Loren Fong, Ph.D.

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Work Titles
UCLA Professor In-Residence, Medicine Member, Center for Duchenne Muscular Dystrophy Member, Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research Member, JCCC Signal Transduction and Therapeutics Program Area Faculty, Cardiology
Education:
Degrees:
Ph.D., University of California, Los Angeles
B.Sc., University of California, Davis

Contact Information:

Email Address:

lfong@mednet.ucla.edu


Office Phone Number:

(310) 825-4997

Department Address:

UCLA Med-Cardio
650 Charles E. Young Dr. South
CHS A2-237
Los Angeles, CA 90095


Office Address:

695 Charles E. Young Dr. South
Gonda 4506C
Los Angeles, CA 90095


Detailed Biography:

Loren Fong is a Professor of Medicine in the division of cardiology at UCLA’s David Geffen School of Medicine. Dr. Fong did his undergraduate studies at UCD, and his Ph.D. training in the department of pharmacology at UCLA. Following postdoctoral studies in lipoprotein metabolism at UCSD with Dr. Daniel Steinberg, he joined the faculty at the PAMF research institute in Palo Alto to pursue studies on lipoprotein oxidation, macrophage foam cell formation, and chylomicron remnant metabolism. In 2004, Dr. Fong returned to Los Angeles and joined the faculty at UCLA. His laboratory currently investigates mechanisms of intravascular triglyceride metabolism and the childhood premature aging disease Hutchinson-Gilford progeria syndrome. 

Publications:

A selected list of publications:

He Cuiwen, Migawa Michael T, Chen Kai, Weston Thomas A, Tanowitz Michael, Song Wenxin, Guagliardo Paul, Iyer K Swaminathan, Bennett C Frank, Fong Loren G, Seth Punit P, Young Stephen G, Jiang Haibo   High-resolution visualization and quantification of nucleic acid-based therapeutics in cells and tissues using Nanoscale secondary ion mass spectrometry (NanoSIMS) Nucleic acids research, 2021; 49(1): 1-14.
Chen Natalie Y, Kim Paul H, Tu Yiping, Yang Ye, Heizer Patrick J, Young Stephen G, Fong Loren G   Increased expression of LAP2β eliminates nuclear membrane ruptures in nuclear lamin-deficient neurons and fibroblasts Proceedings of the National Academy of Sciences of the United States of America, 2021; 118(25): .
Kim Paul H, Chen Natalie Y, Heizer Patrick J, Tu Yiping, Weston Thomas A, Fong Jared L-C, Gill Navjot Kaur, Rowat Amy C, Young Stephen G, Fong Loren G   Nuclear membrane ruptures underlie the vascular pathology in a mouse model of Hutchinson-Gilford progeria syndrome JCI insight, 2021; 6(16): .
Lutz Jens, Dunaj-Kazmierowska Malgorzata, Arcan Sven, Kassner Ursula, Miyashita Kazuya, Murakami Masami, Ploug Michael, Fong Loren G, Young Stephen G, Nakajima Katsuyuki, Beigneux Anne P   Chylomicronemia From GPIHBP1 Autoantibodies Successfully Treated With Rituximab: A Case Report Annals of internal medicine, 2020; 173(9): 764-765.
Miyashita Kazuya, Lutz Jens, Hudgins Lisa C, Toib Dana, Ashraf Ambika P, Song Wenxin, Murakami Masami, Nakajima Katsuyuki, Ploug Michael, Fong Loren G, Young Stephen G, Beigneux Anne P   Chylomicronemia from GPIHBP1 autoantibodies Journal of lipid research, 2020; 61(11): 1365-1376.
He Cuiwen, Jiang Haibo, Song Wenxin, Riezman Howard, Tontonoz Peter, Weston Thomas A, Guagliardo Paul, Kim Paul H, Jung Rachel, Heizer Patrick, Fong Loren G, Young Stephen G   Cultured macrophages transfer surplus cholesterol into adjacent cells in the absence of serum or high-density lipoproteins Proceedings of the National Academy of Sciences of the United States of America, 2020; 117(19): 10476-10483.
Heizer Patrick J, Yang Ye, Tu Yiping, Kim Paul H, Chen Natalie Y, Hu Yan, Yoshinaga Yuko, de Jong Pieter J, Vergnes Laurent, Morales Jazmin E, Li Robert L, Jackson Nicholas, Reue Karen, Young Stephen G, Fong Loren G   Deficiency in ZMPSTE24 and resulting farnesyl-prelamin A accumulation only modestly affect mouse adipose tissue stores Journal of lipid research, 2020; 61(3): 413-421.
Meng Xia, Zeng Wenwen, Young Stephen G, Fong Loren G   GPIHBP1, a partner protein for lipoprotein lipase, is expressed only in capillary endothelial cells Journal of lipid research, 2020; 61(5): 591.
Ashraf Ambika P, Miyashita Kazuya, Nakajima Katsuyuki, Murakami Masami, Hegele Robert A, Ploug Michael, Fong Loren G, Young Stephen G, Beigneux Anne P   Intermittent chylomicronemia caused by intermittent GPIHBP1 autoantibodies Journal of clinical lipidology, 2020; 14(2): 197-200.
Chen Natalie Y, Kim Paul H, Fong Loren G, Young Stephen G   Nuclear membrane ruptures, cell death, and tissue damage in the setting of nuclear lamin deficiencies Nucleus (Austin, Tex.), 2020; 11(1): 237-249.
He Cuiwen, Song Wenxin, Weston Thomas A, Tran Caitlyn, Kurtz Ira, Zuckerman Jonathan E, Guagliardo Paul, Miner Jeffrey H, Ivanov Sergey V, Bougoure Jeremy, Hudson Billy G, Colon Selene, Voziyan Paul A, Bhave Gautam, Fong Loren G, Young Stephen G, Jiang Haibo   Peroxidasin-mediated bromine enrichment of basement membranes Proceedings of the National Academy of Sciences of the United States of America, 2020; 117(27): 15827-15836.
Jiang Haibo, He Cuiwen, Fong Loren G, Young Stephen G   The fatty acids from LPL-mediated processing of triglyceride-rich lipoproteins are taken up rapidly by cardiomyocytes Journal of lipid research, 2020; 61(5): 591.
Luz John G, Beigneux Anne P, Asamoto DeeAnn K, He Cuiwen, Song Wenxin, Allan Christopher M, Morales Jazmin, Tu Yiping, Kwok Adam, Cottle Thomas, Meiyappan Muthuraman, Fong Loren G, Kim Judy E, Ploug Michael, Young Stephen G, Birrane Gabriel   The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase Journal of lipid research, 2020; 61(10): 1347-1359.
Chen Natalie Y, Yang Ye, Weston Thomas A, Belling Jason N, Heizer Patrick, Tu Yiping, Kim Paul, Edillo Lovelyn, Jonas Steven J, Weiss Paul S, Fong Loren G, Young Stephen G   An absence of lamin B1 in migrating neurons causes nuclear membrane ruptures and cell death Proceedings of the National Academy of Sciences of the United States of America, 2019; 116(51): 25870-25879.
Allan Christopher M, Heizer Patrick J, Tu Yiping, Sandoval Norma P, Jung Rachel S, Morales Jazmin E, Sajti Eniko, Troutman Ty D, Saunders Thomas L, Cusanovich Darren A, Beigneux Anne P, Romanoski Casey E, Fong Loren G, Young Stephen G   An upstream enhancer regulates Journal of lipid research, 2019; 60(4): 869-879.
Gill Navjot Kaur, Ly Chau, Kim Paul H, Saunders Cosmo A, Fong Loren G, Young Stephen G, Luxton G W Gant, Rowat Amy C   DYT1 Dystonia Patient-Derived Fibroblasts Have Increased Deformability and Susceptibility to Damage by Mechanical Forces Frontiers in cell and developmental biology, 2019; 7(1): 103.
Young Stephen G, Fong Loren G, Beigneux Anne P, Allan Christopher M, He Cuiwen, Jiang Haibo, Nakajima Katsuyuki, Meiyappan Muthuraman, Birrane Gabriel, Ploug Michael   GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism Cell metabolism, 2019; 30(1): 51-65.
Hu Xuchen, Matsumoto Ken, Jung Rachel S, Weston Thomas A, Heizer Patrick J, He Cuiwen, Sandoval Norma P, Allan Christopher M, Tu Yiping, Vinters Harry V, Liau Linda M, Ellison Rochelle M, Morales Jazmin E, Baufeld Lynn J, Bayley Nicholas A, He Liqun, Betsholtz Christer, Beigneux Anne P, Nathanson David A, Gerhardt Holger, Young Stephen G, Fong Loren G, Jiang Haibo   GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients eLife, 2019; 8(1): 103.
Zhang Peixiang, Csaki Lauren S, Ronquillo Emilio, Baufeld Lynn J, Lin Jason Y, Gutierrez Alexis, Dwyer Jennifer R, Brindley David N, Fong Loren G, Tontonoz Peter, Young Stephen G, Reue Karen   Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis The Journal of clinical investigation, 2019; 129(1): 281-295.
Beigneux Anne P, Allan Christopher M, Sandoval Norma P, Cho Geoffrey W, Heizer Patrick J, Jung Rachel S, Stanhope Kimber L, Havel Peter J, Birrane Gabriel, Meiyappan Muthuraman, Gill John E, Murakami Masami, Miyashita Kazuya, Nakajima Katsuyuki, Ploug Michael, Fong Loren G, Young Stephen G   Lipoprotein lipase is active as a monomer Proceedings of the National Academy of Sciences of the United States of America, 2019; 116(13): 6319-6328.
Hu Xuchen, Weston Thomas A, He Cuiwen, Jung Rachel S, Heizer Patrick J, Young Brian D, Tu Yiping, Tontonoz Peter, Wohlschlegel James A, Jiang Haibo, Young Stephen G, Fong Loren G   Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia eLife, 2019; 8(51): 25870-25879.
Birrane Gabriel, Beigneux Anne P, Dwyer Brian, Strack-Logue Bettina, Kristensen Kristian Kølby, Francone Omar L, Fong Loren G, Mertens Haydyn D T, Pan Clark Q, Ploug Michael, Young Stephen G, Meiyappan Muthuraman   Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis Proceedings of the National Academy of Sciences of the United States of America, 2019; 116(5): 1723-1732.
Kristensen KK, Midtgaard SR, Mysling S, Kovrov O, Hansen LB, Skar-Gislinge N, Beigneux AP, Kragelund BB, Olivecrona G, Young SG, Jørgensen TJD, Fong LG, Ploug M.   A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase Proceedings of the National Academy of Sciences of the United States of America, 2018; 115(26): E6020-E6029.
Kim PH, Luu J, Heizer P, Tu Y, Weston TA, Chen N, Lim C, Li RL, Lin PY, Dunn JCY, Hodzic D, Young SG, Fong LG.   Disrupting the LINC complex in smooth muscle cells reduces aortic disease in a mouse model of Hutchinson-Gilford progeria syndrome Science Translational Medicine, 2018; 10(460): 10100-10105.
Chen NY, Kim P, Weston TA, Edillo LA, Tu Y, Fong LG, Young SG   Fibroblasts lacking nuclear lamins do not have nuclear blebs or protrusions but nevertheless have frequent nuclear membrane ruptures Proceedings of the National Academy of Sciences of the United States of America, 2018; 115(40): 10100-10105.
Rajbhandari P, Thomas BJ, Feng AC, Hong C, Wang J, Vergnes L, Sallam T, Wang B, Sandhu J, Seldin MM, Lusis AJ, Fong LG, Katz M, Lee R, Young SG, Reue K, Smale ST, Tontonoz P.   IL-10 signaling remodels adipose chromatin architecture to limit thermogenesis and energy expenditure Cell, 2018; 172(1-2): 218-233.e17.
Larsson M, Allan CM, Heizer PJ, Tu Y, Sandoval NP, Jung RS, Walzem RL, Beigneux AP, Young SG, Fong LG   Impaired thermogenesis and sharp increases in plasma triglyceride levels in GPIHBP1-deficient mice during cold exposure Journal of Lipid Research, 2018; 59(4): 706-713.
He C, Hu X, Weston TA, Jung RS, Sandhu J, Huang S, Heizer P, Kim J, Ellison R, Xu J, Kilburn M, Bensinger SJ, Riezman H, Tontonoz P, Fong LG, Jiang H, Young SG.   Macrophages release plasma membrane-derived particles rich in accessible cholesterol Proceedings of the National Academy of Sciences of the United States of America, 2018; 115(36): E8499-E8508.
He C, Weston TA, Jung RS, Heizer P, Larsson M, Hu X, Allan CM, Tontonoz P, Reue K, Beigneux AP, Ploug M, Holme A, Kilburn M, Guagliardo P, Ford DA, Fong LG, Young SG, Jiang H.   NanoSIMS analysis of intravascular lipolysis and lipid movement across capillaries and into cardiomyocytes Cell Metabolism, 2018; 27(5): 1055-1066.e3.
He Cuiwen, Hu Xuchen, Weston Thomas A, Jung Rachel S, Heizer Patrick, Tu Yiping, Ellison Rochelle, Matsumoto Ken, Gerhardt Holger, Tontonoz Peter, Fong Loren G, Young Stephen G, Jiang Haibo   NanoSIMS imaging reveals unexpected heterogeneity in nutrient uptake by brown adipocytes Biochemical and biophysical research communications, 2018; 504(4): 899-902.
Allan Christopher M, Heizer Patrick J, Jung Cris J, Tu Yiping, Tran Deanna, Young Lorraine C, Fong Loren G, de Jong Pieter J, Beigneux Anne P, Young Stephen G   Palmoplantar keratoderma in Slurp1/Slurp2 double-knockout mice Journal of dermatological science, 2018; 89(1): 85-87.
Levy Y, Ross JA, Niglas M, Snetkov VA, Lynham S, Liao CY, Puckelwartz MJ, Hsu YM, McNally EM, Alsheimer M, Harridge SD, Young SG, Fong LG, Español Y, Lopez-Otin C, Kennedy BK, Lowe DA, Ochala J.   Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness JCI Insight, 2018; 3(19): 899-902.
Allan Christopher M, Tran Deanna, Tu Yiping, Heizer Patrick J, Young Lorraine C, Fong Loren G, Beigneux Anne P, Young Stephen G   A hypomorphic Egfr allele does not ameliorate the palmoplantar keratoderma caused by SLURP1 deficiency Experimental dermatology, 2017; 26(11): 1134-1136.
Larsson M, Allan CM, Jung RS, Heizer P, Beigneux AP, Young SG, Fong LG.   Apolipoprotein C-III inhibits triglyceride hydrolysis by GPIHBP1-bound LPL Journal of Lipid Research, 2017; 58(9): 1893-1902.
Beigneux AP, Miyashita K, Ploug M, Blom DJ, Ai M, Linton MF, Khovidhunkit W, Dufour R, Garg A, McMahon MA, Pullinger CR, Sandoval NP, Hu X, Allan CM, Larsson M, Machida T, Murakami M, Reue K, Tontonoz P, Goldberg IJ, Moulin P, Charrière S, Fong LG, Nakajima K, Young SG.   Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia The New England Journal of Medicine, 2017; 376(17): 1647-1658.
Hu Xuchen, Dallinga-Thie Geesje M, Hovingh G Kees, Chang Sandy Y, Sandoval Norma P, Dang Tiffany Ly P, Fukamachi Isamu, Miyashita Kazuya, Nakajima Katsuyuki, Murakami Masami, Fong Loren G, Ploug Michael, Young Stephen G, Beigneux Anne P   GPIHBP1 autoantibodies in a patient with unexplained chylomicronemia Journal of clinical lipidology, 2017; 11(4): 964-971.
He Cuiwen, Hu Xuchen, Jung Rachel S, Weston Thomas A, Sandoval Norma P, Tontonoz Peter, Kilburn Matthew R, Fong Loren G, Young Stephen G, Jiang Haibo   High-resolution imaging and quantification of plasma membrane cholesterol by NanoSIMS Proceedings of the National Academy of Sciences of the United States of America, 2017; 114(8): 2000-2005.
He C, Hu X, Jung RS, Larsson M, Tu Y, Duarte-Vogel S, Kim P, Sandoval NP, Price TR, Allan CM, Raney B, Jiang H, Bensadoun A, Walzem RL, Kuo RI, Beigneux AP, Fong LG, Young SG.   Lipoprotein lipase reaches the capillary lumen in chickens despite an apparent absence of GPIHBP1 JCI Insight, 2017; 2(20): 1134-1136.
Allan CM, Larsson M, Jung RS, Ploug M, Bensadoun A, Beigneux AP, Fong LG, Young SG.   Mobility of "HSPG-bound" LPL explains how LPL is able to reach GPIHBP1 on capillaries Journal of Lipid Research, 2017; 58(1): 216-225.
Hu Xuchen, Sleeman Mark W, Miyashita Kazuya, Linton MacRae F, Allan Christopher M, He Cuiwen, Larsson Mikael, Tu Yiping, Sandoval Norma P, Jung Rachel S, Mapar Alaleh, Machida Tetsuo, Murakami Masami, Nakajima Katsuyuki, Ploug Michael, Fong Loren G, Young Stephen G, Beigneux Anne P   Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish the binding of LPL Journal of lipid research, 2017; 58(1): 208-215.
Allan CM, Jung CJ, Larsson M, Heizer PJ, Tu Y, Sandoval NP, Dang TLP, Jung RS, Beigneux AP, de Jong PJ, Fong LG, Young SG.   Mutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in capillaries and abolishes LPL binding Journal of Lipid Research, 2017; 58(7): 1453-1461.
He Cuiwen, Fong Loren G, Young Stephen G, Jiang Haibo   NanoSIMS imaging: an approach for visualizing and quantifying lipids in cells and tissues Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2017; 65(3): 669-672.
Allan Christopher M, Larsson Mikael, Hu Xuchen, He Cuiwen, Jung Rachel S, Mapar Alaleh, Voss Constance, Miyashita Kazuya, Machida Tetsuo, Murakami Masami, Nakajima Katsuyuki, Bensadoun André, Ploug Michael, Fong Loren G, Young Stephen G, Beigneux Anne P   An LPL-specific monoclonal antibody, 88B8, that abolishes the binding of LPL to GPIHBP1 Journal of lipid research, 2016; 57(10): 1889-1898.
Fong LG, Young SG, Beigneux AP, Bensadoun A, Oberer M, Jiang H, Ploug M.   GPIHBP1 and plasma triglyceride metabolism Trends in Endocrinology and Metabolism: TEM, 2016; 27(7): 455-69.
Tu Y, Sánchez-Iglesias S, Araújo-Vilar D, Fong LG, Young SG.   LMNA missense mutations causing familial partial lipodystrophy do not lead to an accumulation of prelamin A Nucleus (Austin, Tex.), 2016; 7(5): 512-521.
Razafsky D, Ward C, Potter C, Zhu W, Xue Y, Kefalov VJ, Fong LG, Young SG, Hodzic D.   Lamin B1 and lamin B2 are long-lived proteins with distinct functions in retinal development Molecular Biology of the Cell, 2016; 27(12): 1928-37.
Lee JM, Nobumori C, Tu Y, Choi C, Yang SH, Jung HJ, Vickers TA, Rigo F, Bennett CF, Young SG, Fong LG.   Modulation of LMNA splicing as a strategy to treat prelamin A diseases The Journal of Clinical Investigation, 2016; 126(4): 1592-602.
Allan Christopher M, Procaccia Shiri, Tran Deanna, Tu Yiping, Barnes Richard H, Larsson Mikael, Allan Bernard B, Young Lorraine C, Hong Cynthia, Tontonoz Peter, Fong Loren G, Young Stephen G, Beigneux Anne P   Palmoplantar Keratoderma in Slurp2-Deficient Mice The Journal of investigative dermatology, 2016; 136(2): 436-443.
Vergnes Laurent, Chin Robert G, de Aguiar Vallim Thomas, Fong Loren G, Osborne Timothy F, Young Stephen G, Reue Karen   SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression Journal of lipid research, 2016; 57(3): 410-21.
Mysling S, Kristensen KL, Larsson M, Beigneux AP, Gårdsvoll H, Fong LG, Bensadouen A, Jørgensen TJD, Young SG, Ploug M.   The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain eLife, 2016; 5(2): e12095.
Beigneux Anne P, Fong Loren G, Bensadoun André, Davies Brandon S J, Oberer Monika, Gårdsvoll Henrik, Ploug Michael, Young Stephen G   GPIHBP1 missense mutations often cause multimerization of GPIHBP1 and thereby prevent lipoprotein lipase binding Circulation research, 2015; 116(4): 624-32.
Yang SH, Procaccia S, Jung HJ, Nobumori C, Tatar A, Tu Y, Bayguinov YR, Hwang SJ, Tran D, Ward SM, Fong LG, Young SG.   Mice that express farnesylated versions of prelamin A in neurons develop achalasia Human Molecular Genetics, 2015; 24(10): 2826-40.
Tapia O, Fong LG, Huber MD, Young SG, Gerace L.   Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases PloS One, 2015; 10(3): e0116196.
Bensadoun André, Mottler Charlene D, Pelletier Chris, Wu Daniel, Seo Jane J, Leung Calvin S, Adeyo Oludotun, Goulbourne Chris N, Gin Peter, Fong Loren G, Young Stephen G, Beigneux Anne P   A new monoclonal antibody, 4-1a, that binds to the amino terminus of human lipoprotein lipase Biochimica et biophysica acta, 2014; 1841(7): 970-6.
Jung HJ, Tatar A, Tu Y, Nobumori C, Yang SH, Goulbourne CN, Herrmann H, Fong LG, Young SG.   An absence of nuclear lamins in keratinocytes leads to ichthyosis, defective epidermal barrier function, and intrusion of nuclear membranes and endoplasmic reticulum into the nuclear chromatin Molecular and Cellular Biology, 2014; 34(24): 4534-44.
Lee JM, Jung HJ, Fong LG, Young SG.   Do lamin B1 and lamin B2 have redundant functions? Nucleus (Austin, Tex.), 2014; 5(4): 287-92.
Turlo Kirsten, Leung Calvin S, Seo Jane J, Goulbourne Chris N, Adeyo Oludotun, Gin Peter, Voss Constance, Bensadoun André, Fong Loren G, Young Stephen G, Beigneux Anne P   Equivalent binding of wild-type lipoprotein lipase (LPL) and S447X-LPL to GPIHBP1, the endothelial cell LPL transporter Biochimica et biophysica acta, 2014; 1841(7): 963-9.
Jiang H, Goulbourne CN, Tatar A, Turlo K, Wu D, Beigneux AP, Grovenor CRM, Fong LG, Young SG   High-resolution imaging of dietary lipids in cells and tissues by NanoSIMS analysis Journal of Lipid Research, 2014; 55(10): 2156-66.
Csaki LS, Dwyer JR, Li X, Nguyen MHK, Dewald J, Brindley DN, Lusis AJ, Yoshinaga Y, de Jong P, Fong LG, Young SG, Reue K.   Lipin-1 and lipin-3 together determine adiposity in vivo Molecular Metabolism, 2014; 3(2): 145-54.
Plengpanich Wanee, Young Stephen G, Khovidhunkit Weerapan, Bensadoun André, Karnman Hirankorn, Ploug Michael, Gårdsvoll Henrik, Leung Calvin S, Adeyo Oludotun, Larsson Mikael, Muanpetch Suwanna, Charoen Supannika, Fong Loren G, Niramitmahapanya Sathit, Beigneux Anne P   Multimerization of glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) and familial chylomicronemia from a serine-to-cysteine substitution in GPIHBP1 Ly6 domain The Journal of biological chemistry, 2014; 289(28): 19491-9.
Jung HJ, Tu Y, Yang SH, Tatar A, Nobumori C, Wu D, Young SG, Fong LG.   New Lmna knock-in mice provide a molecular mechanism for the 'segmental aging' in Hutchinson-Gilford progeria syndrome Human Molecular Genetics, 2014; 23(6): 1506-15.
Young SG, Jung HJ, Lee JM, Fong LG.   Nuclear lamins and neurobiology Molecular and Cellular Biology, 2014; 34(15): 2776-85.
Adeyo Oludotun, Allan Bernard B, Barnes Richard H, Goulbourne Chris N, Tatar Angelica, Tu Yiping, Young Lorraine C, Weinstein Michael M, Tontonoz Peter, Fong Loren G, Beigneux Anne P, Young Stephen G   Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice The Journal of investigative dermatology, 2014; 134(6): 1589-1598.
Lee JM, Tu Y, Tatar A, Wu D, Nobumori C, Jung HJ, Yoshinaga Y, Coffinier C, de Jong PJ, Fong LG, Young SG.   Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2 Molecular Biology of the Cell, 2014; 25(10): 1666-75.
Degagné E, Pandurangan A, Bandhuvula P, Kumar A, Eltanawy A, Zhang M, Yoshinaga Y, Nefedov M, de Jong PJ, Fong LG, Young SG, Bittman R, Ahmedi Y, Saba JD.   Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs The Journal of Clinical Investigation, 2014; 124(12): 5368-84.
Goulbourne CN, Gin P, Tatar A, Nobumori C, Hoenger A, Jiang H, Grovenor CRM, Adeyo O, Esko JD, Goldberg IJ, Reue K, Tontonoz P, Bensadoun A, Beigneux AP, Young SG, Fong LG.   The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries Cell Metabolism, 2014; 19(5): 849-60.
Hong C, Marshall SM, McDaniel AL, Graham M, Layne JD, Cai L, Scotti E, Boyadjian R, Kim J, Chamberlain BT, Tangirala RK, Jung ME, Fong L, Lee R, Young SG, Temel RE, Tontonoz P.   The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice Cell Metabolism, 2014; 20(5): 910-918.
Villanueva CJ, Vergnes L, Wang J, Drew BG, Hong C, Tu Y, Hu Y, Peng X, Xu F, Saez E, Wroblewski K, Hevener AL, Reue K, Fong LG, Young SG, Tontonoz P.   Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs Cell Metabolism, 2013; 17(3): 423-35.
Jung HJ, Nobumori C, Goulbourne CN, Tu Y, Lee JM, Tatar A, Wu D, Yoshinaga Y, de Jong PJ, Coffinier C, Fong LG, Young SG.   Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration Proceedings of the National Academy of Sciences of the United States of America, 2013; 110(21): E1923-32.
Scotti Elena, Calamai Martino, Goulbourne Chris N, Zhang Li, Hong Cynthia, Lin Ron R, Choi Jinkuk, Pilch Paul F, Fong Loren G, Zou Peng, Ting Alice Y, Pavone Francesco S, Young Stephen G, Tontonoz Peter   IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor Molecular and cellular biology, 2013; 33(8): 1503-14.
Csaki LS, Dwyer JR, Fong LG, Tontonoz P, Young SG, Reue K.   Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling Progress in Lipid Research, 2013; 52(3): 305-16.
Jung HJ, Lee JM, Yang SH, Young SG, Fong LG.   Nuclear lamins in the brain - new insights into function and regulation Molecular Neurobiology, 2013; 47(1): 290-301.
Ibrahim MX, Sayin VI, Akula MK, Liu M, Fong LG, Young SG, Bergo MO.   Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria Science (New York, N.Y.), 2013; 340(6138): 1330-3.
Young SG, Yang SH, Davies BSJ, Jung HJ, Fong LG.   Targeting protein prenylation in progeria Science Translational Medicine, 2013; 5(171): 171ps3.
Davies BSJ, Goulbourne CN, Barnes RH, Turlo KA, Gin P, Vaughan S, Vaux David J, Bensadoun A, Beigneux AP, Fong LG, Young SG.   Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells Journal of Lipid Research, 2012; 53(12): 2690-7.
Gin P, Goulbourne CN, Adeyo O, Beigneux AP, Davies BSJ, Tat S, Voss CV, Bensadoun A, Fong LG, Young SG.   Chylomicronemia mutations yield new insights into interactions between lipoprotein lipase and GPIHBP1 Human Molecular Genetics, 2012; 21(13): 2961-72.
Smith Stuart, Witkowski Andrzej, Moghul Ayesha, Yoshinaga Yuko, Nefedov Michael, de Jong Pieter, Feng Dejiang, Fong Loren, Tu Yiping, Hu Yan, Young Stephen G, Pham Thomas, Cheung Carling, Katzman Shana M, Brand Martin D, Quinlan Casey L, Fens Marcel, Kuypers Frans, Misquitta Stephanie, Griffey Stephen M, Tran Son, Gharib Afshin, Knudsen Jens, Hannibal-Bach Hans Kristian, Wang Grace, Larkin Sandra, Thweatt Jennifer, Pasta Saloni   Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium PloS one, 2012; 7(10): e47196.
Zhang L, Reue K, Fong LG, Young SG, Tontonoz P.   Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis Arteriosclerosis, Thrombosis, and Vascular Biology, 2012; 32(11): 2541-6.
Chang SY, Hudon-Miller SE, Yang SH, Jung HJ, Lee JM, Farber E, Subramanian T, Andres DA, Spielmann HP, Hrycyna CA, Young SG, Fong LG.   Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24 Journal of Lipid Research, 2012; 53(6): 1176-82.
Young SG, Fong LG.   Lowering plasma cholesterol by raising LDL receptors--revisited The New England Journal of Medicine, 2012; 366(12): 1154-5.
Dwyer JR, Donkor J, Zhang P, Csaki LS, Vergnes L, Lee JM, Dewald J, Brindley DN, Atti E, Tetradis S, Yoshinaga Y, De Jong PJ, Fong LG, Young SG, Reue K.   Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(37): E2486-95.
Davies Brandon S J, Beigneux Anne P, Fong Loren G, Young Stephen G   New wrinkles in lipoprotein lipase biology Current opinion in lipidology, 2012; 23(1): 35-42.
Weinstein Michael M, Goulbourne Christopher N, Davies Brandon S J, Tu Yiping, Barnes Richard H, Watkins Steven M, Davis Ryan, Reue Karen, Tontonoz Peter, Beigneux Anne P, Fong Loren G, Young Stephen G   Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice Arteriosclerosis, thrombosis, and vascular biology, 2012; 32(2): 230-5.
Jung HJ, Coffinier C, Choe Y, Beigneux AP, Davies BSJ, Yang SH, Barnes RH, Hong J, Sun T, Pleasure SJ, Young SG, Fong LG.   Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(7): E423-31.
Yang SH, Chang SY, Tu Y, Lawson GW, Bergo MO, Fong LG, Young SG.   Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases Journal of Lipid Research, 2012; 53(1): 77-86.
Borowsky Alexander D, Bandhuvula Padmavathi, Kumar Ashok, Yoshinaga Yuko, Nefedov Mikhail, Fong Loren G, Zhang Meng, Baridon Brian, Dillard Lisa, de Jong Pieter, Young Stephen G, West David B, Saba Julie D   Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues Journal of lipid research, 2012; 53(9): 1920-31.
Young SG, Jung HJ, Coffinier C, Fong LG.   Understanding the roles of nuclear A- and B-type lamins in brain development The Journal of Biological Chemistry, 2012; 287(20): 16103-10.
Yang SH, Chang SY, Ren S, Wang Y, Andres DA, Spielmann HP, Fong LG, Young SG.   Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin Human Molecular Genetics, 2011; 20(3): 436-44.
Yang SH, Chang SY, Yin L, Tu Y, Hu Y, Yoshinaga Y, de Jong PJ, Fong LG, Young SG.   An absence of both lamin B1 and lamin B2 in keratinocytes has no effect on cell proliferation or the development of skin and hair Human Molecular Genetics, 2011; 20(18): 3537-44.
Yang SH, Jung HJ, Coffinier C, Fong LG, Young SG.   Are B-type lamins essential in all mammalian cells? Nucleus (Austin, Tex.), 2011; 2(6): 562-9.
Beigneux AP, Davies BSJ, Tat S, Chen J, Gin P, Voss CV, Weinstein MM, Bensadoun A, Pullinger CR, Fong LG, Young SG.   Assessing the role of the glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) three-finger domain in binding lipoprotein lipase The Journal of Biological Chemistry, 2011; 286(22): 19735-43.
Gin P, Beigneux AP, Voss C, Davies BSJ, Beckstead JA, Ryan RO, Bensadoun A, Fong LG, Young SG.   Binding preferences for GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells Arteriosclerosis, Thrombosis, and Vascular Biology, 2011; 31(1): 176-82.
Coffinier C, Jung HJ, Nobumori C, Chang S, Tu Y, Barnes RH, Yoshinaga Y, de Jong PJ, Vergnes L, Reue K, Fong LG, Young SG.   Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons Molecular Biology of the Cell, 2011; 22(23): 4683-93.
Young Stephen G, Davies Brandon S J, Voss Constance V, Gin Peter, Weinstein Michael M, Tontonoz Peter, Reue Karen, Bensadoun André, Fong Loren G, Beigneux Anne P   GPIHBP1, an endothelial cell transporter for lipoprotein lipase Journal of lipid research, 2011; 52(11): 1869-84.
Davies BSJ, Coffinier C, Yang SH, Barnes RH, Jung HJ, Young SG, Fong LG.   Investigating the purpose of prelamin A processing Nucleus (Austin, Tex.), 2011; 2(1): 4-9.
Voss Constance V, Davies Brandon S J, Tat Shelly, Gin Peter, Fong Loren G, Pelletier Christopher, Mottler Charlene D, Bensadoun André, Beigneux Anne P, Young Stephen G   Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1 Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(19): 7980-4.
Verstraeten VLRM, Peckham LA, Olive M, Capell BC, Collins FS, Nabel EG, Young SG, Fong LG, Lammerding J.   Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(12): 4997-5002.
Scotti E, Hong C, Yoshinaga Y, Tu Y, Hu Y, Zelcer N, Boyadjian R, de Jong PJ, Young SG, Fong LG, Tontonoz P.   Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists Molecular and Cellular Biology, 2011; 31(9): 1885-93.
Patwari P, Emilsson V, Schadt EE, Chutkow WA, Lee S, Marsili A, Zhang Y, Dobrin R, Cohen DE, Larsen P R, Zavacki AM, Fong LG, Young SG, Lee RT.   The arrestin domain-containing 3 protein regulates body mass and energy expenditure Cell Metabolism, 2011; 14(5): 671-83.
Coffinier C, Chang SY, Nobumori C, Tu Y, Farber EA, Toth JI, Fong LG, Young SG.   Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(11): 5076-81.
Davies BSJ, Barnes RH, Tu Y, Ren S, Andres DA, Spielmann HP, Lammerding J, Wang Y, Young SG, Fong LG.   An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria Human Molecular Genetics, 2010; 19(13): 2682-94.
Yang SH, Chang SY, Andres DA, Spielmann HP, Young SG, Fong LG.   Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria Journal of Lipid Research, 2010; 51(2): 400-5.
Weinstein MM, Tu Y, Beigneux AP, Davies BSJ, Gin P, Voss C, Walzem RL, Reue K, Tontonoz P, Bensadoun A, Fong LG, Young SG.   Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice Arteriosclerosis, Thrombosis, and Vascular Biology, 2010; 30(11): 2106-13.
Bishop JR, Passos-Bueno MR, Fong L, Stanford KI, Gonzales JC, Yeh E, Young SG, Bensadoun A, Witztum JL, Esko JD, Moulton KS.   Deletion of the basement membrane heparan sulfate proteoglycan type XVIII collagen causes hypertriglyceridemia in mice and humans PloS One, 2010; 5(11): e13919.
Coffinier C, Jung HJ, Li Z, Nobumori C, Yun UJ, Farber EA, Davies BS, Weinstein MM, Yang SH, Lammerding J, Farahani JN, Bentolila LA, Fong LG, Young SG.   Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice The Journal of Biological Chemistry, 2010; 285(27): 20818-26.
Davies BSJ, Beigneux AP, Barnes RH, Tu Y, Gin P, Weinstein MM, Nobumori C, Nyrén R, Goldberg I, Olivecrona G, Bensadoun A, Young SG, Fong LG.   GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries Cell Metabolism, 2010; 12(1): 42-52.
Lee R, Chang SY, Trinh H, Tu Y, White AC, Davies BSJ, Bergo MO, Fong LG, Lowry WE, Young SG.   Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes Human Molecular Genetics, 2010; 19(8): 1603-17.
Coffinier C, Fong LG, Young SG.   LINCing lamin B2 to neuronal migration: growing evidence for cell-specific roles of B-type lamins Nucleus (Austin, Tex.), 2010; 1(5): 407-11.
Olivecrona Gunilla, Ehrenborg Ewa, Semb Henrik, Makoveichuk Elena, Lindberg Anna, Hayden Michael R, Gin Peter, Davies Brandon S J, Weinstein Michael M, Fong Loren G, Beigneux Anne P, Young Stephen G, Olivecrona Thomas, Hernell Olle   Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia Journal of lipid research, 2010; 51(6): 1535-45.
Olafsen T, Young SG, Davies BSJ, Beigneux AP, Kenanova VE, Voss C, Young G, Wong KP, Barnes RH, Tu Y, Weinstein MM, Nobumori C, Huang SC, Goldberg IJ, Bensadoun A, Wu AM, Fong LG.   Unexpected expression pattern for glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) in mouse tissues revealed by positron emission tomography scanning The Journal of Biological Chemistry, 2010; 285(50): 39239-48.

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