Charles Lassman, M.D., Ph.D.

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A Short Biography:

Charles R. Lassman, MD, PhD is Professor in the Department of Pathology & Laboratory Medicine at the Geffen UCLA School of Medicine. Dr. Lassman did his undergraduate work at George Washington University, received his M.D. and Ph.D. at the University of Pittsburgh School of Medicine where he studied the alternate processing of immunooglobulin mRNA under the direction of Dr. Christine Milcarek. He did Post doctoral work on Trypanasoma brucei brucei at the University of Geneva, Switzerland under the direction of Dr. Jacques Deshusses. He completed residency training in Anatomic Pathology at Stanford University including fellowships in Surgical Pathology under the direction of Dr. Richard Kempson and immunodiagnosis under the direction of Dr. Roger Warnke and Dr. Robert Rouse. He completed a final year of training at Stanford University as a “Junior Attending” which also served as a fellowship year in Liver and Renal Pathology under the direction of Dr. Richard Sibley. He joined the faculty in the Department of Pathology at UCLA in 1997. Dr. Lassman is the director of Liver and renal pathology at UCLA and was the Director of The Surgical Pathology Fellowship the Pathology Residency Programs as well as the Vice chair for clinical education from 2003 until 2014. He continues on as Associate director of the residency and surgical pathology fellowship programs. He has been a member of the Education Committee of the California Society of Pathologists since 2003.
Work Titles
UCLA Chief, Liver Pathology Chief, Renal Pathology Professor, Pathology and Laboratory Medicine Associate Director, Pathology Residency Training Program Associate Director, Surgical Pathology Fellowship
Education:
Degrees:
M.D., University of Pittsburgh School of Medicine, 1992
Ph.D., University of Pittsburgh School of Medicine, 1992
Fellowship:
1995 - 1996 Stanford University Medical Center
1994 - 1995 Stanford University Medical Center
Residency:
1992 - 1994 Stanford University Medical Center
Certifications:
Certifications:
1996 American Board of Pathology

Contact Information:

Email Address:

classman@mednet.ucla.edu


Website:

Web-Profile

Fax Number:

(310) 267-2058

Work Address:

CHS 13-145


Publications:

A selected list of publications:

Petrowsky Henrik, Kaldas Fady, Peacock Warwick, Fisher Dean, Hong Johnny C, Lassman Charles, Busuttil Ronald W   Twenty-four years after liver transplantation, the recipient becomes a body donor Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2013; 19(1): 110-2.
Lee Young Joon, Lu David S K, Osuagwu Ferdnand, Lassman Charles   Irreversible electroporation in porcine liver: short- and long-term effect on the hepatic veins and adjacent tissue by CT with pathological correlation Investigative radiology, 2012; 47(11): 671-5.
Pongpaibul Ananya, Venick Robert S, McDiarmid Sue V, Lassman Charles R   Histopathology of de novo autoimmune hepatitis Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2012; 18(7): 811-8.
Naini Bita V, Lassman Charles R   Total parenteral nutrition therapy and liver injury: a histopathologic study with clinical correlation Human pathology, 2012; 43(6): 826-33.
Levy Mary, Trivedi Anand, Zhang Jun, Miles Lili, Mattis Aras N, Kim Grace E, Lassman Charles, Anders Robert A, Misdraji Joseph, Yerian Lisa M, Xu Haodong, Dhall Deepti, Wang Hanlin L   Expression of glypican-3 in undifferentiated embryonal sarcoma and mesenchymal hamartoma of the liver Human pathology, 2012; 43(5): 695-701.
Hong Johnny C, Koroleff Dimitri, Xia Victor, Chang Chun Ming, Duarte Sergio M, Xu Junming, Lassman Charles, Kupiec-Weglinski Jerzy, Coito Ana J, Busuttil Ronald W   Regulated hepatic reperfusion mitigates ischemia-reperfusion injury and improves survival after prolonged liver warm ischemia: a pilot study on a novel concept of organ resuscitation in a large animal model Journal of the American College of Surgeons, 2012; 214(4): 505-15; discussion 515-6.
Chestovich Paul J, Uchida Yoichiro, Chang William, Ajalat Mark, Lassman Charles, Sabat Robert, Busuttil Ronald W, Kupiec-Weglinski Jerzy W   Interleukin-22: implications for liver ischemia-reperfusion injury Transplantation, 2012; 93(5): 485-92.
Wozniak Laura J, Yang Hui-Min, Lassman Charles R, Federman Noah, Wu Steven S   Extramedullary acute myelocytic leukemia following liver transplantation for VOD with immunodeficiency Journal of pediatric gastroenterology and nutrition, 2011; 53(3): 346-9.
Ziegler Mary E, Chen Tingchao, LeBlanc James F, Wei Xuelian, Gjertson David W, Li Ker-Chau, Khalighi Mazdak A, Lassman Charles R, Veale Jeffrey L, Gritsch H Albin, Reed Elaine F   Apolipoprotein A1 and C-terminal fragment of ?-1 antichymotrypsin are candidate plasma biomarkers associated with acute renal allograft rejection Transplantation, 2011; 92(4): 388-95.
Freitas Maria Cecilia S, Uchida Yoichiro, Lassman Charles, Danovitch Gabriel M, Busuttil Ronald W, Kupiec-Weglinski Jerzy W   Type I interferon pathway mediates renal ischemia/reperfusion injury Transplantation, 2011; 92(2): 131-8.
Hong Johnny C, Petrowsky Henrik, Kaldas Fady M, Farmer Douglas G, Durazo Francisco A, Finn Richard S, Saab Sammy, Han Steven-Huy, Lee Percy, Markovic Daniela, Lassman Charles, Hiatt Jonathan R, Busuttil Ronald W   Predictive index for tumor recurrence after liver transplantation for locally advanced intrahepatic and hilar cholangiocarcinoma Journal of the American College of Surgeons, 2011; 212(4): 514-20; discussion 520-1.
Jakate Shriram, Yabes Annoel, Giusto Deborah, Naini Bita, Lassman Charles, Yeh Matthew M, Ferrell Linda D   Diffuse cirrhosis-like hepatocellular carcinoma: a clinically and radiographically undetected variant mimicking cirrhosis The American journal of surgical pathology, 2010; 34(7): 935-41.
Ra Seong H, Kaplan Jeffrey B, Lassman Charles R   Focal nodular hyperplasia after orthotopic liver transplantation Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2010; 16(1): 98-103.
Yu Nam C, Raman Steven S, Kim Young Jun, Lassman Charles, Chang Xinlian, Lu David S K   Microwave liver ablation: influence of hepatic vein size on heat-sink effect in a porcine model Journal of vascular and interventional radiology : JVIR, 2008; 19(7): 1087-92.
Meng Lingzhong, Wu Zheng, Wang Yue, Lassman Charles, Busuttil Ronald W, Zhai Yuan, Kupiec-Weglinski Jerzy W   Differential impact of CD154 costimulation blockade on alloreactive effector and regulatory T cells in murine renal transplant recipients Transplantation, 2008; 85(9): 1332-8.
Tabibian James H, Lassman Charles R, Margolis Daniel J, Landaverde Carmen, Busuttil Ronald W, Durazo Francisco A   Intraductal oncocytic papillary neoplasm of the liver: case and review of a rare variant Annals of hepatology, 2008; 7(2): 168-73.
Zhai Yuan, Shen Xiu-Da, Gao Feng, Zhao Alice, Freitas Maria Cecilia, Lassman Charles, Luster Andrew D, Busuttil Ronald W, Kupiec-Weglinski Jerzy W   CXCL10 regulates liver innate immune response against ischemia and reperfusion injury Hepatology (Baltimore, Md.), 2008; 47(1): 207-14.
Ra Seong H, Bradley Robert F, Fishbein Michael C, Busuttil Ronald W, Lu David S K, Lassman Charles R   Recurrent hepatic lymphangiomatosis after orthotopic liver transplantation Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2007; 13(11): 1593-7.
Shen Xiu-Da, Ke Bibo, Zhai Yuan, Gao Feng, Tsuchihashi Sei-Ichiro, Lassman Charles R, Busuttil Ronald W, Kupiec-Weglinski Jerzy W   Absence of toll-like receptor 4 (TLR4) signaling in the donor organ reduces ischemia and reperfusion injury in a murine liver transplantation model Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2007; 13(10): 1435-43.
Duffy John P, Vardanian Andrew, Benjamin Elizabeth, Watson Melissa, Farmer Douglas G, Ghobrial Rafik M, Lipshutz Gerald, Yersiz Hasan, Lu David S K, Lassman Charles, Tong Myron J, Hiatt Jonathan R, Busuttil Ronald W   Liver transplantation criteria for hepatocellular carcinoma should be expanded: a 22-year experience with 467 patients at UCLA Annals of surgery, 2007; 246(3): 502-9; discussion 509-11.
Hoglen Niel C, Anselmo Dean M, Katori Masamichi, Kaldas Marian, Shen Xiu-Da, Valentino Karen L, Lassman Charles, Busuttil Ronald W, Kupiec-Weglinski Jerzy W, Farmer Douglas G   A caspase inhibitor, IDN-6556, ameliorates early hepatic injury in an ex vivo rat model of warm and cold ischemia Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2007; 13(3): 361-6.
Veale Jeffrey L, Liang Leonard W, Zhang Qiuheng, Gjertson David W, Du Zeying, Bloomquist Erik W, Jia Juan, Qian Lei, Wilkinson Alan H, Danovitch Gabriel M, Pham Phuong-Thu T, Rosenthal J Thomas, Lassman Charles R, Braun Jonathan, Reed Elaine F, Gritsch H Albin   Noninvasive diagnosis of cellular and antibody-mediated rejection by perforin and granzyme B in renal allografts Human immunology, 2006; 67(10): 777-86.
Gritsch H Albin, Demetris Anthony J, Adeyi Oyedele, Bellamy Chris O C, Clouston Andrew, Charlotte Frederic, Czaja Albert, Daskal Ierachmiel, El-Monayeri Magda S, Fontes Paulo, Fung John, Gridelli Bruno, Guido Maria, Haga Hironori, Hart John, Honsova Eva, Hubscher Stefan, Itoh Tomoo, Jhala Nirag, Jungmann Patricia, Khettry Urmila, Lassman Charles, Ligato Saverio, Lunz John G, Marcos Amadeo, Minervini Marta Ida, Mölne Johan, Nalesnik Mike, Nasser Imad, Neil Desley, Ochoa Erin, Pappo Orit, Randhawa Parmjeet, Reinholt Finn P, Ruiz Phil, Sebagh Mylène, Spada Marco, Sonzogni Aurelio, Tsamandas Athanassios C, Wernerson Annika, Wu Tong, Yilmaz Funda   Liver biopsy interpretation for causes of late liver allograft dysfunction Hepatology (Baltimore, Md.), 2006; 44(2): 489-501.
Zhai Yuan, Shen Xiu-da, Hancock Wayne W, Gao Feng, Qiao Bo, Lassman Charles, Belperio John A, Strieter Robert M, Busuttil Ronald W, Kupiec-Weglinski Jerzy W   CXCR3+CD4+ T cells mediate innate immune function in the pathophysiology of liver ischemia/reperfusion injury Journal of immunology (Baltimore, Md. : 1950), 2006; 176(10): 6313-22.
Yu Nam C, Lu David S K, Raman Steven S, Dupuy Damian E, Simon Caroline J, Lassman Charles, Aswad Bassam I, Ianniti David, Busuttil Ronald W   Hepatocellular carcinoma: microwave ablation with multiple straight and loop antenna clusters--pilot comparison with pathologic findings Radiology, 2006; 239(1): 269-75.
Wallace W Dean, Reed Elaine F, Ross David, Lassman Charles R, Fishbein Michael C   C4d staining of pulmonary allograft biopsies: an immunoperoxidase study The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2005; 24(10): 1565-70.
Cameron Andrew M, Truty Jadwiga, Truell Jeff, Lassman Charles, Zimmerman Michael A, Kelly Burnett S, Farmer Douglas G, Hiatt Jonathan R, Ghobrial Rafik, Busuttil Ronald W   Fulminant hepatic failure from primary hepatic lymphoma: successful treatment with orthotopic liver transplantation and chemotherapy Transplantation, 2005; 80(7): 993-6.
Shen Xiu-Da, Gao Feng, Ke Bibo, Zhai Yuan, Lassman Charles R, Tsuchihashi Sei-Ichiro, Farmer Douglas G, Busuttil Ronald W, Kupiec-Weglinski Jerzy W   Inflammatory responses in a new mouse model of prolonged hepatic cold ischemia followed by arterialized orthotopic liver transplantation Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2005; 11(10): 1273-81.
Lu David S K, Yu Nam C, Raman Steven S, Lassman Charles, Tong Myron J, Britten Carolyn, Durazo Francisco, Saab Sammy, Han Steven, Finn Richard, Hiatt Jonathan R, Busuttil Ronald W   Percutaneous radiofrequency ablation of hepatocellular carcinoma as a bridge to liver transplantation Hepatology (Baltimore, Md.), 2005; 41(5): 1130-7.
Lu David S K, Yu Nam C, Raman Steven S, Limanond Piyaporn, Lassman Charles, Murray Kathryn, Tong Myron J, Amado Rafael G, Busuttil Ronald W   Radiofrequency ablation of hepatocellular carcinoma: treatment success as defined by histologic examination of the explanted liver Radiology, 2005; 234(3): 954-60.
Saab Sammy, Cho Daniel, Lassman R Charles, Gajjar Nupoor A, Ghobrial Mark, Busuttil Ronald W   Recurrent non-alcoholic steatohepatitis in a living related liver transplant recipient Journal of hepatology, 2005; 42(1): 148-9.
Fondevila Constantino, Shen Xiu-Da, Tsuchiyashi Seiichiro, Yamashita Kenichiro, Csizmadia Eva, Lassman Charles, Busuttil Ronald W, Kupiec-Weglinski Jerzy W, Bach Fritz H   Biliverdin therapy protects rat livers from ischemia and reperfusion injury Hepatology (Baltimore, Md.), 2004; 40(6): 1333-41.
Zhai Yuan, Shen Xiu-da, O'Connell Ryan, Gao Feng, Lassman Charles, Busuttil Ronald W, Cheng Genhong, Kupiec-Weglinski Jerzy W   Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway Journal of immunology (Baltimore, Md. : 1950), 2004; 173(12): 7115-9.
Saab Sammy, Kalmaz Denise, Gajjar Nupoor A, Hiatt Jonathan, Durazo Francisco, Han Steven, Farmer Douglas G, Ghobrial R Mark, Yersiz Hasan, Goldstein Leonard I, Lassman Charles R, Busuttil Ronald W   Outcomes of acute rejection after interferon therapy in liver transplant recipients Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2004; 10(7): 859-67.
Durazo Francisco A, Lassman Charles, Han Steven H B, Saab Sammy, Lee Nancy P, Kawano Marvin, Saggi Bob, Gordon Sherilyn, Farmer Douglas G, Yersiz Hasan, Goldstein R Leonard I, Ghobrial Mark, Busuttil Ronald W   Fulminant liver failure due to usnic acid for weight loss The American journal of gastroenterology, 2004; 99(5): 950-2.
Limanond Piyaporn, Raman Steven S, Lassman Charles, Sayre James, Ghobrial R Mark, Busuttil Ronald W, Saab Sammy, Lu David S K   Macrovesicular hepatic steatosis in living related liver donors: correlation between CT and histologic findings Radiology, 2004; 230(1): 276-80.
Ke Bibo, Shen Xiu-Da, Lassman Charles R, Gao Feng, Busuttil Ronald W, Kupiec-Weglinski Jerzy W   Cytoprotective and antiapoptotic effects of IL-13 in hepatic cold ischemia/reperfusion injury are heme oxygenase-1 dependent American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2003; 3(9): 1076-82.
Ke Bibo, Shen Xiu-Da, Lassman Charles R, Gao Feng, Katori Masamichi, Busuttil Ronald W, Kupiec-Weglinski Jerzy W   Interleukin-13 gene transfer protects rat livers from antigen-independent injury induced by ischemia and reperfusion Transplantation, 2003; 75(8): 1118-23.
Saab Sammy, Hu Rena, Ibrahim Ayman B, Goldstein Leonard I, Kunder Gregg, Durazo Francisco, Han Steven, Yersiz Hasan, Ghobrial Rafik M, Farmer Douglas G, Busuttil Ronald W, Lassman Charles   Discordance between ALT values and fibrosis in liver transplant recipients treated with ribavirin for recurrent hepatitis C American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2003; 3(3): 328-33.
Shen Xiu-Da, Ke Bibo, Zhai Yuan, Gao Feng, Anselmo Dean, Lassman Charles R, Busuttil Ronald W, Kupiec-Weglinski Jerzy W   Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotection Hepatology (Baltimore, Md.), 2003; 37(2): 296-303.
Ghobrial Rafik M, Saab Sammy, Lassman Charles, Lu David S k, Raman Steven, Limanond Piyagorn, Kunder Greg, Marks Karyn, Amersi Farin, Anselmo Dean, Chen Pauline, Farmer Douglas, Han Steven, Durazo Francisco, Goldstein Leonard I, Busuttil Ronald W   Donor and recipient outcomes in right lobe adult living donor liver transplantation Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2002; 8(10): 901-9.
Pham Phuong-Thu T, Danovitch Gabriel M, Wilkinson Alan H, Gritsch H Albin, Pham Phuong-Chi T, Eric Tong M, Kendrick Elizabeth, Charles Lassman R, Tsai Han-Mou   Inhibitors of ADAMTS13: a potential factor in the cause of thrombotic microangiopathy in a renal allograft recipient Transplantation, 2002; 74(8): 1077-80.
Wu Mark Li-cheng, Dry Sarah M, Lassman Charles R   Deeper examination of negative colorectal biopsies American journal of clinical pathology, 2002; 117(3): 424-8.

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