Jeffrey Abramson, Ph.D.

A Short Biography:

Jeff Abramson has recently joined the faculty of UCLA in January of 2005. Although his primary training is in Biochemistry and Structural Biology he was recruited by the Department of Physiology. Dr. Abramson earned his B.S. in Biotechnology at California Polytechnic University Pomona and his Ph.D. in Biochemistry at Uppsala University, Sweden. He then went to Imperial College London for his postdoctoral training where he furthered his skills in membrane protein crystallography. Dr. Abramson is currently collaborating with a number of groups within the Department of Physiology where he is utilizing robotics for crystallization as well as visualization in order to increase throughput of membrane protein structures.

Work Titles
UCLA Associate Professor, Physiology Member, Biochemistry, Biophysics & Structural Biology GPB Home Area Member, I3T Theme Member, Molecular, Cellular & Integrative Physiology GPB Home Area
Education:
Degrees:
Ph.D., Uppsala University, Sweden

Contact Information:

Fax Number:

310-206-5661

Office Phone Number:

310-825-3913

Laboratory Address:

Laboratory
CHS 53-254


Work Address:

Office
CHS 53-260
Mailcode 775118


Publications:

A selected list of publications:

Abramson, J. Iwata, S. Kaback, H. R.   Lactose permease as a paradigm for membrane transport proteins (Review) Mol Membr Biol, 2004; 21(4): 227-36.
Iwata, M. Abramson, J. Byrne, B. Iwata, S.   Structure and function of quinone binding membrane proteins Adv Protein Chem, 2003; 63: 151-76.
Jormakka, M. Tornroth, S. Abramson, J. Byrne, B. Iwata, S.   Purification and crystallization of the respiratory complex formate dehydrogenase-N from Escherichia coli Acta Crystallogr D Biol Crystallogr, 2002; 58(Pt 1): 160-2.
Svensson-Ek, M. Abramson, J. Larsson, G. Tornroth, S. Brzezinski, P. Iwata, S.   The X-ray crystal structures of wild-type and EQ(I-286) mutant cytochrome c oxidases from Rhodobacter sphaeroides J Mol Biol, 2002; 321(2): 329-39.
Nicoll DA, Sawaya MR, Kwon S, Cascio D, Philipson KD, Abramson J.   The crystal structure of the primary Ca2+ sensor of the Na+/Ca2+ exchanger reveals a novel Ca2+ binding motif J Biol Chem , 2006; 281(31): 21577-81.
Abramson, J Kaback, HR Iwata, S   Structural comparison of lactose permease and the glycerol-3-phosphate antiporter: members of the major facilitator superfamily Current opinion in structural biology. , 2004; 14(4): 413-9.
Abramson, J Smirnova, I Kasho, V Verner, G Iwata, S Kaback, HR   The lactose permease of Escherichia coli: overall structure, the sugar-binding site and the alternating access model for transport FEBS letters. , 2003; 555(1): 96-101.
Abramson, J Smirnova, I Kasho, V Verner, G Kaback, HR Iwata, S   Structure and mechanism of the lactose permease of Escherichia coli Science. , 2003; 301(5633): 610-5.
Abramson, J Svensson-Ek, M Byrne, B Iwata, S   Structure of cytochrome c oxidase: a comparison of the bacterial and mitochondrial enzymes Biochimica et biophysica acta. , 2001; 1544(1-2): 1-9.
Abramson, J Riistama, S Larsson, G Jasaitis, A Svensson-Ek, M Laakkonen, L Puustinen, A Iwata, S Wikström, M   The structure of the ubiquinol oxidase from Escherichia coli and its ubiquinone binding site Nature structural biology. , 2000; 7(10): 910-7.
Byrne, B Abramson, J Jansson, M Holmgren, E Iwata, S   Fusion protein approach to improve the crystal quality of cytochrome bo(3) ubiquinol oxidase from Escherichia coli Biochimica et biophysica acta. , 2000; 1459(2-3): 449-55.
Abramson, J Larsson, G Byrne, B Puustinen, A Garcia-Horsman, A Iwata, S   Purification, crystallization and preliminary crystallographic studies of an integral membrane protein, cytochrome bo3 ubiquinol oxidase from Escherichia coli Acta crystallographica. Section D, Biological crystallography. , 2000; 56 ( Pt 8): 1076-8.
Sivars, U Abramson, J Iwata, S Tjerneld, F   Affinity partitioning of a poly(histidine)-tagged integral membrane protein, cytochrome bo3 ubiquinol oxidase, in a detergent--polymer aqueous two-phase system containing metal-chelating polymer Journal of chromatography. B, Biomedical sciences and applications. , 2000; 743(1-2): 307-16.

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