Lin Chang, M.D.

A Short Biography:

Dr. Chang earned her medical degree from the UCLA School of Medicine and completed her internship and residency in internal medicine at Harbor-UCLA Medical Center. She completed her gastroenterology fellowship training at the UCLA affiliated training program in gastroenterology. Dr. Chang’s clinical expertise is in functional gastrointestinal disorders which include irritable bowel syndrome (IBS), chronic constipation and functional dyspepsia. Her research is focused on the pathophysiology of IBS related to stress, sex differences, genetic and epigenetic factors, neuroendocrine alterations, and gut microbiome and the treatment of IBS. She is the co-director of the G. Oppenheimer Center for Neurobiology of Stress and Resilience. She is vice-chief of the Vatche and Tamar Manoukian Division of Digestive Diseases at UCLA. She is also the program director of the UCLA Gastroenterology Fellowship Program. Dr. Chang is a recipient of the Janssen Award in Gastroenterology for Basic or Clinical Research and the AGA Distinguished Clinician Award. She has authored more than 120 original research articles, 55 review articles, and 20 book chapters on her specialty interests and is a frequent speaker at national and international meetings. Active in professional organizations, she is a member of the Rome Foundation Board of Directors, serves as clinical research councilor of the AGA Governing Board, previously served as president of the American Neurogastroenterology and Motility Society (ANMS), and is a fellow of the American Gastroenterological Association (AGA) and American College of Gastroenterology (ACG). She is a member of the NIH Clinical, Integrative and Molecular Gastroenterology Study Section and FDA GI Advisory Committee.

Work Titles
UCLA Director, Digestive Health and Nutrition Clinic Director, UCLA GI Fellowship Training Program Professor, Digestive Diseases/Gastroenterology Co-Director, Center for Neurobiology of Stress Member, Iris Cantor - UCLA Women's Health Center Member, Center for Functional Bowel and Motility Disorders Member, Center for Small Bowel Diseases Member, Inflammatory Bowel Disease Consultation Group
M.D., UCLA School of Medicine, 1986
1989 - 1992 Harbor - UCLA Medical Center
1986 - 1987 Harbor - UCLA Medical Center
1987 - 1989 Harbor - UCLA Medical Center
1993 American Board of Internal Medicine
1989 American Board of Internal Medicine

Contact Information:

Fax Number:


Work Phone Number:


Mailing Address:

10833 Le Conte Ave
CHS 42-210, MC 737818
Los Angeles, CA 90095

Work Address:

Practice Location
100 UCLA Medical Plaza #303
Los Angeles, CA 90095


A selected list of publications:

Kim Sharon, Chang Lin   A mindful way through IBS: reducing abdominal pain and improving quality of life Gastroenterology, 2012; 142(5): 1247-50; author reply 1250.
Bradford Kara, Shih Wendy, Videlock Elizabeth J, Presson Angela P, Naliboff Bruce D, Mayer Emeran A, Chang Lin   Association between early adverse life events and irritable bowel syndrome Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2012; 10(4): 385-90.e1-3.
Naliboff Bruce D, Kim Sharon E, Bolus Roger, Bernstein Charles N, Mayer Emeran A, Chang Lin   Gastrointestinal and psychological mediators of health-related quality of life in IBS and IBD: a structural equation modeling analysis The American journal of gastroenterology, 2012; 107(3): 451-9.
Chang Lin, Adeyemo Mopelola, Karagiannides Iordanis, Karagiannidis Iordanis, Videlock Elizabeth J, Bowe Collin, Shih Wendy, Presson Angela P, Yuan Pu-Qing, Cortina Galen, Gong Hua, Singh Sharat, Licudine Arlene, Mayer Minou, Tache Yvette, Pothoulakis Charalabos, Mayer Emeran A   Serum and colonic mucosal immune markers in irritable bowel syndrome The American journal of gastroenterology, 2012; 107(2): 262-72.
Connolly Lynn, Chang Lin   Combined orocecal scintigraphy and lactulose hydrogen breath testing demonstrate that breath testing detects orocecal transit, not small intestinal bacterial overgrowth in patients with irritable bowel syndrome Gastroenterology, 2011; 141(3): 1118-21.
Chang Lin   The role of stress on physiologic responses and clinical symptoms in irritable bowel syndrome Gastroenterology, 2011; 140(3): 761-5.
Spiegel Brennan M R, Khanna Dinesh, Bolus Roger, Agarwal Nikhil, Khanna Puja, Chang Lin   Understanding gastrointestinal distress: a framework for clinical practice The American journal of gastroenterology, 2011; 106(3): 380-5.
Wang Hank, Chang Lin   The Walkerton outbreak revisited at year 8: predictors, prevalence, and prognosis of postinfectious irritable bowel syndrome Gastroenterology, 2011; 140(2): 726-8; discussion 728-9.
Chang Lin, Lacy Brian E, Spiegel Brennan M R   An Evidence-based Approach to Therapy in IBS-D: A Case Study Compendium Gastroenterology & hepatology, 2010; 6(9 Suppl 15): 1-12.
Spiegel Brennan M R, Farid Mary, Esrailian Eric, Talley Jennifer, Chang Lin   Is irritable bowel syndrome a diagnosis of exclusion?: a survey of primary care providers, gastroenterologists, and IBS experts The American journal of gastroenterology, 2010; 105(4): 848-58.
Chang Lin, Tong Kenneth, Ameen Vanessa   Ischemic colitis and complications of constipation associated with the use of alosetron under a risk management plan: clinical characteristics, outcomes, and incidences The American journal of gastroenterology, 2010; 105(4): 866-75.
Chang Lin, Drossman Douglas A   Rome Foundation Endpoints and Outcomes Conference 2009: Optimizing Clinical Trials in FGID The American journal of gastroenterology, 2010; 105(4): 722-30.
Videlock Elizabeth J, Adeyemo Mopelola, Licudine Arlene, Hirano Miyoshi, Ohning Gordon, Mayer Minou, Mayer Emeran A, Chang Lin   Childhood trauma is associated with hypothalamic-pituitary-adrenal axis responsiveness in irritable bowel syndrome Gastroenterology, 2009; 137(6): 1954-62.
Spiegel Brennan, Harris Lucinda, Lucak Susan, Mayer Emeran, Naliboff Bruce, Bolus Roger, Esrailian Eric, Chey William D, Lembo Anthony, Karsan Hetal, Tillisch Kirsten, Dulai Gareth, Talley Jennifer, Chang Lin   Developing valid and reliable health utilities in irritable bowel syndrome: results from the IBS PROOF Cohort The American journal of gastroenterology, 2009; 104(8): 1984-91.
Spiegel Brennan M R, Chey William D, Chang Lin   Bacterial overgrowth and irritable bowel syndrome: unifying hypothesis or a spurious consequence of proton pump inhibitors? The American journal of gastroenterology, 2008; 103(12): 2972-6.
Adeyemo Mopelola A, Chang Lin   New treatments for irritable bowel syndrome in women Women's health (London, England), 2008; 4(6): 605-22; quiz 623.
Naliboff Bruce D, Waters Allison M, Labus Jennifer S, Kilpatrick Lisa, Craske Michelle G, Chang Lin, Negoro Hideki, Ibrahimovic Hana, Mayer Emeran A, Ornitz Edward   Increased acoustic startle responses in IBS patients during abdominal and nonabdominal threat Psychosomatic medicine, 2008; 70(8): 920-7.
Spiegel Brennan, Strickland Amy, Naliboff Bruce D, Mayer Emeran A, Chang Lin   Predictors of patient-assessed illness severity in irritable bowel syndrome The American journal of gastroenterology, 2008; 103(10): 2536-43.
Videlock Elizabeth J, Chang Lin   Irritable bowel syndrome: current approach to symptoms, evaluation, and treatment Gastroenterology clinics of North America, 2007; 36(3): 665-85, x.
Labus Jennifer S, Mayer Emeran A, Chang Lin, Bolus Roger, Naliboff Bruce D   The central role of gastrointestinal-specific anxiety in irritable bowel syndrome: further validation of the visceral sensitivity index Psychosomatic medicine, 2007; 69(1): 89-98.
Chang Lin, Mayer Emeran A, Labus Jennifer S, Schmulson Max, Lee Oh Young, Olivas Teresa I, Stains Jean, Naliboff Bruce D   Effect of sex on perception of rectosigmoid stimuli in irritable bowel syndrome American journal of physiology. Regulatory, integrative and comparative physiology, 2006; 291(2): R277-84.
Naliboff Bruce D, Berman Steve, Suyenobu Brandall, Labus Jennifer S, Chang Lin, Stains Jean, Mandelkern Mark A, Mayer Emeran A   Longitudinal change in perceptual and brain activation response to visceral stimuli in irritable bowel syndrome patients Gastroenterology, 2006; 131(2): 352-65.
Chang Lin, Chey William D, Harris Lucinda, Olden Kevin, Surawicz Christina, Schoenfeld Philip   Incidence of ischemic colitis and serious complications of constipation among patients using alosetron: systematic review of clinical trials and post-marketing surveillance data The American journal of gastroenterology, 2006; 101(5): 1069-79.
Spiegel Brennan M R, Gralnek Ian M, Bolus Roger, Chang Lin, Dulai Gareth S, Naliboff Bruce, Mayer Emeran A   Is a negative colonoscopy associated with reassurance or improved health-related quality of life in irritable bowel syndrome? Gastrointestinal endoscopy, 2005; 62(6): 892-9.

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