Rhonda Voskuhl, M.D.

A Short Biography:

Dr. Voskuhl received her M.D. from Vanderbilt Medical School and completed a neurology residency at the University of Texas Southwestern. She did a five year fellowship in at the National Institutes of Health (NIH). Dr. Voskuhl joined UCLA as Assistant Professor of Neurology in 1995, was promoted to Associate Professor in 2000 and Professor in 2004. She is Director of the UCLA MS Program. She received the Jack H. Skirball Endowed Chair in Multiple Sclerosis in 2006. She has received numerous grants from the NIH, the Conrad N. Hilton Foundation, and the National Multiple Sclerosis Society (NMSS), including the Harry Weaver Neuroscience Scholar Award. Dr. Voskuhl was recently selected for the prestigious Berlin Institute of Health Excellence Award for Sex and Gender Aspects in Health Research, an international award conferred in Berlin, Germany in 2018. Prof. Voskuhl has been selected to give the 2019 Kenneth P. Johnson Memorial Lecture by the Americas Committee for the Treatment and Research in Multiple Sclerosis (ACTRIMS). She is also President-Elect for the international Organization for the Study of Sex Differences (OSSD). 

Dr. Voskuhl has led in the study of sex differences in disease for over two decades. She served on the NIH Task Force on Women’s Health 1997 and the NMSS Task Force on Gender and Autoimmunity 1997 resulting in a publication in Science identifying the gaps in knowledge in sex differences research and an NIH/NMSS co-funding initiative for grants on sex differences research, for which she and others were funded. She has had continuous funding as PI for her research for over 20 years, including two current RO1 grants from the National Institutes of Health (NIH): one on sex differences in MS and the other to discover novel treatments targeting disabilities in MS based on gene expression in the brain. Dr. Voskuhl's research has been highlighted in Science in 2010 and commented upon in editorials on sex differences research in Nature in 2014 and 2017. She has been a guest on National Public Radio's "Morning Edition" in 2014 and "All Things Considered" in 2016.

The Voskuhl laboratory is focused on understanding the pathogenesis of neurodegenerative diseases such as multiple sclerosis (MS) through the use of mouse models. Dr. Voskuhl employs a “"Bedside to Bench to Bedside”" approach where basic research starts with known clinical observations. These observations are investigated for underlying mechanism in the laboratory. Findings in the laboratory then reveal new treatments to be tested in clinical trials. A major clinical observation of interest is sex differences in MS and other neurodegnerative and autoimmune diseases. Dr. Voskuhl has led investigations into the effect of sex hormones and sex chromosomes on both inflammation and neurodegeneration. She has translated this basic science to the clinic by being the Principle Investigator on 4 treatment trials in MS, two of which were multicenter trials at several sites across the U.S. Another clinical observation being investigated through funding by the Conrad N. Hilton Foundation investigates the difference in disabilties between MS patients,  aiming to discover neuroprotective treatments tailored for each MS disability (walking, vision and cognition) by analysis of gene expression across brain in a disability-specific manner. This cell-specific and region-specific transcriptomics approach is also being aimed toward preventing cognitive decline of brain aging.


Work Titles
UCLA Jack H. Skirball Chair, Multiple Sclerosis Research Director, Multiple Sclerosis Program Professor, Neurology Professor In-Residence, Semel Institute for Neuroscience and Human Behavior
Education:
Degrees:
M.D., Vanderbilt University School of Medicine, 1986
Fellowship:
1990 - 1993 National Institutes of Health, The Clinical Center
Internship:
1986 - 1987 Presbyterian Hospital of Dallas
Residency:
1987 - 1990 Parkland Health and Hospital System
Certifications:
Certifications:
1992 American Board of Psychiatry and Neurology
Honors and Awards:
2018 - Berlin Institute of Health, Berlin Institute of Health Excellence Award for Sex and Gender Aspects in Health Research.
2006 - UCLA, Jack H. Skirball Chair in Multiple Sclerosis Research
1997 - National MS Society, Harry Weaver Neuroscience Scholar

Contact Information:

Detailed Biography:

Dr. Voskuhl is the Director of the UCLA MS Program, holds the Jack H. Skirball Chair in MS, and is a Professor in the UCLA Dept. of Neurology. She has received national and international awards for her research and has continuous funding for over 20 years. Professor Voskuhl uses a "Bedside to Bench to Bedside" approach, basing reserach on clinical observations, understanding them in the lab, then designing novel clincal trials. She sees MS patients in the neurology clinic and mentors at the postdoctoral, graduate, and undergradate levels. 

Publications:

Voskuhl Rhonda R, Wang HeJing, Wu T C Jackson, Sicotte Nancy L, Nakamura Kunio, Kurth Florian, Itoh Noriko, Bardens Jenny, Bernard Jacqueline T, Corboy John R, Cross Anne H, Dhib-Jalbut Suhayl, Ford Corey C, Frohman Elliot M, Giesser Barbara, Jacobs Dina, Kasper Lloyd H, Lynch Sharon, Parry Gareth, Racke Michael K, Reder Anthony T, Rose John, Wingerchuk Dean M, MacKenzie-Graham Allan J, Arnold Douglas L, Tseng Chi Hong, Elashoff Robert   Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial The Lancet. Neurology, 2016; 15(1): 35-46.
Voskuhl Rhonda   Preclinical studies of sex differences: a clinical perspective Biology of sex differences, 2016; 7: 7.
Itoh Noriko, Itoh Yuichiro, Tassoni Alessia, Ren Emily, Kaito Max, Ohno Ai, Ao Yan, Farkhondeh Vista, Johnsonbaugh Hadley, Burda Josh, Sofroniew Michael V, Voskuhl Rhonda R   Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes Proceedings of the National Academy of Sciences of the United States of America, 2018; 115(2): E302-E309.
Kim Roy Y, Mangu Darian, Hoffman Alexandria S, Kovash Rojan, Jung Eunice, Itoh Noriko, Voskuhl Rhonda   Oestrogen receptor β ligand acts on CD11c+ cells to mediate protection in experimental autoimmune encephalomyelitis Brain : a journal of neurology, 2018; 141(1): 132-147.
Voskuhl Rhonda R, Sawalha Amr H, Itoh Yuichiro   Sex chromosome contributions to sex differences in multiple sclerosis susceptibility and progression Multiple sclerosis (Houndmills, Basingstoke, England), 2018; 24(1): 22-31.
Voskuhl Rhonda, Momtazee Callene   Pregnancy: Effect on Multiple Sclerosis, Treatment Considerations, and Breastfeeding Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2017; 14(4): 974-984.
Klein Robyn S, Voskuhl Rhonda, Segal Benjamin M, Dittel Bonnie N, Lane Thomas E, Bethea John R, Carson Monica J, Colton Carol, Rosi Susanna, Anderson Aileen, Piccio Laura, Goverman Joan M, Benveniste Etty N, Brown Melissa A, Tiwari-Woodruff Seema Kaushalya, Harris Tajie H, Cross Anne H   Speaking out about gender imbalance in invited speakers improves diversity Nature immunology, 2017; 18(5): 475-478.
Itoh Noriko, Kim Roy, Peng Mavis, DiFilippo Emma, Johnsonbaugh Hadley, MacKenzie-Graham Allan, Voskuhl Rhonda R   Bedside to bench to bedside research: Estrogen receptor beta ligand as a candidate neuroprotective treatment for multiple sclerosis Journal of neuroimmunology, 2017; 304(5): 63-71.
Golden Lisa C, Voskuhl Rhonda   The importance of studying sex differences in disease: The example of multiple sclerosis Journal of neuroscience research, 2017; 95(1-2): 633-643.
Gold Stefan M, Voskuhl Rhonda R   Pregnancy and multiple sclerosis: from molecular mechanisms to clinical application Seminars in immunopathology, 2016; 38(6): 709-718.
Voskuhl Rhonda, Patti Francesco   Hormone replacement in menopausal women with multiple sclerosis: Looking back, thinking forward Neurology, 2016; 87(14): 1430-1431.
MacKenzie-Graham Allan, Kurth Florian, Itoh Yuichiro, Wang He-Jing, Montag Michael J, Elashoff Robert, Voskuhl Rhonda R   Disability-Specific Atlases of Gray Matter Loss in Relapsing-Remitting Multiple Sclerosis JAMA neurology, 2016; 73(8): 944-53.
Voskuhl Rhonda, Wang HeJing, Elashoff Robert M   Why use sex hormones in relapsing-remitting multiple sclerosis? - Authors' reply The Lancet. Neurology, 2016; 15(8): 790-791.
Voskuhl Rhonda   It is time to conduct phase 3 clinical trials of sex hormones in MS - Yes Multiple sclerosis (Houndmills, Basingstoke, England), 2018; 24(11): 1413-1415.
MacKenzie-Graham Allan, Brook Jenny, Kurth Florian, Itoh Yuichiro, Meyer Cassandra, Montag Michael J, Wang He-Jing, Elashoff Robert, Voskuhl Rhonda R   Estriol-mediated neuroprotection in multiple sclerosis localized by voxel-based morphometry Brain and behavior, 2018; 8(9): e01086.

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