Anjie Zhen, Ph.D.

A Short Biography:

Dr. Zhen's research interests are focused on gene and cell based therapy for treating HIV infection, cancer, and other chronic conditions. Her laboratory is interested in engineering long term immunity against HIV and cancer by genetically modifying hematopoietic stem cells and T cells with chimeric antigen receptors. In addition, her laboratory is interested in studying mechanisms of immune exhaustion/dysfunction during chronic HIV infection, cancer and other chronic conditions and applying the findings to further enhance innate and engineered immune responses.

Work Titles
UCLA Assistant Professor, Hematology Oncology
Education:
Degrees:
Ph.D.

Contact Information:

Email Address:

AZhen@mednet.ucla.edu


Work Phone Number:

310-206-9719

Laboratory Address:

615 Charles E Young Drive South
Los Angeles, CA 90095


Publications:

A selected list of publications:

Norton Thomas D*, Zhen Anjie*, Tada Takuya, Kim Jennifer, Kitchen Scott, Landau Nathaniel R   Lentiviral Vector-Based Dendritic Cell Vaccine Suppresses HIV Replication in Humanized Mice Molecular therapy : the journal of the American Society of Gene Therapy, 2019; 27(5): 960-973.
Carrillo Mayra A, Zhen Anjie, Kitchen Scott G   The Use of the Humanized Mouse Model in Gene Therapy and Immunotherapy for HIV and Cancer Frontiers in immunology, 2018; 9(20): 746.
Zhen Anjie, Peterson Christopher W, Carrillo Mayra A, Reddy Sowmya Somashekar, Youn Cindy S, Lam Brianna B, Chang Nelson Y, Martin Heather A, Rick Jonathan W, Kim Jennifer, Neel Nick C, Rezek Valerie K, Kamata Masakazu, Chen Irvin S Y, Zack Jerome A, Kiem Hans-Peter, Kitchen Scott G   Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS PLoS pathogens, 2017; 13(12): e1006753.
Zhen Anjie, Carrillo Mayra A, Kitchen Scott G   Chimeric antigen receptor engineered stem cells: a novel HIV therapy Immunotherapy, 2017; 9(5): 401-410.
Zhen Anjie, Rezek Valerie, Youn Cindy, Lam Brianna, Chang Nelson, Rick Jonathan, Carrillo Mayra, Martin Heather, Kasparian Saro, Syed Philip, Rice Nicholas, Brooks David G, Kitchen Scott G   Targeting type I interferon-mediated activation restores immune function in chronic HIV infection The Journal of clinical investigation, 2017; 127(1): 260-268.
Zhen Anjie, Kamata Masakazu, Rezek Valerie, Rick Jonathan, Levin Bernard, Kasparian Saro, Chen Irvin Sy, Yang Otto O, Zack Jerome A, Kitchen Scott G   HIV-specific Immunity Derived From Chimeric Antigen Receptor-engineered Stem Cells Molecular therapy : the journal of the American Society of Gene Therapy, 2015; 23(8): 1358-1367.

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