Mathew Marsden, Ph.D.

A Short Biography:

My research is focused on developing methods for eliminating the HIV reservoirs that persist during antiretroviral therapy. This primarily involves investigating the biology of latently infected CD4+ T cells and chronically infected macrophages, and exploring new approaches to deplete the virus that is harbored by these cells.

Work Titles
UCLA Assistant Professor, Hematology-Oncology

Contact Information:

Email Address:


A selected list of publications:

Matthew D Marsden & Jerome A Zack   HIV cure strategies: a complex approach for a complicated viral reservoir? Future Virology, 2019; 14(1): 5-8.
Llewellyn George N, Seclèn Eduardo, Wietgrefe Stephen, Liu Siyu, Chateau Morgan, Pei Hua, Perkey Katherine, Marsden Matthew D, Hinkley Sarah J, Paschon David E, Holmes Michael C, Zack Jerome A, Louie Stan G, Haase Ashley T, Cannon Paula M   A humanized mouse model of HIV-1 latency with enrichment of latent virus in PD-1+ and TIGIT+ CD4 T cells Journal of virology, 2019; .
Marsden Matthew D, Wu Xiaomeng, Navab Sara M, Loy Brian A, Schrier Adam J, DeChristopher Brian A, Shimizu Akira J, Hardman Clayton T, Ho Stephen, Ramirez Christina M, Wender Paul A, Zack Jerome A   Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents Virology, 2018; 520: 83-93.
Marsden Matthew D, Zack Jerome A   Humanized Mouse Models for Human Immunodeficiency Virus Infection Annual review of virology, 2017; 4(1): 393-412.
Marsden Matthew D, Loy Brian A, Wu Xiaomeng, Ramirez Christina M, Schrier Adam J, Murray Danielle, Shimizu Akira, Ryckbosch Steven M, Near Katherine E, Chun Tae-Wook, Wender Paul A, Zack Jerome A   In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication PLoS pathogens, 2017; 13(9): e1006575.
Shimizu Saki, Ringpis Gene-Errol, Marsden Matthew D, Cortado Ruth V, Wilhalme Holly M, Elashoff David, Zack Jerome A, Chen Irvin S Y, An Dong Sung   RNAi-Mediated CCR5 Knockdown Provides HIV-1 Resistance to Memory T Cells in Humanized BLT Mice Molecular therapy. Nucleic acids, 2015; 4: e227.
Marsden Matthew D, Zack Jerome A   Studies of retroviral infection in humanized mice Virology, 2015; 479-480: 297-309.
Marsden Matthew D, Zack Jerome A   Experimental Approaches for Eliminating Latent HIV Forum on immunopathological diseases and therapeutics, 2015; 6(1-2): 91-99.
Sanchez David Jesse, Miranda Daniel, Marsden Matthew D, Dizon Thomas Michael A, Bontemps Johnny R, Davila Sergio J, Del Mundo Lara E, Ha Thai, Senaati Ashkon, Zack Jerome A, Cheng Genhong   Disruption of Type I Interferon Induction by HIV Infection of T Cells PloS one, 2015; 10(9): e0137951.
Marsden Matthew D, Zack Jerome A   Double trouble: HIV latency and CTL escape Cell host & microbe, 2015; 17(2): 141-2.
*Buehler Daniel C, *Marsden Matthew D, Shen Sean, Toso Daniel B, Wu Xiaomeng, Loo Joseph A, Zhou Z Hong, Kickhoefer Valerie A, Wender Paul A, Zack Jerome A, Rome Leonard H *Equal contributing authors   Bioengineered vaults: self-assembling protein shell-lipophilic core nanoparticles for drug delivery ACS nano, 2014; 8(8): 7723-32.
Marsden Matthew D, Zack Jerome A   Neutralizing the HIV reservoir Cell, 2014; 158(5): 971-2.
Marsden Matthew D, Zack Jerome A   HIV/AIDS eradication Bioorganic & medicinal chemistry letters, 2013; 23(14): 4003-10.
Beans Elizabeth J, Fournogerakis Dennis, Gauntlett Carolyn, Heumann Lars V, Kramer Rainer, Marsden Matthew D, Murray Danielle, Chun Tae-Wook, Zack Jerome A, Wender Paul A   Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivo Proceedings of the National Academy of Sciences of the United States of America, 2013; 110(29): 11698-703.
Liu Su-Yang, Aliyari Roghiyh, Chikere Kelechi, Li Guangming, Marsden Matthew D, Smith Jennifer K, Pernet Olivier, Guo Haitao, Nusbaum Rebecca, Zack Jerome A, Freiberg Alexander N, Su Lishan, Lee Benhur, Cheng Genhong   Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol Immunity, 2013; 38(1): 92-105.
*DeChristopher Brian A, *Loy Brian A, *Marsden Matthew D, *Schrier Adam J, Zack Jerome A, Wender Paul A. *Equal Contributing Authors   Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro Nature chemistry, 2012; 4(9): 705-10.
Marsden Matthew D, Krogstad Paul A, Zack Jerome A   Virological evidence supporting the use of raltegravir in HIV post-exposure prophylaxis regimens Antiviral therapy, 2012; 17(7): 1375-9.
Marsden Matthew D, Kovochich Michael, Suree Nuttee, Shimizu Saki, Mehta Roshni, Cortado Ruth, Bristol Gregory, An Dong Sung, Zack Jerome A   HIV latency in the humanized BLT mouse Journal of virology, 2012; 86(1): 339-47.
Marsden Matthew D, Burke Bryan P, Zack Jerome A   HIV latency is influenced by regions of the viral genome outside of the long terminal repeats and regulatory genes Virology, 2011; 417(2): 394-9.
Kovochich Michael, Marsden Matthew D, Zack Jerome A   Activation of latent HIV using drug-loaded nanoparticles PloS one, 2011; 6(4): e18270.
Marsden Matthew D, Avancena Patricia, Kitchen Christina M R, Hubbard Trish, Zack Jerome A   Single mutations in HIV integrase confer high-level resistance to raltegravir in primary human macrophages Antimicrobial agents and chemotherapy, 2011; 55(8): 3696-702.
Marsden Matthew D, Zack Jerome A   Establishment and maintenance of HIV latency: model systems and opportunities for intervention Future virology, 2010; 5(1): 97-109.
Marsden Matthew D, Zack Jerome A   Eradication of HIV: current challenges and new directions The Journal of antimicrobial chemotherapy, 2009; 63(1): 7-10.
Galic Zoran, Kitchen Scott G, Subramanian Aparna, Bristol Greg, Marsden Matthew D, Balamurugan Arumugam, Kacena Amelia, Yang Otto, Zack Jerome A   Generation of T lineage cells from human embryonic stem cells in a feeder free system Stem cells (Dayton, Ohio), 2009; 27(1): 100-7.
Subramanian Aparna, Guo Beichu, Marsden Matthew D, Galic Zoran, Kitchen Scott, Kacena Amelia, Brown Helen J, Cheng Genhong, Zack Jerome A   Macrophage differentiation from embryoid bodies derived from human embryonic stem cells Journal of stem cells, 2009; 4(1): 29-45.
Marsden Matthew D, Xu Jie, Hamer Dean, Zack Jerome A   Short communication: Activating stimuli enhance immunotoxin-mediated killing of HIV-infected macrophages AIDS research and human retroviruses, 2008; 24(11): 1399-404.
Burke Bryan, Brown Helen J, Marsden Matthew D, Bristol Gregory, Vatakis Dimitrios N, Zack Jerome A   Primary cell model for activation-inducible human immunodeficiency virus Journal of virology, 2007; 81(14): 7424-34.
Marsden Matthew D, Zack Jerome A   Human immunodeficiency virus bearing a disrupted central DNA flap is pathogenic in vivo Journal of virology, 2007; 81(11): 6146-50.
McCrossan M, Marsden M, Carnie F W, Minnis S, Hansoti B, Anthony I C, Brettle R P, Bell J E, Simmonds P   An immune control model for viral replication in the CNS during presymptomatic HIV infection Brain : a journal of neurology, 2006; 129(Pt 2): 503-16.
Morris A, Marsden M, Halcrow K, Hughes E S, Brettle R P, Bell J E, Simmonds P   Mosaic structure of the human immunodeficiency virus type 1 genome infecting lymphoid cells and the brain: evidence for frequent in vivo recombination events in the evolution of regional populations Journal of virology, 1999; 73(10): 8720-31.

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