Richard Staba, Ph.D.

A Short Biography:

In 2002, Richard Staba received his Ph.D. in Neurobiology from UCLA in the laboratories of Charles Wilson, Ph.D. and Jerome Engel, Jr. M.D., Ph.D.  where he investigated the spatiotemporal properties of high frequency oscillations and single neuron firing patterns in mesial temporal structures of patients with drug-resistant epilepsy. He did his postdoctoral research training with Daniel Barth, Ph.D. at the University of Colorado in Boulder studying the neurophysiology of vibrissa stimulation-evoked fast network oscillations in non-primate somatosensory cortex. In 2005, he joined the UCLA faculty as Assistant Professor and is currently Associate Professor in Neurology at the David Geffen School of Medicine. Dr. Staba's research focuses on the mechanisms supporting the generation and spread of seizures, post-traumatic epilepsy, and the neurophysiology of sleep.


Work Titles
UCLA Associate Professor, Neurology
Education:
Degrees:
Ph.D., Department of Neurobiology, UCLA

Contact Information:

Work Email Address:

rstaba@mednet.ucla.edu


Website:


Office Address:

710 Westwood Plaza


Publications:

View a up-to-date publication list: PubMed Listing

A selected list of publications:

Weiss Shennan A, Staba Richard, Bragin Anatol, Moxon Karen, Sperling Michael, Avoli Massimo, Engel Jerome   "Interneurons and principal cell firing in human limbic areas at focal seizure onset" Neurobiology of disease, 2019; 124: 183-188.
Perucca Piero, Smith Gregory, Santana-Gomez Cesar, Bragin Anatol, Staba Richard   Electrophysiological biomarkers of epileptogenicity after traumatic brain injury Neurobiology of disease, 2019; 123: 69-74.
Ndode-Ekane Xavier Ekolle, Santana-Gomez Cesar, Casillas-Espinosa Pablo M, Ali Idrish, Brady Rhys D, Smith Gregory, Andrade Pedro, Immonen Riikka, Puhakka Noora, Hudson Matthew R, Braine Emma L, Shultz Sandy R, Staba Richard J, O'Brien Terence J, Pitkänen Asla   Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis Epilepsy research, 2019; 151: 7-16.
Immonen Riikka, Smith Gregory, Brady Rhys D, Wright David, Johnston Leigh, Harris Neil G, Manninen Eppu, Salo Raimo, Branch Craig, Duncan Dominique, Cabeen Ryan, Ndode-Ekane Xavier Ekolle, Gomez Cesar Santana, Casillas-Espinosa Pablo M, Ali Idrish, Shultz Sandy R, Andrade Pedro, Puhakka Noora, Staba Richard J, O'Brien Terence J, Toga Arthur W, Pitkänen Asla, Gröhn Olli   Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis Epilepsy research, 2019; 150: 46-57.
Kamnaksh Alaa, Puhakka Noora, Ali Idrish, Smith Gregory, Aniceto Roxanne, McCullough Jesse, Das Gupta Shalini, Ndode-Ekane Xavier Ekolle, Brady Rhys, Casillas-Espinosa Pablo, Hudson Matt, Santana-Gomez Cesar, Immonen Riikka, Abreu Pedro Andrade de, Jones Nigel, Shultz Sandy, Staba Richard J, O'Brien Terence J, Agoston Denes, Pitkänen Asla   Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis Epilepsy research, 2019; 149: 92-101.
Ciszek Robert, Ndode-Ekane Xavier Ekolle, Gomez Cesar Santana, Casillas-Espinosa Pablo M, Ali Idrish, Smith Gregory, Puhakka Noora, Lapinlampi Niina, Andrade Pedro, Kamnaksh Alaa, Immonen Riikka, Paananen Tomi, Hudson Matthew R, Brady Rhys D, Shultz Sandy R, O'Brien Terence J, Staba Richard J, Tohka Jussi, Pitkänen Asla   Informatics tools to assess the success of procedural harmonization in preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis Epilepsy research, 2019; 150: 17-26.
Pitkänen Asla, O'Brien Terence J, Staba Richard   Preface - Practical and theoretical considerations for performing a multi-center preclinical biomarker discovery study of post-traumatic epileptogenesis: lessons learned from the EpiBioS4Rx consortium Epilepsy research, 2019; 150: 17-26.
Vespa Paul M, Shrestha Vikesh, Abend Nicholas, Agoston Denes, Au Alicia, Bell Michael J, Bleck Thomas P, Blanco Manuel Buitrago, Claassen Jan, Diaz-Arrastia Ramon, Duncan Dominique, Ellingson Ben, Foreman Brandon, Gilmore Emily J, Hirsch Lawrence, Hunn Martin, Kamnaksh Alaa, McArthur David, Morokoff Andrew, O'Brien Terrence, O'Phelan Kristine, Robertson Courtney L, Rosenthal Eric, Staba Richard, Toga Arthur, Willyerd Frederick A, Zimmermann Lara, Yam Elisa, Martinez Susana, Real Courtney, Engel Jerome   The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol Neurobiology of disease, 2019; 123: 110-114.
Li Lin, Bragin Anatol, Staba Richard, Engel Jerome   Unit firing and oscillations at seizure onset in epileptic rodents Neurobiology of disease, 2019; 124: 183-188.
Waldman Zachary J, Shimamoto Shoichi, Song Inkyung, Orosz Iren, Bragin Anatol, Fried Itzhak, Engel Jerome, Staba Richard, Sperling Michael R, Weiss Shennan A   A method for the topographical identification and quantification of high frequency oscillations in intracranial electroencephalography recordings Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2018; 129(1): 308-318.
Vakharia Vejay N, Duncan John S, Witt Juri-Alexander, Elger Christian E, Staba Richard, Engel Jerome   Getting the best outcomes from epilepsy surgery Annals of neurology, 2018; 83(4): 676-690.
Elahian Bahareh, Lado Nathan E, Mankin Emily, Vangala Sitaram, Misra Amrit, Moxon Karen, Fried Itzhak, Sharan Ashwini, Yeasin Mohammed, Staba Richard, Bragin Anatol, Avoli Massimo, Sperling Michael R, Engel Jerome, Weiss Shennan A   Low-voltage fast seizures in humans begin with increased interneuron firing Annals of neurology, 2018; 84(4): 588-600.
Engel Jerome, Bragin Anatol, Staba Richard   Nonictal EEG biomarkers for diagnosis and treatment Epilepsia open, 2018; 3(Suppl Suppl 2): 120-126.
Shimamoto Shoichi, Waldman Zachary J, Orosz Iren, Song Inkyung, Bragin Anatol, Fried Itzhak, Engel Jerome, Staba Richard, Sharan Ashwini, Wu Chengyuan, Sperling Michael R, Weiss Shennan A   Utilization of independent component analysis for accurate pathological ripple detection in intracranial EEG recordings recorded extra- and intra-operatively Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2018; 129(1): 296-307.
Weiss Shennan Aibel, Berry Brent, Chervoneva Inna, Waldman Zachary, Guba Jonathan, Bower Mark, Kucewicz Michal, Brinkmann Benjamin, Kremen Vaclav, Khadjevand Fatemeh, Varatharajah Yogatheesan, Guragain Hari, Sharan Ashwini, Wu Chengyuan, Staba Richard, Engel Jerome, Sperling Michael, Worrell Gregory   Visually validated semi-automatic high-frequency oscillation detection aides the delineation of epileptogenic regions during intra-operative electrocorticography Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2018; 129(10): 2089-2098.
Song Inkyung, Orosz Iren, Chervoneva Inna, Waldman Zachary J, Fried Itzhak, Wu Chengyuan, Sharan Ashwini, Salamon Noriko, Gorniak Richard, Dewar Sandra, Bragin Anatol, Engel Jerome, Sperling Michael R, Staba Richard, Weiss Shennan A   Bimodal coupling of ripples and slower oscillations during sleep in patients with focal epilepsy Epilepsia, 2017; 58(11): 1972-1984.
Gloss David, Nevitt Sarah J, Staba Richard   The role of high-frequency oscillations in epilepsy surgery planning The Cochrane database of systematic reviews, 2017; 10(11): CD010235.
Jiruska Premysl, Alvarado-Rojas Catalina, Schevon Catherine A, Staba Richard, Stacey William, Wendling Fabrice, Avoli Massimo   Update on the mechanisms and roles of high-frequency oscillations in seizures and epileptic disorders Epilepsia, 2017; 58(8): 1330-1339.
Galanopoulou Aristea S, Wong Michael, Binder Devin, Hartman Adam L, Powell Elizabeth M, Roopra Avtar, Staba Richard, Vezzani Annamaria, Fureman Brandy, Dingledine Ray, Dingledine Ray   2014 Epilepsy Benchmarks Area II: Prevent Epilepsy and Its Progression Epilepsy currents, 2016; 16(3): 187-91.
Lopour Beth A, Staba Richard J, Stern John M, Fried Itzhak, Ringach Dario L   Characterization of long-range functional connectivity in epileptic networks by neuronal spike-triggered local field potentials Journal of neural engineering, 2016; 13(2): 026031.
Weiss Shennan Aibel, Alvarado-Rojas Catalina, Bragin Anatol, Behnke Eric, Fields Tony, Fried Itzhak, Engel Jerome, Staba Richard   Ictal onset patterns of local field potentials, high frequency oscillations, and unit activity in human mesial temporal lobe epilepsy Epilepsia, 2016; 57(1): 111-21.
Bragin Anatol, Li Lin, Almajano Joyel, Alvarado-Rojas Catalina, Reid Aylin Y, Staba Richard J, Engel Jerome   Pathologic electrographic changes after experimental traumatic brain injury Epilepsia, 2016; 13(2): .
Weiss Shennan A, Orosz Iren, Salamon Noriko, Moy Stephanie, Wei Linqing, Van't Klooster Maryse A, Knight Robert T, Harper Ronald M, Bragin Anatol, Fried Itzhak, Engel Jerome, Staba Richard J   Ripples on spikes show increased phase-amplitude coupling in mesial temporal lobe epilepsy seizure-onset zones Epilepsia, 2016; 57(11): 1916-1930.
Reid Aylin Y, Bragin Anatol, Giza Christopher C, Staba Richard J, Engel Jerome   The progression of electrophysiologic abnormalities during epileptogenesis after experimental traumatic brain injury Epilepsia, 2016; 57(10): 1558-1567.
Menendez de la Prida Liset, Staba Richard J, Dian Joshua A   Conundrums of high-frequency oscillations (80-800 Hz) in the epileptic brain Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, 2015; 32(3): 207-19.
Memarian Negar, Madsen Sarah K, Macey Paul M, Fried Itzhak, Engel Jerome, Thompson Paul M, Staba Richard J   Ictal depth EEG and MRI structural evidence for two different epileptogenic networks in mesial temporal lobe epilepsy PloS one, 2015; 10(4): e0123588.
Memarian Negar, Kim Sally, Dewar Sandra, Engel Jerome, Staba Richard J   Multimodal data and machine learning for surgery outcome prediction in complicated cases of mesial temporal lobe epilepsy Computers in biology and medicine, 2015; 64: 67-78.
Staba Richard J, Stead Matt, Worrell Gregory A   Electrophysiological biomarkers of epilepsy Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2014; 11(2): 334-46.
Reid Aylin Y, Staba Richard J   Limbic networks: clinical perspective International review of neurobiology, 2014; 114(2): 89-120.
Gloss David, Nolan Sarah J, Staba Richard   The role of high-frequency oscillations in epilepsy surgery planning The Cochrane database of systematic reviews, 2014; 1(2): CD010235.
Staba Richard J, Worrell Gregory A   What is the importance of abnormal "background" activity in seizure generation? Advances in experimental medicine and biology, 2014; 813(2): 43-54.
Engel Jerome, Thompson Paul M, Stern John M, Staba Richard J, Bragin Anatol, Mody Istvan   Connectomics and epilepsy Current opinion in neurology, 2013; 26(2): 186-94.
Blouin Ashley M, Fried Itzhak, Wilson Charles L, Staba Richard J, Behnke Eric J, Lam Hoa A, Maidment Nigel T, Karlsson Karl Æ, Lapierre Jennifer L, Siegel Jerome M   Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction Nature communications, 2013; 4(3): 1547.
Blouin Ashley M, Fried Itzhak, Wilson Charles L, Staba Richard J, Behnke Eric J, Lam Hoa A, Maidment Nigel T, Karlsson Karl Æ, Lapierre Jennifer L, Siegel Jerome M   Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction Nature communications, 2013; 4(1): 1547.
San-Juan Daniel, Mayorga Adriana Patricia M, Calcáneo Juan de Dios Del Castillo, González-Aragón Maricarmen Fernández, Alonso-Vanegas Mario, Rico Carolina Domínguez, Staba Richard J, Anschel David J, Cole Andrew J   Periodic epileptiform discharges in mesial temporal lobe epilepsy with hippocampal sclerosis Seizure : the journal of the British Epilepsy Association, 2013; 22(9): 735-42.
Memarian Negar, Thompson Paul M, Engel Jerome, Staba Richard J   Quantitative analysis of structural neuroimaging of mesial temporal lobe epilepsy Imaging in medicine, 2013; 5(3): .
Alvarado-Rojas Catalina, Lehongre Katia, Bagdasaryan Juliana, Bragin Anatol, Staba Richard, Engel Jerome, Navarro Vincent, Le Van Quyen Michel   Single-unit activities during epileptic discharges in the human hippocampal formation Frontiers in computational neuroscience, 2013; 7(9): 140.
Staba RJ, Ekstrom AD, Suthana NA, Burggren A, Fried I, Engel J, Bookheimer SY   Gray matter loss correlates with mesial temporal lobe neuronal hyperexcitability inside the human seizure-onset zone Epilepsia, 2012; 53(1): 25-34.
Jacobs J, Staba R, Asano E, Otsubo H, Wu J Y, Zijlmans M, Mohamed I, Kahane P, Dubeau F, Navarro V, Gotman J   High-frequency oscillations (HFOs) in clinical epilepsy Progress in neurobiology, 2012; .
Staba RJ, Bragin A   High-frequency oscillations and other electrophysiological biomarkers of epilepsy: underlying mechanisms Biomarkers in medicine, 2011; 5(5): 545-56.
Nir Y, Staba RJ, Andrillon T, Vyazovskiy VV, Cirelli C, Fried I, Tononi G   Regional slow waves and spindles in human sleep Neuron, 2011; 70(1): 153-69.
Andrillon T, Nir Y, Staba RJ, Ferrarelli F, Cirelli C, Tononi G, Fried I   Sleep spindles in humans: insights from intracranial EEG and unit recordings The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011; 31(49): 17821-34.
San-Juan D, Tapia CA, Gonzalez-Aragon MF, Mayorga AM, Staba RJ, Alonso-Vanegas M   The prognostic role of electrocorticography in tailored temporal lobe surgery Seizure : the journal of the British Epilepsy Association, 2011; 20(7): 564-9.
Bragin A, Engel J, Staba RJ   High-frequency oscillations in epileptic brain Current opinion in neurology, 2010; 23(2): 151-6.
Le Van Quyen M, Staba R, Bragin A, Dickson C, Valderrama M, Fried I, Engel J   Large-scale microelectrode recordings of high-frequency gamma oscillations in human cortex during sleep The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010; 30(23): 7770-82.
Engel J, Akhtari M, Bragin A, Fried I, Ogren JA, Staba RJ, Salamon N, Thompson PM   New approaches to structural and functional imaging in focal epilepsy Epilepsia, 2010; 51 Suppl 1(2): 83-6.
Engel J, Bragin A, Staba R, Mody I   High-frequency oscillations: what is normal and what is not? Epilepsia, 2009; 50(4): 598-604.
Ogren JA, Bragin A, Wilson CL, Hoftman GD, Lin JJ, Dutton RA, Fields TA, Toga AW, Thompson PM, Engel J, Staba RJ   Three-dimensional hippocampal atrophy maps distinguish two common temporal lobe seizure-onset patterns Epilepsia, 2009; 50(6): 1361-70.
Ogren JA, Wilson CL, Bragin A, Lin JJ, Salamon N, Dutton RA, Luders E, Fields TA, Fried I, Toga AW, Thompson PM, Engel J, Staba RJ   Three-dimensional surface maps link local atrophy and fast ripples in human epileptic hippocampus Annals of neurology, 2009; 66(6): 783-91.
Le Van Quyen M, Bragin A, Staba R, Crepon B, Wilson CL, Engel J   Cell type-specific firing during ripple oscillations in the hippocampal formation of humans The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008; 28(24): 6104-10.
Staba RJ, Frighetto L, Behnke EJ, Mathern GW, Fields T, Bragin A, Ogren J, Fried I, Wilson CL, Engel J   Increased fast ripple to ripple ratios correlate with reduced hippocampal volumes and neuron loss in temporal lobe epilepsy patients Epilepsia, 2007; 48(11): 2130-8.
Staba RJ, Ard TD, Benison AM, Barth DS   Intracortical pathways mediate nonlinear fast oscillation (>200 Hz) interactions within rat barrel cortex Journal of neurophysiology, 2005; 93(5): 2934-9.
Staba RJ, Bergmann PC, Barth DS   Dissociation of slow waves and fast oscillations above 200 Hz during GABA application in rat somatosensory cortex The Journal of physiology, 2004; 561(Pt 1): 205-14.
Staba RJ, Wilson CL, Bragin A, Jhung D, Fried I, Engel J   High-frequency oscillations recorded in human medial temporal lobe during sleep Annals of neurology, 2004; 56(1): 108-15.
Brett-Green B, Paulsen M, Staba RJ, Fifkova E, Barth DS   Two distinct regions of secondary somatosensory cortex in the rat: topographical organization and multisensory responses Journal of neurophysiology, 2004; 91(3): 1327-36.
Staba RJ, Brett-Green B, Paulsen M, Barth DS   Effects of ventrobasal lesion and cortical cooling on fast oscillations (>200 Hz) in rat somatosensory cortex Journal of neurophysiology, 2003; 89(5): 2380-8.
Bragin A, Wilson CL, Staba RJ, Reddick M, Fried I, Engel J   Interictal high-frequency oscillations (80-500 Hz) in the human epileptic brain: entorhinal cortex Annals of neurology, 2002; 52(4): 407-15.
Staba RJ, Wilson CL, Bragin A, Fried I, Engel J   Quantitative analysis of high-frequency oscillations (80-500 Hz) recorded in human epileptic hippocampus and entorhinal cortex Journal of neurophysiology, 2002; 88(4): 1743-52.
Staba RJ, Wilson CL, Fried I, Engel J   Single neuron burst firing in the human hippocampus during sleep Hippocampus, 2002; 12(6): 724-34.
Staba RJ, Wilson CL, Bragin A, Fried I, Engel J   Sleep states differentiate single neuron activity recorded from human epileptic hippocampus, entorhinal cortex, and subiculum The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002; 22(13): 5694-704.
Shouse MN , Staba RJ, Saquib SF, Farber PR   Long-lasting effects of feline amygdala kindling on monoamines, seizures and sleep Brain research, 2001; 892(1): 147-65.
Shouse MN, Staba RJ, Ko PY, Saquib SF, Farber PR   Monoamines and seizures: microdialysis findings in locus ceruleus and amygdala before and during amygdala kindling Brain research, 2001; 892(1): 176-92.
Shouse MN, Staba RJ, Saquib SF, Farber PR   Monoamines and sleep: microdialysis findings in pons and amygdala Brain research, 2000; 860(1-2): 181-9.
Shouse MN, Farber PR, Staba RJ   Physiological basis: how NREM sleep components can promote and REM sleep components can suppress seizure discharge propagation Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2000; 111 Suppl 2(1): S9-S18.
Rector DM, Richard CA, Staba RJ, Harper RM   Sleep states alter ventral medullary surface responses to blood pressure challenges American journal of physiology. Regulatory, integrative and comparative physiology, 2000; 278(4): R1090-8.

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