Anjie Zhen

Title(s)Assistant Adjunct Professor, Medicine
SchoolMedicine
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    Collapse Research 
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    Define the effects and mechanism of THC and CBD on IFN-I mediated inflammation and immune dysfunction during HIV infection
    NIH R01DA052841Sep 30, 2020 - Jul 31, 2025
    Role: Principal Investigator
    A Universal CAR-NK Cell Targeting Various Epitopes of HIV-1
    NIH R21AI155117Jul 13, 2020 - Jun 30, 2022
    Role: Co-Principal Investigator
    Targeting Autophagy to Restore Anti-HIV T Cell Response
    NIH R21AI140866Jul 3, 2018 - Jun 30, 2020
    Role: Principal Investigator
    Characterization and restoration of exhausted immune responses in humanized Bone marrow-liver-thymus (BLT) mice infected with HIV-1
    NIH F32AI118565Jul 1, 2016 - Jun 30, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Stem cell-derived CAR T cells show greater persistence, trafficking, and plasma viral control compared to ex vivo transduced CAR T cells in vivo. Mol Ther. 2024 Feb 26. Carrillo MA, Zhen A, Mu W, Rezek V, Martin H, Peterson CW, Kiem HP, Kitchen SG. PMID: 38414243.
      View in: PubMed   Mentions:    Fields:    
    2. Examining Chronic Inflammation, Immune Metabolism, and T Cell Dysfunction in HIV Infection. Viruses. 2024 Jan 31; 16(2). Mu W, Patankar V, Kitchen S, Zhen A. PMID: 38399994.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Targeting autophagy to treat HIV immune dysfunction. Autophagy Rep. 2023; 2(1). Mu W, Martin H, Zhen A. PMID: 38435700; PMCID: PMC10906968.
      View in: PubMed   Mentions:
    4. Efficient manufacturing and engraftment of CCR5 gene-edited HSPCs following busulfan conditioning in nonhuman primates. Mol Ther Methods Clin Dev. 2023 Sep 14; 30:276-287. Murray J, Einhaus T, Venkataraman R, Radtke S, Zhen A, Carrillo MA, Kitchen SG, Peterson CW, Kiem HP. PMID: 37575091; PMCID: PMC10415663.
      View in: PubMed   Mentions: 1  
    5. Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STINGA230 Variants. bioRxiv. 2023 Jul 10. Tang Z, Zhao J, Li Y, Tomer S, Selvaraju M, Tien N, Sun D, Johnson DK, Zhen A, Li P, Wang J. PMID: 37425806; PMCID: PMC10327114.
      View in: PubMed   Mentions:
    6. Autophagy inducer rapamycin treatment reduces IFN-I-mediated Inflammation and improves anti-HIV-1 T cell response in vivo. JCI Insight. 2022 11 22; 7(22). Mu W, Rezek V, Martin H, Carrillo MA, Tomer S, Hamid P, Lizarraga MA, Tibbe TD, Yang OO, Jamieson BD, Kitchen SG, Zhen A. PMID: 36509289; PMCID: PMC9746825.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    7. Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice. J Vis Exp. 2022 10 06; (188). Mu W, Zhen A, Carrillo MA, Rezek V, Martin H, Lizarraga M, Kitchen S. PMID: 36282697.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. Cannabidiol modulates expression of type I IFN response genes and HIV infection in macrophages. Front Immunol. 2022; 13:926696. Tomer S, Mu W, Suryawanshi G, Ng H, Wang L, Wennerberg W, Rezek V, Martin H, Chen I, Kitchen S, Zhen A. PMID: 36248834; PMCID: PMC9560767.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    9. Correction: Robust CAR-T memory formation and function via hematopoietic stem cell delivery. PLoS Pathog. 2021 Aug; 17(8):e1009895. Zhen A, Carrillo MA, Mu W, Rezek V, Martin H, Hamid P, Chen ISY, Yang OO, Zack JA, Kitchen SG. PMID: 34460861; PMCID: PMC8405002.
      View in: PubMed   Mentions: 1     Fields:    
    10. Robust CAR-T memory formation and function via hematopoietic stem cell delivery. PLoS Pathog. 2021 04; 17(4):e1009404. Zhen A, Carrillo MA, Mu W, Rezek V, Martin H, Hamid P, Chen ISY, Yang OO, Zack JA, Kitchen SG. PMID: 33793675; PMCID: PMC8016106.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    11. Stem cell-derived CAR T cells traffic to HIV reservoirs in macaques. JCI Insight. 2021 01 11; 6(1). Barber-Axthelm IM, Barber-Axthelm V, Sze KY, Zhen A, Suryawanshi GW, Chen IS, Zack JA, Kitchen SG, Kiem HP, Peterson CW. PMID: 33427210; PMCID: PMC7821595.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    12. A Universal CAR-NK Cell Targeting Various Epitopes of HIV-1 gp160. ACS Chem Biol. 2020 08 21; 15(8):2299-2310. Lim RM, Rong L, Zhen A, Xie J. PMID: 32667183; PMCID: PMC8152219.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    13. Interferon-Inducible MicroRNA miR-128 Modulates HIV-1 Replication by Targeting TNPO3 mRNA. J Virol. 2019 10 15; 93(20). Bochnakian A, Zhen A, Zisoulis DG, Idica A, KewalRamani VN, Neel N, Daugaard I, Hamdorf M, Kitchen S, Lee K, Pedersen IM. PMID: 31341054; PMCID: PMC6798100.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    14. Lentiviral Vector-Based Dendritic Cell Vaccine Suppresses HIV Replication in Humanized Mice. Mol Ther. 2019 05 08; 27(5):960-973. Norton TD, Zhen A, Tada T, Kim J, Kitchen S, Landau NR. PMID: 30962161; PMCID: PMC6520467.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    15. The Use of the Humanized Mouse Model in Gene Therapy and Immunotherapy for HIV and Cancer. Front Immunol. 2018; 9:746. Carrillo MA, Zhen A, Kitchen SG. PMID: 29755454; PMCID: PMC5932400.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    16. Correction: Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS. PLoS Pathog. 2018 03; 14(3):e1006891. Zhen A, Peterson CW, Carrillo MA, Reddy SS, Youn CS, Lam BB, Chang NY, Martin HA, Rick JW, Kim J, Neel NC, Rezek VK, Kamata M, Chen ISY, Zack JA, Kiem HP, Kitchen SG. PMID: 29529058; PMCID: PMC5846784.
      View in: PubMed   Mentions: 5     Fields:    
    17. Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS. PLoS Pathog. 2017 12; 13(12):e1006753. Zhen A, Peterson CW, Carrillo MA, Reddy SS, Youn CS, Lam BB, Chang NY, Martin HA, Rick JW, Kim J, Neel NC, Rezek VK, Kamata M, Chen ISY, Zack JA, Kiem HP, Kitchen SG. PMID: 29284044; PMCID: PMC5746250.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    18. New approaches for the enhancement of chimeric antigen receptors for the treatment of HIV. Transl Res. 2017 09; 187:83-92. Carrillo MA, Zhen A, Zack JA, Kitchen SG. PMID: 28755872.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    19. Chimeric antigen receptor engineered stem cells: a novel HIV therapy. Immunotherapy. 2017 Mar; 9(5):401-410. Zhen A, Carrillo MA, Kitchen SG. PMID: 28357916; PMCID: PMC5618937.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    20. Targeting type I interferon-mediated activation restores immune function in chronic HIV infection. J Clin Invest. 2017 01 03; 127(1):260-268. Zhen A, Rezek V, Youn C, Lam B, Chang N, Rick J, Carrillo M, Martin H, Kasparian S, Syed P, Rice N, Brooks DG, Kitchen SG. PMID: 27941243; PMCID: PMC5199686.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimalsCells
    21. Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model. J Vis Exp. 2016 07 02; (113). Zhen A, Rezek V, Youn C, Rick J, Lam B, Chang N, Zack J, Kamata M, Kitchen S. PMID: 27404517; PMCID: PMC4993349.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    22. Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence. PLoS Pathog. 2016 Jan; 12(1):e1005356. Cunningham CR, Champhekar A, Tullius MV, Dillon BJ, Zhen A, de la Fuente JR, Herskovitz J, Elsaesser H, Snell LM, Wilson EB, de la Torre JC, Kitchen SG, Horwitz MA, Bensinger SJ, Smale ST, Brooks DG. PMID: 26808628; PMCID: PMC4726812.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    23. Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling. Cell. 2015 Dec 17; 163(7):1716-29. York AG, Williams KJ, Argus JP, Zhou QD, Brar G, Vergnes L, Gray EE, Zhen A, Wu NC, Yamada DH, Cunningham CR, Tarling EJ, Wilks MQ, Casero D, Gray DH, Yu AK, Wang ES, Brooks DG, Sun R, Kitchen SG, Wu TT, Reue K, Stetson DB, Bensinger SJ. PMID: 26686653; PMCID: PMC4783382.
      View in: PubMed   Mentions: 214     Fields:    Translation:HumansAnimalsCells
    24. HIV-specific Immunity Derived From Chimeric Antigen Receptor-engineered Stem Cells. Mol Ther. 2015 Aug; 23(8):1358-1367. Zhen A, Kamata M, Rezek V, Rick J, Levin B, Kasparian S, Chen IS, Yang OO, Zack JA, Kitchen SG. PMID: 26050990; PMCID: PMC4817874.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    25. CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection. J Virol. 2014 Sep 01; 88(17):9934-46. Zhen A, Krutzik SR, Levin BR, Kasparian S, Zack JA, Kitchen SG. PMID: 24942581; PMCID: PMC4136363.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    26. Stem-cell-based gene therapy for HIV infection. Viruses. 2013 Dec 24; 6(1):1-12. Zhen A, Kitchen S. PMID: 24368413; PMCID: PMC3917429.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    27. Smoke-free or not: a pilot evaluation in selected Beijing Hospitals. BMC Public Health. 2013 Oct 17; 13:964. Stillman FA, Kaufman MR, Zhen A, Yang J, Wang J, Zhao N. PMID: 24134057; PMCID: PMC3853022.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansPHPublic Health
    28. Reduced APOBEC3H variant anti-viral activities are associated with altered RNA binding activities. PLoS One. 2012; 7(7):e38771. Zhen A, Du J, Zhou X, Xiong Y, Yu XF. PMID: 22859935; PMCID: PMC3408456.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    29. Prevention of rotavirus gastroenteritis in infants and children: rotavirus vaccine safety, efficacy, and potential impact of vaccines. Biologics. 2010 Aug 09; 4:213-29. Chandran A, Fitzwater S, Zhen A, Santosham M. PMID: 20714358; PMCID: PMC2921258.
      View in: PubMed   Mentions: 26  
    30. A single amino acid difference in human APOBEC3H variants determines HIV-1 Vif sensitivity. J Virol. 2010 Feb; 84(4):1902-11. Zhen A, Wang T, Zhao K, Xiong Y, Yu XF. PMID: 19939923; PMCID: PMC2812409.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
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