Marilene Wang, M.D.

A Short Biography:

Marilene B. Wang is a head and neck surgeon who has been a faculty member of the Department of Head and Neck Surgery at UCLA School of Medicine since 1992 and is currently a Professor-in-Residence. Dr. Wang earned her B.A. in Mathematics with highest honors at La Sierra University, Riverside, CA in 1982. She earned her M.D. at Loma Linda University School of Medicine, Loma Linda, CA in 1986 and graduated first in her class of 134. She completed her residency in Head and Neck Surgery at UCLA in 1992. She won the First Place Award in Resident Clinical Research from the American Academy of Otolaryngology--Head and Neck Surgery in 1991. She was a recipient of a Research Training Award from the American Triological Society in 1993. Dr. Wang was given an Honor Award from the American Academy of Otolaryngology--Head and Neck Surgery in 2001 and a Distinguished Service Award in 2013. She was a member of the Faculty Executive Committee at the School of Medicine from 1998-2001. She is committed to medical student and resident education both in the clinical setting and in the laboratory. She has mentored many students and residents in her head and neck cancer research laboratory, and several have won prestigious awards for their projects in the laboratory, including the Shirley Baron Award from the Western Section of the Triological Society, a Basic Science Award for resident research from the American Academy of Otolaryngology--Head and Neck Surgery, and a First Place Award for the Poster Session of the Triological Society. She specializes in treatment of nasal and sinus diseases, skullbase tumors, head and neck cancer, thyroid/parathyroid disease, and snoring/sleep apnea. She utilizes minimally invasive endoscopic techniques for sinus surgery and removal of skullbase tumors, including endoscopic removal of juvenile nasal angiofibromas, inverting papillomas, and selected malignancies. She also is active in the Pituitary Tumor and Endosopic Neurosurgery Programs.


Work Titles
UCLA Director, Nasal and Sinus Disease Center Professor, Surgery Member, Head and Neck Surgery Member, Head and Neck Surgical Oncology Member, JCCC Signal Transduction and Therapeutics Program Area Member, Pituitary Tumor and Neuroendocrine Program Member, Snoring and Sleep Apnea Center Principal Investigator, Center for Oral/Head & Neck Oncology Research
Education:
Degrees:
M.D., Loma Linda University School of Medicine, 1986
Internship:
1986 - 1987 UCLA School of Medicine
Residency:
1987 - 1992 UCLA School of Medicine
Certifications:
Certifications:
1993 American Board of Otolaryngology

Contact Information:

Mailing Address:

200 UCLA Medical Plaza
Suite 550
Los Angeles, CA 90095


Detailed Biography:

Dr. Marilene B. Wang is a Professor in the Department of Head and Neck Surgery at the UCLA David Geffen School of Medicine, where she is co-director of the Endoscopic Skull Base program.  She received her BA in mathematics from La Sierra University, Riverside, CA, and her MD from Loma Linda University School of Medicine.  She completed her residency in Head and Neck Surgery at UCLA and was recruited afterward to serve on the faculty.  Her practice is focused on rhinology and endoscopic skull base surgery.  She has an active cancer research laboratory, studying cell cycle regulation and curcumin suppression of head and neck cancer, which has received NIH and other extramural funding. She has mentored numerous students and residents in her laboratory, many of whom have gone on to distinguished professional careers. She has published over 170 peer-reviewed scientific articles, 14 book chapters, and presented over 200 abstracts or lectures at meetings all over the world.  She is on the Editorial Review Board for The Laryngoscope  and is a reviewer for numerous other academic journals.   She has been named to the Best Doctors of America database, Best Doctors in Southern California, and Best Doctors in Los Angeles.  She was Chair of the Awards Committee for the American Rhinologic Society (ARS) 2014-2017, Chair of the Constitution and Bylaws Committee for the American Head and Neck Society (AHNS) 2017-present, Chair of the Complementary/Integrative Medicine Committee for the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) 2013-2017, and is an active member of multiple other committees for the AAO-HNS, ARS, AHNS, and American Thyroid Association.  She received a Distinguished Service Award from the AAO-HNS in 2013, a Presidential Citation from the Triological Society in 2015, and was named a Cochrane Scholar in 2014.  She has served on the Board of Trustees for La Sierra University since 2012.

Publications:

A selected list of publications:

Goel Alexander N, Sangar Sophia, Mukdad Laith, Heaton Chase M, Ryan William R, Wang Marilene B, Long Jennifer L, St John Maie A   Patterns of care and survival impact of adjuvant chemoradiotherapy for oropharyngeal cancer with intermediate-risk features Head & neck, 2019; 41(9): 3177-3186.
Patel Kunal S, Shu Chen Jia, Yuan Frank, Attiah Mark, Wilson Bayard, Wang Marilene B, Bergsneider Marvin, Kim Won   Prediction of post-operative delayed hyponatremia after endoscopic transsphenoidal surgery Clinical neurology and neurosurgery, 2019; 182(9): 87-91.
Goel Alexander N, Frangos Mariana, Raghavan Govind, Sangar Sophia, Lazaro Stephanie, Wang Marilene B, Long Jennifer L, St John Maie A   Survival impact of treatment delays in surgically managed oropharyngeal cancer and the role of human papillomavirus status Head & neck, 2019; 41(6): 1756-1769.
Kuan Edward C, Nasser Hassan B, Carey Ryan M, Workman Alan D, Alonso Jose E, Wang Marilene B, John Maie A St, Palmer James N, Adappa Nithin D, Tajudeen Bobby A   A Population-Based Analysis of Nodal Metastases in Esthesioneuroblastomas of the Sinonasal Tract The Laryngoscope, 2019; 129(5): 1025-1029.
Nguyen Chau T, Taw Malcolm B, Wang Marilene B   Integrative care of the patient with head and neck cancer Laryngoscope investigative otolaryngology, 2018; 3(5): 364-371.
Goel Alexander N, Yang Jason Y, Wang Marilene B, Lee Jivianne T, St John Maie A, Long Jennifer L   Predictors, costs, and causes of readmission after surgery for sinonasal cancer: a national perspective International forum of allergy & rhinology, 2018; 8(9): 1056-1064.
Yoo Frederick, Chan Carmen, Kuan Edward C, Bergsneider Marvin, Wang Marilene B   Comparison of Male and Female Prolactinoma Patients Requiring Surgical Intervention Journal of neurological surgery. Part B, Skull base, 2018; 79(4): 394-400.
Orloff Lisa A, Wiseman Sam M, Bernet Victor J, Fahey Thomas J, Shaha Ashok R, Shindo Maisie L, Snyder Samuel K, Stack Brendan C, Sunwoo John B, Wang Marilene B   American Thyroid Association Statement on Postoperative Hypoparathyroidism: Diagnosis, Prevention, and Management in Adults Thyroid : official journal of the American Thyroid Association, 2018; 28(7): 830-841.
Yoo Frederick, Kuan Edward C, Heaney Anthony P, Bergsneider Marvin, Wang Marilene B   Corticotrophic pituitary carcinoma with cervical metastases: case series and literature review Pituitary, 2018; 21(3): 290-301.
Kuan Edward C, Yoo Frederick, Chyu Jennifer, Oh Angela, Bergsneider Marvin, Wang Marilene B   Quality of Life before and after Endoscopic Pituitary Surgery as Measured by the Short-Form-36 Journal of neurological surgery. Part B, Skull base, 2018; 79(3): 314-318.
Kuan Edward C, Yoo Frederick, Patel Pratik B, Su Brooke M, Bergsneider Marvin, Wang Marilene B   An Algorithm for Sellar Reconstruction Following the Endoscopic Endonasal Approach: A Review of 300 Consecutive Cases Journal of neurological surgery. Part B, Skull base, 2018; 79(2): 177-183.
Vahabzadeh-Hagh Andrew M, Rwigema Jean-Claude M, Nabili Vishad, Wang Marilene B, Lorentz William C   Predictors of prolongation in radiation treatment time in a veteran population treated with chemoradiation for oropharyngeal cancer Acta oto-laryngologica, 2018; 138(1): 80-84.
Kuan Edward C, Peng Kevin A, Suh Jeffrey D, Bergsneider Marvin, Wang Marilene B   Otolaryngic manifestations of Cushing disease Ear, nose, & throat journal, 2017; 96(8): E28-E30.
Kuan Edward C, Yoo Frederick, Kim Won, Badran Karam W, Heineman Thomas E, Sepahdari Ali R, Bergsneider Marvin, Wang Marilene B   Anatomic Variations in Pituitary Endocrinopathies: Implications for the Surgical Corridor Journal of neurological surgery. Part B, Skull base, 2017; 78(2): 105-111.
Tajudeen Bobby A, Kuan Edward C, Adappa Nithin D, Han Joseph K, Chandra Rakesh K, Palmer James N, Kennedy David W, Wang Marilene B, Suh Jeffrey D   Ectopic Pituitary Adenomas Presenting as Sphenoid or Clival Lesions: Case Series and Management Recommendations Journal of neurological surgery. Part B, Skull base, 2017; 78(2): 120-124.
Yoo Frederick, Kuan Edward C, Bergsneider Marvin, Wang Marilene B   Free Mucosal Graft Reconstruction of the Septum after Nasoseptal Flap Harvest: A Novel Technique Using a Posterior Septal Free Mucosal Graft Journal of neurological surgery. Part B, Skull base, 2017; 78(2): 201-206.
Yoo Frederick, Wang Marilene B, Bergsneider Marvin, Suh Jeffrey D   Single Layer Repair of Large Anterior Skull Base Defects without Vascularized Mucosal Flap Journal of neurological surgery. Part B, Skull base, 2017; 78(2): 139-144.
Kuan Edward C, Peng Kevin A, Thompson Christopher F, Suh Jeffrey D, Wang Marilene B   Sinonasal quality of life outcomes following laser treatment of epistaxis related to hereditary hemorrhagic telangiectasia Lasers in medical science, 2017; 32(3): 527-531.
Feinstein Aaron J, Shay Sophie G, Chang Elena, Lewis Michael S, Wang Marilene B   Treatment outcomes in veterans with HPV-positive head and neck cancer American journal of otolaryngology, 2017; 38(2): 188-192.
Mallen-St Clair Jon, Alani Mustafa, Wang Marilene B, Srivatsan Eri S   Human papillomavirus in oropharyngeal cancer: The changing face of a disease Biochimica et biophysica acta, 2016; 1866(2): 141-150.
Tajudeen Bobby A, Adappa Nithin D, Kuan Edward C, Schwartz Joseph S, Suh Jeffrey D, Wang Marilene B, Palmer James N   Smell preservation following endoscopic unilateral resection of esthesioneuroblastoma: a multi-institutional experience International forum of allergy & rhinology, 2016; 6(10): 1047-1050.
Kang James J, Liu Isabelle Y, Wang Marilene B, Srivatsan Eri S   A review of gigaxonin mutations in giant axonal neuropathy (GAN) and cancer Human genetics, 2016; 135(7): 675-84.
Chivukula Srinivas, Everson Richard, Linetsky Michael, Heaney Anthony, Bonelli Laura, Wang Marilene B, Bergsneider Marvin   Challenging Diagnosis and Surgical Management of a Symptomatic Sellar Spine World neurosurgery, 2016; 91(7): 669.e7-669.e10.
Wu Arthur W, Bhuta Sunita, Salamon Noriko, Martin Neil, Wang Marilene B   Chondroid chordoma of the sella turcica mimicking a pituitary adenoma Ear, nose, & throat journal, 2015; 94(10-11): E47-9.
Wang Marilene B, Liu Isabelle Y, Gornbein Jeffrey A, Nguyen Chau T   HPV-Positive Oropharyngeal Carcinoma: A Systematic Review of Treatment and Prognosis Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2015; 153(5): 758-69.
Kuan Edward C, Peng Kevin A, Kita Ashley E, Bergsneider Marvin, Wang Marilene B   Acromegaly: otolaryngic manifestations following pituitary surgery American journal of otolaryngology, 2015; 36(4): 521-5.
Shay Sophie Grace, Chang Elena, Lewis Michael S, Wang Marilene B   Characteristics of Human Papillomavirus-Associated Head and Neck Cancers in a Veteran Population JAMA otolaryngology-- head & neck surgery, 2015; 141(9): 790-6.
Peng Kevin A, Kuan Edward C, Unger Lindsey, Lorentz William C, Wang Marilene B, Long Jennifer L   A swallow preservation protocol improves function for veterans receiving chemoradiation for head and neck cancer Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2015; 152(5): 863-7.
Kuan Edward C, Diaz Miguel Fernando Palma, Chiu Alexander G, Bergsneider Marvin, Wang Marilene B, Suh Jeffrey D   Sinonasal and skull base pleomorphic adenoma: a case series and literature review International forum of allergy & rhinology, 2015; 5(5): 460-8.
Tajudeen Bobby A, Mundi Jagmeet, Suh Jeffrey D, Bergsneider Marvin, Wang Marilene B   Endoscopic endonasal surgery for recurrent pituitary tumors: technical challenges to the surgical approach Journal of neurological surgery. Part B, Skull base, 2015; 76(1): 50-6.
Tajudeen Bobby A, Arshi Armin, Suh Jeffrey D, Palma-Diaz Miguel Fernando, Bergsneider Marvin, Abemayor Elliot, St John Maie, Wang Marilene B   Esthesioneuroblastoma: an update on the UCLA experience, 2002-2013 Journal of neurological surgery. Part B, Skull base, 2015; 76(1): 43-9.
Kuan Edward C, Suh Jeffrey D, Wang Marilene B   Empty nose syndrome Current allergy and asthma reports, 2015; 15(1): 493.
Tajudeen Bobby A, Arshi Armin, Suh Jeffrey D, St John Maie, Wang Marilene B   Importance of tumor grade in esthesioneuroblastoma survival: a population-based analysis JAMA otolaryngology-- head & neck surgery, 2014; 140(12): 1124-9.
Veena Mysore S, Wilken Reason, Zheng Jun-Ying, Gholkar Ankur, Venkatesan Natarajan, Vira Darshni, Ahmed Sameer, Basak Saroj K, Dalgard Clifton L, Ravichandran Sandhiya, Batra Raj K, Kasahara Noriyuki, Elashoff David, Fishbein Michael C, Whitelegge Julian P, Torres Jorge Z, Wang Marilene B, Srivatsan Eri S   p16 Protein and gigaxonin are associated with the ubiquitination of NFκB in cisplatin-induced senescence of cancer cells The Journal of biological chemistry, 2014; 289(50): 34921-37.
McLaughlin Nancy, Martin Neil A, Upadhyaya Pooja, Bari Ausaf A, Buxey Farzad, Wang Marilene B, Heaney Anthony P, Bergsneider Marvin   Assessing the cost of contemporary pituitary care Neurosurgical focus, 2014; 37(5): E7.
Peng Kevin A, Grogan Tristan, Wang Marilene B   Head and neck sarcomas: analysis of the SEER database Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2014; 151(4): 627-33.
Tajudeen Bobby A, Vorasubin Nopawan, Sanaiha Yas, Palma-Diaz Miguel Fernando, Suh Jeffrey D, Wang Marilene B   Sinonasal mucosal melanoma: 20-year experience at a tertiary referral center International forum of allergy & rhinology, 2014; 4(7): 592-7.
Zhang Yong, Sun Jie, Lin Chien-Chung, Abemayor Elliot, Wang Marilene B, Wong David T W   The emerging landscape of salivary diagnostics Oral health and dental management, 2014; 13(2): 200-10.
Bergsneider Marvin, Mirsadraei Leili, Yong William H, Salamon Noriko, Linetsky Michael, Wang Marilene B, McArthur David L, Heaney Anthony P   The pituitary stalk effect: is it a passing phenomenon? Journal of neuro-oncology, 2014; 117(3): 477-84.
Duarte Victor M, Liu Yuan F, Rafizadeh Sassan, Tajima Tracey, Nabili Vishad, Wang Marilene B   Comparison of dental health of patients with head and neck cancer receiving IMRT vs conventional radiation Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2014; 150(1): 81-6.
Duarte Victor M, Chhetri Dinesh K, Liu Yuan F, Erman Andrew A, Wang Marilene B   Swallow preservation exercises during chemoradiation therapy maintains swallow function Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2013; 149(6): 878-84.
Deconde Adam S, Sanaiha Yas, Suh Jeffrey D, Bhuta Sunita, Bergsneider Marvin, Wang Marilene B   Metastatic disease to the clivus mimicking clival chordomas Journal of neurological surgery. Part B, Skull base, 2013; 74(5): 292-9.
Vorasubin Nopawan, Vira Darshni, Suh Jeffrey D, Bhuta Sunita, Wang Marilene B   Schneiderian papillomas: comparative review of exophytic, oncocytic, and inverted types American journal of rhinology & allergy, 2013; 27(4): 287-92.
Thompson Christopher F, Kim Brandon J, Lai Chi, Grogan Tristan, Elashoff David, St John Maie A, Wang Marilene B   Sinonasal rhabdomyosarcoma: prognostic factors and treatment outcomes International forum of allergy & rhinology, 2013; 3(8): 678-83.
Taw Malcolm B, Nguyen Chau T, Wang Marilene B   Complementary and integrative treatments: rhinosinusitis Otolaryngologic clinics of North America, 2013; 46(3): 345-66.
Appel Julia Goulart, Bergsneider Marvin, Vinters Harry, Salamon Noriko, Wang Marilene B, Heaney Anthony P   Acromegaly due to an ectopic pituitary adenoma in the clivus: case report and review of literature Pituitary, 2012; 15 Suppl 1(3): S53-6.
Bergsneider Marvin, Xue Kai, Suh Jeffrey D, Wang Marilene B   Barrier-limited multimodality closure for reconstruction of wide sellar openings Neurosurgery, 2012; 71(1 Suppl Operative): 68-75; discussion 75-6.
Thompson Christopher F, Wang Marilene B, Kim Brandon J, Bergsneider Marvin, Suh Jeffrey D   Incidence and management of epistaxis after endoscopic skull base surgery ORL; journal for oto-rhino-laryngology and its related specialties, 2012; 74(6): 315-9.
Suh Jeffrey D, Wu Arthur W, Taw Malcolm B, Nguyen Chau, Wang Marilene B   Treatment of recalcitrant chronic rhinosinusitis with integrative East-West medicine: a pilot study Archives of otolaryngology--head & neck surgery, 2012; 138(3): 294-300.
Vira Darshni, Bhuta Sunita, Wang Marilene B   Respiratory epithelial adenomatoid hamartomas The Laryngoscope, 2011; 121(12): 2706-9.
Wu Arthur W, Nguyen Chau, Wang Marilene B   What is the best treatment for papillary thyroid microcarcinoma? The Laryngoscope, 2011; 121(9): 1828-9.
Suh Jeffrey D, Ramakrishnan Vijay R, Zhang Paul J, Wu Arthur W, Wang Marilene B, Palmer James N, Chiu Alexander G   Diagnosis and endoscopic management of sinonasal schwannomas ORL; journal for oto-rhino-laryngology and its related specialties, 2011; 73(6): 308-12.
Armin Bob B, Nabili Vishad, Wang Marilene B   Pathology quiz case 2. Disseminated histoplasmosis caused by Histoplasma capsulatum Archives of otolaryngology--head & neck surgery, 2011; 137(3): 307, 309-10.
Yang Isaac, Wang Marilene B, Bergsneider Marvin   Making the transition from microsurgery to endoscopic trans-sphenoidal pituitary neurosurgery Neurosurgery clinics of North America, 2010; 21(4): 643-51, vi.
Cohen Marc, Wang Marilene B   Schwannoma of the tongue: two case reports and review of the literature European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2009; 266(11): 1823-9.
Long Jennifer L, Strocker Ali M, Wang Marilene B, Blackwell Keith E   EGFR expression in primary squamous cell carcinoma of the thyroid The Laryngoscope, 2009; 119(1): 89-90.
Joo Daekeun, Chhetri Dinesh K, Wang Marilene B   Endoscopic removal of juvenile nasopharyngeal angiofibromas: a video presentation The Laryngoscope, 2008; 118(6): e1-3.
Salvado Amanda R, Wang Marilene B   Treatment of complete nasal vestibule stenosis with vestibular stents and mitomycin C Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2008; 138(6): 795-6.
Cohen Marc, Wang Marilene B, Nguyen Chau T   Radiology quiz case 2. Rhinoscleroma and cervical emphysema Archives of otolaryngology--head & neck surgery, 2007; 133(6): 615, 617-8.
Mowry Sarah E, LoTempio Maria M, Sadeghi Ahmad, Wang Kevin H, Wang Marilene B   Quality of life outcomes in laryngeal and oropharyngeal cancer patients after chemoradiation Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2006; 135(4): 565-70.
Tsai Veling W, Cameron Robert B, Wang Marilene B   Thyroidectomy for substernal goiter via a mediastinoscopic approach Ear, nose, & throat journal, 2006; 85(8): 528-9.
Luu Quang C, Lasky Joseph L, Moore Theodore B, Nelson Scott, Wang Marilene B   Treatment of embryonal rhabdomyosarcoma of the sinus and orbit with chemotherapy, radiation, and endoscopic surgery Journal of pediatric surgery, 2006; 41(6): e15-7.
Yip Helena T, Chopra Rajesh, Chakrabarti Rita, Veena Mysore S, Ramamurthy Bharathi, Srivatsan Eri S, Wang Marilene B   Cisplatin-induced growth arrest of head and neck cancer cells correlates with increased expression of p16 and p53 Archives of otolaryngology--head & neck surgery, 2006; 132(3): 317-26.
Paiva Marcos B, Bublik Michael, Castro Dan J, Udewitz Matthew, Wang Marilene B, Kowalski Luis Paulo, Sercarz Joel   Intratumor injections of cisplatin and laser thermal therapy for palliative treatment of recurrent cancer Photomedicine and laser surgery, 2005; 23(6): 531-5.
LoTempio Maria M, Wang Kevin H, Sadeghi Ahmed, Delacure Mark D, Juillard Guy F, Wang Marilene B   Comparison of quality of life outcomes in laryngeal cancer patients following chemoradiation vs. total laryngectomy Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2005; 132(6): 948-53.
Namazie Ali, Alavi Sassan, Aghamohammadi Neema, Aghamohammadi Mazda, Calcaterra Thomas C, Wang Marilene B, Srivatsan Eri S   Fluorescence in situ hybridization for detecting TP16 MTS1/CDK41 gene deletions in squamous cell carcinoma of the head and neck Cancer genetics and cytogenetics, 2003; 141(1): 49-55.

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