A Short Biography:
Dr. Zhen's research interests are focused on gene and cell based therapy for treating HIV infection, cancer, and other chronic conditions. Her laboratory is interested in engineering long term immunity against HIV and cancer by genetically modifying hematopoietic stem cells and T cells with chimeric antigen receptors. In addition, her laboratory is interested in studying mechanisms of immune exhaustion/dysfunction during chronic HIV infection, cancer and other chronic conditions and applying the findings to further enhance innate and engineered immune responses.
Publications:
A selected list of publications:
Zhen Anjie, Peterson Christopher W, Carrillo Mayra A, Reddy Sowmya Somashekar, Youn Cindy S, Lam Brianna B, Chang Nelson Y, Martin Heather A, Rick Jonathan W, Kim Jennifer, Neel Nick C, Rezek Valerie K, Kamata Masakazu, Chen Irvin S Y, Zack Jerome A, Kiem Hans-Peter, Kitchen Scott G
Long-term persistence and function of hematopoietic stem cell-derived
chimeric antigen receptor T cells in a nonhuman primate model of
HIV/AIDS
PLoS pathogens,
2017; 13(12):
e1006753.
Zhen Anjie, Rezek Valerie, Youn Cindy, Lam Brianna, Chang Nelson, Rick Jonathan, Carrillo Mayra, Martin Heather, Kasparian Saro, Syed Philip, Rice Nicholas, Brooks David G, Kitchen Scott G
Targeting type I interferon-mediated activation restores immune
function in chronic HIV infection
The Journal of clinical investigation,
2017; 127(1):
260-268.
Zhen Anjie, Kamata Masakazu, Rezek Valerie, Rick Jonathan, Levin Bernard, Kasparian Saro, Chen Irvin Sy, Yang Otto O, Zack Jerome A, Kitchen Scott G
HIV-specific Immunity Derived From Chimeric Antigen
Receptor-engineered Stem Cells
Molecular therapy : the journal of the American Society of Gene Therapy,
2015; 23(8):
1358-1367.
