Dr Gonen is an expert in electron crystallography and cryo EM. He determined the 1.9Å resolution structure of the water channel aquaporin-0 by electron crystallography, the highest resolution for any protein determined by cryo EM techniques at the time. Dr Gonen established his own laboratory at the University of Washington in 2005 together with the very first cryo EM laboratory in the Pacific Northwest, a resource that continues to benefit many researchers at the UW School of Medicine and beyond. He has authored many publications from his laboratory concerning membrane protein structure and function. More recently Dr Gonen was honored with a Career Development award from the American Diabetes Association, became a Member of the Royal Society of New Zealand, as well as being chosen one of only 50 Howard Hughes Medical Institute Early Career Scientists around the country. In 2011 Dr Gonen accepted a position as a Group Leader at the HHMI Janelia Research Campus where he began developing MicroED as a new method for structural biology. With this method Dr Gonen has pushed the boundaries of cryoEM and determined a number of previously unknown structures at resolutions close to 1Å. In 2017 Dr Gonen moved his laboratory to the David Geffen School of Medicine of the University of California, Los Angeles as an Investigator of the Howard Hughes Medical Institute and a Professor of Biological Chemistry and Physiology, where he continues studying membrane protein structure and function using cryoEM and MicroED.
The Gonen laboratory is a laboratory of membrane structural biochemistry. We study the structures and functions of membrane proteins involved in homeostasis. The main methods we use are cryoEM (single particle and MicroED) as well as X-ray crystallography.
1996 Science Deans Honors List for Organic Chemistry
1996 Science Deans Honors List for Inorganic Chemistry
1997 Science Deans Honors List for Inorganic Chemistry
1997 Summer Research Scholarship, University of Auckland New Zealand
1998 Senior Prize in Biological Sciences, University of Auckland New Zealand
1998 First Class Honors in Biological Sciences, University of Auckland New Zealand
1999 Doctoral Scholarship, Unibersity of Auckland, New Zealand
2009 American Diabetes Association Career Development Award
2009 Howard Hughes Medical Institute Early Career Scientist
2011 Howard Hughes Medical Institute Janelia Research Campus Group Leader
2012 Member of the Royal Society of New Zealand
2017 Investigator of the Howard Hughes Medical Institute
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