Loren Fong, Ph.D.


Work Titles
UCLA Professor In-Residence, Medicine Member, Center for Duchenne Muscular Dystrophy Member, Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research Member, JCCC Signal Transduction and Therapeutics Program Area Faculty, Cardiology
Education:
Degrees:
Ph.D., University of California, Los Angeles
B.Sc., University of California, Davis

Contact Information:

Office Phone Number:

(310) 825-4997

Department Address:

UCLA Med-Cardio
650 Charles E. Young Dr. South
CHS A2-237
Los Angeles, CA 90095


Office Address:

695 Charles E. Young Dr. South
Gonda 4506C
Los Angeles, CA 90095


Detailed Biography:

Loren Fong is a Professor of Medicine in the division of cardiology at UCLA’s David Geffen School of Medicine. Dr. Fong did his undergraduate studies at UCD, and his Ph.D. training in the department of pharmacology at UCLA. Following postdoctoral studies in lipoprotein metabolism at UCSD with Dr. Daniel Steinberg, he joined the faculty at the PAMF research institute in Palo Alto to pursue studies on lipoprotein oxidation, macrophage foam cell formation, and chylomicron remnant metabolism. In 2004, Dr. Fong returned to Los Angeles and joined the faculty at UCLA. His laboratory currently investigates mechanisms of intravascular triglyceride metabolism and the childhood premature aging disease Hutchinson-Gilford progeria syndrome. 

Publications:

A selected list of publications:

Allan CM, Heizer PJ, Tu Y, Sandoval NP, Jung RS, Morales JE, Sajti E, Troutman TD, Saunders TL, Cusanovich DA, Beigneux AP, Romanoski CE, Fong LG, Young SG.   An upstream enhancer regulates GPIHBP1 expression in a tissue-specific manner Journal of Lipid Research, 2019; 60(4): 869-879.
Beigneux AP, Allan CM, Sandoval NP, Cho GW, Heizer PJ, Jung RS, Stanhope KL, Havel PJ, Birrane G, Meiyappan M, Gill JE, Murakami M, Miyashita K, Nakajima K, Ploug M, Fong LG, Young SG.   Lipoprotein lipase is active as a monomer Proceedings of the National Academy of Sciences of the United States of America, 2019; 116(13): 6319-6328.
Zhang P, Csaki LS, Ronquillo E, Baufeld LJ, Lin JY, Gutierrez A, Dwyer JR, Brindley DN, Fong LG, Tontonoz P, Young SG, Reue K.   Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis The Journal of Clinical Investigation, 2019; 129(1): 281-295.
Birrane G, Beigneux AP, Dwyer B, Strack-Logue B, Kristensen KK, Francone OL, Fong LG, Mertens HDT, Pan CQ, Ploug M, Young SG, Meiyappan M.   Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis Proceedings of the National Academy of Sciences of the United States of America, 2019; 116(5): 1723-1732.
Chen NY, Kim P, Weston TA, Edillo LA, Tu Y, Fong LG, Young SG   Fibroblasts lacking nuclear lamins do not have nuclear blebs or protrusions but nevertheless have frequent nuclear membrane ruptures Proceedings of the National Academy of Sciences of the United States of America, 2018; 115(40): 10100-10105.
He C, Hu X, Weston TA, Jung RS, Heizer P, Tu Y, Ellison R, Matsumoto K, Gerhardt H, Tontonoz P, Fong LG, Young SG, Jiang H.   NanoSIMS imaging reveals unexpected heterogeneity in nutrient uptake by brown adipocytes Biochemical and Biophysical Research Communications, 2018; 504(4): 899-902.
Levy Y, Ross JA, Niglas M, Snetkov VA, Lynham S, Liao CY, Puckelwartz MJ, Hsu YM, McNally EM, Alsheimer M, Harridge SD, Young SG, Fong LG, Español Y, Lopez-Otin C, Kennedy BK, Lowe DA, Ochala J.   Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness JCI Insight, 2018; 3(19): 899-902.
Kim PH, Luu J, Heizer P, Tu Y, Weston TA, Chen N, Lim C, Li RL, Lin PY, Dunn JCY, Hodzic D, Young SG, Fong LG.   Disrupting the LINC complex in smooth muscle cells reduces aortic disease in a mouse model of Hutchinson-Gilford progeria syndrome Science Translational Medicine, 2018; 10(460): 10100-10105.
He C, Hu X, Weston TA, Jung RS, Sandhu J, Huang S, Heizer P, Kim J, Ellison R, Xu J, Kilburn M, Bensinger SJ, Riezman H, Tontonoz P, Fong LG, Jiang H, Young SG.   Macrophages release plasma membrane-derived particles rich in accessible cholesterol Proceedings of the National Academy of Sciences of the United States of America, 2018; 115(36): E8499-E8508.
Kristensen KK, Midtgaard SR, Mysling S, Kovrov O, Hansen LB, Skar-Gislinge N, Beigneux AP, Kragelund BB, Olivecrona G, Young SG, Jørgensen TJD, Fong LG, Ploug M.   A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase Proceedings of the National Academy of Sciences of the United States of America, 2018; 115(26): E6020-E6029.
He C, Weston TA, Jung RS, Heizer P, Larsson M, Hu X, Allan CM, Tontonoz P, Reue K, Beigneux AP, Ploug M, Holme A, Kilburn M, Guagliardo P, Ford DA, Fong LG, Young SG, Jiang H.   NanoSIMS analysis of intravascular lipolysis and lipid movement across capillaries and into cardiomyocytes Cell Metabolism, 2018; 27(5): 1055-1066.e3.
Larsson M, Allan CM, Heizer PJ, Tu Y, Sandoval NP, Jung RS, Walzem RL, Beigneux AP, Young SG, Fong LG   Impaired thermogenesis and sharp increases in plasma triglyceride levels in GPIHBP1-deficient mice during cold exposure Journal of Lipid Research, 2018; 59(4): 706-713.
Rajbhandari P, Thomas BJ, Feng AC, Hong C, Wang J, Vergnes L, Sallam T, Wang B, Sandhu J, Seldin MM, Lusis AJ, Fong LG, Katz M, Lee R, Young SG, Reue K, Smale ST, Tontonoz P.   IL-10 signaling remodels adipose chromatin architecture to limit thermogenesis and energy expenditure Cell, 2018; 172(1-2): 218-233.e17.
Allan CM, Heizer PJ, Jung CJ, Tu Y, Tran D, Young LC, Fong LG, de Jong PJ, Beigneux AP, Young SG.   Palmoplantar keratoderma in Slurp1/Slurp2 double-knockout mice Journal of Dermatological Science, 2018; 89(1): 85-87.
Allan CM, Tran D, Tu Y, Heizer PJ, Young LC, Fong LG, Beigneux AP, Young SG.   A hypomorphic EGFR allele does not ameliorate the palmoplantar keratoderma caused by SLURP1 deficiency Experimental Dermatology, 2017; 26(11): 1134-1136.
Hu X, Dallinga-Thie GM, Hovingh GK, Chang SY, Sandoval NP, Dang TLP, Fukamachi I, Miyashita K, Nakajima K, Murakami M, Fong LG, Ploug M, Young SG, Beigneux AP.   GPIHBP1 autoantibodies in a patient with unexplained chylomicronemia Journal of Clinical Lipidology, 2017; 11(4): 964-971.
He C, Hu X, Jung RS, Larsson M, Tu Y, Duarte-Vogel S, Kim P, Sandoval NP, Price TR, Allan CM, Raney B, Jiang H, Bensadoun A, Walzem RL, Kuo RI, Beigneux AP, Fong LG, Young SG.   Lipoprotein lipase reaches the capillary lumen in chickens despite an apparent absence of GPIHBP1 JCI Insight, 2017; 2(20): 1134-1136.
Larsson M, Allan CM, Jung RS, Heizer P, Beigneux AP, Young SG, Fong LG.   Apolipoprotein C-III inhibits triglyceride hydrolysis by GPIHBP1-bound LPL Journal of Lipid Research, 2017; 58(9): 1893-1902.
Allan CM, Jung CJ, Larsson M, Heizer PJ, Tu Y, Sandoval NP, Dang TLP, Jung RS, Beigneux AP, de Jong PJ, Fong LG, Young SG.   Mutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in capillaries and abolishes LPL binding Journal of Lipid Research, 2017; 58(7): 1453-1461.
Beigneux AP, Miyashita K, Ploug M, Blom DJ, Ai M, Linton MF, Khovidhunkit W, Dufour R, Garg A, McMahon MA, Pullinger CR, Sandoval NP, Hu X, Allan CM, Larsson M, Machida T, Murakami M, Reue K, Tontonoz P, Goldberg IJ, Moulin P, Charrière S, Fong LG, Nakajima K, Young SG.   Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia The New England Journal of Medicine, 2017; 376(17): 1647-1658.
He C, Fong LG, Young SG, Jiang H.   NanoSIMS imaging: an approach for visualizing and quantifying lipids in cells and tissues Journal of Investigative Medicine: The Official Publication of the American Federation for Clinical Research, 2017; 65(3): 669-672.
He C, Hu X, Jung RS, Weston TA, Sandoval NP, Tontonoz P, Kilburn MR, Fong LG, Young SG, Jiang H.   High-resolution imaging and quantification of plasma membrane cholesterol by NanoSIMS Proceedings of the National Academy of Sciences of the United States of America, 2017; 114(8): 2000-2005.
Allan CM, Larsson M, Jung RS, Ploug M, Bensadoun A, Beigneux AP, Fong LG, Young SG.   Mobility of "HSPG-bound" LPL explains how LPL is able to reach GPIHBP1 on capillaries Journal of Lipid Research, 2017; 58(1): 216-225.
Hu X, Sleeman MW, Miyashita K, Linton MF, Allan CM, He C, Larsson M, Tu Y, Sandoval NP, Jung RS, Mapar A, Machida T, Murakami M, Nakajima K, Ploug M, Fong LG, Young SG, Beigneux AP.   Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish the binding of LPL Journal of Lipid Research, 2017; 58(1): 208-215.
Allan CM, Larsson M, Hu X, He C, Jung RS, Mapar A, Voss C, Miyashita K, Machida T, Murakami M, Nakajima K, Bensadoun A, Ploug M, Fong LG, Young SG, Beigneux AP.   An LPL-specific monoclonal antibody, 88B8, that abolishes the binding of LPL to GPIHBP1 Journal of Lipid Research, 2016; 57(10): 1889-1898.
Tu Y, Sánchez-Iglesias S, Araújo-Vilar D, Fong LG, Young SG.   LMNA missense mutations causing familial partial lipodystrophy do not lead to an accumulation of prelamin A Nucleus (Austin, Tex.), 2016; 7(5): 512-521.
Fong LG, Young SG, Beigneux AP, Bensadoun A, Oberer M, Jiang H, Ploug M.   GPIHBP1 and plasma triglyceride metabolism Trends in Endocrinology and Metabolism: TEM, 2016; 27(7): 455-69.
Razafsky D, Ward C, Potter C, Zhu W, Xue Y, Kefalov VJ, Fong LG, Young SG, Hodzic D.   Lamin B1 and lamin B2 are long-lived proteins with distinct functions in retinal development Molecular Biology of the Cell, 2016; 27(12): 1928-37.
Lee JM, Nobumori C, Tu Y, Choi C, Yang SH, Jung HJ, Vickers TA, Rigo F, Bennett CF, Young SG, Fong LG.   Modulation of LMNA splicing as a strategy to treat prelamin A diseases The Journal of Clinical Investigation, 2016; 126(4): 1592-602.
Vergnes L, Chin RG, de Aguiar Vallim T, Fong LG, Osborne TF, Young SG, Reue K.   SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression Journal of Lipid Research, 2016; 57(3): 410-21.
Allan CM, Procaccia S, Tran D, Tu Y, Barnes RH, Larsson M, Allan BB, Young LC, Hong C, Tontonoz P, Fong LG, Young SG, Beigneux AP.   Palmoplantar keratoderma in SLURP2-deficient mice The Journal of Investigative Dermatology, 2016; 136(2): 436-443.
Mysling S, Kristensen KL, Larsson M, Beigneux AP, Gårdsvoll H, Fong LG, Bensadouen A, Jørgensen TJD, Young SG, Ploug M.   The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain eLife, 2016; 5(2): e12095.
Yang SH, Procaccia S, Jung HJ, Nobumori C, Tatar A, Tu Y, Bayguinov YR, Hwang SJ, Tran D, Ward SM, Fong LG, Young SG.   Mice that express farnesylated versions of prelamin A in neurons develop achalasia Human Molecular Genetics, 2015; 24(10): 2826-40.
Tapia O, Fong LG, Huber MD, Young SG, Gerace L.   Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases PloS One, 2015; 10(3): e0116196.
Beigneux AP, Fong LG, Bensadoun A, Davies BSJ, Oberer M, Gårdsvoll H, Ploug M, Young SG.   GPIHBP1 missense mutations often cause multimerization of GPIHBP1 and thereby prevent lipoprotein lipase binding Circulation Research, 2015; 116(4): 624-32.
Jung HJ, Tatar A, Tu Y, Nobumori C, Yang SH, Goulbourne CN, Herrmann H, Fong LG, Young SG.   An absence of nuclear lamins in keratinocytes leads to ichthyosis, defective epidermal barrier function, and intrusion of nuclear membranes and endoplasmic reticulum into the nuclear chromatin Molecular and Cellular Biology, 2014; 34(24): 4534-44.
Degagné E, Pandurangan A, Bandhuvula P, Kumar A, Eltanawy A, Zhang M, Yoshinaga Y, Nefedov M, de Jong PJ, Fong LG, Young SG, Bittman R, Ahmedi Y, Saba JD.   Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs The Journal of Clinical Investigation, 2014; 124(12): 5368-84.
Hong C, Marshall SM, McDaniel AL, Graham M, Layne JD, Cai L, Scotti E, Boyadjian R, Kim J, Chamberlain BT, Tangirala RK, Jung ME, Fong L, Lee R, Young SG, Temel RE, Tontonoz P.   The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice Cell Metabolism, 2014; 20(5): 910-918.
Jiang H, Goulbourne CN, Tatar A, Turlo K, Wu D, Beigneux AP, Grovenor CRM, Fong LG, Young SG   High-resolution imaging of dietary lipids in cells and tissues by NanoSIMS analysis Journal of Lipid Research, 2014; 55(10): 2156-66.
Young SG, Jung HJ, Lee JM, Fong LG.   Nuclear lamins and neurobiology Molecular and Cellular Biology, 2014; 34(15): 2776-85.
Bensadoun A, Mottler CD, Pelletier C, Wu D, Seo JJ, Leung CS, Adeyo O, Goulbourne CN, Gin P, Fong LG, Young SG, Beigneux AP.   A new monoclonal antibody, 4-1a, that binds to the amino terminus of human lipoprotein lipase Biochimica et Biophysica Acta, 2014; 1841(7): 970-6.
Lee JM, Jung HJ, Fong LG, Young SG.   Do lamin B1 and lamin B2 have redundant functions? Nucleus (Austin, Tex.), 2014; 5(4): 287-92.
Turlo K, Leung CS, Seo JJ, Goulbourne CN, Adeyo O, Gin P, Voss C, Bensadoun A, Fong LG, Young SG, Beigneux AP.   Equivalent binding of wild-type lipoprotein lipase (LPL) and S447X-LPL to GPIHBP1, the endothelial cell LPL transporter Biochimica et Biophysica Acta, 2014; 1841(7): 963-9.
Plengpanich W, Young SG, Khovidhunkit W, Bensadoun A, Karnman H, Ploug M, Gårdsvoll H, Leung CS, Adeyo O, Larsson M, Muanpetch S, Charoen S, Fong LG, Niramitmahapanya S, Beigneux AP.   Multimerization of glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) and familial chylomicronemia from a serine-to-cysteine substitution in GPIHBP1 Ly6 domain The Journal of Biological Chemistry, 2014; 289(28): 19491-9.
Jiang H, Favaro E, Goulbourne CN, Rakowska PD, Hughes GM, Ryadnov MG, Fong LG, Young SG, Ferguson DJP, Harris AL, Grovenor CRM.   Stable isotope imaging of biological samples with high resolution secondary ion mass spectrometry and complementary techniques Methods (San Diego, Calif.), 2014; 68(2): 317-24.
Adeyo O, Allan BB, Barnes RH, Goulbourne CN, Tatar A, Tu Y, Young LC, Weinstein MM, Tontonoz P, Fong LG, Beigneux AP, Young SG.   Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice The Journal of Investigative Dermatology, 2014; 134(6): 1589-1598.
Lee JM, Tu Y, Tatar A, Wu D, Nobumori C, Jung HJ, Yoshinaga Y, Coffinier C, de Jong PJ, Fong LG, Young SG.   Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2 Molecular Biology of the Cell, 2014; 25(10): 1666-75.
Goulbourne CN, Gin P, Tatar A, Nobumori C, Hoenger A, Jiang H, Grovenor CRM, Adeyo O, Esko JD, Goldberg IJ, Reue K, Tontonoz P, Bensadoun A, Beigneux AP, Young SG, Fong LG.   The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries Cell Metabolism, 2014; 19(5): 849-60.
Csaki LS, Dwyer JR, Li X, Nguyen MHK, Dewald J, Brindley DN, Lusis AJ, Yoshinaga Y, de Jong P, Fong LG, Young SG, Reue K.   Lipin-1 and lipin-3 together determine adiposity in vivo Molecular Metabolism, 2014; 3(2): 145-54.
Jung HJ, Tu Y, Yang SH, Tatar A, Nobumori C, Wu D, Young SG, Fong LG.   New Lmna knock-in mice provide a molecular mechanism for the 'segmental aging' in Hutchinson-Gilford progeria syndrome Human Molecular Genetics, 2014; 23(6): 1506-15.
Csaki LS, Dwyer JR, Fong LG, Tontonoz P, Young SG, Reue K.   Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling Progress in Lipid Research, 2013; 52(3): 305-16.
Ibrahim MX, Sayin VI, Akula MK, Liu M, Fong LG, Young SG, Bergo MO.   Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria Science (New York, N.Y.), 2013; 340(6138): 1330-3.
Jung HJ, Nobumori C, Goulbourne CN, Tu Y, Lee JM, Tatar A, Wu D, Yoshinaga Y, de Jong PJ, Coffinier C, Fong LG, Young SG.   Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration Proceedings of the National Academy of Sciences of the United States of America, 2013; 110(21): E1923-32.
Scotti E, Calamai M, Goulbourne CN, Zhang L, Hong C, Lin RR, Choi J, Pilch PF, Fong LG, Zou P, Ting AY, Pavone FS, Young SG, Tontonoz P.   IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor Molecular and Cellular Biology, 2013; 33(8): 1503-14.
Villanueva CJ, Vergnes L, Wang J, Drew BG, Hong C, Tu Y, Hu Y, Peng X, Xu F, Saez E, Wroblewski K, Hevener AL, Reue K, Fong LG, Young SG, Tontonoz P.   Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs Cell Metabolism, 2013; 17(3): 423-35.
Jung HJ, Lee JM, Yang SH, Young SG, Fong LG.   Nuclear lamins in the brain - new insights into function and regulation Molecular Neurobiology, 2013; 47(1): 290-301.
Young SG, Yang SH, Davies BSJ, Jung HJ, Fong LG.   Targeting protein prenylation in progeria Science Translational Medicine, 2013; 5(171): 171ps3.
Davies BSJ, Goulbourne CN, Barnes RH, Turlo KA, Gin P, Vaughan S, Vaux David J, Bensadoun A, Beigneux AP, Fong LG, Young SG.   Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells Journal of Lipid Research, 2012; 53(12): 2690-7.
Adeyo O, Goulbourne CN, Bensadoun A, Beigneux AP, Fong LG, Young SG.   Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 and the intravascular processing of triglyceride-rich lipoproteins Journal of Internal Medicine, 2012; 272(6): 528-40.
Zhang L, Reue K, Fong LG, Young SG, Tontonoz P.   Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis Arteriosclerosis, Thrombosis, and Vascular Biology, 2012; 32(11): 2541-6.
Dwyer JR, Donkor J, Zhang P, Csaki LS, Vergnes L, Lee JM, Dewald J, Brindley DN, Atti E, Tetradis S, Yoshinaga Y, De Jong PJ, Fong LG, Young SG, Reue K.   Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(37): E2486-95.
Borowsky AD, Bandhuvula P, Kumar A, Yoshinaga Y, Nefedov M, Fong LG, Zhang M, Baridon B, Dillard L, de Jong P, Young SG, West DB, Saba JD.   Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues Journal of Lipid Research, 2012; 53(9): 1920-31.
Gin P, Goulbourne CN, Adeyo O, Beigneux AP, Davies BSJ, Tat S, Voss CV, Bensadoun A, Fong LG, Young SG.   Chylomicronemia mutations yield new insights into interactions between lipoprotein lipase and GPIHBP1 Human Molecular Genetics, 2012; 21(13): 2961-72.
Chang SY, Hudon-Miller SE, Yang SH, Jung HJ, Lee JM, Farber E, Subramanian T, Andres DA, Spielmann HP, Hrycyna CA, Young SG, Fong LG.   Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24 Journal of Lipid Research, 2012; 53(6): 1176-82.
Young SG, Jung HJ, Coffinier C, Fong LG.   Understanding the roles of nuclear A- and B-type lamins in brain development The Journal of Biological Chemistry, 2012; 287(20): 16103-10.
Young SG, Fong LG.   Lowering plasma cholesterol by raising LDL receptors--revisited The New England Journal of Medicine, 2012; 366(12): 1154-5.
Smith S, Witkowski A, Moghul A, Yoshinaga Y, Nefedov M, de Jong P, Feng D, Fong L, Tu Y, Hu Y, Young SG, Pham T, Cheung C, Katzman SM, Brand MD, Quinlan CL, Fens M, Kuypers F, Misquitta S, Griffey SM, Tran S, Gharib A, Knudsen J, Hannibal-Bach HK, Wang G, Larkin S, Thweatt J, Pasta S.   Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium PloS One, 2012; 7(10): e47196.
Davies BSJ, Beigneux AP, Fong LG, Young SG.   New wrinkles in lipoprotein lipase biology Current Opinion in Lipidology, 2012; 23(1): 35-42.
Weinstein MM, Goulbourne CN, Davies BSJ, Tu Y, Barnes RH, Watkins SM, Davis R, Reue K, Tontonoz P, Beigneux AP, Fong LG, Young SG.   Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice Arteriosclerosis, Thrombosis, and Vascular Biology, 2012; 32(2): 230-5.
Jung HJ, Coffinier C, Choe Y, Beigneux AP, Davies BSJ, Yang SH, Barnes RH, Hong J, Sun T, Pleasure SJ, Young SG, Fong LG.   Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(7): E423-31.
Yang SH, Chang SY, Tu Y, Lawson GW, Bergo MO, Fong LG, Young SG.   Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases Journal of Lipid Research, 2012; 53(1): 77-86.
Coffinier C, Jung HJ, Nobumori C, Chang S, Tu Y, Barnes RH, Yoshinaga Y, de Jong PJ, Vergnes L, Reue K, Fong LG, Young SG.   Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons Molecular Biology of the Cell, 2011; 22(23): 4683-93.
Yang SH, Jung HJ, Coffinier C, Fong LG, Young SG.   Are B-type lamins essential in all mammalian cells? Nucleus (Austin, Tex.), 2011; 2(6): 562-9.
Young SG, Davies BSJ, Voss CV, Gin P, Weinstein MM, Tontonoz P, Reue K, Bensadoun A, Fong Loren G, Beigneux AP.   GPIHBP1, an endothelial cell transporter for lipoprotein lipase Journal of Lipid Research, 2011; 52(11): 1869-84.
Patwari P, Emilsson V, Schadt EE, Chutkow WA, Lee S, Marsili A, Zhang Y, Dobrin R, Cohen DE, Larsen P R, Zavacki AM, Fong LG, Young SG, Lee RT.   The arrestin domain-containing 3 protein regulates body mass and energy expenditure Cell Metabolism, 2011; 14(5): 671-83.
Yang SH, Chang SY, Yin L, Tu Y, Hu Y, Yoshinaga Y, de Jong PJ, Fong LG, Young SG.   An absence of both lamin B1 and lamin B2 in keratinocytes has no effect on cell proliferation or the development of skin and hair Human Molecular Genetics, 2011; 20(18): 3537-44.
Beigneux AP, Davies BSJ, Tat S, Chen J, Gin P, Voss CV, Weinstein MM, Bensadoun A, Pullinger CR, Fong LG, Young SG.   Assessing the role of the glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) three-finger domain in binding lipoprotein lipase The Journal of Biological Chemistry, 2011; 286(22): 19735-43.
Voss CV, Davies BSJ, Tat S, Gin P, Fong LG, Pelletier C, Mottler CD, Bensadoun A, Beigneux AP, Young SG.   Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1 Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(19): 7980-4.
Scotti E, Hong C, Yoshinaga Y, Tu Y, Hu Y, Zelcer N, Boyadjian R, de Jong PJ, Young SG, Fong LG, Tontonoz P.   Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists Molecular and Cellular Biology, 2011; 31(9): 1885-93.
Verstraeten VLRM, Peckham LA, Olive M, Capell BC, Collins FS, Nabel EG, Young SG, Fong LG, Lammerding J.   Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(12): 4997-5002.
Yang SH, Chang SY, Ren S, Wang Y, Andres DA, Spielmann HP, Fong LG, Young SG.   Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin Human Molecular Genetics, 2011; 20(3): 436-44.
Gin P, Beigneux AP, Voss C, Davies BSJ, Beckstead JA, Ryan RO, Bensadoun A, Fong LG, Young SG.   Binding preferences for GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells Arteriosclerosis, Thrombosis, and Vascular Biology, 2011; 31(1): 176-82.
Davies BSJ, Coffinier C, Yang SH, Barnes RH, Jung HJ, Young SG, Fong LG.   Investigating the purpose of prelamin A processing Nucleus (Austin, Tex.), 2011; 2(1): 4-9.
Olafsen T, Young SG, Davies BSJ, Beigneux AP, Kenanova VE, Voss C, Young G, Wong KP, Barnes RH, Tu Y, Weinstein MM, Nobumori C, Huang SC, Goldberg IJ, Bensadoun A, Wu AM, Fong LG.   Unexpected expression pattern for glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) in mouse tissues revealed by positron emission tomography scanning The Journal of Biological Chemistry, 2010; 285(50): 39239-48.
Weinstein MM, Tu Y, Beigneux AP, Davies BSJ, Gin P, Voss C, Walzem RL, Reue K, Tontonoz P, Bensadoun A, Fong LG, Young SG.   Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice Arteriosclerosis, Thrombosis, and Vascular Biology, 2010; 30(11): 2106-13.
Bishop JR, Passos-Bueno MR, Fong L, Stanford KI, Gonzales JC, Yeh E, Young SG, Bensadoun A, Witztum JL, Esko JD, Moulton KS.   Deletion of the basement membrane heparan sulfate proteoglycan type XVIII collagen causes hypertriglyceridemia in mice and humans PloS One, 2010; 5(11): e13919.
Coffinier C, Fong LG, Young SG.   LINCing lamin B2 to neuronal migration: growing evidence for cell-specific roles of B-type lamins Nucleus (Austin, Tex.), 2010; 1(5): 407-11.
Davies BSJ, Barnes RH, Tu Y, Ren S, Andres DA, Spielmann HP, Lammerding J, Wang Y, Young SG, Fong LG.   An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria Human Molecular Genetics, 2010; 19(13): 2682-94.
Coffinier C, Jung HJ, Li Z, Nobumori C, Yun UJ, Farber EA, Davies BS, Weinstein MM, Yang SH, Lammerding J, Farahani JN, Bentolila LA, Fong LG, Young SG.   Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice The Journal of Biological Chemistry, 2010; 285(27): 20818-26.
Davies BSJ, Beigneux AP, Barnes RH, Tu Y, Gin P, Weinstein MM, Nobumori C, Nyrén R, Goldberg I, Olivecrona G, Bensadoun A, Young SG, Fong LG.   GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries Cell Metabolism, 2010; 12(1): 42-52.
Olivecrona G, Ehrenborg E, Semb H, Makoveichuk E, Lindberg A, Hayden MR, Gin P, Davies BSJ, Weinstein MM, Fong LG, Beigneux AP, Young SG, Olivecrona T, Hernell O.   Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia Journal of Lipid Research, 2010; 51(6): 1535-45.
Franssen R, Young SG, Peelman F, Hertecant J, Sierts JA, Schimmel AWM, Bensadoun A, Kastelein JJP, Fong LG, Dallinga-Thie GM, Beigneux AP.   Chylomicronemia with low postheparin lipoprotein lipase levels in the setting of GPIHBP1 defects Circulation. Cardiovascular Genetics, 2010; 3(2): 169-78.
Lee R, Chang SY, Trinh H, Tu Y, White AC, Davies BSJ, Bergo MO, Fong LG, Lowry WE, Young SG.   Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes Human Molecular Genetics, 2010; 19(8): 1603-17.
Coffinier C, Chang SY, Nobumori C, Tu Y, Farber EA, Toth JI, Fong LG, Young SG.   Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(11): 5076-81.
Yang SH, Chang SY, Andres DA, Spielmann HP, Young SG, Fong LG.   Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria Journal of Lipid Research, 2010; 51(2): 400-5.
Weinstein MM, Yin L, Tu Y, Wang X, Wu X, Castellani LW, Walzem RL, Lusis AJ, Fong LG, Beigneux AP, Young SG.   Chylomicronemia elicits atherosclerosis in mice--brief report Arteriosclerosis, Thrombosis, and Vascular Biology, 2010; 30(1): 20-3.
Chan LN, Hart C, Guo L, Nyberg T, Davies BSJ, Fong LG, Young SG, Agnew BJ, Tamanoi F.   A novel approach to tag and identify geranylgeranylated proteins Electrophoresis, 2009; 30(20): 3598-606.
Beigneux AP, Gin P, Davies BSJ, Weinstein MM, Bensadoun A, Fong LG, Young SG.   Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein lipase The Journal of Biological Chemistry, 2009; 284(44): 30240-7.
Im SS, Hammond LE, Yousef L, Nugas-Selby C, Shin DJ, Seo YK, Fong LG, Young SG, Osborne TF.   Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2 Molecular and Cellular Biology, 2009; 29(17): 4864-72.
Fong LG, Vickers TA, Farber EA, Choi C, Yun UJ, Hu Y, Yang SH, Coffinier C, Lee R, Yin L, Davies BSJ, Andres DA, Spielmann HP, Bennett CF, Young SG.   Activating the synthesis of progerin, the mutant prelamin A in Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides Human Molecular Genetics, 2009; 18(13): 2462-71.
Worman HJ, Fong LG, Muchir A, Young SG.   Laminopathies and the long strange trip from basic cell biology to therapy The Journal of Clinical Investigation, 2009; 119(7): 1825-36.
Yang SH, Bergo MO, Farber E, Qiao X, Fong LG, Young SG.   Caution! Analyze transcripts from conditional knockout alleles Transgenic Research, 2009; 18(3): 483-9.
Beigneux AP, Franssen R, Bensadoun A, Gin P, Melford K, Peter J, Walzem RL, Weinstein MM, Davies BSJ, Kuivenhoven JA, Kastelein JJP, Fong LG, Dallinga-Thie GM, Young SG   Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase Arteriosclerosis, Thrombosis, and Vascular Biology, 2009; 29(6): 956-62.
Davies BSJ, Fong LG, Yang SH, Coffinier C, Young SG.   The posttranslational processing of prelamin A and disease Annual Review of Genomics and Human Genetics, 2009; 10(3): 153-74.
Davies BSJ, Yang SH, Farber E, Lee R, Buck SB, Andres DA, Spielmann HP, Agnew BJ, Tamanoi F, Fong LG, Young SG.   Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome Journal of Lipid Research, 2009; 50(1): 126-34.
Weinstein MM, Yin L, Beigneux AP, Davies Brandon S J, Gin Peter, Estrada K, Melford K, Bishop JR, Esko JD, Dallinga-Thie GM, Fong LG, Bensadoun A, Young SG.   Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice The Journal of Biological Chemistry, 2008; 283(50): 34511-8.
Davies BSJ, Waki H, Beigneux AP, Farber E Weinstein MM, Wilpitz DC, Tai LJ, Evans RM, Fong LG, Tontonoz P, Young SG.   The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma Molecular Endocrinology (Baltimore, Md.), 2008; 22(11): 2496-504.
Yang SH, Andres DA, Spielmann HP, Young SG, Fong LG.   Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated The Journal of Clinical Investigation, 2008; 118(10): 3291-300.

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