Jessica Rexach, M.D., Ph.D.

A Short Biography:

New therapeutic targets are needed for neurodegenerative disease including Alzheimer’s and related dementias. The immune system includes many of the most successful therapeutic targets in medicine. My lab seeks to uncover mechanism by which glia and immune factors influence disease pathology in dementia to inform novel therapeutic strategies. We integrate single cell and tissue transcriptomics, epigenetic profiling, and human genetics to identify cell-specific and multicellular neuroimmune signaling networks in human dementias by applying systems biology and functional genomics. We use transgenic mouse models and human iPSC-derived 3D neuronal-glial cultures to test the roles and mechanisms of these signaling networks. This includes building and utilizing robust gene co-expression modules as conserved molecular disease phenotypes from which to study the effects of genetic and chemical perturbations. A major focus of our current work is the interplay of glial immune signaling, chromatin instability, and neuronal dysfunction in dementia, including the role of interferon-mediated immune suppression in disease pathology.

Work Titles
UCLA Assistant Professor, Neurology Member, Genetics & Genomics GPB Home Area

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A selected list of publications:

Ngo Kathie J, Rexach Jessica E, Lee Hane, Petty Lauren E, Perlman Susan, Valera Juliana M, Deignan Joshua L, Mao Yuanming, Aker Mamdouh, Posey Jennifer E, Jhangiani Shalini N, Coban-Akdemir Zeynep H, Boerwinkle Eric, Muzny Donna, Nelson Alexandra B, Hassin-Baer Sharon, Poke Gemma, Neas Katherine, Geschwind Michael D, Grody Wayne W, Gibbs Richard, Geschwind Daniel H, Lupski James R, Below Jennifer E, Nelson Stanley F, Fogel Brent L   A diagnostic ceiling for exome sequencing in cerebellar ataxia and related neurological disorders Human mutation, 2019; .
Xiao Changrui, M Binkley Elaine, Rexach Jessica, Knight-Johnson Amy, Khemani Pravin, Fogel Brent L, Das Soma, M Stone Edwin, Gomez Christopher M   A family with spinocerebellar ataxia and retinitis pigmentosa attributed to an Neurology. Genetics, 2019; 5(5): e357.
Rexach Jessica, Lee Hane, Martinez-Agosto Julian A, Németh Andrea H, Fogel Brent L   Clinical application of next-generation sequencing to the practice of neurology The Lancet. Neurology, 2019; 18(5): 492-503.
Lee Hane, Martinez-Agosto Julian A, Rexach Jessica, Fogel Brent L   Next generation sequencing in clinical diagnosis The Lancet. Neurology, 2019; 18(5): 426.
Swarup Vivek, Hinz Flora I, Rexach Jessica E, Noguchi Ken-Ichi, Toyoshiba Hiroyoshi, Oda Akira, Hirai Keisuke, Sarkar Arjun, Seyfried Nicholas T, Cheng Chialin, Haggarty Stephen J, Haggarty Stephen J, Grossman Murray, Van Deerlin Vivianna M, Trojanowski John Q, Lah James J, Levey Allan I, Kondou Shinichi, Geschwind Daniel H   Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia Nature medicine, 2019; 25(1): 152-164.
Wang Andrew C, Jensen Elizabeth H, Rexach Jessica E, Vinters Harry V, Hsieh-Wilson Linda C   Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration Proceedings of the National Academy of Sciences of the United States of America, 2016; 113(52): 15120-15125.
Trikamji Bhavesh, Rexach Jessica, Mishra Shri K   A Case of Spinocerebellar Ataxia With a Reversible Splenium Lesion Due to Malnutrition and Vitamin Deficiency Journal of clinical neuromuscular disease, 2015; 17(2): 95-7.
Clark Peter M, Rexach Jessica E, Hsieh-Wilson Linda C   Visualization of O-GlcNAc glycosylation stoichiometry and dynamics using resolvable poly(ethylene glycol) mass tags Current protocols in chemical biology, 2013; 5(4): 281-302.
Rexach Jessica E, Clark Peter M, Mason Daniel E, Neve Rachael L, Peters Eric C, Hsieh-Wilson Linda C   Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation Nature chemical biology, 2012; 8(3): 253-61.
Rexach Jessica E, Rogers Claude J, Yu Seok-Ho, Tao Jifang, Sun Yi E, Hsieh-Wilson Linda C   Quantification of O-glycosylation stoichiometry and dynamics using resolvable mass tags Nature chemical biology, 2010; 6(9): 645-51.
Rexach Jessica E, Clark Peter M, Hsieh-Wilson Linda C   Chemical approaches to understanding O-GlcNAc glycosylation in the brain Nature chemical biology, 2008; 4(2): 97-106.
Khidekel Nelly, Ficarro Scott B, Clark Peter M, Bryan Marian C, Swaney Danielle L, Rexach Jessica E, Sun Yi E, Coon Joshua J, Peters Eric C, Hsieh-Wilson Linda C   Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics Nature chemical biology, 2007; 3(6): 339-48.

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