Weizhe Hong, Ph.D.

A Short Biography:

Dr. Weizhe Hong is an Assistant Professor in the Department of Biological Chemistry and the Department of Neurobiology at UCLA David Geffen School of Medicine. Dr. Hong received a B.S. degree in biological sciences at Tsinghua University. When he was in high school and college, he worked on mechanisms of protein folding and microbial stress response. He received his PhD degree in 2012 at Stanford University, under the guidance of Liqun Luo. His PhD research focused on the cellular and molecular mechanisms of wiring specificity during olfactory system development. He was a Helen Hay Whitney Postdoctoral Fellow at the California Institute of Technology, working with his advisor David Anderson on neural mechanisms underlying social and emotional behaviors. Dr. Hong received the Genetics Society of America’s Larry Sandler Memorial Award for the best PhD dissertation on the Drosophila research, and presented the Larry Katz Memorial Lecture in the Cold Spring Harbor Conference for the best PhD dissertation on neural circuit research.


Work Titles
UCLA Assistant Professor, Biological Chemistry Assistant Professor, Neurobiology Member, Bioinformatics GPB Home Area Member, Gene Regulation GPB Home Area Member, Molecular, Cellular & Integrative Physiology GPB Home Area Member, Neuroscience GPB Home Area
Education:
Degrees:
Ph.D., Stanford University
Honors and Awards:
2017 Searle Scholar Award
2017 Sloan Research Fellowship, Alfred P. Sloan Foundation
2016 NARSAD Young Investigator Award, Brain and Behavior Research Foundation
2013 Helen Hay Whitney Fellowship
2018 Packard Fellowship

Contact Information:

Email Address:

whong@ucla.edu


Website:

Lab website

Research Interest:

Neural circuit mechanism of social behavior

Social behaviors are exhibited by a wide range of animal species and are of ubiquitous adaptive value; many social behaviors, such as aggression, pair bonding, and mating, are essential for the health, survival, and reproduction of animals. The control of social behavior is of vital importance in social species such as humans; impairment in social function is a prominent feature of several neuropsychiatric disorders, such as autism and schizophrenia. However, despite its importance, many fundamental questions regarding the neural mechanisms underlying social behavior and its disorders still remain unanswered. One central question is how neural circuits, important computing units in the brain, process and integrate information for the decision and execution of specific social behaviors. To address this question, the Hong lab applies a multidisciplinary approach to investigating social behavior, using techniques including but not limited to:

  • Single-cell RNA-seq and bioinformatics to comprehensively identify and characterize diverse neuronal cell types in social behavior circuits and their molecular profiles with single-cell resolution.
  • Optogenetics and chemogenetics to manipulate neuronal circuit activities in different neuronal subtypes in different social behaviors, to determine their causal roles, and to map their functional connections.
  • Fiber photometry, miniscope imaging, and neural computation to map neural network activities during social behaviors and to uncover the encoding of sensory processing and behavioral decisions in neuronal ensembles.
  • Advanced engineering technology and machine learning to make the analysis of social behaviors more efficient, objective, quantitative, and ethologically relevant.

Detailed Biography:

The Hong Lab employs a multidisciplinary approach to identify the molecular and neural circuit mechanisms underlying normal social behaviors as well as their dysregulations in neuropsychiatric disorders. Social behaviors are essential for the survival and reproduction of animals. The control of social behavior is of particular importance in social species such as humans. Abnormalities in social behaviors are associated with several neuropsychiatric disorders, such as autism spectrum disorders and schizophrenia.  Despite its importance, many fundamental questions regarding social behavior and its disorders still remain unanswered. We aim to understand how social behavior is regulated at the molecular and circuit level and how social behavior and social experience lead to molecular and circuit level changes in the brain.

We study these questions across molecular, circuit, and behavioral levels, by linking genes to circuits to behaviors. To do that, we take a multi-disciplinary approach and utilize a variety of experimental and computational technologies, including but not limited to optogenetics/chemogenetics, in vivo/vitro calcium imaging and electrophysiology, various genetic and molecular biology techniques, systems approaches such as next-generation sequencing and bioinformatics, and engineering and computational approaches such as machine learning and computer vision.

Publications:

A selected list of publications:

Chen P, Hong W^   Neural Circuit Mechanisms of Social Behavior Neuron, 2018; 98(1): 16-30.
Wu YE, Pan L, Zuo Y, Li X, Hong W^   Detecting Activated Cell Populations Using Single-Cell RNA-Seq Neuron, 2017; 96(2): 313-329.e6.
Hong W^, Kennedy A, Burgos-Artizzu XP, Zelikowsky M, Navonne SG, Perona P^, Anderson DJ^   Automated measurement of mouse social behaviors using depth sensing, video tracking, and machine learning Proc. Natl. Acad. Sci. USA, 2015; 112(38): E5351-60.
Pearce MM, Spartz EJ, Hong W, Luo L, Kopito RR   Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain Nature communications, 2015; 6(38): 6768.
Ward A*, Hong W*, Favaloro V, Luo L   Toll receptors instruct axon and dendrite targeting and participate in synaptic partner matching in a Drosophila olfactory circuit Neuron, 2015; 85(5): 1013-28.
Hong W, Kim DW, Anderson DJ   Antagonistic control of social versus repetitive self-grooming behaviors by separable amygdala neuronal subsets Cell, 2014; 158(6): 1348-61.
Hong W^, Luo L   Genetic control of wiring specificity in the fly olfactory system Genetics, 2014; 196(1): 17-29.
Hong W^   Science & SciLifeLab Prize. Assembly of a neural circuit Science, 2013; 342(6163): 1186.
Hong W*, Wu YE*, Fu X, Chang Z   Chaperone-dependent mechanisms for acid resistance in enteric bacteria Trends in microbiology, 2012; 20(7): 328-35.
Hong W, Mosca TJ, Luo L   Teneurins instruct synaptic partner matching in an olfactory map Nature, 2012; 484(7393): 201-7.
Mosca TJ*, Hong W*, Dani VS, Favaloro V, Luo L   Trans-synaptic Teneurin signalling in neuromuscular synapse organization and target choice Nature, 2012; 484(7393): 237-41.
de Wit J*, Hong W*, Luo L, Ghosh A   Role of leucine-rich repeat proteins in the development and function of neural circuits Annual review of cell and developmental biology, 2011; 27(7393): 697-729.
Hong W, Luo L   Dendritic tiling through TOR signalling The EMBO journal, 2009; 28(24): 3783-4.
Hong W, Zhu H, Potter CJ, Barsh G, Kuruzu M, Zinn K, Luo L   Leucine-rich repeat transmembrane proteins instruct discrete dendrite targeting in an olfactory map Nature Neuroscience, 2009; 12(12): 1542-50.
Wu YE*, Hong W*, Zhang L, Liu C, Chang Z   Conserved amphiphilic feature is essential for periplasmic chaperone HdeA to support acid resistance in enteric bacteria The Biochemical journal, 2008; 412(2): 389-97.
Jiao W, Hong W, Li P, Sun S, Ma J, Qian M, Hu M, Chang Z   The dramatically increased chaperone activity of small heat-shock protein IbpB is retained for an extended period of time after the stress condition is removed The Biochemical journal, 2008; 410(1): 63-70.
Liu C, Mao K, Zhang M, Sun Z, Hong W, Li C, Peng B, Chang Z   The SH3-like domain switches its interaction partners to modulate the repression activity of mycobacterial iron-dependent transcription regulator in response to metal ion fluctuations Journal of Biological Chemistry, 2008; 283(4): 2439-53.
Hong W, Jiao W, Hu J, Zhang J, Liu C, Fu X, Shen D, Xia B, Chang Z   Periplasmic protein HdeA exhibits chaperone-like activity exclusively within stomach pH range by transforming into disordered conformation Journal of Biological Chemistry, 2005; 280(29): 27029-34.
Liu Y, Fu X, Shen J, Zhang H, Hong W, Chang Z   Periplasmic proteins of Escherichia coli are highly resistant to aggregation: reappraisal for roles of molecular chaperones in periplasm Biochemical and biophysical research communications, 2004; 316(3): 795-801.

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