Monica Cappelletti, Ph.D.

A Short Biography:

Dr. Cappelletti earned her MS in Medical Biotechnology and her PhD in Molecular Medicine/Immunology at the University of Milan, Italy. During her graduate training in Dr. Della Bella’s lab, Dr. Cappelletti focused on uncovering the immunological processes associated with the alteration of immune cell populations in pregnancy disorders. For her postdoctoral training, she moved to Cincinnati Children’s Hospital Medical Center in Dr. Divanovic’s lab, where she focused on understanding the molecular mechanisms underlying the regulation of innate immune signaling and inflammation in infection and immune-associated induction of preterm birth. Specifically, her aim was to uncover the cellular and molecular pathways underlying the role of inflammation and type I IFN/IFNAR axis in induction of preterm birth. In August 2017, she was recruited to UCLA in Dr. Kallapur’s lab and her project was focused on preclinical evaluation of promising drugs to prevent inflammation associated preterm labor and investigating mechanisms of intrauterine inflammation and fetal inflammation in both Rhesus and mouse models of pregnancy complications. In March 2021, Dr. Cappelletti became Director of the Immune Assessment Core and Adjunct Assistant Professor with the Department of Pathology and Laboratory Medicine.


Work Titles
UCLA Adjunct Assistant Professor, Pathology and Laboratory Medicine
Education:
Degrees:
Ph.D.

Contact Information:

Publications:

A selected list of publications:

Cappelletti Monica, Doll Jessica R, Stankiewicz Traci E, Lawson Matthew J, Sauer Vivien, Wen Bingqiang, Kalinichenko Vladimir V, Sun Xiaofei, Tilburgs Tamara, Divanovic Senad   Maternal regulation of inflammatory cues is required for induction of preterm birth JCI insight, 2020; 5(22): .
Toothaker Jessica M, Presicce Pietro, Cappelletti Monica, Stras Stephanie F, McCourt Collin C, Chougnet Claire A, Kallapur Suhas G, Konnikova Liza   Immune Cells in the Placental Villi Contribute to Intra-amniotic Inflammation Frontiers in immunology, 2020; 11(1): 866.
Chan Calvin C, Damen Michelle S M A, Moreno-Fernandez Maria E, Stankiewicz Traci E, Cappelletti Monica, Alarcon Pablo C, Oates Jarren R, Doll Jessica R, Mukherjee Rajib, Chen Xiaoting, Karns Rebekah, Weirauch Matthew T, Helmrath Michael A, Inge Thomas H, Divanovic Senad   Type I interferon sensing unlocks dormant adipocyte inflammatory potential Nature communications, 2020; 11(1): 2745.
Jain Viral G, Kong Fansheng, Kallapur Suhas G, Presicce Pietro, Senthamaraikannnan Paranthaman, Cappelletti Monica, Chougnet Claire A, Bhattacharyya Sandip, Pasare Chandrashekhar, Muglia Louis J   IRAK1 Is a Critical Mediator of Inflammation-Induced Preterm Birth Journal of immunology (Baltimore, Md. : 1950), 2020; 204(10): 2651-2660.
Cappelletti Monica, Presicce Pietro, Kallapur Suhas G   Immunobiology of Acute Chorioamnionitis Frontiers in immunology, 2020; 11(10): 649.
Presicce Pietro, Cappelletti Monica, Senthamaraikannan Paranthaman, Ma Feiyang, Morselli Marco, Jackson Courtney M, Mukherjee Shibabrata, Miller Lisa A, Pellegrini Matteo, Jobe Alan H, Chougnet Claire A, Kallapur Suhas G   TNF-Signaling Modulates Neutrophil-Mediated Immunity at the Feto-Maternal Interface During LPS-Induced Intrauterine Inflammation Frontiers in immunology, 2020; 11(10): 558.
Mukherjee Rajib, Moreno-Fernandez Maria E, Giles Daniel A, Cappelletti Monica, Stankiewicz Traci E, Chan Calvin C, Divanovic Senad   Nicotinamide adenine dinucleotide phosphate (reduced) oxidase 2 modulates inflammatory vigor during nonalcoholic fatty liver disease progression in mice Hepatology communications, 2018; 2(5): 546-560.
Cappelletti Monica, Lawson Matthew J, Chan Calvin C, Wilburn Adrienne N, Divanovic Senad   Differential outcomes of TLR2 engagement in inflammation-induced preterm birth Journal of leukocyte biology, 2018; 103(3): 535-543.
Moreno-Fernandez Maria E, Giles Daniel A, Stankiewicz Traci E, Sheridan Rachel, Karns Rebekah, Cappelletti Monica, Lampe Kristin, Mukherjee Rajib, Sina Christian, Sallese Anthony, Bridges James P, Hogan Simon P, Aronow Bruce J, Hoebe Kasper, Divanovic Senad   Peroxisomal ╬▓-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease JCI insight, 2018; 3(6): 546-560.
Giles Daniel A, Moreno-Fernandez Maria E, Stankiewicz Traci E, Graspeuntner Simon, Cappelletti Monica, Wu David, Mukherjee Rajib, Chan Calvin C, Lawson Matthew J, Klarquist Jared, S├╝nderhauf Annika, Softic Samir, Kahn C Ronald, Stemmer Kerstin, Iwakura Yoichiro, Aronow Bruce J, Karns Rebekah, Steinbrecher Kris A, Karp Christopher L, Sheridan Rachel, Shanmukhappa Shiva K, Reynaud Damien, Haslam David B, Sina Christian, Rupp Jan, Hogan Simon P, Divanovic Senad   Erratum: Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling Nature medicine, 2017; 23(10): 1241.

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