Zhilin Qu, Ph.D.


Work Titles
UCLA Professor In-Residence, Medicine Member, Molecular, Cellular & Integrative Physiology GPB Home Area Faculty, Cardiovascular Research Laboratory Faculty, Cardiology
Education:
Degrees:
Ph.D., Beijing Normal University

Contact Information:

Email Address:

zqu@mednet.ucla.edu


Website:




Fax Number:

310-206-9133

Work Phone Number:

310-794-6050

Mailing Address:

A2-237 CHS
650 Charles E. Young Drive South
University of California, Los Angeles
Los Angeles, CA 90095


Detailed Biography:

Zhilin Qu earned his B.S., M.S., and Ph.D. in Physics and Nonlinear Dynamics at the Beijing Normal University, China. Before he became a postdoctoral fellow in the Cardiovascular Research Laboratory at UCLA, his main research field was general nonlinear dynamics, such as chaos and chaos control in spatiotemporal systems. During his postdoctoral research, he worked on the mechanisms of cardiac fibrillation, the leading cause of sudden cardiac death. He collaborated extensively with experimental biologists to confirm the theories he has developed for cardiac arrhythmias. Dr. Qu became an Assistant Professor of Medicine in 2001 and is a co-director of the Cardiac Simulation Laboratory at UCLA. In collaboration with experimental cell and molecular biologists, Dr. Qu initiated a new research field in 2001, modeling the cell growth and cell cycle control. He is also collaborating with other experimental biologists in the Cardiovascular Research Laboratory to study signaling in cardiac ischemic injury and protection. He is a recipient of two national science awards of China and the fellowship award of the American Heart Association, Western States Affiliate. Dr. Qu's research goal is to use the approaches of systems biology and nonlinear dynamics, integrating mathematical modeling with biological experiments, to understand the mechanisms of cardiac arrhythmias, cell growth and cell cycle control, and the dynamics for biological signal transduction.

Publications:

Liu Michael B, Ko Christopher Y, Song Zhen, Garfinkel Alan, Weiss James N, Qu Zhilin   A Dynamical Threshold for Cardiac Delayed Afterdepolarization-Mediated Triggered Activity Biophysical journal, 2016; 111(11): 2523-2533.
Huang Xiaodong, Kim Tae Yun, Koren Gideon, Choi Bum-Rak, Qu Zhilin   Spontaneous initiation of premature ventricular complexes and arrhythmias in type 2 long QT syndrome American journal of physiology. Heart and circulatory physiology, 2016; 311(6): H1470-H1484.
Chiamvimonvat Nipavan, Chen-Izu Ye, Clancy Colleen E, Deschenes Isabelle, Dobrev Dobromir, Heijman Jordi, Izu Leighton, Qu Zhilin, Ripplinger Crystal M, Vandenberg Jamie I, Weiss James N, Koren Gideon, Banyasz Tamas, Grandi Eleonora, Sanguinetti Michael C, Bers Donald M, Nerbonne Jeanne M   Potassium currents in the heart: Functional roles in repolarization, arrhythmia and therapeutics The Journal of physiology, 2016; 311(6): H1470-H1484.
Qu Zhilin, Liu Michael B, Nivala Michael   A unified theory of calcium alternans in ventricular myocytes Scientific reports, 2016; 6(6): 35625.
Weiss James N, Qu Zhilin, Shivkumar Kalyanam   Ablating atrial fibrillation: A translational science perspective for clinicians Heart rhythm : the official journal of the Heart Rhythm Society, 2016; 13(9): 1868-77.
Ponnaluri Aditya V S, Perotti Luigi E, Liu Michael, Qu Zhilin, Weiss James N, Ennis Daniel B, Klug William S, Garfinkel Alan   Electrophysiology of Heart Failure Using a Rabbit Model: From the Failing Myocyte to Ventricular Fibrillation PLoS computational biology, 2016; 12(6): e1004968.
Song Zhen, Karma Alain, Weiss James N, Qu Zhilin   Long-Lasting Sparks: Multi-Metastability and Release Competition in the Calcium Release Unit Network PLoS computational biology, 2016; 12(1): e1004671.
Lau Emily, Kossidas Konstantinos, Kim Tae Yun, Kunitomo Yukiko, Ziv Ohad, Song Zhen, Taylor Chantel, Schofield Lorraine, Yammine Joe, Liu Gongxin, Peng Xuwen, Qu Zhilin, Koren Gideon, Choi Bum-Rak   Correction: Spatially Discordant Alternans and Arrhythmias in Tachypacing-Induced Cardiac Myopathy in Transgenic LQT1 Rabbits: The Importance of IKs and Ca2+ Cycling PloS one, 2015; 10(7): e0132198.
Pezhouman Arash, Singh Neha, Song Zhen, Nivala Michael, Eskandari Anahita, Cao Hong, Bapat Aneesh, Ko Christopher Y, Nguyen Thao P, Qu Zhilin, Karagueuzian Hrayr S, Weiss James N   Molecular Basis of Hypokalemia-Induced Ventricular Fibrillation Circulation, 2015; 132(16): 1528-37.
Liu Michael B, Lange Enno de, Garfinkel Alan, Weiss James N, Qu Zhilin   Delayed Afterdepolarizations Generate Both Triggers and A Vulnerable Substrate Promoting Reentry in Cardiac Tissue Heart rhythm : the official journal of the Heart Rhythm Society, 2015; .
Weiss James N, Garfinkel Alan, Karagueuzian Hrayr S, Nguyen Thao P, Olcese Riccardo, Chen Peng-Sheng, Qu Zhilin   Perspective: a dynamics-based classification of ventricular arrhythmias Journal of molecular and cellular cardiology, 2015; 82(5): 136-52.
Madhvani Roshni V, Angelini Marina, Xie Yuanfang, Pantazis Antonios, Suriany Silvie, Borgstrom Nils P, Garfinkel Alan, Qu Zhilin, Weiss James N, Olcese Riccardo   Targeting the late component of the cardiac L-type Ca2+ current to suppress early afterdepolarizations The Journal of general physiology, 2015; 145(5): 395-404.
Song Zhen, Ko Christopher Y, Nivala Michael, Weiss James N, Qu Zhilin   Calcium-voltage coupling in the genesis of early and delayed afterdepolarizations in cardiac myocytes Biophysical journal, 2015; 108(8): 1908-21.
Chan Yi-Hsin, Tsai Wei-Chung, Song Zhen, Ko Christopher Y, Qu Zhilin, Weiss James N, Lin Shien-Fong, Chen Peng-Sheng, Jones Larry R, Chen Zhenhui   Acute reversal of phospholamban inhibition facilitates the rhythmic whole-cell propagating calcium waves in isolated ventricular myocytes Journal of molecular and cellular cardiology, 2015; 80(6): 126-35.
Clancy Colleen E, Chen-Izu Ye, Bers Donald M, Belardinelli Luiz, Boyden Penelope A, Csernoch Laszlo, Despa Sanda, Fermini Bernard, Hool Livia C, Izu Leighton, Kass Robert S, Lederer W Jonathan, Louch William E, Maack Christoph, Matiazzi Alicia, Qu Zhilin, Rajamani Sridharan, Rippinger Crystal M, Sejersted Ole M, O'Rourke Brian, Weiss James N, Varró András, Zaza Antonio   Deranged sodium to sudden death The Journal of physiology, 2015; 593(6): 1331-45.
Nguyen Thao P, Singh Neha, Xie Yuanfang, Qu Zhilin, Weiss James N   Repolarization Reserve Evolves Dynamically During the Cardiac Action Potential: Effects of Transient Outward Currents on Early Afterdepolarizations Circulation. Arrhythmia and electrophysiology, 2015; 593(6): .
Qu Zhilin, Weiss James N   Mechanisms of ventricular arrhythmias: from molecular fluctuations to electrical turbulence Annual review of physiology, 2015; 77(6): 29-55.
Nivala Michael, Song Zhen, Weiss James N, Qu Zhilin   T-tubule disruption promotes calcium alternans in failing ventricular myocytes: mechanistic insights from computational modeling Journal of molecular and cellular cardiology, 2015; 79(6): 32-41.
Kim Tae Yun, Kunitomo Yukiko, Pfeiffer Zachary, Patel Divyang, Hwang Jungmin, Harrison Kathryn, Patel Brijesh, Jeng Paul, Ziv Ohad, Lu Yichun, Peng Xuwen, Qu Zhilin, Koren Gideon, Choi Bum-Rak   Complex excitation dynamics underlie polymorphic ventricular tachycardia in a transgenic rabbit model of long QT syndrome type 1 Heart rhythm : the official journal of the Heart Rhythm Society, 2015; 12(1): 220-8.
Lau Emily, Kossidas Konstantinos, Kim Tae Yun, Kunitomo Yukiko, Ziv Ohad, Zhen Song, Taylor Chantel, Schofield Lorraine, Yammine Joe, Liu Gongxin, Peng Xuwen, Qu Zhilin, Koren Gideon, Choi Bum-Rak   Spatially Discordant Alternans and Arrhythmias in Tachypacing-Induced Cardiac Myopathy in Transgenic LQT1 Rabbits: The Importance of IKs and Ca2+ Cycling PloS one, 2015; 10(5): e0122754.
Qu Zhilin, Hu Gang, Garfinkel Alan, Weiss James N   Nonlinear and Stochastic Dynamics in the Heart Physics reports, 2014; 543(2): 61-162.
Nguyen Thao P, Qu Zhilin, Weiss James N   Cardiac fibrosis and arrhythmogenesis: the road to repair is paved with perils Journal of molecular and cellular cardiology, 2014; 70(2): 83-91.
Pezhouman Arash, Madahian Sepideh, Stepanyan Hayk, Ghukasyan Hayk, Qu Zhilin, Belardinelli Luiz, Karagueuzian Hrayr S   Selective inhibition of late sodium current suppresses ventricular tachycardia and fibrillation in intact rat hearts Heart rhythm : the official journal of the Heart Rhythm Society, 2014; 11(3): 492-501.
Krishnamoorthi Shankarjee, Perotti Luigi E, Borgstrom Nils P, Ajijola Olujimi A, Frid Anna, Ponnaluri Aditya V, Weiss James N, Qu Zhilin, Klug William S, Ennis Daniel B, Garfinkel Alan   Simulation Methods and Validation Criteria for Modeling Cardiac Ventricular Electrophysiology PloS one, 2014; 9(12): e114494.
Nivala Michael, Ko Christopher Y, Nivala Melissa, Weiss James N, Qu Zhilin   The emergence of subcellular pacemaker sites for calcium waves and oscillations The Journal of physiology, 2013; 591(Pt 21): 5305-20.
Qu Zhilin, Xie Lai-Hua, Olcese Riccardo, Karagueuzian Hrayr S, Chen Peng-Sheng, Garfinkel Alan, Weiss James N   Early afterdepolarizations in cardiac myocytes: beyond reduced repolarization reserve Cardiovascular research, 2013; 99(1): 6-15.
Karagueuzian Hrayr S, Nguyen Thao P, Qu Zhilin, Weiss James N   Oxidative stress, fibrosis, and early afterdepolarization-mediated cardiac arrhythmias Frontiers in physiology, 2013; 4: 19.
Qu Zhilin, Nivala Michael, Weiss James N   Calcium alternans in cardiac myocytes: order from disorder Journal of molecular and cellular cardiology, 2013; 58: 100-9.
Chang Marvin G, de Lange Enno, Calmettes Guillaume, Garfinkel Alan, Qu Zhilin, Weiss James N   Pro- and antiarrhythmic effects of ATP-sensitive potassium current activation on reentry during early afterdepolarization-mediated arrhythmias Heart rhythm : the official journal of the Heart Rhythm Society, 2013; 10(4): 575-82.
Qu Zhilin   Controlling cardiacalternans Heart rhythm : the official journal of the Heart Rhythm Society, 2012; 4: .
Weiss James N, Karma Alain, Maclellan W Robb, Deng Mario, Rau Christoph D, Rees Colin M, Wang Jessica, Wisniewski Nicholas, Eskin Eleazar, Horvath Steve, Qu Zhilin, Wang Yibin, Lusis Aldons J   "Good enough solutions" and the genetics of complex diseases Circulation research, 2012; 111(4): 493-504.
Nivala Michael, Qu Zhilin   Calcium alternans in a couplon network model of ventricular myocytes: role of sarcoplasmic reticulum load American journal of physiology. Heart and circulatory physiology, 2012; 303(3): H341-52.
Xi Yutao, Ai Tomohiko, De Lange Enno, Li Zhaohui, Wu Geru, Brunelli Luca, Kyle W Buck, Turker Isik, Cheng Jie, Ackerman Michael J, Kimura Akinori, Weiss James N, Qu Zhilin, Kim Jeffrey J, Faulkner Georgine, Vatta Matteo   Loss-of-Function of hNav1.5 by ZASP1-D117N Associated with Intraventricular Conduction Disturbances in Left Ventricular Noncompaction Circulation. Arrhythmia and electrophysiology, 2012; .
Zhao Zhenghang, Xie Yuanfang, Wen Hairuo, Xiao Dandan, Allen Charelle, Fefelova Nadezhda, Dun Wen, Boyden Penelope A, Qu Zhilin, Xie Lai-Hua   Role of the transient outward potassium current in the genesis of early afterdepolarizations in cardiac cells Cardiovascular research, 2012; 95(3): 308-16.
de Lange Enno, Xie Yuanfang, Qu Zhilin   Synchronization of Early Afterdepolarizations and Arrhythmogenesis in Heterogeneous Cardiac Tissue Models Biophysical journal, 2012; 103(2): 365-73.
Nivala Michael, Ko Christopher Y, Nivala Melissa, Weiss James N, Qu Zhilin   Criticality in intracellular calcium signaling in cardiac myocytes Biophysical journal, 2012; 102(11): 2433-42.
Chang Marvin G, Chang Connie Y, de Lange Enno, Xu Linmiao, O'Rourke Brian, Karagueuzian Hrayr S, Tung Leslie, Marbán Eduardo, Garfinkel Alan, Weiss James N, Qu Zhilin, Abraham M Roselle   Dynamics of early afterdepolarization-mediated triggered activity in cardiac monolayers Biophysical journal, 2012; 102(12): 2706-14.
Xu Lida, Li Zhuang, Qu Zhilin, Di Zengru   Resonance drifts of spiral waves on media of periodic excitability Physical review. E, Statistical, nonlinear, and soft matter physics, 2012; 85(4 Pt 2): 046216.
Liu Gong-Xin, Choi Bum-Rak, Ziv Ohad, Li Weiyan, de Lange Enno, Qu Zhilin, Koren Gideon   Differential conditions for early after-depolarizations and triggered activity in cardiomyocytes derived from transgenic LQT1 and LQT2 rabbits The Journal of physiology, 2012; 590(Pt 5): 1171-80.
Nguyen Thao P, Xie Yuanfang, Garfinkel Alan, Qu Zhilin, Weiss James N   Arrhythmogenic consequences of myofibroblast-myocyte coupling Cardiovascular research, 2012; 93(2): 242-51.
Nivala Michael, de Lange Enno, Rovetti Robert, Qu Zhilin   Computational modeling and numerical methods for spatiotemporal calcium cycling in ventricular myocytes Frontiers in physiology, 2012; 3(2): 114.
Chang Marvin G, Sato Daisuke, de Lange Enno, Lee Jong-Hwan, Karagueuzian Hrayr S, Garfinkel Alan, Weiss James N, Qu Zhilin   Bi-stable wave propagation and early afterdepolarization-mediated cardiac arrhythmias Heart rhythm : the official journal of the Heart Rhythm Society, 2012; 9(1): 115-22.
Madhvani Roshni V, Xie Yuanfang, Pantazis Antonios, Garfinkel Alan, Qu Zhilin, Weiss James N, Olcese Riccardo   Shaping a new Ca²⁺ conductance to suppress early afterdepolarizations in cardiac myocytes The Journal of physiology, 2011; 589(Pt 24): 6081-92.
Nivala Melissa, Korge Paavo, Nivala Michael, Weiss James N, Qu Zhilin   Linking flickering to waves and whole-cell oscillations in a mitochondrial network model Biophysical journal, 2011; 101(9): 2102-11.
Qu Zhilin, Garfinkel Alan, Weiss James N, Nivala Melissa   Multi-scale modeling in biology: how to bridge the gaps between scales? Progress in biophysics and molecular biology, 2011; 107(1): 21-31.
Korge Paavo, Yang Ling, Yang Jun-Hai, Wang Yibin, Qu Zhilin, Weiss James N   Protective role of transient pore openings in calcium handling by cardiac mitochondria The Journal of biological chemistry, 2011; 286(40): 34851-7.
Qu Zhilin   Chaos in the genesis and maintenance of cardiac arrhythmias Progress in biophysics and molecular biology, 2011; 105(3): 247-57.
Baher Alex A, Uy Matthew, Xie Fagen, Garfinkel Alan, Qu Zhilin, Weiss James N   Bidirectional ventricular tachycardia: ping pong in the His-Purkinje system Heart rhythm : the official journal of the Heart Rhythm Society, 2011; 8(4): 599-605.
Maruyama Mitsunori, Lin Shien-Fong, Xie Yuanfang, Chua Su-Kiat, Joung Boyoung, Han Seongwook, Shinohara Tetsuji, Shen Mark J, Qu Zhilin, Weiss James N, Chen Peng-Sheng   Genesis of phase 3 early afterdepolarizations and triggered activity in acquired long-QT syndrome Circulation. Arrhythmia and electrophysiology, 2011; 4(1): 103-11.
Weiss James N, Nivala Michael, Garfinkel Alan, Qu Zhilin   Alternans and arrhythmias: from cell to heart Circulation research, 2011; 108(1): 98-112.
de Diego Carlos, Chen Fuhua, Xie Yuanfang, Pai Rakesh K, Slavin Leonid, Parker John, Lamp Scott T, Qu Zhilin, Weiss James N, Valderrábano Miguel   Anisotropic conduction block and reentry in neonatal rat ventricular myocyte monolayers American journal of physiology. Heart and circulatory physiology, 2011; 300(1): H271-8.
Morita Norishige, Lee Jong Hwan, Xie Yuanfang, Sovari Ali, Qu Zhilin, Weiss James N, Karagueuzian Hrayr S   Suppression of re-entrant and multifocal ventricular fibrillation by the late sodium current blocker ranolazine Journal of the American College of Cardiology, 2011; 57(3): 366-75.
Weiss James N, Garfinkel Alan, Karagueuzian Hrayr S, Chen Peng-Sheng, Qu Zhilin   Early afterdepolarizations and cardiac arrhythmias Heart rhythm : the official journal of the Heart Rhythm Society, 2010; 7(12): 1891-9.
Ren Xiaoyan, Nicoll Debora A, Xu Lida, Qu Zhilin, Philipson Kenneth D   Transmembrane segment packing of the Na(+)/Ca(2+) exchanger investigated with chemical cross-linkers Biochemistry, 2010; 49(39): 8585-91.
Xie Yuanfang, Sato Daisuke, Garfinkel Alan, Qu Zhilin, Weiss James N   So little source, so much sink: requirements for afterdepolarizations to propagate in tissue Biophysical journal, 2010; 99(5): 1408-15.
Sato Daisuke, Xie Lai-Hua, Nguyen Thao P, Weiss James N, Qu Zhilin   Irregularly appearing early afterdepolarizations in cardiac myocytes: random fluctuations or dynamical chaos? Biophysical journal, 2010; 99(3): 765-73.
Rovetti Robert, Cui Xiaohua, Garfinkel Alan, Weiss James N, Qu Zhilin   Spark-induced sparks as a mechanism of intracellular calcium alternans in cardiac myocytes Circulation research, 2010; 106(10): 1582-91.
Yang Ling, Korge Paavo, Weiss James N, Qu Zhilin   Mitochondrial oscillations and waves in cardiac myocytes: insights from computational models Biophysical journal, 2010; 98(8): 1428-38.
Qu Zhilin, Xie Yuanfang, Garfinkel Alan, Weiss James N   T-wave alternans and arrhythmogenesis in cardiac diseases Frontiers in physiology, 2010; 1(8): 154.
Xie Yuanfang, Garfinkel Alan, Camelliti Patrizia, Kohl Peter, Weiss James N, Qu Zhilin   Effects of fibroblast-myocyte coupling on cardiac conduction and vulnerability to reentry: A computational study Heart rhythm : the official journal of the Heart Rhythm Society, 2009; 6(11): 1641-9.
Morita Norishige, Sovari Ali A, Xie Yuanfang, Fishbein Michael C, Mandel William J, Garfinkel Alan, Lin Shien-Fong, Chen Peng-Sheng, Xie Lai-Hua, Chen Fuhua, Qu Zhilin, Weiss James N, Karagueuzian Hrayr S   Increased susceptibility of aged hearts to ventricular fibrillation during oxidative stress American journal of physiology. Heart and circulatory physiology, 2009; 297(5): H1594-605.
Sato Daisuke, Xie Yuanfang, Weiss James N, Qu Zhilin, Garfinkel Alan, Sanderson Allen R   Acceleration of cardiac tissue simulation with graphic processing units Medical & biological engineering & computing, 2009; 47(9): 1011-5.
Xie Yuanfang, Garfinkel Alan, Weiss James N, Qu Zhilin   Cardiac alternans induced by fibroblast-myocyte coupling: mechanistic insights from computational models American journal of physiology. Heart and circulatory physiology, 2009; 297(2): H775-84.
Cui Xiaohua, Rovetti Robert J, Yang Ling, Garfinkel Alan, Weiss James N, Qu Zhilin   Period-doubling bifurcation in an array of coupled stochastically excitable elements subjected to global periodic forcing Physical review letters, 2009; 103(4): 044102.
Tran Diana X, Sato Daisuke, Yochelis Arik, Weiss James N, Garfinkel Alan, Qu Zhilin   Bifurcation and chaos in a model of cardiac early afterdepolarizations Physical review letters, 2009; 102(25): 258103.
Xu Lida, Qu Zhilin, Di Zengru   Drifting dynamics of dense and sparse spiral waves in heterogeneous excitable media Physical review. E, Statistical, nonlinear, and soft matter physics, 2009; 79(3 Pt 2): 036212.
Sato Daisuke, Xie Lai-Hua, Sovari Ali A, Tran Diana X, Morita Norishige, Xie Fagen, Karagueuzian Hrayr, Garfinkel Alan, Weiss James N, Qu Zhilin   Synchronization of chaotic early afterdepolarizations in the genesis of cardiac arrhythmias Proceedings of the National Academy of Sciences of the United States of America, 2009; 106(9): 2983-8.
Yang Jun-Hai, Yang Ling, Qu Zhilin, Weiss James N   Glycolytic oscillations in isolated rabbit ventricular myocytes The Journal of biological chemistry, 2008; 283(52): 36321-7.
Yang Ling, Vondriska Thomas M, Han Zhangang, Maclellan W Robb, Weiss James N, Qu Zhilin   Deducing topology of protein-protein interaction networks from experimentally measured sub-networks BMC bioinformatics, 2008; 9(6): 301.
Xie Lai-Hua, Sato Daisuke, Garfinkel Alan, Qu Zhilin, Weiss James N   Intracellular Ca alternans: coordinated regulation by sarcoplasmic reticulum release, uptake, and leak Biophysical journal, 2008; 95(6): 3100-10.
Wang Shihong, Xie Yuanfang, Qu Zhilin   Coupled Iterated Map Models of Action Potential Dynamics in a One-dimensional Cable of Cardiac Cells New journal of physics, 2008; 10(5): 55001-55024.
Mahajan Aman, Shiferaw Yohannes, Sato Daisuke, Baher Ali, Olcese Riccardo, Xie Lai-Hua, Yang Ming-Jim, Chen Peng-Sheng, Restrepo Juan G, Karma Alain, Garfinkel Alan, Qu Zhilin, Weiss James N   A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates Biophysical journal, 2008; 94(2): 392-410.
Mahajan Aman, Sato Daisuke, Shiferaw Yohannes, Baher Ali, Xie Lai-Hua, Peralta Robert, Olcese Riccardo, Garfinkel Alan, Qu Zhilin, Weiss James N   Modifying L-type calcium current kinetics: consequences for cardiac excitation and arrhythmia dynamics Biophysical journal, 2008; 94(2): 411-23.
Tran Diana X, Yang Ming-Jim, Weiss James N, Garfinkel Alan, Qu Zhilin   Vulnerability to re-entry in simulated two-dimensional cardiac tissue: effects of electrical restitution and stimulation sequence Chaos (Woodbury, N.Y.), 2007; 17(4): 043115.
Qu Zhilin, Weiss James N   The chicken or the egg? Voltage and calcium dynamics in the heart American journal of physiology. Heart and circulatory physiology, 2007; 293(4): H2054-5.
Xie Yuanfang, Hu Gang, Sato Daisuke, Weiss James N, Garfinkel Alan, Qu Zhilin   Dispersion of refractoriness and induction of reentry due to chaos synchronization in a model of cardiac tissue Physical review letters, 2007; 99(11): 118101.
Yang Ming-Jim, Tran Diana X, Weiss James N, Garfinkel Alan, Qu Zhilin   The pinwheel experiment revisited: effects of cellular electrophysiological properties on vulnerability to cardiac reentry American journal of physiology. Heart and circulatory physiology, 2007; 293(3): H1781-90.
Han Zhangang, Vondriska Thomas M, Yang Ling, Robb MacLellan W, Weiss James N, Qu Zhilin   Signal transduction network motifs and biological memory Journal of theoretical biology, 2007; 246(4): 755-61.
Sato Daisuke, Shiferaw Yohannes, Qu Zhilin, Garfinkel Alan, Weiss James N, Karma Alain   Inferring the cellular origin of voltage and calcium alternans from the spatial scales of phase reversal during discordant alternans Biophysical journal, 2007; 92(4): L33-5.
Hayashi Hideki, Shiferaw Yohannes, Sato Daisuke, Nihei Motoki, Lin Shien-Fong, Chen Peng-Sheng, Garfinkel Alan, Weiss James N, Qu Zhilin   Dynamic origin of spatially discordant alternans in cardiac tissue Biophysical journal, 2007; 92(2): 448-60.
Qu Zhilin, Shiferaw Yohannes, Weiss James N   Nonlinear dynamics of cardiac excitation-contraction coupling: an iterated map study Physical review. E, Statistical, nonlinear, and soft matter physics, 2007; 75(1 Pt 1): 011927.
Baher Ali, Qu Zhilin, Hayatdavoudi Ashkan, Lamp Scott T, Yang Ming-Jim, Xie Fagen, Turner Stephen, Garfinkel Alan, Weiss James N   Short-term cardiac memory and mother rotor fibrillation American journal of physiology. Heart and circulatory physiology, 2007; 292(1): H180-9.
Weiss James N, Yang Ling, Qu Zhilin   Systems biology approaches to metabolic and cardiovascular disorders: network perspectives of cardiovascular metabolism Journal of lipid research, 2006; 47(11): 2355-66.
Shiferaw Yohannes, Qu Zhilin, Garfinkel Alan, Karma Alain, Weiss James N   Nonlinear dynamics of paced cardiac cells Annals of the New York Academy of Sciences, 2006; 1080(11): 376-94.
Qu Zhilin, Weiss James N   Dynamics and cardiac arrhythmias Journal of cardiovascular electrophysiology, 2006; 17(9): 1042-9.
Sato Daisuke, Shiferaw Yohannes, Garfinkel Alan, Weiss James N, Qu Zhilin, Karma Alain   Spatially discordant alternans in cardiac tissue: role of calcium cycling Circulation research, 2006; 99(5): 520-7.
Qu Zhilin, Garfinkel Alan, Weiss James N   Vulnerable window for conduction block in a one-dimensional cable of cardiac cells, 1: single extrasystoles Biophysical journal, 2006; 91(3): 793-804.
Qu Zhilin, Garfinkel Alan, Weiss James N   Vulnerable window for conduction block in a one-dimensional cable of cardiac cells, 2: multiple extrasystoles Biophysical journal, 2006; 91(3): 805-15.
Yang Ling, Han Zhangang, Robb MacLellan W, Weiss James N, Qu Zhilin   Linking cell division to cell growth in a spatiotemporal model of the cell cycle Journal of theoretical biology, 2006; 241(1): 120-33.
Weiss James N, Karma Alain, Shiferaw Yohannes, Chen Peng-Sheng, Garfinkel Alan, Qu Zhilin   From pulsus to pulseless: the saga of cardiac alternans Circulation research, 2006; 98(10): 1244-53.
Qu Zhilin   Critical mass hypothesis revisited: role of dynamical wave stability in spontaneous termination of cardiac fibrillation American journal of physiology. Heart and circulatory physiology, 2006; 290(1): H255-63.
Qu Zhilin, Weiss James N   Effects of Na(+) and K(+) channel blockade on vulnerability to and termination of fibrillation in simulated normal cardiac tissue American journal of physiology. Heart and circulatory physiology, 2005; 289(4): H1692-701.
Weiss James N, Qu Zhilin, Chen Peng-Sheng, Lin Shien-Fong, Karagueuzian Hrayr S, Hayashi Hideki, Garfinkel Alan, Karma Alain   The dynamics of cardiac fibrillation Circulation, 2005; 112(8): 1232-40.
Miyauchi Mizuho, Qu Zhilin, Miyauchi Yasushi, Zhou Sheng-Mei, Pak Hui, Mandel William J, Fishbein Michael C, Chen Peng-Sheng, Karagueuzian Hrayr S   Chronic nicotine in hearts with healed ventricular myocardial infarction promotes atrial flutter that resembles typical human atrial flutter American journal of physiology. Heart and circulatory physiology, 2005; 288(6): H2878-86.
Han Zhangang, Yang Ling, MacLellan W Robb, Weiss James N, Qu Zhilin   Hysteresis and cell cycle transitions: how crucial is it? Biophysical journal, 2005; 88(3): 1626-34.
Qu Zhilin   Dynamical effects of diffusive cell coupling on cardiac excitation and propagation: a simulation study American journal of physiology. Heart and circulatory physiology, 2004; 287(6): H2803-12.
Wu Tsu-Juey, Lin Shien-Fong, Baher Ali, Qu Zhilin, Garfinkel Alan, Weiss James N, Ting Chih-Tai, Chen Peng-Sheng   Mother rotors and the mechanisms of D600-induced type 2 ventricular fibrillation Circulation, 2004; 110(15): 2110-8.
Qu Zhilin   Nonlinear dynamic control of irregular cardiac rhythms Journal of cardiovascular electrophysiology, 2004; 15(10): 1186-7.
Qu Zhilin, Weiss James N, MacLellan W Robb   Coordination of cell growth and cell division: a mathematical modeling study Journal of cell science, 2004; 117(Pt 18): 4199-207.
Yang Ling, MacLellan W Robb, Han Zhangang, Weiss James N, Qu Zhilin   Multisite phosphorylation and network dynamics of cyclin-dependent kinase signaling in the eukaryotic cell cycle Biophysical journal, 2004; 86(6): 3432-43.
Omichi Chikaya, Lamp Scott T, Lin Shien-Fong, Yang Junzhong, Baher Ali, Zhou Shengmei, Attin Mina, Lee Moon-Hyoung, Karagueuzian Hrayr S, Kogan Boris, Qu Zhilin, Garfinkel Alan, Chen Peng-Sheng, Weiss James N   Intracellular Ca dynamics in ventricular fibrillation American journal of physiology. Heart and circulatory physiology, 2004; 286(5): H1836-44.
Qu Zhilin, Karagueuzian Hrayr S, Garfinkel Alan, Weiss James N   Effects of Na(+) channel and cell coupling abnormalities on vulnerability to reentry: a simulation study American journal of physiology. Heart and circulatory physiology, 2004; 286(4): H1310-21.
Xie Fagen, Qu Zhilin, Yang Junzhong, Baher Ali, Weiss James N, Garfinkel Alan   A simulation study of the effects of cardiac anatomy in ventricular fibrillation The Journal of clinical investigation, 2004; 113(5): 686-93.
Qu Zhilin, MacLellan W Robb, Weiss James N   Dynamics of the cell cycle: checkpoints, sizers, and timers Biophysical journal, 2003; 85(6): 3600-11.
Yang Junzhong, Xie Fagen, Qu Zhilin, Garfinkel Alan   Mechanism for spiral wave breakup in excitable and oscillatory media Physical review letters, 2003; 91(14): 148302.
Weiss James N, Chen Peng-Sheng, Qu Zhilin, Karagueuzian Hrayr S, Lin Shien-Fong, Garfinkel Alan, Karma Alain   Effects of the excitation-contraction uncouplers diamine monoxime (DAM) and cytochalasin D (CytoD) on induced arrhythmias in the rabbit ventricle Journal of cardiovascular electrophysiology, 2003; 14(3): 331-2; author reply 332-4.
Qu Zhilin, Weiss James N, MacLellan W Robb   Regulation of the mammalian cell cycle: a model of the G1-to-S transition American journal of physiology. Cell physiology, 2003; 284(2): C349-64.
Weiss James N, Qu Zhilin, Garfinkel Alan   Understanding biological complexity: lessons from the past FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003; 17(1): 1-6.
Ohara Toshihiko, Qu Zhilin, Lee Moon-Hyoung, Ohara Keiko, Omichi Chikaya, Mandel William J, Chen Peng-Sheng, Karagueuzian Hrayr S   Increased vulnerability to inducible atrial fibrillation caused by partial cellular uncoupling with heptanol American journal of physiology. Heart and circulatory physiology, 2002; 283(3): H1116-22.
Xie Fagen, Qu Zhilin, Garfinkel Alan, Weiss James N   Electrical refractory period restitution and spiral wave reentry in simulated cardiac tissue American journal of physiology. Heart and circulatory physiology, 2002; 283(1): H448-60.
Swissa Moshe, Qu Zhilin, Ohara Toshihiko, Lee Moon-Hyoung, Lin Shien-Fong, Garfinkel Alan, Karagueuzian Hrayr S, Weiss James N, Chen Peng-Sheng   Action potential duration restitution and ventricular fibrillation due to rapid focal excitation American journal of physiology. Heart and circulatory physiology, 2002; 282(5): H1915-23.
Weiss James N, Chen Peng-Sheng, Qu Zhilin, Karagueuzian Hrayr S, Lin Shin-Fong, Garfinkel Alan   Electrical restitution and cardiac fibrillation Journal of cardiovascular electrophysiology, 2002; 13(3): 292-5.
Valderrábano Miguel, Yang Junzhong, Omichi Chikaya, Kil John, Lamp Scott T, Qu Zhilin, Lin Shien-Fong, Karagueuzian Hrayr S, Garfinkel Alan, Chen Peng-Sheng, Weiss James N   Frequency analysis of ventricular fibrillation in Swine ventricles Circulation research, 2002; 90(2): 213-22.
Lee M H, Qu Z, Fishbein G A, Lamp S T, Chang E H, Ohara T, Voroshilovsky O, Kil J R, Hamzei A R, Wang N C, Lin S F, Weiss J N, Garfinkel A, Karagueuzian H S, Chen P S   Patterns of wave break during ventricular fibrillation in isolated swine right ventricle American journal of physiology. Heart and circulatory physiology, 2001; 281(1): H253-65.
Xie F, Qu Z, Garfinkel A, Weiss J N   Effects of simulated ischemia on spiral wave stability American journal of physiology. Heart and circulatory physiology, 2001; 280(4): H1667-73.
Xie F, Qu Z, Weiss J N, Garfinkel A   Coexistence of multiple spiral waves with independent frequencies in a heterogeneous excitable medium Physical review. E, Statistical, nonlinear, and soft matter physics, 2001; 63(3 Pt 1): 031905.
Xie F, Qu Z, Garfinkel A, Weiss J N   Electrophysiological heterogeneity and stability of reentry in simulated cardiac tissue American journal of physiology. Heart and circulatory physiology, 2001; 280(2): H535-45.
Weiss J N, Chen P S, Qu Z, Karagueuzian H S, Garfinkel A   Ventricular fibrillation: how do we stop the waves from breaking? Circulation research, 2000; 87(12): 1103-7.
Qu Z, Garfinkel A, Chen P S, Weiss J N   Mechanisms of discordant alternans and induction of reentry in simulated cardiac tissue Circulation, 2000; 102(14): 1664-70.
Voroshilovsky O, Qu Z, Lee M H, Ohara T, Fishbein G A, Huang H L, Swerdlow C D, Lin S F, Garfinkel A, Weiss J N, Karagueuzian H S, Chen P S   Mechanisms of ventricular fibrillation induction by 60-Hz alternating current in isolated swine right ventricle Circulation, 2000; 102(13): 1569-74.
Qu Z, Xie F, Garfinkel A, Weiss J N   Origins of spiral wave meander and breakup in a two-dimensional cardiac tissue model Annals of biomedical engineering, 2000; 28(7): 755-71.
Qu Z, Kil J, Xie F, Garfinkel A, Weiss J N   Scroll wave dynamics in a three-dimensional cardiac tissue model: roles of restitution, thickness, and fiber rotation Biophysical journal, 2000; 78(6): 2761-75.
Garfinkel A, Kim Y H, Voroshilovsky O, Qu Z, Kil J R, Lee M H, Karagueuzian H S, Weiss J N, Chen P S   Preventing ventricular fibrillation by flattening cardiac restitution Proceedings of the National Academy of Sciences of the United States of America, 2000; 97(11): 6061-6.
Qu Z, Weiss J N, Garfinkel A   From local to global spatiotemporal chaos in a cardiac tissue model Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics, 2000; 61(1): 727-32.
Qu Z, Garfinkel A   An advanced algorithm for solving partial differential equation in cardiac conduction IEEE transactions on bio-medical engineering, 1999; 46(9): 1166-8.
Kim Y H, Xie F, Yashima M, Wu T J, Valderrábano M, Lee M H, Ohara T, Voroshilovsky O, Doshi R N, Fishbein M C, Qu Z, Garfinkel A, Weiss J N, Karagueuzian H S, Chen P S   Role of papillary muscle in the generation and maintenance of reentry during ventricular tachycardia and fibrillation in isolated swine right ventricle Circulation, 1999; 100(13): 1450-9.
Weiss J N, Garfinkel A, Karagueuzian H S, Qu Z, Chen P S   Chaos and the transition to ventricular fibrillation: a new approach to antiarrhythmic drug evaluation Circulation, 1999; 99(21): 2819-26.
Cao J M, Qu Z, Kim Y H, Wu T J, Garfinkel A, Weiss J N, Karagueuzian H S, Chen P S   Spatiotemporal heterogeneity in the induction of ventricular fibrillation by rapid pacing: importance of cardiac restitution properties Circulation research, 1999; 84(11): 1318-31.
Uchida T, Yashima M, Gotoh M, Qu Z, Garfinkel A, Weiss J N, Fishbein M C, Mandel W J, Chen P S, Karagueuzian H S   Mechanism of acceleration of functional reentry in the ventricle: effects of ATP-sensitive potassium channel opener Circulation, 1999; 99(5): 704-12.
Qu Z, Weiss J N, Garfinkel A   Cardiac electrical restitution properties and stability of reentrant spiral waves: a simulation study The American journal of physiology, 1999; 276(1 Pt 2): H269-83.
Xiao JH, Hu G, Qu Z   Synchronization of Spatiotemporal Chaos and Its Application to Spread-Spectrum Communication Physical review letters, 1996; 77(20): 4162-4165.
Zhilin Qu, Gang Hu, Benkun Ma, Gang Tian   Spatiotemporally periodic patterns in symmetrically coupled map lattices Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics, 1994; 50(1): 163-170.
Qu Z, Gang H   Spatiotemporally periodic states, periodic windows, and intermittency in coupled-map lattices Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics, 1994; 49(2): 1099-1108.
Hu G, Qu Z   Controlling spatiotemporal chaos in coupled map lattice systems Physical review letters, 1994; 72(1): 68-71.
Zhilin Qu, Gang Hu, Benkun Ma   Relaxation from an intrinsically unstable state to the metastable state in a colored-noise-driven system Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics, 1993; 47(4): 2361-2365.

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