Scott Kitchen, Ph.D.

A Short Biography:

Dr. Scott Kitchen's research interests are focused on investigating the effects of viral infection, as well as other cellular abnormalities, on human hematopoiesis and on exploring ways to correct defects that exist in immunity to viral and cellular antigens. Kitchen's laboratory is interested in understanding the mechanisms that limit the immune systems' ability to clear infection or cancer and in developing ways that augment these responses. They are interested in developing gene therapy-based approaches to engineer human hematopoietic stem cells to reconstitute and/or enhance immune responses following their development into mature cells that specifically target HIV infection as well as other viral and cellular antigens. His laboratory is interested in the development of humanized mouse models that allow the characterization of human hematopoiesis and engineered immunity in a surrogate in vivo host.


Work Titles
CTSI Member, CTSI
UCLA Director, UCLA CFAR/JCCC Humanized Mouse Core Laboratory Associate Professor, Medicine Member, Tumor Immunology Program at the Jonsson Comprehensive Cancer Center (JCCC)
Education:
Degrees:
Ph.D., University of California, Los Angeles

Contact Information:

Email Address:

skitchen@ucla.edu


Work Phone Number:

310-983-1251

Mailing Address:

UCLA AIDS Institute
615 Charles E. Young Dr. S.
Los Angeles, CA 90095


Research Interest:

Immunology, Virology, Malignancy

Dr. Kitchen's research interests are focused on investigating the mechanisms that limit the human immune systems' ability to clear chronic infections or malignancies and in developing ways that augment and enhance these responses.  He is interested in the development of models that allow the characterization of human hematopoiesis and gene therapy based engineered immunity in vivo.

Publications:

A selected list of publications:

Mu William, Sharma Madhav, Heymans Rachel, Ritou Eleni, Rezek Valerie, Hamid Philip, Kossyvakis Athanasios, Sen Roy Shubhendu, Grijalva Victor, Chattopadhyay Arnab, Papesh Jeremy, Meriwether David, Kitchen Scott G, Fogelman Alan M, Reddy Srinivasa T, Kelesidis Theodoros   Apolipoprotein A-I mimetics attenuate macrophage activation in chronic treated HIV AIDS (London, England), 2021; 35(4): 543-553.
Barber-Axthelm Isaac M, Barber-Axthelm Valerie, Sze Kai Yin, Zhen Anjie, Suryawanshi Gajendra W, Chen Irvin Sy, Zack Jerome A, Kitchen Scott G, Kiem Hans-Peter, Peterson Christopher W   Stem cell-derived CAR T cells traffic to HIV reservoirs in macaques JCI insight, 2021; 6(1): 543-553.
Stripecke Renata, Münz Christian, Schuringa Jan Jacob, Bissig Karl-Dimiter, Soper Brian, Meeham Terrence, Yao Li-Chin, Di Santo James P, Brehm Michael, Rodriguez Estefania, Wege Anja Kathrin, Bonnet Dominique, Guionaud Silvia, Howard Kristina E, Kitchen Scott, Klein Florian, Saeb-Parsy Kourosh, Sam Johannes, Sharma Amar Deep, Trumpp Andreas, Trusolino Livio, Bult Carol, Shultz Leonard   Innovations, challenges, and minimal information for standardization of humanized mice EMBO molecular medicine, 2020; 12(7): e8662.
Mu Wenli, Carrillo Mayra A, Kitchen Scott G   Engineering CAR T Cells to Target the HIV Reservoir Frontiers in cellular and infection microbiology, 2020; 10(1): 410.
Norton Thomas D, Zhen Anjie, Tada Takuya, Kim Jennifer, Kitchen Scott, Landau Nathaniel R   Lentiviral Vector-Based Dendritic Cell Vaccine Suppresses HIV Replication in Humanized Mice Molecular therapy : the journal of the American Society of Gene Therapy, 2019; 27(5): 960-973.
Carrillo Mayra A, Zhen Anjie, Kitchen Scott G   The Use of the Humanized Mouse Model in Gene Therapy and Immunotherapy for HIV and Cancer Frontiers in immunology, 2018; 9(5): 746.
Zhen Anjie, Peterson Christopher W, Carrillo Mayra A, Reddy Sowmya Somashekar, Youn Cindy S, Lam Brianna B, Chang Nelson Y, Martin Heather A, Rick Jonathan W, Kim Jennifer, Neel Nick C, Rezek Valerie K, Kamata Masakazu, Chen Irvin S Y, Zack Jerome A, Kiem Hans-Peter, Kitchen Scott G   Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS PLoS pathogens, 2017; 13(12): e1006753.
Carrillo Mayra A, Zhen Anjie, Zack Jerome A, Kitchen Scott G   New approaches for the enhancement of chimeric antigen receptors for the treatment of HIV Translational research : the journal of laboratory and clinical medicine, 2017; 187(12): 83-92.
Zhen Anjie, Carrillo Mayra A, Kitchen Scott G   Chimeric antigen receptor engineered stem cells: a novel HIV therapy Immunotherapy, 2017; 9(5): 401-410.
Zhen Anjie, Rezek Valerie, Youn Cindy, Lam Brianna, Chang Nelson, Rick Jonathan, Carrillo Mayra, Martin Heather, Kasparian Saro, Syed Philip, Rice Nicholas, Brooks David G, Kitchen Scott G   Targeting type I interferon-mediated activation restores immune function in chronic HIV infection The Journal of clinical investigation, 2017; 127(1): 260-268.
Kitchen Scott G, Zack Jerome A   Engineering HIV-Specific Immunity with Chimeric Antigen Receptors AIDS patient care and STDs, 2016; 30(12): 556-561.
Ali Ayub, Kitchen Scott G, Chen Irvin S Y, Ng Hwee L, Zack Jerome A, Yang Otto O   HIV-1-Specific Chimeric Antigen Receptors Based on Broadly Neutralizing Antibodies Journal of virology, 2016; 90(15): 6999-7006.
Zhen Anjie, Rezek Valerie, Youn Cindy, Rick Jonathan, Lam Brianna, Chang Nelson, Zack Jerome, Kamata Masakazu, Kitchen Scott   Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model Journal of visualized experiments : JoVE, 2016; 90(113): 6999-7006.
Cunningham Cameron R, Champhekar Ameya, Tullius Michael V, Dillon Barbara Jane, Zhen Anjie, de la Fuente Justin Rafael, Herskovitz Jonathan, Elsaesser Heidi, Snell Laura M, Wilson Elizabeth B, de la Torre Juan Carlos, Kitchen Scott G, Horwitz Marcus A, Bensinger Steven J, Smale Stephen T, Brooks David G   Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence PLoS pathogens, 2016; 12(1): e1005356.
York Autumn G, Williams Kevin J, Argus Joseph P, Zhou Quan D, Brar Gurpreet, Vergnes Laurent, Gray Elizabeth E, Zhen Anjie, Wu Nicholas C, Yamada Douglas H, Cunningham Cameron R, Tarling Elizabeth J, Wilks Moses Q, Casero David, Gray David H, Yu Amy K, Wang Eric S, Brooks David G, Sun Ren, Kitchen Scott G, Wu Ting-Ting, Reue Karen, Stetson Daniel B, Bensinger Steven J   Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling Cell, 2015; 163(7): 1716-29.
Zhen Anjie, Kamata Masakazu, Rezek Valerie, Rick Jonathan, Levin Bernard, Kasparian Saro, Chen Irvin Sy, Yang Otto O, Zack Jerome A, Kitchen Scott G   HIV-specific Immunity Derived From Chimeric Antigen Receptor-engineered Stem Cells Molecular therapy : the journal of the American Society of Gene Therapy, 2015; 23(8): 1358-67.
Zhen Anjie, Krutzik Stephan R, Levin Bernard R, Kasparian Saro, Zack Jerome A, Kitchen Scott G   CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection Journal of virology, 2014; 88(17): 9934-46.
Zhen Anjie, Kitchen Scott   Stem-cell-based gene therapy for HIV infection Viruses, 2014; 6(1): 1-12.
Kitchen Scott G, Levin Bernard R, Bristol Gregory, Rezek Valerie, Kim Sohn, Aguilera-Sandoval Christian, Balamurugan Arumugam, Yang Otto O, Zack Jerome A   In vivo suppression of HIV by antigen specific T cells derived from engineered hematopoietic stem cells PLoS pathogens, 2012; 8(4): e1002649.
Vatakis Dimitrios N, Bristol Gregory C, Kim Sohn G, Levin Bernard, Liu Wei, Radu Caius G, Kitchen Scott G, Zack Jerome A   Using the BLT humanized mouse as a stem cell based gene therapy tumor model Journal of visualized experiments : JoVE, 2012; (70): e4181.
Kitchen Scott G, Shimizu Saki, An Dong Sung   Stem cell-based anti-HIV gene therapy Virology, 2011; 411(2): 260-72.
Kitchen Scott G, Zack Jerome A   Stem cell-based approaches to treating HIV infection Current opinion in HIV and AIDS, 2011; 6(1): 68-73.
Epeldegui Marta, Thapa Dharma R, De la Cruz Justin, Kitchen Scott, Zack Jerome A, Martínez-Maza Otoniel   CD40 ligand (CD154) incorporated into HIV virions induces activation-induced cytidine deaminase (AID) expression in human B lymphocytes PloS one, 2010; 5(7): e11448.
Kitchen Christina M R, Krogstad Paul, Kitchen Scott G   In Vivo validation of a bioinformatics based tool to identify reduced replication capacity in HIV-1 The open medical informatics journal, 2010; 4(7): 225-32.
Kitchen Scott G, Bennett Michael, Galić Zoran, Kim Joanne, Xu Qing, Young Alan, Lieberman Alexis, Joseph Aviva, Goldstein Harris, Ng Hwee, Yang Otto, Zack Jerome A   Engineering antigen-specific T cells from genetically modified human hematopoietic stem cells in immunodeficient mice PloS one, 2009; 4(12): e8208.
Galić Zoran, Kitchen Scott G, Subramanian Aparna, Bristol Greg, Marsden Matthew D, Balamurugan Arumugam, Kacena Amelia, Yang Otto, Zack Jerome A   Generation of T lineage cells from human embryonic stem cells in a feeder free system Stem cells (Dayton, Ohio), 2009; 27(1): 100-7.
Subramanian Aparna, Guo Beichu, Marsden Matthew D, Galic Zoran, Kitchen Scott, Kacena Amelia, Brown Helen J, Cheng Genhong, Zack Jerome A   Macrophage differentiation from embryoid bodies derived from human embryonic stem cells Journal of stem cells, 2009; 4(1): 29-45.
Kitchen Christina Mr, Nuño Miriam, Kitchen Scott G, Krogstad Paul   Enfuvirtide antiretroviral therapy in HIV-1 infection Therapeutics and clinical risk management, 2008; 4(2): 433-9.
Galic Zoran, Kitchen Scott G, Kacena Amelia, Subramanian Aparna, Burke Bryan, Cortado Ruth, Zack Jerome A   T lineage differentiation from human embryonic stem cells Proceedings of the National Academy of Sciences of the United States of America, 2006; 103(31): 11742-7.
Kitchen Scott G, Whitmire Jason K, Jones Nicole R, Galic Zoran, Kitchen Christina M R, Ahmed Rafi, Zack Jerome A   The CD4 molecule on CD8+ T lymphocytes directly enhances the immune response to viral and cellular antigens Proceedings of the National Academy of Sciences of the United States of America, 2005; 102(10): 3794-9.
Kitchen Scott G, Jones Nicole R, LaForge Stuart, Whitmire Jason K, Vu Bien-Aimee, Galic Zoran, Brooks David G, Brown Stephen J, Kitchen Christina M R, Zack Jerome A   CD4 on CD8(+) T cells directly enhances effector function and is a target for HIV infection Proceedings of the National Academy of Sciences of the United States of America, 2004; 101(23): 8727-32.

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