Xinmin Li, Ph.D.

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Work Titles
CTSI Member, CTSI
UCLA Director, JCCC Genomics Shared Resource / UCLA Clinical Microarray Core Professor, Pathology and Laboratory Medicine Professor, Transplant/Immunogenetics Testing Member, JCCC Cancer and Stem Cell Biology Program Area
Education:
Degrees:
Ph.D.

Contact Information:

Work Email Address:

xinminli@mednet.ucla.edu


Website:

UCLA Clinical Microarray Laboratory

Work Phone Number:

310-825-3664

Mailing Address:

Work
650 Charles Young Dr. South,
Los Angeles, CA 90095


Detailed Biography:

Xinmin Li earned his M.S. in quantitative genetics in China and Ph.D. in molecular genetics at the University of Nottingham in the United Kingdom. After he completed his post-doc training at the University of Adelaide in Australia, Dr. Li was appointed as assistant professor in the Department of Medicine, Loma Linda University in 1999. From 2001-2007, Dr. Li was a Senior research Professional (PI) and Director of Functional Genomics facility at the University of Chicago. He joined the UCLA faculty in 2007 as Professor of genomics.

Publications:

A selected list of publications:

Nakatsu Martin N, Vartanyan Lily, Vu Daniel M, Ng Madelena Y, Li Xinmin, Deng Sophie X   Preferential biological processes in the human limbus by differential gene profiling PloS one, 2013; 8(4): e61833.
Zhongyi Zhang, Weihua Yuan, Lin Sun, Frances L. Szeto, Kari E. Wong, Xinmin Li, Juan Kong, and Yan Chun Li   1,25-Dihydroxyvitamin D3 Suppresses High Glucose-Induced MCP-1 Expression in Mesangial Cells by Targeting NF-†B. Kidney International 72, 193–201, 2007; .
Xinmin Li, Hali Wang, Edward Touma, Yuchen Qi, Emma Rousseau, Richard J. Quigg, James T. Ryaby   TP508 Accelerates Fracture Repair by Promoting Cell Growth over Cell Death Biochem Biophys Res Commun 364(1):187-93. , 2007; .
Lugassy Claire, Wadehra Madhuri, Li Xinmin, Corselli Mirko, Akhavan David, Binder Scott W, Péault Bruno, Cochran Alistair J, Mischel Paul S, Kleinman Hynda K, Barnhill Raymond L   Pilot study on "pericytic mimicry" and potential embryonic/stem cell properties of angiotropic melanoma cells interacting with the abluminal vascular surface Cancer microenvironment : official journal of the International Cancer Microenvironment Society, 2013; 6(1): 19-29.
Kulkarni Rajan P, Plaisier Seema, Ra Seong H, Li Xinmin, Lee Delphine J, Hillman Joseph D, Binder Scott W   Genetic profiling of BRAF inhibitor-induced keratoacanthomas reveals no induction of MAP kinase pathway expression The Journal of investigative dermatology, 2013; 133(3): 830-3.
Ra Seong H, Su Albert, Li Xinmin, Binder Scott   Molecularly enriched pathways and differentially expressed genes distinguishing cutaneous squamous cell carcinoma from pseudoepitheliomatous hyperplasia Diagnostic molecular pathology : the American journal of surgical pathology, part B, 2013; 22(1): 41-7.
Nguyen Kovochich Anne, Arensman Michael, Lay Anna R, Rao Nagesh P, Donahue Timothy, Li Xinmin, French Samuel W, Dawson David W   HOXB7 promotes invasion and predicts survival in pancreatic adenocarcinoma Cancer, 2013; 119(3): 529-39.
Magnusson Mattias, Sierra Maria I, Sasidharan Rajkumar, Prashad Sacha L, Romero Melissa, Saarikoski Pamela, Van Handel Ben, Huang Andy, Li Xinmin, Mikkola Hanna K A   Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability PloS one, 2013; 8(1): e53912.
He Huanhuan, Xu Jingying, Warren Carmen M, Duan Dan, Li Xinmin, Wu Lily, Iruela-Arispe M Luisa   Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages Blood, 2012; 120(15): 3152-62.
Van Handel Ben, Montel-Hagen Amélie, Sasidharan Rajkumar, Nakano Haruko, Ferrari Roberto, Boogerd Cornelis J, Schredelseker Johann, Wang Yanling, Hunter Sean, Org Tõnis, Zhou Jian, Li Xinmin, Pellegrini Matteo, Chen Jau-Nian, Orkin Stuart H, Kurdistani Siavash K, Evans Sylvia M, Nakano Atsushi, Mikkola Hanna K A   Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium Cell, 2012; 150(3): 590-605.
Koh Stephen S, Wei Jia-Perng J, Li Xinmin, Huang Rong R, Doan Ngan B, Scolyer Richard A, Cochran Alistair J, Binder Scott W   Differential gene expression profiling of primary cutaneous melanoma and sentinel lymph node metastases Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2012; 40(4): .
Donahue Timothy R, Tran Linh M, Hill Reginald, Li Yunfeng, Kovochich Anne, Calvopina Joseph H, Patel Sanjeet G, Wu Nanping, Hindoyan Antreas, Farrell James J, Li Xinmin, Dawson David W, Wu Hong   Integrative survival-based molecular profiling of human pancreatic cancer Clinical cancer research : an official journal of the American Association for Cancer Research, 2012; 18(5): 1352-63.
Li Xinmin, Zhou Jian, Nahas Shareef A, Wan Haolei, Hu Hailiang, Gatti Richard A   Common copy number variations in fifty radiosensitive cell lines Genomics, 2012; 99(2): 96-100.
Graham Rondell P D, Dry Sarah, Li Xinmin, Binder Scott, Bahrami Armita, Raimondi Susana C, Dogan Ahmet, Chakraborty Subhankar, Souchek Joshua J, Folpe Andrew L   Ossifying fibromyxoid tumor of soft parts: a clinicopathologic, proteomic, and genomic study The American journal of surgical pathology, 2011; 35(11): 1615-25.
Ra Seong Hui, Li Xinmin, Binder Scott   Molecular discrimination of cutaneous squamous cell carcinoma from actinic keratosis and normal skin Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2011; 24(7): 963-73.
Sheth Sachiv, Li Xinmin, Binder Scott, Dry Sarah M   Differential gene expression profiles of neurothekeomas and nerve sheath myxomas by microarray analysis Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2011; 24(3): 343-54.
Lindgren Anne G, Natsuhara Kyle, Tian E, Vincent John J, Li Xinmin, Jiao Jing, Wu Hong, Banerjee Utpal, Clark Amander T   Loss of Pten causes tumor initiation following differentiation of murine pluripotent stem cells due to failed repression of Nanog PloS one, 2011; 6(1): e16478.
Chacko Sara A, Sul James, Song Yiqing, Li Xinmin, LeBlanc James, You Yuko, Butch Anthony, Liu Simin   Magnesium supplementation, metabolic and inflammatory markers, and global genomic and proteomic profiling: a randomized, double-blind, controlled, crossover trial in overweight individuals The American journal of clinical nutrition, 2011; 93(2): 463-73.
Thapa Dharma R, Li Xinmin, Jamieson Beth D, Martínez-Maza Otoniel   Overexpression of microRNAs from the miR-17-92 paralog clusters in AIDS-related non-Hodgkin's lymphomas PloS one, 2011; 6(6): e20781.
Reeves Mark E, Baldwin Scott W, Baldwin Melissa L, Chen Shin-Tai, Moretz Jeremy M, Aragon Robert J, Li Xinmin, Strong Donna D, Mohan Subburaman, Amaar Yousef G   Ras-association domain family 1C protein promotes breast cancer cell migration and attenuates apoptosis BMC cancer, 2010; 10(8): 562.
Evseenko Denis, Zhu Yuhua, Schenke-Layland Katja, Kuo Jeffrey, Latour Brooke, Ge Shundi, Scholes Jessica, Dravid Gautam, Li Xinmin, MacLellan W Robb, Crooks Gay M   Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(31): 13742-7.
Kong Juan, Kim Gene H, Wei Minjie, Sun Tao, Li George, Liu Shu Q, Li Xinmin, Bhan Ishir, Zhao Qun, Thadhani Ravi, Li Yan Chun   Therapeutic effects of vitamin D analogs on cardiac hypertrophy in spontaneously hypertensive rats The American journal of pathology, 2010; 177(2): 622-31.
Jiao Feng, Chiu Hank, Jiao Yan, de Rijk Waldemar G, Li Xinmin, Eckstein Eugene C, Beamer Wesley G, Gu Weikuan   Quantitative trait loci for tibial bone strength in C57BL/6J and C3H/HeJ inbred strains of mice Journal of genetics, 2010; 89(1): 21-7.
Jiao Yan, Jin Xiudong, Yan Jian, Jiao Feng, Li Xinmin, Roe Bruce A, Jarrett Harry W, Gu Weikuan   An insertion of intracisternal A-particle retrotransposon in a novel member of the phosphoglycerate mutase family in the lew allele of mutant mice Genes & genetic systems, 2009; 84(5): 327-34.
Jiao Yan, Cai Chun, Kermany Mohammad Habiby, Yan Jian, Cai Qing, Miller Darla, Goldowitz Daniel, Li Xinmin, Yoo Tai-June, Gu Weikuan   ENU induced single mutation locus on chr 16 leads to high-frequency hearing loss in mice Genes & genetic systems, 2009; 84(3): 219-24.
Sharff Katie A, Song Wen-Xin, Luo Xiaoji, Tang Ni, Luo Jinyong, Chen Jin, Bi Yang, He Bai-Cheng, Huang Jiayi, Li Xinmin, Jiang Wei, Zhu Gao-Hui, Su Yuxi, He Yun, Shen Jikun, Wang Yi, Chen Liang, Zuo Guo-Wei, Liu Bo, Pan Xiaochuan, Reid Russell R, Luu Hue H, Haydon Rex C, He Tong-Chuan   Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells The Journal of biological chemistry, 2009; 284(1): 649-59.
Li Xinmin, Quigg Richard J, Zhou Jian, Gu Weikuan, Nagesh Rao P, Reed Elaine F   Clinical utility of microarrays: current status, existing challenges and future outlook Current genomics, 2008; 9(7): 466-74.
Qiang Wang, Youli Wang, Andrew W. Minto, Jinhua Wang, Qun Shi, Xinmin Li, and Richard J. Quigg   MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2008; .
Jiao Yan, Jin Xiudong, Yan Jian, Zhang Chi, Jiao Feng, Li Xinmin, Roe Bruce A, Mount David B, Gu Weikuan   A deletion mutation in Slc12a6 is associated with neuromuscular disease in gaxp mice Genomics, 2008; 91(5): 407-14.
Wang Qiang, Li Yan Chun, Wang Jinhua, Kong Juan, Qi Yuchen, Quigg Richard J, Li Xinmin   miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130 Proceedings of the National Academy of Sciences of the United States of America, 2008; 105(8): 2889-94.
Schrump David S, Fischette Maria R, Nguyen Dao M, Zhao Ming, Li Xinmin, Kunst Tricia F, Hancox Ana, Hong Julie A, Chen G Aaron, Kruchin Evgeny, Wright John J, Rosing Douglas R, Sparreboom Alex, Figg William D, Steinberg Seth M   Clinical and molecular responses in lung cancer patients receiving Romidepsin Clinical cancer research : an official journal of the American Association for Cancer Research, 2008; 14(1): 188-98.
Jiao Yan, Yan Jian, Jiao Feng, Yang Hongbin, Donahue Leah Rae, Li Xinmin, Roe Bruce A, Stuart John, Gu Weikuan   A single nucleotide mutation in Nppc is associated with a long bone abnormality in lbab mice BMC genetics, 2007; 8(1): 16.
Yan Jian, Jiao Yan, Jiao Feng, Stuart John, Donahue Leah Rae, Beamer Wesley G, Li Xinmin, Roe Bruce A, LeDoux Mark S, Gu Weikuan   Effects of carbonic anhydrase VIII deficiency on cerebellar gene expression profiles in the wdl mouse Neuroscience letters, 2007; 413(3): 196-201.
Yan James T, Jiao James T, Li James T, Jiao James T, Beamer James T, Rosen James T, Gu James T   Evaluation of gene expression profiling in a mouse model of L-gulonolactone oxidase gene deficiency Genetics and molecular biology, 2007; 30(2): 322-329.
Li Xinmin, Wang Hali, Touma Edward, Rousseau Emma, Quigg Richard J, Ryaby James T   Genetic network and pathway analysis of differentially expressed proteins during critical cellular events in fracture repair Journal of cellular biochemistry, 2007; 100(2): 527-43.
Jiao Yan, Yan Jian, Zhao Yu, Donahue Leah Rae, Beamer Wesley G, Li Xinmin, Roe Bruce A, Ledoux Mark S, Gu Weikuan   Carbonic anhydrase-related protein VIII deficiency is associated with a distinctive lifelong gait disorder in waddles mice Genetics, 2005; 171(3): 1239-46.
Jiao Yan, Li Xinmin, Beamer Wesley G, Yan Jian, Tong Yiai, Goldowitz Daniel, Roe Bruce, Gu Weikuan   A deletion causing spontaneous fracture identified from a candidate region of mouse Chromosome 14 Mammalian genome : official journal of the International Mammalian Genome Society, 2005; 16(1): 20-31.
Masinde Godfred L, Li Xinmin, Gu Weikuan, Davidson Heather, Hamilton-Ulland Melanie, Wergedal Jon, Mohan Subburaman, Baylink David J   Quantitative trait loci (QTL) for lean body mass and body length in MRL/MPJ and SJL/J F(2) mice Functional & integrative genomics, 2002; 2(3): 98-104.
Masinde Godfred L, Li Xinmin, Gu Weikuan, Hamilton-Ulland Melanie, Mohan Subburaman, Baylink David J   Quantitative trait loci that harbor genes regulating muscle size in (MRL/MPJ x SJL/J) F(2) mice Functional & integrative genomics, 2002; 2(3): 120-5.
Li Xinmin, Masinde Godfred, Gu Weikuan, Wergedal Jon, Mohan Subburaman, Baylink David J   Genetic dissection of femur breaking strength in a large population (MRL/MpJ x SJL/J) of F2 Mice: single QTL effects, epistasis, and pleiotropy Genomics, 2002; 79(5): 734-40.
Li Xinmin, Masinde Godfred, Gu Weikuan, Wergedal Jon, Hamilton-Ulland Melanie, Xu Shizhong, Mohan Subburaman, Baylink David J   Chromosomal regions harboring genes for the work to femur failure in mice Functional & integrative genomics, 2002; 1(6): 367-74.
Gu Weikuan, Li Xinmin, Lau K-H William, Edderkaoui Bouchra, Donahae Leah R, Rosen Clifford J, Beamer Wesley G, Shultz Kathryn L, Srivastava Apurva, Mohan Subburaman, Baylink David J   Gene expression between a congenic strain that contains a quantitative trait locus of high bone density from CAST/EiJ and its wild-type strain C57BL/6J Functional & integrative genomics, 2002; 1(6): 375-86.
Li Xinmin, Gu Weikuan, Mohan Subburaman, Baylink David J   DNA microarrays: their use and misuse Microcirculation (New York, N.Y. : 1994), 2002; 9(1): 13-22.

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