David Brooks, Ph.D.

Work Titles
UCLA Assistant Professor, Microbiology, Immunology & Molecular Genetics Member, Tumor Immunology Program at the Jonsson Comprehensive Cancer Center (JCCC)
B.S., University of Arizona, Tuscon, 1992 - 1996

Contact Information:

Fax Number:


Office Phone Number:


Mailing Address:

BOX 957364, 290A BSRB
Los Angeles, CA 90095

Work Address:

Los Angeles, CA 90095


A selected list of publications:

Wilson Elizabeth B, Yamada Douglas H, Elsaesser Heidi, Herskovitz Jonathan, Deng Jane, Cheng Genhong, Aronow Bruce J, Karp Christopher L, Brooks David G   Blockade of chronic type I interferon signaling to control persistent LCMV infection Science (New York, N.Y.), 2013; 340(6129): 202-7.
Wilson Elizabeth B, Brooks David G   Inflammation makes T cells sensitive Immunity, 2013; 38(1): 5-7.
Kidani Yoko, Elsaesser Heidi, Hock M Benjamin, Vergnes Laurent, Williams Kevin J, Argus Joseph P, Marbois Beth N, Komisopoulou Evangelia, Wilson Elizabeth B, Osborne Timothy F, Graeber Thomas G, Reue Karen, Brooks David G, Bensinger Steven J   Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity Nature immunology, 2013; 14(5): 489-99.
Wilson Elizabeth B, Kidani Yoko, Elsaesser Heidi, Barnard Jennifer, Raff Laura, Karp Christopher L, Bensinger Steven, Brooks David G   Emergence of Distinct Multiarmed Immunoregulatory Antigen-Presenting Cells during Persistent Viral Infection Cell host & microbe, 2012; 11(5): 481-91.
Tomassian Tamar, Humphries Lisa A, Liu Scot D, Silva Oscar, Brooks David G, Miceli M Carrie   Caveolin-1 orchestrates TCR synaptic polarity, signal specificity, and function in CD8 T cells Journal of immunology (Baltimore, Md. : 1950), 2011; 187(6): 2993-3002.
Brooks David   Social animal: how the new sciences of human nature can help make sense of a life New Yorker (New York, N.Y. : 1925), 2011; 350(Pt 1): 26-32.
Wilson Elizabeth B, Brooks David G   The role of IL-10 in regulating immunity to persistent viral infections Current topics in microbiology and immunology, 2011; 350(Pt 1): 39-65.
Fahey Laura M, Wilson Elizabeth B, Elsaesser Heidi, Fistonich Chris D, McGavern Dorian B, Brooks David G   Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells The Journal of experimental medicine, 2011; 208(5): 987-99.
Brooks David G, Walsh Kevin B, Elsaesser Heidi, Oldstone Michael B A   IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(7): 3018-23.
Alter Galit, Kavanagh Daniel, Rihn Suzannah, Luteijn Rutger, Brooks David, Oldstone Michael, van Lunzen Jan, Altfeld Marcus   IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection The Journal of clinical investigation, 2010; 120(6): 1905-13.
Fahey Laura M, Brooks David G   Opposing positive and negative regulation of T cell activity during viral persistence Current opinion in immunology, 2010; 22(3): 348-54.
Wilson Elizabeth B, Brooks David G   Translating insights from persistent LCMV infection into anti-HIV immunity Immunologic research, 2010; 48(1-3): 3-13.
Elsaesser Heidi, Sauer Karsten, Brooks David G   IL-21 is required to control chronic viral infection Science (New York, N.Y.), 2009; 324(5934): 1569-72.
Brooks David G   Suppressing the suppressor Blood, 2009; 114(2): 233.
Garidou Lucile, Heydari Sara, Truong Phi, Brooks David G, McGavern Dorian B   Therapeutic memory T cells require costimulation for effective clearance of a persistent viral infection Journal of virology, 2009; 83(17): 8905-15.
Brooks David G, Ha Sang-Jun, Elsaesser Heidi, Sharpe Arlene H, Freeman Gordon J, Oldstone Michael B A   IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection Proceedings of the National Academy of Sciences of the United States of America, 2008; 105(51): 20428-33.
Brooks, D.G., Lee, A.M., Elsaesser, H., McGavern, D.B. and Oldstone, M.B.A.   IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection, Journal of Experimental Medicine, 2008; 205: 533-541.
Hryniewicz Anna, Price David A, Moniuszko Marcin, Boasso Adriano, Edghill-Spano Yvette, West Sadie M, Venzon David, Vaccari Monica, Tsai Wen-Po, Tryniszewska Elzbieta, Nacsa Janos, Villinger Francois, Ansari Aftab A, Trindade Christopher J, Morre Michel, Brooks David, Arlen Philip, Brown Helen J, Kitchen Christina M R, Zack Jerome A, Douek Daniel C, Shearer Gene M, Lewis Mark G, Koup Richard A, Franchini Genoveffa   Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaques Journal of immunology (Baltimore, Md. : 1950), 2007; 178(6): 3492-504.
Homann Dirk, Lewicki Hanna, Brooks David, Eberlein Jens, Mallet-Designé Valerie, Teyton Luc, Oldstone Michael B A   Mapping and restriction of a dominant viral CD4+ T cell core epitope by both MHC class I and MHC class II Virology, 2007; 363(1): 113-23.
Brooks, D.G., Trifilo, M.J., Edelmann, K.H., Teyton, L., McGavern, D.B. and Oldstone, M.B.A.   Interleukin-10 determines viral clearance or persistence in vivo, Nature Medicine, 2006; 12: 1301-1309.
Brooks, D.G., McGavern, D.B. and Oldstone, M.B.A.   Re-programming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection, Journal of Clinical Investigation, 2006; 161: 1675-1685.
Brooks, D.G., Teyton, L, Oldstone, M.B.A. and McGavern, D.B.   Intrinsic functional dysregulation of CD4 T cell occurs rapidly during persistent viral infection, Journal of Virology, 2005; 79: 10514-10527.

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