Publications:
A selected list of publications:
Li Zhihua, Mirams Gary R, Yoshinaga Takashi, Ridder Bradley J, Han Xiaomei, Chen Janell E, Stockbridge Norman L, Wisialowski Todd A, Damiano Bruce, Severi Stefano, Morissette Pierre, Kowey Peter R, Holbrook Mark, Smith Godfrey, Rasmusson Randall L, Liu Michael, Song Zhen, Qu Zhilin, Leishman Derek J, Steidl-Nichols Jill, Rodriguez Blanca, Bueno-Orovio Alfonso, Zhou Xin, Passini Elisa, Edwards Andrew G, Morotti Stefano, Ni Haibo, Grandi Eleonora, Clancy Colleen E, Vandenberg Jamie, Hill Adam, Nakamura Mikiko, Singer Thomas, Polonchuk Liudmila, Greiter-Wilke Andrea, Wang Ken, Nave Stephane, Fullerton Aaron, Sobie Eric A, Paci Michelangelo, Musuamba Tshinanu Flora, Strauss David G
General Principles for the Validation of Proarrhythmia Risk Prediction
Models: An Extension of the CiPA In Silico Strategy
Clinical pharmacology and therapeutics,
2020; 107(1):
102-111.
Hwang Jungmin, Kim Tae Yun, Terentyev Dmitry, Zhong Mingwang, Kabakov Anatoli Y, Bronk Peter, Arunachalam Karuppiah, Belardinelli Luiz, Rajamani Sridharan, Kunitomo Yukiko, Pfeiffer Zachary, Lu Yichun, Peng Xuwen, Odening Katja E, Qu Zhilin, Karma Alain, Koren Gideon, Choi Bum-Rak
Late INa Blocker GS967 Supresses Polymorphic Ventricular Tachycardia in a Transgenic Rabbit Model of Long QT Type 2
Circulation. Arrhythmia and electrophysiology,
2020; 13(8):
e006875.
Fei Yu-Dong, Chen Mu, Guo Shuai, Ueoka Akira, Chen Zhenhui, Rubart-von der Lohe Michael, Everett Thomas H, Qu Zhilin, Weiss James N, Chen Peng-Sheng
Simultaneous activation of the small conductance calcium-activated
potassium current by acetylcholine and inhibition of sodium current by
ajmaline cause J-wave syndrome in Langendorff-perfused rabbit
ventricles
Heart rhythm,
2020;
.
Kim Tae Yun, Jeng Paul, Hwang JungMin, Pfeiffer Zachary, Patel Divyang, Cooper Leroy L, Kossidas Konstantinos, Centracchio Jason, Peng Xuwen, Koren Gideon, Qu Zhilin, Choi Bum-Rak
Short-Long Heart Rate Variation Increases Dispersion of Action
Potential Duration in Long QT Type 2 Transgenic Rabbit Model
Scientific reports,
2019; 9(1):
14849.
Wan Juyi, Chen Mu, Wang Zhuo, Everett Thomas H, Rubart-von der Lohe Michael, Shen Changyu, Qu Zhilin, Weiss James N, Boyden Penelope A, Chen Peng-Sheng
Small-conductance calcium-activated potassium current modulates the
ventricular escape rhythm in normal rabbit hearts
Heart rhythm,
2019; 16(4):
615-623.
Campbell Kenneth S, Beard Daniel A, Qu Zhilin
The Heart by Numbers
Biophysical journal,
2019; 117(12):
E1-E3.
Chen Mu, Xu Dong-Zhu, Wu Adonis Z, Guo Shuai, Wan Juyi, Yin Dechun, Lin Shien-Fong, Chen Zhenhui, Rubart-von der Lohe Michael, Everett Thomas H, Qu Zhilin, Weiss James N, Chen Peng-Sheng
Concomitant SK current activation and sodium current inhibition cause
J wave syndrome
JCI insight,
2018; 3(22):
e1006382.
Xie An, Song Zhen, Liu Hong, Zhou Anyu, Shi Guangbin, Wang Qiongying, Gu Lianzhi, Liu Man, Xie Lai-Hua, Qu Zhilin, Dudley Samuel C
Mitochondrial Ca
Journal of the American Heart Association,
2018; 7(8):
1341-1355.
Choi Bum-Rak, Li Weiyan, Terentyev Dmitry, Kabakov Anatoli Y, Zhong Mingwang, Rees Colin M, Terentyeva Radmila, Kim Tae Yun, Qu Zhilin, Peng Xuwen, Karma Alain, Koren Gideon
Transient Outward K
Circulation. Arrhythmia and electrophysiology,
2018; 11(6):
e005414.
Chiamvimonvat Nipavan, Chen-Izu Ye, Clancy Colleen E, Deschenes Isabelle, Dobrev Dobromir, Heijman Jordi, Izu Leighton, Qu Zhilin, Ripplinger Crystal M, Vandenberg Jamie I, Weiss James N, Koren Gideon, Banyasz Tamas, Grandi Eleonora, Sanguinetti Michael C, Bers Donald M, Nerbonne Jeanne M
Potassium currents in the heart: Functional roles in repolarization,
arrhythmia and therapeutics
The Journal of physiology,
2016; 311(6):
H1470-H1484.
Chan Yi-Hsin, Tsai Wei-Chung, Song Zhen, Ko Christopher Y, Qu Zhilin, Weiss James N, Lin Shien-Fong, Chen Peng-Sheng, Jones Larry R, Chen Zhenhui
Acute reversal of phospholamban inhibition facilitates the rhythmic
whole-cell propagating calcium waves in isolated ventricular myocytes
Journal of molecular and cellular cardiology,
2015; 80(6):
126-35.
Kim Tae Yun, Kunitomo Yukiko, Pfeiffer Zachary, Patel Divyang, Hwang Jungmin, Harrison Kathryn, Patel Brijesh, Jeng Paul, Ziv Ohad, Lu Yichun, Peng Xuwen, Qu Zhilin, Koren Gideon, Choi Bum-Rak
Complex excitation dynamics underlie polymorphic ventricular
tachycardia in a transgenic rabbit model of long QT syndrome type 1
Heart rhythm : the official journal of the Heart Rhythm Society,
2015; 12(1):
220-8.
Lau Emily, Kossidas Konstantinos, Kim Tae Yun, Kunitomo Yukiko, Ziv Ohad, Song Zhen, Taylor Chantel, Schofield Lorraine, Yammine Joe, Liu Gongxin, Peng Xuwen, Qu Zhilin, Koren Gideon, Choi Bum-Rak
Correction: Spatially Discordant Alternans and Arrhythmias in
Tachypacing-Induced Cardiac Myopathy in Transgenic LQT1 Rabbits: The
Importance of IKs and Ca2+ Cycling
PloS one,
2015; 10(7):
e0132198.
Clancy Colleen E, Chen-Izu Ye, Bers Donald M, Belardinelli Luiz, Boyden Penelope A, Csernoch Laszlo, Despa Sanda, Fermini Bernard, Hool Livia C, Izu Leighton, Kass Robert S, Lederer W Jonathan, Louch William E, Maack Christoph, Matiazzi Alicia, Qu Zhilin, Rajamani Sridharan, Rippinger Crystal M, Sejersted Ole M, O'Rourke Brian, Weiss James N, Varró András, Zaza Antonio
Deranged sodium to sudden death
The Journal of physiology,
2015; 593(6):
1331-45.
Pezhouman Arash, Singh Neha, Song Zhen, Nivala Michael, Eskandari Anahita, Cao Hong, Bapat Aneesh, Ko Christopher Y, Nguyen Thao P, Qu Zhilin, Karagueuzian Hrayr S, Weiss James N
Molecular Basis of Hypokalemia-Induced Ventricular Fibrillation
Circulation,
2015; 132(16):
1528-37.
Lau Emily, Kossidas Konstantinos, Kim Tae Yun, Kunitomo Yukiko, Ziv Ohad, Zhen Song, Taylor Chantel, Schofield Lorraine, Yammine Joe, Liu Gongxin, Peng Xuwen, Qu Zhilin, Koren Gideon, Choi Bum-Rak
Spatially Discordant Alternans and Arrhythmias in Tachypacing-Induced
Cardiac Myopathy in Transgenic LQT1 Rabbits: The Importance of IKs and
Ca2+ Cycling
PloS one,
2015; 10(5):
e0122754.
Madhvani Roshni V, Angelini Marina, Xie Yuanfang, Pantazis Antonios, Suriany Silvie, Borgstrom Nils P, Garfinkel Alan, Qu Zhilin, Weiss James N, Olcese Riccardo
Targeting the late component of the cardiac L-type Ca2+ current to
suppress early afterdepolarizations
The Journal of general physiology,
2015; 145(5):
395-404.
Krishnamoorthi Shankarjee, Perotti Luigi E, Borgstrom Nils P, Ajijola Olujimi A, Frid Anna, Ponnaluri Aditya V, Weiss James N, Qu Zhilin, Klug William S, Ennis Daniel B, Garfinkel Alan
Simulation Methods and Validation Criteria for Modeling Cardiac
Ventricular Electrophysiology
PloS one,
2014; 9(12):
e114494.
Weiss James N, Karma Alain, Maclellan W Robb, Deng Mario, Rau Christoph D, Rees Colin M, Wang Jessica, Wisniewski Nicholas, Eskin Eleazar, Horvath Steve, Qu Zhilin, Wang Yibin, Lusis Aldons J
"Good enough solutions" and the genetics of complex diseases
Circulation research,
2012; 111(4):
493-504.
Chang Marvin G, Chang Connie Y, de Lange Enno, Xu Linmiao, O'Rourke Brian, Karagueuzian Hrayr S, Tung Leslie, Marbán Eduardo, Garfinkel Alan, Weiss James N, Qu Zhilin, Abraham M Roselle
Dynamics of early afterdepolarization-mediated triggered activity in
cardiac monolayers
Biophysical journal,
2012; 102(12):
2706-14.
Xi Yutao, Ai Tomohiko, De Lange Enno, Li Zhaohui, Wu Geru, Brunelli Luca, Kyle W Buck, Turker Isik, Cheng Jie, Ackerman Michael J, Kimura Akinori, Weiss James N, Qu Zhilin, Kim Jeffrey J, Faulkner Georgine, Vatta Matteo
Loss-of-Function of hNav1.5 by ZASP1-D117N Associated with
Intraventricular Conduction Disturbances in Left Ventricular
Noncompaction
Circulation. Arrhythmia and electrophysiology,
2012;
.
Zhao Zhenghang, Xie Yuanfang, Wen Hairuo, Xiao Dandan, Allen Charelle, Fefelova Nadezhda, Dun Wen, Boyden Penelope A, Qu Zhilin, Xie Lai-Hua
Role of the transient outward potassium current in the genesis of
early afterdepolarizations in cardiac cells
Cardiovascular research,
2012; 95(3):
308-16.
de Diego Carlos, Chen Fuhua, Xie Yuanfang, Pai Rakesh K, Slavin Leonid, Parker John, Lamp Scott T, Qu Zhilin, Weiss James N, Valderrábano Miguel
Anisotropic conduction block and reentry in neonatal rat ventricular
myocyte monolayers
American journal of physiology. Heart and circulatory physiology,
2011; 300(1):
H271-8.
Maruyama Mitsunori, Lin Shien-Fong, Xie Yuanfang, Chua Su-Kiat, Joung Boyoung, Han Seongwook, Shinohara Tetsuji, Shen Mark J, Qu Zhilin, Weiss James N, Chen Peng-Sheng
Genesis of phase 3 early afterdepolarizations and triggered activity
in acquired long-QT syndrome
Circulation. Arrhythmia and electrophysiology,
2011; 4(1):
103-11.
Morita Norishige, Sovari Ali A, Xie Yuanfang, Fishbein Michael C, Mandel William J, Garfinkel Alan, Lin Shien-Fong, Chen Peng-Sheng, Xie Lai-Hua, Chen Fuhua, Qu Zhilin, Weiss James N, Karagueuzian Hrayr S
Increased susceptibility of aged hearts to ventricular fibrillation
during oxidative stress
American journal of physiology. Heart and circulatory physiology,
2009; 297(5):
H1594-605.
Sato Daisuke, Xie Lai-Hua, Sovari Ali A, Tran Diana X, Morita Norishige, Xie Fagen, Karagueuzian Hrayr, Garfinkel Alan, Weiss James N, Qu Zhilin
Synchronization of chaotic early afterdepolarizations in the genesis
of cardiac arrhythmias
Proceedings of the National Academy of Sciences of the United States of America,
2009; 106(9):
2983-8.
Mahajan Aman, Shiferaw Yohannes, Sato Daisuke, Baher Ali, Olcese Riccardo, Xie Lai-Hua, Yang Ming-Jim, Chen Peng-Sheng, Restrepo Juan G, Karma Alain, Garfinkel Alan, Qu Zhilin, Weiss James N
A rabbit ventricular action potential model replicating cardiac
dynamics at rapid heart rates
Biophysical journal,
2008; 94(2):
392-410.
Mahajan Aman, Sato Daisuke, Shiferaw Yohannes, Baher Ali, Xie Lai-Hua, Peralta Robert, Olcese Riccardo, Garfinkel Alan, Qu Zhilin, Weiss James N
Modifying L-type calcium current kinetics: consequences for cardiac
excitation and arrhythmia dynamics
Biophysical journal,
2008; 94(2):
411-23.
Weiss James N, Qu Zhilin, Chen Peng-Sheng, Lin Shien-Fong, Karagueuzian Hrayr S, Hayashi Hideki, Garfinkel Alan, Karma Alain
The dynamics of cardiac fibrillation
Circulation,
2005; 112(8):
1232-40.
Omichi Chikaya, Lamp Scott T, Lin Shien-Fong, Yang Junzhong, Baher Ali, Zhou Shengmei, Attin Mina, Lee Moon-Hyoung, Karagueuzian Hrayr S, Kogan Boris, Qu Zhilin, Garfinkel Alan, Chen Peng-Sheng, Weiss James N
Intracellular Ca dynamics in ventricular fibrillation
American journal of physiology. Heart and circulatory physiology,
2004; 286(5):
H1836-44.
Valderrábano Miguel, Yang Junzhong, Omichi Chikaya, Kil John, Lamp Scott T, Qu Zhilin, Lin Shien-Fong, Karagueuzian Hrayr S, Garfinkel Alan, Chen Peng-Sheng, Weiss James N
Frequency analysis of ventricular fibrillation in Swine ventricles
Circulation research,
2002; 90(2):
213-22.
Lee M H, Qu Z, Fishbein G A, Lamp S T, Chang E H, Ohara T, Voroshilovsky O, Kil J R, Hamzei A R, Wang N C, Lin S F, Weiss J N, Garfinkel A, Karagueuzian H S, Chen P S
Patterns of wave break during ventricular fibrillation in isolated
swine right ventricle
American journal of physiology. Heart and circulatory physiology,
2001; 281(1):
H253-65.
Voroshilovsky O, Qu Z, Lee M H, Ohara T, Fishbein G A, Huang H L, Swerdlow C D, Lin S F, Garfinkel A, Weiss J N, Karagueuzian H S, Chen P S
Mechanisms of ventricular fibrillation induction by 60-Hz alternating
current in isolated swine right ventricle
Circulation,
2000; 102(13):
1569-74.
Uchida T, Yashima M, Gotoh M, Qu Z, Garfinkel A, Weiss J N, Fishbein M C, Mandel W J, Chen P S, Karagueuzian H S
Mechanism of acceleration of functional reentry in the ventricle:
effects of ATP-sensitive potassium channel opener
Circulation,
1999; 99(5):
704-12.
Kim Y H, Xie F, Yashima M, Wu T J, Valderrábano M, Lee M H, Ohara T, Voroshilovsky O, Doshi R N, Fishbein M C, Qu Z, Garfinkel A, Weiss J N, Karagueuzian H S, Chen P S
Role of papillary muscle in the generation and maintenance of reentry
during ventricular tachycardia and fibrillation in isolated swine
right ventricle
Circulation,
1999; 100(13):
1450-9.