Loes Olde Loohuis, Ph.D.

A Short Biography:

We study the genetics of severe mental illness. By utilizing and developing computational approaches to leverage multi-level data, including psychiatric phenotypes, health records and molecular phenotypes, we aim to characterize and predict psychiatric disease trajectories. We have a special focus on studying genetic and environmental risk factors that contribute to the cause and course of illness in Latin American populations.

Work Titles
UCLA Assistant Professor, Psychiatry and Biobehavioral Sciences Member, Bioinformatics GPB Home Area

Contact Information:


View a up-to-date publication list: https://www.ncbi.nlm.nih.gov/myncbi/loes.olde%20loohuis.1/bibliography/public/

A selected list of publications:

Olde Loohuis Loes M, Mennigen Eva, Ori Anil P S, Perkins Diana, Robinson Elise, Addington Jean, Cadenhead Kristin S, Cornblatt Barbara A, Mathalon Daniel H, McGlashan Thomas H, Seidman Larry J, Keshavan Matcheri S, Stone William S, Tsuang Ming T, Walker Elaine F, Woods Scott W, Cannon Tyrone D, Gur Ruben C, Gur Raquel E, Bearden Carrie E, Ophoff Roel A   Genetic and clinical analyses of psychosis spectrum symptoms in a large multiethnic youth cohort reveal significant link with ADHD Translational psychiatry, 2021; 11(1): 80.
Krebs Catharine E, Ori Anil P S, Vreeker Annabel, Wu Timothy, Cantor Rita M, Boks Marco P M, Kahn Rene S, Olde Loohuis Loes M, Ophoff Roel A   Whole blood transcriptome analysis in bipolar disorder reveals strong lithium effect Psychological medicine, 2020; 50(15): 2575-2586.
Mansolf Maxwell, Vreeker Annabel, Reise Steven P, Freimer Nelson B, Glahn David C, Gur Raquel E, Moore Tyler M, Pato Carlos N, Pato Michele T, Palotie Aarno, Holm Minna, Suvisaari Jaana, Partonen Timo, Kieseppä Tuula, Paunio Tiina, Boks Marco, Kahn René, Ophoff Roel A, Bearden Carrie E, Loohuis Loes Olde, Teshiba Terri, deGeorge Daniella, Bilder Robert M, Bilder Robert M, Bilder Robert M   Extensions of Multiple-Group Item Response Theory Alignment: Application to Psychiatric Phenotypes in an International Genomics Consortium Educational and psychological measurement, 2020; 80(5): 870-909.
Service Susan K, Vargas Upegui Cristian, Castaño Ramírez Mauricio, Port Allison M, Moore Tyler M, Munoz Umanes Marfred, Agudelo Arango Luis Guillermo, Díaz-Zuluaga Ana M, Melo Espejo Juanita, López María Cecilia, Palacio Juan David, Ruiz Sánchez Sergio, Valencia Johanna, Teshiba Terri M, Espinoza Alesandra, Olde Loohuis Loes, De la Hoz Gomez Juan, Brodey Benjamin B, Sabatti Chiara, Escobar Javier I, Reus Victor I, Lopez Jaramillo Carlos, Gur Ruben C, Bearden Carrie E, Freimer Nelson B   Distinct and shared contributions of diagnosis and symptom domains to cognitive performance in severe mental illness in the Paisa population: a case-control study The lancet. Psychiatry, 2020; 7(5): 411-419.
Perkins Diana O, Olde Loohuis Loes, Barbee Jenna, Ford John, Jeffries Clark D, Addington Jean, Bearden Carrie E, Cadenhead Kristin S, Cannon Tyrone D, Cornblatt Barbara A, Mathalon Daniel H, McGlashan Thomas H, Seidman Larry J, Tsuang Ming, Walker Elaine F, Woods Scott W   Polygenic Risk Score Contribution to Psychosis Prediction in a Target Population of Persons at Clinical High Risk The American journal of psychiatry, 2020; 177(2): 155-163.
Mennigen Eva, Jolles Dietsje D, Hegarty Catherine E, Gupta Mohan, Jalbrzikowski Maria, Olde Loohuis Loes M, Ophoff Roel A, Karlsgodt Katherine H, Bearden Carrie E   State-Dependent Functional Dysconnectivity in Youth With Psychosis Spectrum Symptoms Schizophrenia bulletin, 2020; 46(2): 408-421.
Hill Brian L, Brown Robert, Gabel Eilon, Rakocz Nadav, Lee Christine, Cannesson Maxime, Baldi Pierre, Olde Loohuis Loes, Johnson Ruth, Jew Brandon, Maoz Uri, Mahajan Aman, Sankararaman Sriram, Hofer Ira, Halperin Eran   An automated machine learning-based model predicts postoperative mortality using readily-extractable preoperative electronic health record data British journal of anaesthesia, 2019; 123(6): 877-886.
Jalbrzikowski Maria, Freedman David, Hegarty Catherine E, Mennigen Eva, Karlsgodt Katherine H, Olde Loohuis Loes M, Ophoff Roel A, Gur Raquel E, Bearden Carrie E   Structural Brain Alterations in Youth With Psychosis and Bipolar Spectrum Symptoms Journal of the American Academy of Child and Adolescent Psychiatry, 2019; 58(11): 1079-1091.

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