Publications:
A selected list of publications:
He Cuiwen, Migawa Michael T, Chen Kai, Weston Thomas A, Tanowitz Michael, Song Wenxin, Guagliardo Paul, Iyer K Swaminathan, Bennett C Frank, Fong Loren G, Seth Punit P, Young Stephen G, Jiang Haibo
High-resolution visualization and quantification of nucleic acid-based
therapeutics in cells and tissues using Nanoscale secondary ion mass
spectrometry (NanoSIMS)
Nucleic acids research,
2021; 49(1):
1-14.
Kim Paul H, Chen Natalie Y, Heizer Patrick J, Tu Yiping, Weston Thomas A, Fong Jared L-C, Gill Navjot Kaur, Rowat Amy C, Young Stephen G, Fong Loren G
Nuclear membrane ruptures underlie the vascular pathology in a mouse
model of Hutchinson-Gilford progeria syndrome
JCI insight,
2021; 6(16):
.
Lutz Jens, Dunaj-Kazmierowska Malgorzata, Arcan Sven, Kassner Ursula, Miyashita Kazuya, Murakami Masami, Ploug Michael, Fong Loren G, Young Stephen G, Nakajima Katsuyuki, Beigneux Anne P
Chylomicronemia From GPIHBP1 Autoantibodies Successfully Treated With
Rituximab: A Case Report
Annals of internal medicine,
2020; 173(9):
764-765.
Miyashita Kazuya, Lutz Jens, Hudgins Lisa C, Toib Dana, Ashraf Ambika P, Song Wenxin, Murakami Masami, Nakajima Katsuyuki, Ploug Michael, Fong Loren G, Young Stephen G, Beigneux Anne P
Chylomicronemia from GPIHBP1 autoantibodies
Journal of lipid research,
2020; 61(11):
1365-1376.
He Cuiwen, Jiang Haibo, Song Wenxin, Riezman Howard, Tontonoz Peter, Weston Thomas A, Guagliardo Paul, Kim Paul H, Jung Rachel, Heizer Patrick, Fong Loren G, Young Stephen G
Cultured macrophages transfer surplus cholesterol into adjacent cells
in the absence of serum or high-density lipoproteins
Proceedings of the National Academy of Sciences of the United States of America,
2020; 117(19):
10476-10483.
Heizer Patrick J, Yang Ye, Tu Yiping, Kim Paul H, Chen Natalie Y, Hu Yan, Yoshinaga Yuko, de Jong Pieter J, Vergnes Laurent, Morales Jazmin E, Li Robert L, Jackson Nicholas, Reue Karen, Young Stephen G, Fong Loren G
Deficiency in ZMPSTE24 and resulting farnesyl-prelamin A accumulation
only modestly affect mouse adipose tissue stores
Journal of lipid research,
2020; 61(3):
413-421.
He Cuiwen, Song Wenxin, Weston Thomas A, Tran Caitlyn, Kurtz Ira, Zuckerman Jonathan E, Guagliardo Paul, Miner Jeffrey H, Ivanov Sergey V, Bougoure Jeremy, Hudson Billy G, Colon Selene, Voziyan Paul A, Bhave Gautam, Fong Loren G, Young Stephen G, Jiang Haibo
Peroxidasin-mediated bromine enrichment of basement membranes
Proceedings of the National Academy of Sciences of the United States of America,
2020; 117(27):
15827-15836.
Luz John G, Beigneux Anne P, Asamoto DeeAnn K, He Cuiwen, Song Wenxin, Allan Christopher M, Morales Jazmin, Tu Yiping, Kwok Adam, Cottle Thomas, Meiyappan Muthuraman, Fong Loren G, Kim Judy E, Ploug Michael, Young Stephen G, Birrane Gabriel
The structural basis for monoclonal antibody 5D2 binding to the
tryptophan-rich loop of lipoprotein lipase
Journal of lipid research,
2020; 61(10):
1347-1359.
Chen Natalie Y, Yang Ye, Weston Thomas A, Belling Jason N, Heizer Patrick, Tu Yiping, Kim Paul, Edillo Lovelyn, Jonas Steven J, Weiss Paul S, Fong Loren G, Young Stephen G
An absence of lamin B1 in migrating neurons causes nuclear membrane
ruptures and cell death
Proceedings of the National Academy of Sciences of the United States of America,
2019; 116(51):
25870-25879.
Allan Christopher M, Heizer Patrick J, Tu Yiping, Sandoval Norma P, Jung Rachel S, Morales Jazmin E, Sajti Eniko, Troutman Ty D, Saunders Thomas L, Cusanovich Darren A, Beigneux Anne P, Romanoski Casey E, Fong Loren G, Young Stephen G
An upstream enhancer regulates
Journal of lipid research,
2019; 60(4):
869-879.
Young Stephen G, Fong Loren G, Beigneux Anne P, Allan Christopher M, He Cuiwen, Jiang Haibo, Nakajima Katsuyuki, Meiyappan Muthuraman, Birrane Gabriel, Ploug Michael
GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride
Metabolism
Cell metabolism,
2019; 30(1):
51-65.
Hu Xuchen, Matsumoto Ken, Jung Rachel S, Weston Thomas A, Heizer Patrick J, He Cuiwen, Sandoval Norma P, Allan Christopher M, Tu Yiping, Vinters Harry V, Liau Linda M, Ellison Rochelle M, Morales Jazmin E, Baufeld Lynn J, Bayley Nicholas A, He Liqun, Betsholtz Christer, Beigneux Anne P, Nathanson David A, Gerhardt Holger, Young Stephen G, Fong Loren G, Jiang Haibo
GPIHBP1 expression in gliomas promotes utilization of
lipoprotein-derived nutrients
eLife,
2019; 8(1):
103.
Zhang Peixiang, Csaki Lauren S, Ronquillo Emilio, Baufeld Lynn J, Lin Jason Y, Gutierrez Alexis, Dwyer Jennifer R, Brindley David N, Fong Loren G, Tontonoz Peter, Young Stephen G, Reue Karen
Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid
homeostasis to regulate chylomicron synthesis
The Journal of clinical investigation,
2019; 129(1):
281-295.
Beigneux Anne P, Allan Christopher M, Sandoval Norma P, Cho Geoffrey W, Heizer Patrick J, Jung Rachel S, Stanhope Kimber L, Havel Peter J, Birrane Gabriel, Meiyappan Muthuraman, Gill John E, Murakami Masami, Miyashita Kazuya, Nakajima Katsuyuki, Ploug Michael, Fong Loren G, Young Stephen G
Lipoprotein lipase is active as a monomer
Proceedings of the National Academy of Sciences of the United States of America,
2019; 116(13):
6319-6328.
Hu Xuchen, Weston Thomas A, He Cuiwen, Jung Rachel S, Heizer Patrick J, Young Brian D, Tu Yiping, Tontonoz Peter, Wohlschlegel James A, Jiang Haibo, Young Stephen G, Fong Loren G
Release of cholesterol-rich particles from the macrophage plasma
membrane during movement of filopodia and lamellipodia
eLife,
2019; 8(51):
25870-25879.
Birrane Gabriel, Beigneux Anne P, Dwyer Brian, Strack-Logue Bettina, Kristensen Kristian Kølby, Francone Omar L, Fong Loren G, Mertens Haydyn D T, Pan Clark Q, Ploug Michael, Young Stephen G, Meiyappan Muthuraman
Structure of the lipoprotein lipase-GPIHBP1 complex that mediates
plasma triglyceride hydrolysis
Proceedings of the National Academy of Sciences of the United States of America,
2019; 116(5):
1723-1732.
Kristensen KK, Midtgaard SR, Mysling S, Kovrov O, Hansen LB, Skar-Gislinge N, Beigneux AP, Kragelund BB, Olivecrona G, Young SG, Jørgensen TJD, Fong LG, Ploug M.
A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase
Proceedings of the National Academy of Sciences of the United States of America,
2018; 115(26):
E6020-E6029.
Kim PH, Luu J, Heizer P, Tu Y, Weston TA, Chen N, Lim C, Li RL, Lin PY, Dunn JCY, Hodzic D, Young SG, Fong LG.
Disrupting the LINC complex in smooth muscle cells reduces aortic disease in a mouse model of Hutchinson-Gilford progeria syndrome
Science Translational Medicine,
2018; 10(460):
10100-10105.
Rajbhandari P, Thomas BJ, Feng AC, Hong C, Wang J, Vergnes L, Sallam T, Wang B, Sandhu J, Seldin MM, Lusis AJ, Fong LG, Katz M, Lee R, Young SG, Reue K, Smale ST, Tontonoz P.
IL-10 signaling remodels adipose chromatin architecture to limit thermogenesis and energy expenditure
Cell,
2018; 172(1-2):
218-233.e17.
Larsson M, Allan CM, Heizer PJ, Tu Y, Sandoval NP, Jung RS, Walzem RL, Beigneux AP, Young SG, Fong LG
Impaired thermogenesis and sharp increases in plasma triglyceride levels in GPIHBP1-deficient mice during cold exposure
Journal of Lipid Research,
2018; 59(4):
706-713.
He C, Hu X, Weston TA, Jung RS, Sandhu J, Huang S, Heizer P, Kim J, Ellison R, Xu J, Kilburn M, Bensinger SJ, Riezman H, Tontonoz P, Fong LG, Jiang H, Young SG.
Macrophages release plasma membrane-derived particles rich in accessible cholesterol
Proceedings of the National Academy of Sciences of the United States of America,
2018; 115(36):
E8499-E8508.
He C, Weston TA, Jung RS, Heizer P, Larsson M, Hu X, Allan CM, Tontonoz P, Reue K, Beigneux AP, Ploug M, Holme A, Kilburn M, Guagliardo P, Ford DA, Fong LG, Young SG, Jiang H.
NanoSIMS analysis of intravascular lipolysis and lipid movement across capillaries and into cardiomyocytes
Cell Metabolism,
2018; 27(5):
1055-1066.e3.
He Cuiwen, Hu Xuchen, Weston Thomas A, Jung Rachel S, Heizer Patrick, Tu Yiping, Ellison Rochelle, Matsumoto Ken, Gerhardt Holger, Tontonoz Peter, Fong Loren G, Young Stephen G, Jiang Haibo
NanoSIMS imaging reveals unexpected heterogeneity in nutrient uptake
by brown adipocytes
Biochemical and biophysical research communications,
2018; 504(4):
899-902.
Allan Christopher M, Heizer Patrick J, Jung Cris J, Tu Yiping, Tran Deanna, Young Lorraine C, Fong Loren G, de Jong Pieter J, Beigneux Anne P, Young Stephen G
Palmoplantar keratoderma in Slurp1/Slurp2 double-knockout mice
Journal of dermatological science,
2018; 89(1):
85-87.
Levy Y, Ross JA, Niglas M, Snetkov VA, Lynham S, Liao CY, Puckelwartz MJ, Hsu YM, McNally EM, Alsheimer M, Harridge SD, Young SG, Fong LG, Español Y, Lopez-Otin C, Kennedy BK, Lowe DA, Ochala J.
Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness
JCI Insight,
2018; 3(19):
899-902.
Beigneux AP, Miyashita K, Ploug M, Blom DJ, Ai M, Linton MF, Khovidhunkit W, Dufour R, Garg A, McMahon MA, Pullinger CR, Sandoval NP, Hu X, Allan CM, Larsson M, Machida T, Murakami M, Reue K, Tontonoz P, Goldberg IJ, Moulin P, Charrière S, Fong LG, Nakajima K, Young SG.
Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia
The New England Journal of Medicine,
2017; 376(17):
1647-1658.
Hu Xuchen, Dallinga-Thie Geesje M, Hovingh G Kees, Chang Sandy Y, Sandoval Norma P, Dang Tiffany Ly P, Fukamachi Isamu, Miyashita Kazuya, Nakajima Katsuyuki, Murakami Masami, Fong Loren G, Ploug Michael, Young Stephen G, Beigneux Anne P
GPIHBP1 autoantibodies in a patient with unexplained chylomicronemia
Journal of clinical lipidology,
2017; 11(4):
964-971.
He Cuiwen, Hu Xuchen, Jung Rachel S, Weston Thomas A, Sandoval Norma P, Tontonoz Peter, Kilburn Matthew R, Fong Loren G, Young Stephen G, Jiang Haibo
High-resolution imaging and quantification of plasma membrane
cholesterol by NanoSIMS
Proceedings of the National Academy of Sciences of the United States of America,
2017; 114(8):
2000-2005.
He C, Hu X, Jung RS, Larsson M, Tu Y, Duarte-Vogel S, Kim P, Sandoval NP, Price TR, Allan CM, Raney B, Jiang H, Bensadoun A, Walzem RL, Kuo RI, Beigneux AP, Fong LG, Young SG.
Lipoprotein lipase reaches the capillary lumen in chickens despite an apparent absence of GPIHBP1
JCI Insight,
2017; 2(20):
1134-1136.
Hu Xuchen, Sleeman Mark W, Miyashita Kazuya, Linton MacRae F, Allan Christopher M, He Cuiwen, Larsson Mikael, Tu Yiping, Sandoval Norma P, Jung Rachel S, Mapar Alaleh, Machida Tetsuo, Murakami Masami, Nakajima Katsuyuki, Ploug Michael, Fong Loren G, Young Stephen G, Beigneux Anne P
Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish
the binding of LPL
Journal of lipid research,
2017; 58(1):
208-215.
Allan CM, Jung CJ, Larsson M, Heizer PJ, Tu Y, Sandoval NP, Dang TLP, Jung RS, Beigneux AP, de Jong PJ, Fong LG, Young SG.
Mutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in capillaries and abolishes LPL binding
Journal of Lipid Research,
2017; 58(7):
1453-1461.
Allan Christopher M, Larsson Mikael, Hu Xuchen, He Cuiwen, Jung Rachel S, Mapar Alaleh, Voss Constance, Miyashita Kazuya, Machida Tetsuo, Murakami Masami, Nakajima Katsuyuki, Bensadoun André, Ploug Michael, Fong Loren G, Young Stephen G, Beigneux Anne P
An LPL-specific monoclonal antibody, 88B8, that abolishes the binding
of LPL to GPIHBP1
Journal of lipid research,
2016; 57(10):
1889-1898.
Lee JM, Nobumori C, Tu Y, Choi C, Yang SH, Jung HJ, Vickers TA, Rigo F, Bennett CF, Young SG, Fong LG.
Modulation of LMNA splicing as a strategy to treat prelamin A diseases
The Journal of Clinical Investigation,
2016; 126(4):
1592-602.
Allan Christopher M, Procaccia Shiri, Tran Deanna, Tu Yiping, Barnes Richard H, Larsson Mikael, Allan Bernard B, Young Lorraine C, Hong Cynthia, Tontonoz Peter, Fong Loren G, Young Stephen G, Beigneux Anne P
Palmoplantar Keratoderma in Slurp2-Deficient Mice
The Journal of investigative dermatology,
2016; 136(2):
436-443.
Mysling S, Kristensen KL, Larsson M, Beigneux AP, Gårdsvoll H, Fong LG, Bensadouen A, Jørgensen TJD, Young SG, Ploug M.
The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain
eLife,
2016; 5(2):
e12095.
Yang SH, Procaccia S, Jung HJ, Nobumori C, Tatar A, Tu Y, Bayguinov YR, Hwang SJ, Tran D, Ward SM, Fong LG, Young SG.
Mice that express farnesylated versions of prelamin A in neurons develop achalasia
Human Molecular Genetics,
2015; 24(10):
2826-40.
Bensadoun André, Mottler Charlene D, Pelletier Chris, Wu Daniel, Seo Jane J, Leung Calvin S, Adeyo Oludotun, Goulbourne Chris N, Gin Peter, Fong Loren G, Young Stephen G, Beigneux Anne P
A new monoclonal antibody, 4-1a, that binds to the amino terminus of
human lipoprotein lipase
Biochimica et biophysica acta,
2014; 1841(7):
970-6.
Jung HJ, Tatar A, Tu Y, Nobumori C, Yang SH, Goulbourne CN, Herrmann H, Fong LG, Young SG.
An absence of nuclear lamins in keratinocytes leads to ichthyosis, defective epidermal barrier function, and intrusion of nuclear membranes and endoplasmic reticulum into the nuclear chromatin
Molecular and Cellular Biology,
2014; 34(24):
4534-44.
Turlo Kirsten, Leung Calvin S, Seo Jane J, Goulbourne Chris N, Adeyo Oludotun, Gin Peter, Voss Constance, Bensadoun André, Fong Loren G, Young Stephen G, Beigneux Anne P
Equivalent binding of wild-type lipoprotein lipase (LPL) and S447X-LPL
to GPIHBP1, the endothelial cell LPL transporter
Biochimica et biophysica acta,
2014; 1841(7):
963-9.
Csaki LS, Dwyer JR, Li X, Nguyen MHK, Dewald J, Brindley DN, Lusis AJ, Yoshinaga Y, de Jong P, Fong LG, Young SG, Reue K.
Lipin-1 and lipin-3 together determine adiposity in vivo
Molecular Metabolism,
2014; 3(2):
145-54.
Plengpanich Wanee, Young Stephen G, Khovidhunkit Weerapan, Bensadoun André, Karnman Hirankorn, Ploug Michael, Gårdsvoll Henrik, Leung Calvin S, Adeyo Oludotun, Larsson Mikael, Muanpetch Suwanna, Charoen Supannika, Fong Loren G, Niramitmahapanya Sathit, Beigneux Anne P
Multimerization of glycosylphosphatidylinositol-anchored high density
lipoprotein-binding protein 1 (GPIHBP1) and familial chylomicronemia
from a serine-to-cysteine substitution in GPIHBP1 Ly6 domain
The Journal of biological chemistry,
2014; 289(28):
19491-9.
Adeyo Oludotun, Allan Bernard B, Barnes Richard H, Goulbourne Chris N, Tatar Angelica, Tu Yiping, Young Lorraine C, Weinstein Michael M, Tontonoz Peter, Fong Loren G, Beigneux Anne P, Young Stephen G
Palmoplantar keratoderma along with neuromuscular and metabolic
phenotypes in Slurp1-deficient mice
The Journal of investigative dermatology,
2014; 134(6):
1589-1598.
Lee JM, Tu Y, Tatar A, Wu D, Nobumori C, Jung HJ, Yoshinaga Y, Coffinier C, de Jong PJ, Fong LG, Young SG.
Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2
Molecular Biology of the Cell,
2014; 25(10):
1666-75.
Degagné E, Pandurangan A, Bandhuvula P, Kumar A, Eltanawy A, Zhang M, Yoshinaga Y, Nefedov M, de Jong PJ, Fong LG, Young SG, Bittman R, Ahmedi Y, Saba JD.
Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs
The Journal of Clinical Investigation,
2014; 124(12):
5368-84.
Goulbourne CN, Gin P, Tatar A, Nobumori C, Hoenger A, Jiang H, Grovenor CRM, Adeyo O, Esko JD, Goldberg IJ, Reue K, Tontonoz P, Bensadoun A, Beigneux AP, Young SG, Fong LG.
The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries
Cell Metabolism,
2014; 19(5):
849-60.
Hong C, Marshall SM, McDaniel AL, Graham M, Layne JD, Cai L, Scotti E, Boyadjian R, Kim J, Chamberlain BT, Tangirala RK, Jung ME, Fong L, Lee R, Young SG, Temel RE, Tontonoz P.
The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice
Cell Metabolism,
2014; 20(5):
910-918.
Villanueva CJ, Vergnes L, Wang J, Drew BG, Hong C, Tu Y, Hu Y, Peng X, Xu F, Saez E, Wroblewski K, Hevener AL, Reue K, Fong LG, Young SG, Tontonoz P.
Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs
Cell Metabolism,
2013; 17(3):
423-35.
Jung HJ, Nobumori C, Goulbourne CN, Tu Y, Lee JM, Tatar A, Wu D, Yoshinaga Y, de Jong PJ, Coffinier C, Fong LG, Young SG.
Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration
Proceedings of the National Academy of Sciences of the United States of America,
2013; 110(21):
E1923-32.
Scotti Elena, Calamai Martino, Goulbourne Chris N, Zhang Li, Hong Cynthia, Lin Ron R, Choi Jinkuk, Pilch Paul F, Fong Loren G, Zou Peng, Ting Alice Y, Pavone Francesco S, Young Stephen G, Tontonoz Peter
IDOL stimulates clathrin-independent endocytosis and multivesicular
body-mediated lysosomal degradation of the low-density lipoprotein
receptor
Molecular and cellular biology,
2013; 33(8):
1503-14.
Davies BSJ, Goulbourne CN, Barnes RH, Turlo KA, Gin P, Vaughan S, Vaux David J, Bensadoun A, Beigneux AP, Fong LG, Young SG.
Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells
Journal of Lipid Research,
2012; 53(12):
2690-7.
Gin P, Goulbourne CN, Adeyo O, Beigneux AP, Davies BSJ, Tat S, Voss CV, Bensadoun A, Fong LG, Young SG.
Chylomicronemia mutations yield new insights into interactions between lipoprotein lipase and GPIHBP1
Human Molecular Genetics,
2012; 21(13):
2961-72.
Smith Stuart, Witkowski Andrzej, Moghul Ayesha, Yoshinaga Yuko, Nefedov Michael, de Jong Pieter, Feng Dejiang, Fong Loren, Tu Yiping, Hu Yan, Young Stephen G, Pham Thomas, Cheung Carling, Katzman Shana M, Brand Martin D, Quinlan Casey L, Fens Marcel, Kuypers Frans, Misquitta Stephanie, Griffey Stephen M, Tran Son, Gharib Afshin, Knudsen Jens, Hannibal-Bach Hans Kristian, Wang Grace, Larkin Sandra, Thweatt Jennifer, Pasta Saloni
Compromised mitochondrial fatty acid synthesis in transgenic mice
results in defective protein lipoylation and energy disequilibrium
PloS one,
2012; 7(10):
e47196.
Chang SY, Hudon-Miller SE, Yang SH, Jung HJ, Lee JM, Farber E, Subramanian T, Andres DA, Spielmann HP, Hrycyna CA, Young SG, Fong LG.
Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24
Journal of Lipid Research,
2012; 53(6):
1176-82.
Dwyer JR, Donkor J, Zhang P, Csaki LS, Vergnes L, Lee JM, Dewald J, Brindley DN, Atti E, Tetradis S, Yoshinaga Y, De Jong PJ, Fong LG, Young SG, Reue K.
Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum
Proceedings of the National Academy of Sciences of the United States of America,
2012; 109(37):
E2486-95.
Weinstein Michael M, Goulbourne Christopher N, Davies Brandon S J, Tu Yiping, Barnes Richard H, Watkins Steven M, Davis Ryan, Reue Karen, Tontonoz Peter, Beigneux Anne P, Fong Loren G, Young Stephen G
Reciprocal metabolic perturbations in the adipose tissue and liver of
GPIHBP1-deficient mice
Arteriosclerosis, thrombosis, and vascular biology,
2012; 32(2):
230-5.
Jung HJ, Coffinier C, Choe Y, Beigneux AP, Davies BSJ, Yang SH, Barnes RH, Hong J, Sun T, Pleasure SJ, Young SG, Fong LG.
Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA
Proceedings of the National Academy of Sciences of the United States of America,
2012; 109(7):
E423-31.
Borowsky Alexander D, Bandhuvula Padmavathi, Kumar Ashok, Yoshinaga Yuko, Nefedov Mikhail, Fong Loren G, Zhang Meng, Baridon Brian, Dillard Lisa, de Jong Pieter, Young Stephen G, West David B, Saba Julie D
Sphingosine-1-phosphate lyase expression in embryonic and adult murine
tissues
Journal of lipid research,
2012; 53(9):
1920-31.
Beigneux AP, Davies BSJ, Tat S, Chen J, Gin P, Voss CV, Weinstein MM, Bensadoun A, Pullinger CR, Fong LG, Young SG.
Assessing the role of the glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) three-finger domain in binding lipoprotein lipase
The Journal of Biological Chemistry,
2011; 286(22):
19735-43.
Gin P, Beigneux AP, Voss C, Davies BSJ, Beckstead JA, Ryan RO, Bensadoun A, Fong LG, Young SG.
Binding preferences for GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells
Arteriosclerosis, Thrombosis, and Vascular Biology,
2011; 31(1):
176-82.
Coffinier C, Jung HJ, Nobumori C, Chang S, Tu Y, Barnes RH, Yoshinaga Y, de Jong PJ, Vergnes L, Reue K, Fong LG, Young SG.
Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons
Molecular Biology of the Cell,
2011; 22(23):
4683-93.
Young Stephen G, Davies Brandon S J, Voss Constance V, Gin Peter, Weinstein Michael M, Tontonoz Peter, Reue Karen, Bensadoun André, Fong Loren G, Beigneux Anne P
GPIHBP1, an endothelial cell transporter for lipoprotein lipase
Journal of lipid research,
2011; 52(11):
1869-84.
Voss Constance V, Davies Brandon S J, Tat Shelly, Gin Peter, Fong Loren G, Pelletier Christopher, Mottler Charlene D, Bensadoun André, Beigneux Anne P, Young Stephen G
Mutations in lipoprotein lipase that block binding to the endothelial
cell transporter GPIHBP1
Proceedings of the National Academy of Sciences of the United States of America,
2011; 108(19):
7980-4.
Scotti E, Hong C, Yoshinaga Y, Tu Y, Hu Y, Zelcer N, Boyadjian R, de Jong PJ, Young SG, Fong LG, Tontonoz P.
Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists
Molecular and Cellular Biology,
2011; 31(9):
1885-93.
Patwari P, Emilsson V, Schadt EE, Chutkow WA, Lee S, Marsili A, Zhang Y, Dobrin R, Cohen DE, Larsen P R, Zavacki AM, Fong LG, Young SG, Lee RT.
The arrestin domain-containing 3 protein regulates body mass and energy expenditure
Cell Metabolism,
2011; 14(5):
671-83.
Davies BSJ, Barnes RH, Tu Y, Ren S, Andres DA, Spielmann HP, Lammerding J, Wang Y, Young SG, Fong LG.
An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria
Human Molecular Genetics,
2010; 19(13):
2682-94.
Weinstein MM, Tu Y, Beigneux AP, Davies BSJ, Gin P, Voss C, Walzem RL, Reue K, Tontonoz P, Bensadoun A, Fong LG, Young SG.
Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice
Arteriosclerosis, Thrombosis, and Vascular Biology,
2010; 30(11):
2106-13.
Bishop JR, Passos-Bueno MR, Fong L, Stanford KI, Gonzales JC, Yeh E, Young SG, Bensadoun A, Witztum JL, Esko JD, Moulton KS.
Deletion of the basement membrane heparan sulfate proteoglycan type XVIII collagen causes hypertriglyceridemia in mice and humans
PloS One,
2010; 5(11):
e13919.
Coffinier C, Jung HJ, Li Z, Nobumori C, Yun UJ, Farber EA, Davies BS, Weinstein MM, Yang SH, Lammerding J, Farahani JN, Bentolila LA, Fong LG, Young SG.
Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice
The Journal of Biological Chemistry,
2010; 285(27):
20818-26.
Davies BSJ, Beigneux AP, Barnes RH, Tu Y, Gin P, Weinstein MM, Nobumori C, Nyrén R, Goldberg I, Olivecrona G, Bensadoun A, Young SG, Fong LG.
GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries
Cell Metabolism,
2010; 12(1):
42-52.
Lee R, Chang SY, Trinh H, Tu Y, White AC, Davies BSJ, Bergo MO, Fong LG, Lowry WE, Young SG.
Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes
Human Molecular Genetics,
2010; 19(8):
1603-17.
Olivecrona Gunilla, Ehrenborg Ewa, Semb Henrik, Makoveichuk Elena, Lindberg Anna, Hayden Michael R, Gin Peter, Davies Brandon S J, Weinstein Michael M, Fong Loren G, Beigneux Anne P, Young Stephen G, Olivecrona Thomas, Hernell Olle
Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in
familial chylomicronemia
Journal of lipid research,
2010; 51(6):
1535-45.
Olafsen T, Young SG, Davies BSJ, Beigneux AP, Kenanova VE, Voss C, Young G, Wong KP, Barnes RH, Tu Y, Weinstein MM, Nobumori C, Huang SC, Goldberg IJ, Bensadoun A, Wu AM, Fong LG.
Unexpected expression pattern for glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) in mouse tissues revealed by positron emission tomography scanning
The Journal of Biological Chemistry,
2010; 285(50):
39239-48.