Paul Vespa, M.D.

A Short Biography:

Dr. Paul Vespa is the Assistant Dean of Critical Care Medicine, Research, the Gary L. Brinderson Family Chair in Neurocritical Care, Professor of Neurology and Neurosurgery at the David Geffen School of Medicine at UCLA. He is the director of the Neurocritical Care program at UCLA. He is a fellow-elect of the American College of Critical Care Medicine and the American Academy of Neurology. He is Chair of United Council of Neurologic Subspecialties. He has clinical and research interests in traumatic brain injury, intracerebral hemorrhage, status epilepticus, stroke, subarachnoid hemorrhage and coma. Dr. Vespa has pioneered the role of brain monitoring in the neurointensive care unit. He has also pioneered robotic telepresence in the Neuro-ICU. He has published over 200 articles and is an editorial board member of several international journals. Dr. Vespa is funded by the National Institutes of Health, the Department of Defense and the State of California Neurotrauma Initiative. Dr. Vespa is leading the strategic planning effort for Critical Care Medicine at UCLA to help shape the future of critical care innovation, patient care and research.

Work Titles
UCLA Assistant Dean Critical Care Medicine, Research Gary L. Brinderson Family Chair , Neurocritical Care Professor, Neurosurgery Professor, Neurology Director, Neurocritical Care
Education:
Degrees:
M.D., Ohio State University College of Medicine, 1990
Fellowship:
1994 - 1996 UCLA School of Medicine
Internship:
1990 - 1991 Riverside Methodist Hospitals
Residency:
1991 - 1994 University of Virginia Medical Center
Certifications:
Certifications:
1998 American Board of Psychiatry and Neurology

Contact Information:

Work Phone Number:

(310) 267-9448

310-794-9805

Mailing Address:

Westwood Outpatient Clinic Suite
300 Stein Plaza, Suite 420
Los Angeles, CA 90095


Office Address:

Ronald Reagan UCLA Medical Center
757 Westwood Plaza
Room 6236A
Los Angeles, CA 90095


Publications:

A selected list of publications:

Gonzalez Nestor R, Hamilton Robert, Bilgin-Freiert Arzu, Dusick Josh, Vespa Paul, Hu Xiao, Asgari Shadnaz   Cerebral hemodynamic and metabolic effects of remote ischemic preconditioning in patients with subarachnoid hemorrhage Acta neurochirurgica. Supplement, 2013; 115(1): 193-8.
Stocchetti Nino, Roux Peter Le, Vespa Paul, Oddo Mauro, Citerio Giuseppe, Andrews Peter J, Stevens Robert D, Sharshar Tarek, Taccone Fabio S, Vincent Jean-Louis   Clinical review: Neuromonitoring - an update Critical care (London, England), 2013; 17(1): 201.
Wright Matthew J, McArthur David L, Alger Jeffry R, Van Horn Jack, Irimia Andrei, Filippou Maria, Glenn Thomas C, Hovda David A, Vespa Paul   Early metabolic crisis-related brain atrophy and cognition in traumatic brain injury Brain imaging and behavior, 2013; .
Vespa Paul M   Hormonal dysfunction in neurocritical patients Current opinion in critical care, 2013; 19(2): 107-12.
Loh Yince, Shi Zhongsong, Liebeskind David, Jahan Reza, Gonzalez Nestor, Vespa Paul M, Starkman Sidney, Saver Jeffrey L, Tateshima Satoshi, Vinuela Fernando, Duckwiler Gary   Incomplete mechanical recanalization of middle cerebral artery occlusions facilitates endogenous recanalization within 5 h Journal of neurointerventional surgery, 2013; 5(3): 217-20.
Mould W Andrew, Carhuapoma J Ricardo, Muschelli John, Lane Karen, Morgan Timothy C, McBee Nichol A, Bistran-Hall Amanda J, Ullman Natalie L, Vespa Paul, Martin Neil A, Awad Issam, Zuccarello Mario, Hanley Daniel F, Hanley Daniel F   Minimally invasive surgery plus recombinant tissue-type plasminogen activator for intracerebral hemorrhage evacuation decreases perihematomal edema Stroke; a journal of cerebral circulation, 2013; 44(3): 627-34.
Wu Hsiao-Ming, Huang Sung-Cheng, Vespa Paul, Hovda David A, Bergsneider Marvin   Redefining the pericontusional penumbra following traumatic brain injury: evidence of deteriorating metabolic derangements based on positron emission tomography Journal of neurotrauma, 2013; 30(5): 352-60.
Riviello James J, Claassen Jan, LaRoche Suzette M, Sperling Michael R, Alldredge Brian, Bleck Thomas P, Glauser Tracy, Shutter Lori, Treiman David M, Vespa Paul M, Bell Rodney, Brophy Gretchen M, Brophy Gretchen M   Treatment of status epilepticus: an international survey of experts Neurocritical care, 2013; 18(2): 193-200.
Hu Xiao, Hamilton Robert, Baldwin Kevin, Vespa Paul M, Bergsneider Marvin   Automated extraction of decision rules for predicting lumbar drain outcome by analyzing overnight intracranial pressure Acta neurochirurgica. Supplement, 2012; 114(1-2): 207-12.
Lee Meng, Saver Jeffrey L, Alger Jeffry R, Hao Qing, Starkman Sidney, Ali Latisha K, Kim Doojin, Ovbiagele Bruce, Vespa Paul M, Froehler Michael T, Tenser Matthew S, Salamon Noriko, Villablanca J Pablo, Jahan Reza, Duckwiler Gary R, Tateshima Satoshi, Gonzalez Nestor, Vinuela Fernando, Liebeskind David S   Blood-brain barrier permeability derangements in posterior circulation ischemic stroke: frequency and relation to hemorrhagic transformation Journal of the neurological sciences, 2012; 313(1-2): 142-6.
Stein Nathan R, McArthur David L, Etchepare Maria, Vespa Paul M   Early cerebral metabolic crisis after TBI influences outcome despite adequate hemodynamic resuscitation Neurocritical care, 2012; 17(1): 49-57.
Brophy Gretchen M, Bell Rodney, Claassen Jan, Alldredge Brian, Bleck Thomas P, Glauser Tracy, Laroche Suzette M, Riviello James J, Shutter Lori, Sperling Michael R, Treiman David M, Vespa Paul M, Vespa Paul M   Guidelines for the evaluation and management of status epilepticus Neurocritical care, 2012; 17(1): 3-23.
Connolly E Sander, Rabinstein Alejandro A, Carhuapoma J Ricardo, Derdeyn Colin P, Dion Jacques, Higashida Randall T, Hoh Brian L, Kirkness Catherine J, Naidech Andrew M, Ogilvy Christopher S, Patel Aman B, Thompson B Gregory, Vespa Paul, Vespa Paul, Vespa Paul, Vespa Paul, Vespa Paul, Vespa Paul   Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association/american Stroke Association Stroke; a journal of cerebral circulation, 2012; 43(6): 1711-37.
Hamilton Robert, Baldwin Kevin, Fuller Jennifer, Vespa Paul, Hu Xiao, Bergsneider Marvin   Intracranial pressure pulse waveform correlates with aqueductal cerebrospinal fluid stroke volume Journal of applied physiology (Bethesda, Md. : 1985), 2012; 113(10): 1560-6.
Scalzo Fabien, Bergsneider Marvin, Vespa Paul M, Martin Neil A, Hu Xiao   Intracranial pressure signal morphology: real-time tracking IEEE pulse, 2012; 3(2): 49-52.
Asgari Shadnaz, Vespa Paul M, Bergsneider Marvin, Hu Xiao   Latency relationships between cerebral blood flow velocity and intracranial pressure Acta neurochirurgica. Supplement, 2012; 114(1-2): 5-9.
Kim Sunghan, Scalzo Fabien, Bergsneider Marvin, Vespa Paul, Martin Neil, Hu Xiao   Noninvasive intracranial pressure assessment based on a data-mining approach using a nonlinear mapping function IEEE transactions on bio-medical engineering, 2012; 59(3): 619-26.
Irimia Andrei, Chambers Micah C, Torgerson Carinna M, Filippou Maria, Hovda David A, Alger Jeffry R, Gerig Guido, Toga Arthur W, Vespa Paul M, Kikinis Ron, Van Horn John D   Patient-tailored connectomics visualization for the assessment of white matter atrophy in traumatic brain injury Frontiers in neurology, 2012; 3(1-2): 10.
Moin Tannaz, Bergsneider Marvin, Vespa Paul, Heaney Anthony P   Pituitary function in patients with normal pressure hydrocephalus before and after neurosurgical correction The Journal of clinical endocrinology and metabolism, 2012; 97(10): 3545-9.
Hamilton Robert B, Baldwin Kevin, Vespa Paul, Bergsneider Marvin, Hu Xiao   Subpeak regional analysis of intracranial pressure waveform morphology based on cerebrospinal fluid hydrodynamics in the cerebral aqueduct and prepontine cistern Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2012; 2012(1-2): 3935-8.
Glenn Thomas C, Sherma Arun K, McArthur David L, Hu Xiao, Hanuscin Christopher R, Furreedan Mehjabeen S, Hovda David A, Vespa Paul M, Martin Neil A   The linear relationship between transcranial Doppler pulsatility indices and intracranial pressure is influenced by traumatic brain injury and vasospasm Acta neurochirurgica. Supplement, 2012; 114(1-2): 11-5.
Vespa Paul, McArthur David L, Stein Nathan, Huang Sung-Cheng, Shao Weber, Filippou Maria, Etchepare Maria, Glenn Thomas, Hovda David A   Tight glycemic control increases metabolic distress in traumatic brain injury: a randomized controlled within-subjects trial Critical care medicine, 2012; 40(6): 1923-9.
Irimia Andrei, Chambers Micah C, Alger Jeffry R, Filippou Maria, Prastawa Marcel W, Wang Bo, Hovda David A, Gerig Guido, Toga Arthur W, Kikinis Ron, Vespa Paul M, Van Horn John D   Comparison of acute and chronic traumatic brain injury using semi-automatic multimodal segmentation of MR volumes Journal of neurotrauma, 2011; 28(11): 2287-306.
Marder Victor J, Blinc Ales, Gruber Theresa, Tratar Gregor, Sabovic Miso, Starkman Sidney, Jahan Reza, Duckwiler Gary, Vinuela Fernando, Tateshima Satoshi, Liebeskind David, Ovbiagele Bruce, Ali Letisha, Kim Doojin, Gonzalez Nestor, Vespa Paul M, Saver Jeffrey L   Comparison of plasmin with recombinant tissue-type plasminogen activator in lysis of cerebral thromboemboli retrieved from patients with acute ischemic stroke Stroke; a journal of cerebral circulation, 2011; 42(8): 2222-8.
Asgari Shadnaz, Bergsneider Marvin, Hamilton Robert, Vespa Paul, Hu Xiao   Consistent changes in intracranial pressure waveform morphology induced by acute hypercapnic cerebral vasodilatation Neurocritical care, 2011; 15(1): 55-62.
Diringer Michael N, Bleck Thomas P, Claude Hemphill J, Menon David, Shutter Lori, Vespa Paul, Bruder Nicolas, Connolly E Sander, Citerio Giuseppe, Gress Daryl, Hänggi Daniel, Hoh Brian L, Lanzino Giuseppe, Le Roux Peter, Rabinstein Alejandro, Schmutzhard Erich, Stocchetti Nino, Suarez Jose I, Treggiari Miriam, Tseng Ming-Yuan, Vergouwen Mervyn D I, Wolf Stefan, Zipfel Gregory, Zipfel Gregory   Critical care management of patients following aneurysmal subarachnoid hemorrhage: recommendations from the Neurocritical Care Society's Multidisciplinary Consensus Conference Neurocritical care, 2011; 15(2): 211-40.
Vespa Paul, Vespa Paul   Deep venous thrombosis prophylaxis Neurocritical care, 2011; 15(2): 295-7.
Vespa Paul, Vespa Paul   Endocrine function following acute SAH Neurocritical care, 2011; 15(2): 361-4.
Kim Sunghan, Hu Xiao, McArthur David, Hamilton Robert, Bergsneider Marvin, Glenn Thomas, Martin Neil, Vespa Paul   Inter-subject correlation exists between morphological metrics of cerebral blood flow velocity and intracranial pressure pulses Neurocritical care, 2011; 14(2): 229-37.
Asgari Shadnaz, Vespa Paul, Bergsneider Marvin, Hu Xiao   Lack of consistent intracranial pressure pulse morphological changes during episodes of microdialysis lactate/pyruvate ratio increase Physiological measurement, 2011; 32(10): 1639-51.
Vespa Paul M, Sergay Stephen M, Kohring John H   Subspecialization in neurology: the role of the United Council for Neurologic Subspecialties Neurology, 2011; 77(18): 1702-5.
Yin Nicole S, Benavides Sebastian, Starkman Sidney, Liebeskind David S, Saver Jeffrey A, Salamon Noriko, Jahan Reza, Duckwiler Gary R, Tateshima Satoshi, Vinuela Fernando, Vespa Paul M, Chute Dennis J, Vinters Harry V   Autopsy findings after intracranial thrombectomy for acute ischemic stroke: a clinicopathologic study of 5 patients Stroke; a journal of cerebral circulation, 2010; 41(5): 938-47.
Wenger Neil S, Vespa Paul M   Ethical issues in patient-physician communication about therapy for cancer: professional responsibilities of the oncologist The oncologist, 2010; 15 Suppl 1(2): 43-8.
Hu Xiao, Xu Peng, Asgari Shadnaz, Vespa Paul, Bergsneider Marvin   Forecasting ICP elevation based on prescient changes of intracranial pressure waveform morphology IEEE transactions on bio-medical engineering, 2010; 57(5): 1070-8.
Hu Xiao, Glenn Thomas, Scalzo Fabien, Bergsneider Marvin, Sarkiss Chris, Martin Neil, Vespa Paul   Intracranial pressure pulse morphological features improved detection of decreased cerebral blood flow Physiological measurement, 2010; 31(5): 679-95.
Shi Zhong-Song, Liebeskind David S, Loh Yince, Saver Jeffrey L, Starkman Sidney, Vespa Paul M, Gonzalez Nestor R, Tateshima Satoshi, Jahan Reza, Feng Lei, Miller Chad, Ali Latisha K, Ovbiagele Bruce, Kim Doojin, Duckwiler Gary R, Viñuela Fernando, Viñuela Fernando   Predictors of subarachnoid hemorrhage in acute ischemic stroke with endovascular therapy Stroke; a journal of cerebral circulation, 2010; 41(12): 2775-81.
Loh Yince, Liebeskind David S, Towfighi Amytis, Vespa Paul, Starkman Sidney, Saver Jeffrey L, Gonzalez Nestor R, Tateshima Satoshi, Jahan Reza, Shi Zhong-Song, Viñuela Fernando, Duckwiler Gary R   Preprocedural basal ganglionic infarction increases the risk of hemorrhagic transformation but not worse outcome following successful recanalization of acute middle cerebral artery occlusions World neurosurgery, 2010; 74(6): 636-40.
Loh Yince, Towfighi Amytis, Liebeskind David S, MacArthur David L, Vespa Paul, Gonzalez Nestor R, Tateshima Satoshi, Starkman Sidney, Saver Jeffrey L, Shi Zhong-Song, Jahan Reza, Viñuela Fernando, Duckwiler Gary R   Basal ganglionic infarction before mechanical thrombectomy predicts poor outcome Stroke; a journal of cerebral circulation, 2009; 40(10): 3315-20.
Alger Jeffry R, Schaewe Timothy J, Lai Tom C, Frew Andrew J, Vespa Paul M, Etchepare Maria, Liebeskind David S, Saver Jeffrey L, Kidwell S Chelsea   Contrast agent dose effects in cerebral dynamic susceptibility contrast magnetic resonance perfusion imaging Journal of magnetic resonance imaging : JMRI, 2009; 29(1): 52-64.
Hamilton Robert, Xu Peng, Asgari Shadnaz, Kasprowicz Magdalena, Vespa Paul, Bergsneider Marvin, Hu Xaio   Forecasting intracranial pressure elevation using pulse waveform morphology Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2009; 2009(6): 4331-4.
Vespa Paul M   Metabolic penumbra in intracerebral hemorrhage Stroke; a journal of cerebral circulation, 2009; 40(5): 1547-8.
Hu Xiao, Xu Peng, Scalzo Fabien, Vespa Paul, Bergsneider Marvin   Morphological clustering and analysis of continuous intracranial pressure IEEE transactions on bio-medical engineering, 2009; 56(3): 696-705.
Vespa Paul   Nonconvulsive seizures in sepsis: what you can't see may hurt you Critical care medicine, 2009; 37(6): 2132-3.
Vespa Paul M   A breath of fresh air: the potential use for hyperoxia in traumatic brain injury Critical care medicine, 2008; 36(1): 363-5.
Hu Xiao, Miller Chad, Vespa Paul, Bergsneider Marvin   Adaptive computation of approximate entropy and its application in integrative analysis of irregularity of heart rate variability and intracranial pressure signals Medical engineering & physics, 2008; 30(5): 631-9.
Hu Xiao, Xu Peng, Lee Darrin J, Vespa Paul, Baldwin Kevin, Bergsneider Marvin   An algorithm for extracting intracranial pressure latency relative to electrocardiogram R wave Physiological measurement, 2008; 29(4): 459-71.
Vespa Paul   Cerebral salt wasting after traumatic brain injury: an important critical care treatment issue Surgical neurology, 2008; 69(3): 230-2.
Miller Paul M, Vespa Paul M   Concurrent Neurocysticercosis and Pulmonary Tuberculosis Neurocritical care, 2008; 36(10): .
Burgess Richard E, Warach Steven, Schaewe Timothy J, Copenhaver Brittany R, Alger Jeffry R, Vespa Paul, Martin Neil, Saver Jeffrey L, Kidwell Chelsea S   Development and validation of a simple conversion model for comparison of intracerebral hemorrhage volumes measured on CT and gradient recalled echo MRI Stroke; a journal of cerebral circulation, 2008; 39(7): 2017-20.
Carmichael S Thomas, Vespa Paul M, Saver Jeffery L, Coppola Giovanni, Geschwind Daniel H, Starkman Sidney, Miller Chad M, Kidwell Chelsea S, Liebeskind David S, Martin Neil A   Genomic profiles of damage and protection in human intracerebral hemorrhage Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2008; 28(11): 1860-75.
Miller Chad M, Vespa Paul, Saver Jeffrey L, Kidwell Chelsea S, Carmichael Stanley T, Alger Jeffry, Frazee John, Starkman Sid, Liebeskind David, Nenov Valeriy, Elashoff Robert, Martin Neil   Image-guided endoscopic evacuation of spontaneous intracerebral hemorrhage Surgical neurology, 2008; 69(5): 441-6; discussion 446.
Vespa Paul M   Intensive glycemic control in traumatic brain injury: what is the ideal glucose range? Critical care (London, England), 2008; 12(5): 175.
Lee Darrin J, Moftakhar Parham, Glenn Thomas C, Vespa Paul M, Martin Neil A   Intra-arterial calcium channel blocker infusion for treatment of severe vasospasm in traumatic brain injury: case report Neurosurgery, 2008; 63(5): E1004-6; discussion E1006.
Cattivelli Federico S, Sayed Ali H, Hu Xiao, Lee Darrin, Vespa Paul   Mathematical models of cerebral hemodynamics for detection of vasospasm in major cerebral arteries Acta neurochirurgica. Supplement, 2008; 102(3): 63-9.
Hu Xiao, Xu Peng, Lee Darrin J, Paul Vespa, Bergsneider Marvin   Morphological changes of intracranial pressure pulses are correlated with acute dilatation of ventricles Acta neurochirurgica. Supplement, 2008; 102(3): 131-6.
Marcoux Judith, McArthur David A, Miller Chad, Glenn Thomas C, Villablanca Pablo, Martin Neil A, Hovda David A, Alger Jeffry R, Vespa Paul M   Persistent metabolic crisis as measured by elevated cerebral microdialysis lactate-pyruvate ratio predicts chronic frontal lobe brain atrophy after traumatic brain injury Critical care medicine, 2008; 36(10): 2871-7.
Bergsneider Marvin, Miller Chad, Vespa Paul M, Hu Xiao   Surgical management of adult hydrocephalus Neurosurgery, 2008; 62 Suppl 2(3): 643-59; discussion 659-60.
Xu Peng, Scalzo Fabien, Bergsneider Marvin, Vespa Paul, Chad Miller, Hu Xiao   Wavelet entropy characterization of elevated intracranial pressure Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2008; 2008(3): 2924-7.
Hu Xiao, Nenov Valeriy, Vespa Paul, Bergsneider Marvin   Characterization of interdependency between intracranial pressure and heart variability signals: a causal spectral measure and a generalized synchronization measure IEEE transactions on bio-medical engineering, 2007; 54(8): 1407-17.
Shields Donald C, Leiphart James W, McArthur David L, Vespa Paul M, LeVan Quyen Michel, Martinerie Jacques, Soss Jason R   Cortical synchrony changes detected by scalp electrode electroencephalograph as traumatic brain injury patients emerge from coma Surgical neurology, 2007; 67(4): 354-9.
Hu Xiao, Nenov Valeriy, Bergsneider Marvin, Glenn Thomas C, Vespa Paul, Martin Neil   Estimation of hidden state variables of the Intracranial system using constrained nonlinear Kalman filters IEEE transactions on bio-medical engineering, 2007; 54(4): 597-610.
Loh Yince, Vespa Paul M, Viñuela Fernando   Focal meningoencephalitis and mycotic aneurysms from suspected aneurysm coil seeding Neurology, 2007; 69(6): 613.
Miller Chad M, Vespa Paul M, McArthur David L, Hirt Daniel, Etchepare Maria   Frameless stereotactic aspiration and thrombolysis of deep intracerebral hemorrhage is associated with reduced levels of extracellular cerebral glutamate and unchanged lactate pyruvate ratios Neurocritical care, 2007; 6(1): 22-9.
Broderick Joseph, Connolly Sander, Feldmann Edward, Hanley Daniel, Kase Carlos, Krieger Derk, Mayberg Marc, Morgenstern Lewis, Ogilvy Christopher S, Vespa Paul, Zuccarello Mario, Zuccarello Mario, Zuccarello Mario, Zuccarello Mario   Guidelines for the management of spontaneous intracerebral hemorrhage in adults: 2007 update: a guideline from the American Heart Association/American Stroke Association Stroke Council, High Blood Pressure Research Council, and the Quality of Care and Outcomes in Research Interdisciplinary Working Group Circulation, 2007; 116(16): e391-413.
Broderick Joseph, Connolly Sander, Feldmann Edward, Hanley Daniel, Kase Carlos, Krieger Derk, Mayberg Marc, Morgenstern Lewis, Ogilvy Christopher S, Vespa Paul, Zuccarello Mario, Zuccarello Mario, Zuccarello Mario, Zuccarello Mario, Zuccarello Mario   Guidelines for the management of spontaneous intracerebral hemorrhage in adults: 2007 update: a guideline from the American Heart Association/American Stroke Association Stroke Council, High Blood Pressure Research Council, and the Quality of Care and Outcomes in Research Interdisciplinary Working Group Stroke; a journal of cerebral circulation, 2007; 38(6): 2001-23.
Hebb Matthew O, McArthur David L, Alger Jeffry, Etchepare Maria, Glenn Thomas C, Bergsneider Marvin, Martin Neil, Vespa Paul M   Impaired percent alpha variability on continuous electroencephalography is associated with thalamic injury and predicts poor long-term outcome after human traumatic brain injury Journal of neurotrauma, 2007; 24(4): 579-90.
Dusick Joshua R, Glenn Thomas C, Lee W N Paul, Vespa Paul M, Kelly Daniel F, Lee Stefan M, Hovda David A, Martin Neil A   Increased pentose phosphate pathway flux after clinical traumatic brain injury: a [1,2-13C2]glucose labeling study in humans Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2007; 27(9): 1593-602.
Vespa Paul M, Miller Chad, Hu Xiao, Nenov Val, Buxey Farzad, Martin Neil A   Intensive care unit robotic telepresence facilitates rapid physician response to unstable patients and decreased cost in neurointensive care Surgical neurology, 2007; 67(4): 331-7.
Vespa Paul M, Miller Chad, McArthur David, Eliseo Mathew, Etchepare Maria, Hirt Daniel, Glenn Thomas C, Martin Neil, Hovda David   Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisis Critical care medicine, 2007; 35(12): 2830-6.
Vespa David, Miller David, McArthur David, Eliseo David, Etchepare David, Hirt David, Glenn David, Martin David, Hovda David   Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisis Critical care medicine, 2007; 35(12): .
Vespa Paul M, O'Phelan Kristine, McArthur David, Miller Chad, Eliseo Matthew, Hirt Daniel, Glenn Thomas, Hovda David A   Pericontusional brain tissue exhibits persistent elevation of lactate/pyruvate ratio independent of cerebral perfusion pressure Critical care medicine, 2007; 35(4): 1153-60.
Marder Victor J, Chute Dennis J, Starkman Sidney, Abolian Anna M, Kidwell Chelsea, Liebeskind David, Ovbiagele Bruce, Vinuela Fernando, Duckwiler Gary, Jahan Reza, Vespa Paul M, Selco Scott, Rajajee Venkatakrishna, Kim Doojin, Sanossian Nerses, Saver Jeffrey L   Analysis of thrombi retrieved from cerebral arteries of patients with acute ischemic stroke Stroke; a journal of cerebral circulation, 2006; 37(8): 2086-93.
Vespa Paul M   Brain tissue oxygen monitoring: a measure of supply and demand Critical care medicine, 2006; 34(6): 1850-2.
Vespa Paul   Continuous electroencephalography for subarachnoid hemorrhage has come of age Neurocritical care, 2006; 4(2): 99-100.
Vespa Paul, Boonyaputthikul Robert, McArthur David L, Miller Chad, Etchepare Maria, Bergsneider Marvin, Glenn Thomas, Martin Neil, Hovda David   Intensive insulin therapy reduces microdialysis glucose values without altering glucose utilization or improving the lactate/pyruvate ratio after traumatic brain injury Critical care medicine, 2006; 34(3): 850-6.
Schrader Lara M, Stern John M, Wilson Charles L, Fields Tony A, Salamon Noriko, Nuwer Marc R, Vespa Paul M, Fried Itzhak   Low frequency electrical stimulation through subdural electrodes in a case of refractory status epilepticus Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2006; 117(4): 781-8.
Vespa Paul M   The implications of cerebral ischemia and metabolic dysfunction for treatment strategies in neurointensive care Current opinion in critical care, 2006; 12(2): 119-23.
Vespa Paul   The three tenors of subarachnoid hemorrhage: fever, anemia, and hyperglycemia Critical care medicine, 2006; 34(3): 897-8.
Cohan Pejman, Wang Christina, McArthur David L, Cook Shon W, Dusick Joshua R, Armin Bob, Swerdloff Ronald, Vespa Paul, Muizelaar Jan Paul, Cryer Henry Gill, Christenson Peter D, Kelly Daniel F   Acute secondary adrenal insufficiency after traumatic brain injury: a prospective study Critical care medicine, 2005; 33(10): 2358-66.
Vespa Paul   Continuous EEG monitoring for the detection of seizures in traumatic brain injury, infarction, and intracerebral hemorrhage: "to detect and protect" Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, 2005; 22(2): 99-106.
Hu Xiao, Nenov Valeriy, Vespa Paul, Bergsneider Marvin   Estimation of hidden state variables of the intracranial system using constrained nonlinear Kalman filters Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2005; 6(2): 5631-4.
Vespa Paul, McArthur David, Miller Chad, O'Phelan Kristine, Frazee John, Kidwell Chelsea, Saver Jeffery, Starkman Sidney, Martin Neil   Frameless stereotactic aspiration and thrombolysis of deep intracerebral hemorrhage is associated with reduction of hemorrhage volume and neurological improvement Neurocritical care, 2005; 2(3): 274-81.
Miller Chad M, Vespa Paul   Intensive care of the acute stroke patient Techniques in vascular and interventional radiology, 2005; 8(2): 92-102.
Hemphill J Claude, Bleck Thomas, Carhuapoma J Ricardo, Chang Cherylee, Diringer Michael, Geocadin Romergryko, Mayer Stephan, Samuels Owen, Vespa Paul, Vespa Paul   Is neurointensive care really optional for comprehensive stroke care? Stroke; a journal of cerebral circulation, 2005; 36(11): 2344-5.
Vespa Paul, Bergsneider Marvin, Hattori Nayoa, Wu Hsiao-Ming, Huang Sung-Cheng, Martin Neil A, Glenn Thomas C, McArthur David L, Hovda David A   Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2005; 25(6): 763-74.
Vespa Paul M   Multimodality monitoring and telemonitoring in neurocritical care: from microdialysis to robotic telepresence Current opinion in critical care, 2005; 11(2): 133-8.
Vespa Paul   Robotic telepresence in the intensive care unit Critical care (London, England), 2005; 9(4): 319-20.
Nuwer Marc R, Hovda David A, Schrader Lara M, Vespa Paul M   Routine and quantitative EEG in mild traumatic brain injury Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2005; 116(9): 2001-25.
Hillered Lars, Vespa Paul M, Hovda David A   Translational neurochemical research in acute human brain injury: the current status and potential future for cerebral microdialysis Journal of neurotrauma, 2005; 22(1): 3-41.
Strong Anthony J, Boutelle Martyn G, Vespa Paul M, Bullock M Ross, Bhatia Robin, Hashemi Parastoo   Treatment of critical care patients with substantial acute ischemic or traumatic brain injury Critical care medicine, 2005; 33(9): 2147-9; author reply 2149.
Hattori Naoya, Bergsneider Marvin, Wu Hsiao-Ming, Glenn Thomas C, Vespa Paul M, Hovda David A, Phelps Michael E, Huang Sung-Cheng   Accuracy of a method using short inhalation of (15)O-O(2) for measuring cerebral oxygen extraction fraction with PET in healthy humans Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2004; 45(5): 765-70.
Ostrem Jill L, Saver Jeffrey L, Alger Jeffry R, Starkman Sidney, Leary Megan C, Duckwiler Gary, Jahan Reza, Vespa Paul, Villablanca J Pablo, Gobin Y Pierre, Vinuela Fernando, Kidwell Chelsea S   Acute basilar artery occlusion: diffusion-perfusion MRI characterization of tissue salvage in patients receiving intra-arterial stroke therapies Stroke; a journal of cerebral circulation, 2004; 35(2): e30-4.
Hattori Naoya, Huang Sung-Cheng, Wu Hsiao-Ming, Liao Weihsun, Glenn Thomas C, Vespa Paul M, Phelps Michael E, Hovda David A, Bergsneider Marvin   Acute changes in regional cerebral (18)F-FDG kinetics in patients with traumatic brain injury Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2004; 45(5): 775-83.
Vespa Paul M, Bleck Thomas P   Neurogenic pulmonary edema and other mechanisms of impaired oxygenation after aneurysmal subarachnoid hemorrhage Neurocritical care, 2004; 1(2): 157-70.
Vespa Paul M   Perfusing the brain after traumatic brain injury: what clinical index should we follow? Critical care medicine, 2004; 32(7): 1621-3.
Vespa Paul, McArthur David L, Alger Jeffry, O'Phelan Kristine, Hattori Naoya, Wu Christine, Glenn Tom, Bergsneider Marvin, Martin Neil A, Hovda David A   Regional heterogeneity of post-traumatic brain metabolism as studied by microdialysis, magnetic resonance spectroscopy and positron emission tomography Brain pathology (Zurich, Switzerland), 2004; 14(2): 210-4.
Wu Hsiao-Ming, Huang Sung-Cheng, Hattori Naoya, Glenn Thomas C, Vespa Paul M, Yu Chin-Lung, Hovda David A, Phelps Michael E, Bergsneider Marvin   Selective metabolic reduction in gray matter acutely following human traumatic brain injury Journal of neurotrauma, 2004; 21(2): 149-61.
Wu Hsiao-Ming, Huang Sung-Cheng, Hattori Naoya, Glenn Thomas C, Vespa Paul M, Hovda David A, Bergsneider Marvin   Subcortical white matter metabolic changes remote from focal hemorrhagic lesions suggest diffuse injury after human traumatic brain injury Neurosurgery, 2004; 55(6): 1306-15; discussio 1316-7.
Vespa Paul M   The golden day after subarachnoid hemorrhage Critical care medicine, 2004; 32(3): 902-4.
Hattori Naoya, Huang Sung-Cheng, Wu Hsiao-Ming, Yeh Eric, Glenn Thomas C, Vespa Paul M, McArthur David, Phelps Michael E, Hovda David A, Bergsneider Marvin   Correlation of regional metabolic rates of glucose with glasgow coma scale after traumatic brain injury Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2003; 44(11): 1709-16.
Glenn Thomas C, Kelly Daniel F, Boscardin W John, McArthur David L, Vespa Paul, Oertel Matthias, Hovda David A, Bergsneider Marvin, Hillered Lars, Martin Neil A   Energy dysfunction as a predictor of outcome after moderate or severe head injury: indices of oxygen, glucose, and lactate metabolism Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2003; 23(10): 1239-50.
Zanier Elisa Roncati, Lee Stefan M, Vespa Paul M, Giza Christopher C, Hovda David A   Increased hippocampal CA3 vulnerability to low-level kainic acid following lateral fluid percussion injury Journal of neurotrauma, 2003; 20(5): 409-20.
Parodi Stephen, Lechner Arno, Osih Regina, Vespa Paul, Pegues David   Nosocomial enterobacter meningitis: risk factors, management, and treatment outcomes Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2003; 37(2): 159-66.
Shih Ludy C, Saver Jeffrey L, Alger Jeffry R, Starkman Sidney, Leary Megan C, Vinuela Fernando, Duckwiler Gary, Gobin Y Pierre, Jahan Reza, Villablanca J Pablo, Vespa Paul M, Kidwell Chelsea S   Perfusion-weighted magnetic resonance imaging thresholds identifying core, irreversibly infarcted tissue Stroke; a journal of cerebral circulation, 2003; 34(6): 1425-30.
Vespa Paul M, McArthur David, O'Phelan Kristine, Glenn Thomas, Etchepare Maria, Kelly Daniel, Bergsneider Marvin, Martin Neil A, Hovda David A   Persistently low extracellular glucose correlates with poor outcome 6 months after human traumatic brain injury despite a lack of increased lactate: a microdialysis study Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2003; 23(7): 865-77.
Leary Megan C, Kidwell Chelsea S, Villablanca J Pablo, Starkman Sidney, Jahan Reza, Duckwiler Gary R, Gobin Y Pierre, Sykes Steven, Gough Kristi J, Ferguson Katrina, Llanes Jennifer N, Masamed Rinat, Tremwel Margaret, Ovbiagele Bruce, Vespa Paul M, Vinuela Fernando, Saver Jeffrey L   Validation of computed tomographic middle cerebral artery "dot"sign: an angiographic correlation study Stroke; a journal of cerebral circulation, 2003; 34(11): 2636-40.
Vespa Paul   What is the optimal threshold for cerebral perfusion pressure following traumatic brain injury? Neurosurgical focus, 2003; 15(6): E4.
Vespa Paul M, Boscardin W John, Hovda David A, McArthur David L, Nuwer Marc R, Martin Neil A, Nenov Valeriy, Glenn Thomas C, Bergsneider Marvin, Kelly Daniel F, Becker Donald P   Early and persistent impaired percent alpha variability on continuous electroencephalography monitoring as predictive of poor outcome after traumatic brain injury Journal of neurosurgery, 2002; 97(1): 84-92.
Oertel Matthias, Kelly Daniel F, Lee Jae Hong, McArthur David L, Glenn Thomas C, Vespa Paul, Boscardin W John, Hovda David A, Martin Neil A   Efficacy of hyperventilation, blood pressure elevation, and metabolic suppression therapy in controlling intracranial pressure after head injury Journal of neurosurgery, 2002; 97(5): 1045-53.
Kidwell Chelsea S, Saver Jeffrey L, Starkman Sidney, Duckwiler Gary, Jahan Reza, Vespa Paul, Villablanca J Pablo, Liebeskind David S, Gobin Y Pierre, Vinuela Fernando, Alger Jeffry R   Late secondary ischemic injury in patients receiving intraarterial thrombolysis Annals of neurology, 2002; 52(6): 698-703.
Kidwell Chelsea S, Saver Jeffrey L, Villablanca J Pablo, Duckwiler Gary, Fredieu Andre, Gough Kristi, Leary Megan C, Starkman Sidney, Gobin Y Pierre, Jahan Reza, Vespa Paul, Liebeskind David S, Alger Jeffry R, Vinuela Fernando   Magnetic resonance imaging detection of microbleeds before thrombolysis: an emerging application Stroke; a journal of cerebral circulation, 2002; 33(1): 95-8.
Kidwell Chelsea S, Saver Jeffrey L, Carneado Joaquin, Sayre James, Starkman Sidney, Duckwiler Gary, Gobin Y Pierre, Jahan Reza, Vespa Paul, Villablanca J Pablo, Liebeskind David S, Vinuela Fernando   Predictors of hemorrhagic transformation in patients receiving intra-arterial thrombolysis Stroke; a journal of cerebral circulation, 2002; 33(3): 717-24.
Chmayssani M, Stein NR, McArthur DL, Vespa PM.   Therapeutic Intravascular Normothermia Reduces The Burden of Metabolic Crisis. Neurocrit Care. 2014 Oct 28. PMID:25348249, , 2014; Neurocrit Care. 2014 Oct 28.: .
Goh SY, Irimia A, Torgerson CM, Tubi MA, Real CR, Hanley DF, Martin NA, Vespa PM, Van Horn JD.   Longitudinal quantification and visualization of intracerebral haemorrhage using multimodal magnetic resonance and diffusion tensor imaging. Brain Inj. 2015; 29(4):438-45, , ; .
Neville TH, Wiley JF, Holmboe ES, Tseng CH, Vespa P, Kleerup EC, Wenger NS   Differences between attendings' and fellows' perceptions of futile treatment in the intensive care unit at one academic health center: implications for training. Acad Med. 2015 Mar;90(3):324-30, , ; .
Vespa P, Tubi M, Claassen J, Blanco M, McArthur D, Velazquez AG, Tu B, Prins M, Nuwer M   Metabolic Crisis occurs with Seizures and Periodic Discharges after Brain Trauma, , 2016; Ann Neurol. 2016 Jan 27: .

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