Steven Nusinowitz

A Short Biography:

Steven Nusinowitz is a visual physiologist in the Department of Ophthalmology at the Stein Eye Institute where he serves as the Director of the Visual Physiology Laboratory for clinical studies and is Director of the Live Imaging and Functional Evaluation (LIFE) Core for animal studies.  He joined Stein Eye as a post-doctoral fellow in 1995 and is now Professor-in Residence at the Stein Eye Institute where he is a member of the Basic Science and the Retinal Degeneration and Ophthalmic Genetics Divisions.   Dr Nusinowitz earned his MA and Ph.D. from York University in Toronto, Canada, where his work was focused on the phenomenology of vision and perception.  Prior to joining UCLA, Dr Nusinowitz was a post-doctoral fellow at Bascom Palmer Eye Institute, University of Florida and at the Retina Foundation of the Southwest, Dallas, Texas, where he studied genotype-phenotype correlations in inherited retinal diseases. Dr Nusinowitz is actively involved in teaching undergraduate and graduate students, as well teaching in the Medical School where he has received several teaching awards.  Currently, Dr Nusinowitz’s primary research interest is the study of the sites and mechanisms of disease action in inherited eye diseases.  He has received grant support from numerous Foundations and the NEI, and has participated in industry-sponsored research where he has been on Scientific Advisory Boards and Data Safety Monitoring Committees. 

 


Work Titles
UCLA Professor, Ophthalmology Member, Stein Eye Institute

Contact Information:

Email Address:

nusinowitz@jsei.ucla.edu


Work Phone Number:

310-794-9463

Mailing Address:

Office
100 Stein Plaza
Los Angeles, CA 90095


Research Interest:

Visual Physiology/Psychophysics

Dr Nusinowitz’s primary research interest is the study of the sites and mechanisms of disease action in inherited eye diseases.  Using electrophysiological and psychophysical techniques, he evaluates patients with diseases of the retina and known genetic abnormalities to better understand how specific gene mutations result in the wide spectrum of disease expression. In the laboratory, Dr Nusinowitz studies mice with retinal disease in order to identify new candidate genes that may be involved in human disease, to better understand the pathophysiology of disease associated with specific genetic variants, and to evaluate the efficacy of a variety of therapeutic interventions. 

Detailed Biography:

Steven Nusinowitz is a visual physiologist in the Department of Ophthalmology at the Stein Eye Institute where he serves as the Director of the Visual Physiology Laboratory for clinical studies and is Director of the Live Imaging and Functional Evaluation (LIFE) Core for animal studies.  He joined Stein Eye as a post-doctoral fellow in 1995 and is now Professor-in Residence at the Stein Eye Institute where he is a member of the Basic Science and the Retinal Degeneration and Ophthalmic Genetics Divisions.   Dr Nusinowitz earned his MA and Ph.D. from York University in Toronto, Canada, where his work was focused on the phenomenology of vision and perception.  Prior to joining UCLA, Dr Nusinowitz was a post-doctoral fellow at Bascom Palmer Eye Institute, University of Florida and at the Retina Foundation of the Southwest, Dallas, Texas, where he studied genotype-phenotype correlations in inherited retinal diseases. Dr Nusinowitz is actively involved in teaching undergraduate and graduate students, as well teaching in the Medical School where he has received several teaching awards.  Currently, Dr Nusinowitz’s primary research interest is the study of the sites and mechanisms of disease action in inherited eye diseases.  He has received grant support from numerous Foundations and the NEI, and has participated in industry-sponsored research where he has been on Scientific Advisory Boards and Data Safety Monitoring Committees. 

 

Publications:

A selected list of publications:

Xu David, Su Daniel, Nusinowitz Steven, Sarraf David   CENTRAL ELLIPSOID LOSS ASSOCIATED WITH CONE DYSTROPHY AND KCNV2 MUTATION Retinal cases & brief reports, 2017; .
Gui Wei, Nusinowitz Steven, Sarraf David   NOVEL CONE DYSTROPHY WITH CENTRAL ELLIPSOID ZONE LOSS ASSOCIATED WITH HUMAN RETINAL FASCIN GENE (FSCN2) MUTATION Retinal cases & brief reports, 2017; .
Parikh Sachin, Le Andrew, Davenport Julian, Gorin Michael B, Nusinowitz Steven, Matynia Anna   An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach Journal of visualized experiments : JoVE, 2016; (118): .
Matynia Anna, Nguyen Eileen, Sun Xiaoping, Blixt Frank W, Parikh Sachin, Kessler Jason, Pérez de Sevilla Müller Luis, Habib Samer, Kim Paul, Wang Zhe Z, Rodriguez Allen, Charles Andrew, Nusinowitz Steven, Edvinsson Lars, Barnes Steven, Brecha Nicholas C, Gorin Michael B   Peripheral Sensory Neurons Expressing Melanopsin Respond to Light Frontiers in neural circuits, 2016; 10(118): 60.
Sarfare Shanta, Dacquay Yann, Askari Syed, Nusinowitz Steven, Hubschman Jean-Pierre   Biocompatibility of a Synthetic Biopolymer for the Treatment of Rhegmatogenous Retinal Detachment Journal of clinical & experimental ophthalmology, 2015; 6(5): 60.
Matynia Anna, Parikh Sachin, Deot Neal, Wong Arie, Kim Paul, Nusinowitz Steven, Gorin Michael B   Light aversion and corneal mechanical sensitivity are altered by intrinscally photosensitive retinal ganglion cells in a mouse model of corneal surface damage Experimental eye research, 2015; 137(5): 57-62.
Gorin Michael B, Weeks Daniel E, Baron Robert V, Conley Yvette P, Ortube Maria C, Nusinowitz Steven   Endophenotypes for Age-Related Macular Degeneration: Extending Our Reach into the Preclinical Stages of Disease Journal of clinical medicine, 2014; 3(4): 1335-56.
Ortube Maria Carolina, Strom Samuel P, Nelson Stanley F, Nusinowitz Steven, Martinez Ariadna, Gorin Michael B   Whole exome sequencing detects homozygosity for ABCA4 p.Arg602Trp missense mutation in a pediatric patient with rapidly progressive retinal dystrophy BMC medical genetics, 2014; 15(4): 11.
Rhee Kun Do, Nusinowitz Steven, Chao Kevin, Yu Fei, Bok Dean, Yang Xian-Jie   CNTF-mediated protection of photoreceptors requires initial activation of the cytokine receptor gp130 in Müller glial cells Proceedings of the National Academy of Sciences of the United States of America, 2013; 110(47): E4520-9.
Pineles Stacy L, Velez Federico G, Isenberg Sherwin J, Fenoglio Zachary, Birch Eileen, Nusinowitz Steven, Demer Joseph L   Functional burden of strabismus: decreased binocular summation and binocular inhibition JAMA ophthalmology, 2013; 131(11): 1413-9.
Tosha Chinatsu, Gorin Michael B, Nusinowitz Steven   Test-retest reliability and inter-ocular symmetry of multi-focal electroretinography in Stargardt disease Current eye research, 2010; 35(1): 63-72.

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