ketan R, Bernthal Nicholas M, Ho Hung S, Stoicea Nicoleta, Apfel Christian C   Current Perspective on the Use of Opioids in Perioperative Medicine: An Evidence-Based Literature Review, National Survey of 70,000 Physicians, and Multidisciplinary Clinical Appraisal Pain medicine (Malden, Mass.), 2017; .
Mer Mervyn, Hodgson Eric, Wallis Lee, Jacobson Barry, Levien Lewis, Snyman Jacques, Sussman Martin J, James Mike, van Gelder Antoine, Allgaier Rachel, Jahr Jonathan S   Hemoglobin glutamer-250 (bovine) in South Africa: consensus usage guidelines from clinician experts who have treated patients Transfusion, 2016; 56(10): 2631-2636.
Soto Roy, Jahr Jonathan S, Pavlin Janet, Sabo Daniel, Philip Beverly K, Egan Talmage D, Rowe Everton, de Bie Joris, Woo Tiffany   Safety and Efficacy of Rocuronium With Sugammadex Reversal Versus Succinylcholine in Outpatient Surgery-A Multicenter, Randomized, Safety Assessor-Blinded Trial American journal of therapeutics, 2016; 23(6): e1654-e1662.
Apfel Christian, Jahr Jonathan R, Kelly Colleen L, Ang Robert Y, Oderda Gary M   Effect of i.v. acetaminophen on total hip or knee replacement surgery: a case-matched evaluation of a national patient database American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2015; 72(22): 1961-8.
Partownavid Parisa, Romito Bryan T, Ching Willy, Berry Ashley A, Barkulis Charles T, Nguyen KimNgan P, Jahr Jonathan S   Sugammadex: A Comprehensive Review of the Published Human Science, Including Renal Studies American journal of therapeutics, 2015; 22(4): 298-317.
Jahr Jonathan S, Miller John E, Hiruma Jessica, Emaus Katie, You Michelle, Meistelman Claude   Sugammadex: A Scientific Review Including Safety and Efficacy, Update on Regulatory Issues, and Clinical Use in Europe American journal of therapeutics, 2015; 22(4): 288-97.
Koh Wonuk, Nguyen Kimngan Pham, Jahr Jonathan S   Intravenous non-opioid analgesia for peri- and postoperative pain management: a scientific review of intravenous acetaminophen and ibuprofen Korean journal of anesthesiology, 2015; 68(1): 3-12.
Roghani Kimia, Holtby Randall J, Jahr Jonathan S   Effects of hemoglobin-based oxygen carriers on blood coagulation Journal of functional biomaterials, 2014; 5(4): 288-95.
Sabo Daniel, Jahr Jonathan, Pavlin Janet, Philip Beverly, Shimode Noriko, Rowe Everton, Woo Tiffany, Soto Roy   The increases in potassium concentrations are greater with succinylcholine than with rocuronium-sugammadex in outpatient surgery: a randomized, multicentre trial Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2014; 61(5): 423-32.
Joshi Girish P, Beck David E, Emerson Roger Hill, Halaszynski Thomas M, Jahr Jonathan S, Lipman Arthur G, Nihira Mikio A, Sheth Ketan R, Simpson Melanie H, Sinatra Raymond S   Defining new directions for more effective management of surgical pain in the United States: highlights of the inaugural Surgical Pain Congress™ The American surgeon, 2014; 80(3): 219-28.
Jahr Jonathan S, Filocamo Peter, Singh Sumit   Intravenous acetaminophen: a review of pharmacoeconomic science for perioperative use American journal of therapeutics, 2013; 20(2): 189-99.
Jahr Jonathan S, Akha Arezou Sadighi, Holtby Randall J   Crosslinked, polymerized, and PEG-conjugated hemoglobin-based oxygen carriers: clinical safety and efficacy of recent and current products Current drug discovery technologies, 2012; 9(3): 158-65.
Sinatra Raymond S, Jahr Jonathan S, Reynolds Lowell, Groudine Scott B, Royal Mike A, Breitmeyer James B, Viscusi Eugene R   Intravenous acetaminophen for pain after major orthopedic surgery: an expanded analysis Pain practice : the official journal of World Institute of Pain, 2012; 12(5): 357-65.
Jahr Jonathan S, Breitmeyer James B, Pan Christine, Royal Mike A, Ang Robert Y   Safety and efficacy of intravenous acetaminophen in the elderly after major orthopedic surgery: subset data analysis from 3, randomized, placebo-controlled trials American journal of therapeutics, 2012; 19(2): 66-75.
Jahr Jonathan S   Are newer generation hemoglobin-based oxygen carriers safe: do they offer an answer? Vascular pharmacology, 2010; 52(5-6): 214.
Jahr Jonathan S, Kapur Patricia A   Advances in anesthesia, preoperative and pain medicine. Introduction American journal of therapeutics, 2009; 16(4): 283.
Jahr J   Do approved blood substitutes reduce myocardial infarction size: is this the critical question? British journal of anaesthesia, 2009; 103(4): 470-1.
Lee Chingmuh, Jahr Jonathan S, Candiotti Keith A, Warriner Brian, Zornow Mark H, Naguib Mohamed   Reversal of profound neuromuscular block by sugammadex administered three minutes after rocuronium: a comparison with spontaneous recovery from succinylcholine Anesthesiology, 2009; 110(5): 1020-5.
Moallempour Mojgan, Jahr Jonathan S, Lim Jennifer C, Weeks David, Butch Anthony, Driessen Bernd   Methemoglobin effects on coagulation: a dose-response study with HBOC-200 (Oxyglobin) in a thrombelastogram model Journal of cardiothoracic and vascular anesthesia, 2009; 23(1): 41-7.
Jahr Jonathan S, Moallempour Mojgan, Lim Jennifer C   HBOC-201, hemoglobin glutamer-250 (bovine), Hemopure (Biopure Corporation) Expert opinion on biological therapy, 2008; 8(9): 1425-33.
Jahr Jonathan S, Mackenzie Colin, Pearce L Bruce, Pitman Arkadiy, Greenburg A Gerson   HBOC-201 as an alternative to blood transfusion: efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgery The Journal of trauma, 2008; 64(6): 1484-97.
Driessen Bernd, Zarucco Laura, Gunther Robert A, Burns Patrick M, Lamb Stephen V, Vincent Stella E, Boston Ray A, Jahr Jonathan S, Cheung Anthony T W   Effects of low-volume hemoglobin glutamer-200 versus normal saline and arginine vasopressin resuscitation on systemic and skeletal muscle blood flow and oxygenation in a canine hemorrhagic shock model Critical care medicine, 2007; 35(9): 2101-9.
Jahr Jonathan S, Walker Valeri, Manoochehri Katayoon   Blood substitutes as pharmacotherapies in clinical practice Current opinion in anaesthesiology, 2007; 20(4): 325-30.
Driessen B, Jahr J S, Lurie F, Gunther R A   Effects of isovolemic resuscitation with hemoglobin-based oxygen carrier Hemoglobin glutamer-200 (bovine) on systemic and mesenteric perfusion and oxygenation in a canine model of hemorrhagic shock: a comparison with 6% hetastarch solution and shed blood Veterinary anaesthesia and analgesia, 2006; 33(6): 368-80.
Sinatra Raymond S, Jahr Jonathan S, Reynolds Lowell W, Viscusi Eugene R, Groudine Scott B, Payen-Champenois Catherine   Efficacy and safety of single and repeated administration of 1 gram intravenous acetaminophen injection (paracetamol) for pain management after major orthopedic surgery Anesthesiology, 2005; 102(4): 822-31.
Osgood Stephen L, Jahr Jonathan S, Desai Poonam, Tsukamoto Jessica, Driessen Bernd   Does methemoglobin from oxidized hemoglobin-based oxygen carrier (hemoglobin Glutamer-200) interfere with lactate measurement (YSI 2700 SELECT Biochemistry Analyzer)? Anesthesia and analgesia, 2005; 100(2): 437-9.
Jahr Jonathan S, Osgood Stephen, Rothenberg Stephen J, Li Qiao-Ling, Butch Anthony W, Gunther Robert, Cheung Anthony, Driessen Bernd   Lactate measurement interference by hemoglobin-based oxygen carriers (Oxyglobin, Hemopure, and Hemolink) Anesthesia and analgesia, 2005; 100(2): 431-6.
Guan Fuyu, Uboh Cornelius E, Soma Lawrence R, Luo Yi, Jahr Jonathan S, Driessen Bernd   Confirmation and quantification of hemoglobin-based oxygen carriers in equine and human plasma by hyphenated liquid chromatography tandem mass spectrometry Analytical chemistry, 2004; 76(17): 5127-35.
Cheung Anthony T W, Driessen Bernd, Jahr Jonathan S, Duong Patricia L, Ramanujam Sahana, Chen Peter C Y, Gunther Robert A   Blood substitute resuscitation as a treatment modality for moderate hypovolemia Artificial cells, blood substitutes, and immobilization biotechnology, 2004; 32(2): 189-207.
Jahr Jonathon S, Varma Namrata   PolyHeme. Northfield Laboratories IDrugs : the investigational drugs journal, 2004; 7(5): 478-82.
Nguyen N T, Anderson J T, Budd M, Fleming N W, Ho H S, Jahr J, Stevens C M, Wolfe B M   Effects of pneumoperitoneum on intraoperative pulmonary mechanics and gas exchange during laparoscopic gastric bypass Surgical endoscopy, 2004; 18(1): 64-71.
Driessen Bernd, Jahr Jonathan S, Lurie Fedor, Golkaryeh Mohammad S, Gunther Robert A   Arterial oxygenation and oxygen delivery after hemoglobin-based oxygen carrier infusion in canine hypovolemic shock: a dose-response study Critical care medicine, 2003; 31(6): 1771-9.
Khan Ahsanul K, Jahr Jonathan S, Nesargi Susmita, Rothenberg Stephen J, Tang Zuping, Cheung Anthony, Gunther Robert A, Kost Gerald J, Driessen Bernd   Does lead interfere with hemoglobin-based oxygen carrier (HBOC) function? A pilot study of lead concentrations in three approved or tested HBOCs and oxyhemoglobin dissociation with HBOCs and/or bovine blood with varying lead concentrations Anesthesia and analgesia, 2003; 96(6): 1813-20, table of contents.
Lurie Fedor, Driessen Bernd, Jahr Jonathan S, Reynoso Rashell, Gunther Robert A   Validity of arterial and mixed venous oxygen saturation measurements in a canine hemorrhage model after resuscitation with varying concentrations of hemoglobin-based oxygen carrier Anesthesia and analgesia, 2003; 96(1): 46-50, table of contents.
Crosby Edward T, Jahr Jonathan S   A revolution in transfusion medication in the last decade American journal of therapeutics, 2002; 9(5): 370.
Lurie Fedor, Jahr Jonathan S, Driessen Bernd   The novel HemoCu plasma/low hemoglobin system accurately measures small concentrations of three different hemoglobin-based oxygen carriers in plasma: hemoglobin glutamer-200 (bovine) (Oxyglobin), hemoglobin glutamer-250 (bovine) (Hemopure), and hemoglobin-Raffimer (Hemolink) Anesthesia and analgesia, 2002; 95(4): 870-3, table of contents.
Levy Jerrold H, Goodnough Lawrence T, Greilich Philip E, Parr Grant V S, Stewart Robert W, Gratz Irwin, Wahr Joyce, Williams John, Comunale Mark E, Doblar Dennis, Silvay George, Cohen Marc, Jahr Jonathan S, Vlahakes Gus J   Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: results of a randomized, double-blind trial The Journal of thoracic and cardiovascular surgery, 2002; 124(1): 35-42.
Jahr Jonathan S, Lurie Fedor, Driessen Bernd, Davis Jessica A, Gosselin Robert, Gunther Robert A   The HemoCue, a point of care B-hemoglobin photometer, measures hemoglobin concentrations accurately when mixed in vitro with canine plasma and three hemoglobin-based oxygen carriers (HBOC) Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2002; 49(3): 243-8.
Cheung A T, Jahr J S, Driessen B, Duong P L, Chan M S, Lurie F, Golkaryeh M S, Kullar R K, Gunther R A   The effects of hemoglobin glutamer-200 (bovine) on the microcirculation in a canine hypovolemia model: a noninvasive computer-assisted intravital microscopy study Anesthesia and analgesia, 2001; 93(4): 832-8.
Chan F P, Jahr J S, Driessen B, Daunt D A, Li K C   Validation of in vivo MR measurement of oxygen saturation after resuscitation with a hemoglobin-based oxygen carrier in a rabbit model Academic radiology, 2001; 8(7): 583-90.
Driessen B, Jahr J S, Lurie F, Griffey S M, Gunther R A   Effects of haemoglobin-based oxygen carrier hemoglobin glutamer-200 (bovine) on intestinal perfusion and oxygenation in a canine hypovolaemia model British journal of anaesthesia, 2001; 86(5): 683-92.
Jahr J S, Lurie F, Xi S, Golkaryeh M, Kuznetsova O, Kullar R, Driessen B   A novel approach to measuring circulating blood volume: the use of a hemoglobin-based oxygen carrier in a rabbit model Anesthesia and analgesia, 2001; 92(3): 609-14.
Driessen B, Jahr J S, Lurie F, Gunther R A   Inadequacy of low-volume resuscitation with hemoglobin-based oxygen carrier hemoglobin glutamer-200 (bovine) in canine hypovolemia Journal of veterinary pharmacology and therapeutics, 2001; 24(1): 61-71.
Jahr J S, Stuart J S   Analysis of the hemodynamic effects of heparinase I and protamine sulfate in the systemic and hindlimb vascular beds of the male rat American journal of therapeutics, 2000; 7(6): 353-7.
Owings J T, Pollock M E, Gosselin R C, Ireland K, Jahr J S, Larkin E C   Anticoagulation of children undergoing cardiopulmonary bypass is overestimated by current monitoring techniques Archives of surgery (Chicago, Ill. : 1960), 2000; 135(9): 1042-7.
Barrons Robert W., Jahr Jonathan S.   A Review of Post--Cardiopulmonary Bypass Bleeding, Aminocaproic Acid, Tranexamic Acid, and Aprotinin American journal of therapeutics, 1996; 3(12): 821-838.
Jahr J S, Kang B, Kaye A D, Kaye A, Paxtor C, Feng C J, Nossaman B D   Analysis of vancomycin in the hindlimb vascular bed of the rat American journal of therapeutics, 1996; 3(10): 681-7.
Jahr Jonathan S., Kang Bin, Paxtor Carlos G., Feng Chang Jian   Hemodynamic Responses to Papaverine: Do Nitric Oxide, Cyclic GMP, or Calcium Mediate the Vasodilation? American journal of therapeutics, 1995; 2(4): 258-264.
Jahr Jonathan S., Feng Chang Jian, Wang Junke, Holton Ronald, Cheng David Y.   The Effect of Cromakalim on the Hindlimb Vascular Bed of the Male Rat: Do Glybenclamide and/or Nitric Oxide Modulate the Vasodilation? American journal of therapeutics, 1994; 1(1): 8-14.
Jahr J S, Holton R H, Feng C J   Effect of desmopressin acetate on hindlimb perfusion pressure in rats: what is the mechanism? Anesthesia and analgesia, 1992; 75(3): 411-5.
Haskins D A, Jahr J S, Texidor M, Ramadhyani U   Single-dose oral omeprazole for reduction of gastric residual acidity in adults for outpatient surgery Acta anaesthesiologica Scandinavica, 1992; 36(6): 513-5.
Jahr J S, Burckart G, Smith S S, Shapiro J, Cook D R   Effects of famotidine on gastric pH and residual volume in pediatric surgery Acta anaesthesiologica Scandinavica, 1991; 35(5): 457-60.
Jahr J S, Marquez J, Cottington E, Cook D R   Hemodynamic performance and histamine levels after desmopressin acetate administration following cardiopulmonary bypass in adult patients Journal of cardiothoracic and vascular anesthesia, 1991; 5(2): 139-41.
Gieraerts R, Navalgund A, Vaes L, Soetens M, Chang J L, Jahr J   Increased incidence of itching and herpes simplex in patients given epidural morphine after cesarean section Anesthesia and analgesia, 1987; 66(12): 1321-4.

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