Rajan Kulkarni, M.D., Ph.D.

Work Titles
California NanoSystems Institute Member, California NanoSystems Institute
UCLA Member, Cancer Nanotechnology Program Clinical Instructor, Dermatology
M.D., UCLA David Geffen School of Medicine, 2009
Ph.D., California Institute of Technology, 2006
2012 - 2014 UCLA School of Medicine, STAR Research Fellowship
2009 - 2010 Santa Clara Valley Medical Center
2010 - 2014 UCLA Medical Center
2014 American Board of Dermatology

Contact Information:

Work Email Address:


Work Phone Number:

(310) 825-5420

(310) 825-6911

Detailed Biography:

Dr. Rajan Kulkarni's research is focused on the development of tools for understanding both cancer heterogeneity and single-cell heterogeneity in tumors and in circulating tumor cells that break off of the main cancer. Kulkarni has worked on developing Vortex Chip for rapid isolation of circulating tumor cells and towards understanding genomic and transcriptomic variability in individual cells, and he has developed advanced tumor clearing techniques for high-resolution 3D imaging of tumors (passive clarity technique, or PACT).


A selected list of publications:

Ra Seong H, Su Albert, Li Xinmin, Zhou Jaime, Cochran Alistair J, Kulkarni Rajan P, Binder Scott W   Keratoacanthoma and squamous cell carcinoma are distinct from a molecular perspective Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2015; 28(6): 799-806.
Dudani Jaideep S, Gossett Daniel R, Tse Henry T K, Lamm Robert J, Kulkarni Rajan P, Carlo Dino Di   Rapid inertial solution exchange for enrichment and flow cytometric detection of microvesicles Biomicrofluidics, 2015; 9(1): 014112.
Yang Bin, Treweek Jennifer B, Kulkarni Rajan P, Deverman Benjamin E, Chen Chun-Kan, Lubeck Eric, Shah Sheel, Cai Long, Gradinaru Viviana   Single-cell phenotyping within transparent intact tissue through whole-body clearing Cell, 2014; 158(4): 945-58.
Weaver Westbrook M, Tseng Peter, Kunze Anja, Masaeli Mahdokht, Chung Aram J, Dudani Jaideep S, Kittur Harsha, Kulkarni Rajan P, Di Carlo Dino   Advances in high-throughput single-cell microtechnologies Current opinion in biotechnology, 2014; 25(4): 114-23.
Sollier Elodie, Go Derek E, Che James, Gossett Daniel R, O'Byrne Sean, Weaver Westbrook M, Kummer Nicolas, Rettig Matthew, Goldman Jonathan, Nickols Nicholas, McCloskey Susan, Kulkarni Rajan P, Di Carlo Dino   Size-selective collection of circulating tumor cells using Vortex technology Lab on a chip, 2014; 14(1): 63-77.
Kulkarni Rajan P, Plaisier Seema, Ra Seong H, Li Xinmin, Lee Delphine J, Hillman Joseph D, Binder Scott W   Genetic profiling of BRAF inhibitor-induced keratoacanthomas reveals no induction of MAP kinase pathway expression The Journal of investigative dermatology, 2013; 133(3): 830-3.
Che James, Mach Albert J, Go Derek E, Talati Ish, Ying Yong, Rao Jianyu, Kulkarni Rajan P, Di Carlo Dino   Microfluidic purification and concentration of malignant pleural effusions for improved molecular and cytomorphological diagnostics PloS one, 2013; 8(10): e78194.
Wettstein Zachary S, Fleming Michael, Chang Aileen Y, Copenhaver David J, Wateska Angela R, Bartsch Sarah M, Lee Bruce Y, Kulkarni Rajan P   Total economic cost and burden of dengue in Nicaragua: 1996-2010 The American journal of tropical medicine and hygiene, 2012; 87(4): 616-22.
Pinto Violet N, Kulkarni Rajan N   A Case Control Study on School Dropouts in Children of Alcohol-Dependent Males Versus that in Abstainers/Social Drinkers' Children Journal of family medicine and primary care, 2012; 1(2): 92-6.
Kulkarni Rajan P, Ituarte Philip H-G, Gunderson Douglas, Yeh Michael W   Clinical pathways improve hospital resource use in endocrine surgery Journal of the American College of Surgeons, 2011; 212(1): 35-41.
Jeyasekharan Anand D, Ayoub Nabieh, Mahen Robert, Ries Jonas, Esposito Alessandro, Rajendra Eeson, Hattori Hiroyoshi, Kulkarni Rajan P, Venkitaraman Ashok R   DNA damage regulates the mobility of Brca2 within the nucleoplasm of living cells Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(50): 21937-42.
Chang Aileen Y, Parrales Maria E, Jimenez Javier, Sobieszczyk Magdalena E, Hammer Scott M, Copenhaver David J, Kulkarni Rajan P   Combining Google Earth and GIS mapping technologies in a dengue surveillance system for developing countries International journal of health geographics, 2009; 8(50): 49.
Kulkarni Rajan P, Sacoolidge John C, Chiu Melvin W   Clinicopathologic challenge International journal of dermatology, 2009; 48(7): 695-6.
Kulkarni Rajan P, Fraser Scott E, Armani Andrea M   Characterization of high-Q optical microcavities using confocal microscopy Optics letters, 2008; 33(24): 2931-3.
Kulkarni Rajan P, Livesey Finbarr, Dodin Laure   Will regulation determine the science agenda? A look at hESCs Regenerative medicine, 2007; 2(5): 839-44.
Armani Andrea M, Kulkarni Rajan P, Fraser Scott E, Flagan Richard C, Vahala Kerry J   Label-free, single-molecule detection with optical microcavities Science (New York, N.Y.), 2007; 317(5839): 783-7.
Kulkarni Rajan P   Nano-Bio-Genesis: tracing the rise of nanotechnology and nanobiotechnology as 'big science' Journal of biomedical discovery and collaboration, 2007; 2(5839): 3.
Süel Gürol M, Kulkarni Rajan P, Dworkin Jonathan, Garcia-Ojalvo Jordi, Elowitz Michael B   Tunability and noise dependence in differentiation dynamics Science (New York, N.Y.), 2007; 315(5819): 1716-9.
Kulkarni Rajan P, Bak-Maier Magdalena, Fraser Scott E   Differences in protein mobility between pioneer versus follower growth cones Proceedings of the National Academy of Sciences of the United States of America, 2007; 104(4): 1207-12.
Cheng Jianjun, Zeidan Ryan, Mishra Swaroop, Liu Aijie, Pun Suzie H, Kulkarni Rajan P, Jensen Gregory S, Bellocq Nathalie C, Davis Mark E   Structure-function correlation of chloroquine and analogues as transgene expression enhancers in nonviral gene delivery Journal of medicinal chemistry, 2006; 49(22): 6522-31.
Kulkarni Rajan P, Castelino Kenneth, Majumdar Arun, Fraser Scott E   Intracellular transport dynamics of endosomes containing DNA polyplexes along the microtubule network Biophysical journal, 2006; 90(5): L42-4.
Rieger Sandra, Kulkarni Rajan P, Darcy Dan, Fraser Scott E, Köster Reinhard W   Quantum dots are powerful multipurpose vital labeling agents in zebrafish embryos Developmental dynamics : an official publication of the American Association of Anatomists, 2005; 234(3): 670-81.
Kulkarni Rajan P, Mishra Swaroop, Fraser Scott E, Davis Mark E   Single cell kinetics of intracellular, nonviral, nucleic acid delivery vehicle acidification and trafficking Bioconjugate chemistry, 2005; 16(4): 986-94.
Kulkarni Rajan P, Wu David D, Davis Mark E, Fraser Scott E   Quantitating intracellular transport of polyplexes by spatio-temporal image correlation spectroscopy Proceedings of the National Academy of Sciences of the United States of America, 2005; 102(21): 7523-8.
Jung Hyungil, Kulkarni Rajan, Collier C Patrick   Dip-pen nanolithography of reactive alkoxysilanes on glass Journal of the American Chemical Society, 2003; 125(40): 12096-7.

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