Dale Bredesen, M.D.

A Short Biography:

Dr. Bredesen is internationally recognized as an expert in the mechanisms of neurodegenerative diseases such as Alzheimer’s disease. He graduated from Caltech, then earned his MD from Duke University Medical Center in Durham, NC. He served as Chief Resident in Neurology at the University of California, San Francisco (UCSF) before joining Nobel laureate Stanley Prusiner’s laboratory at UCSF as an NIH Postdoctoral Fellow. He held faculty positions at UCSF, UCLA and the University of California, San Diego. Dr. Bredesen directed the Program on Aging at the Burnham Institute before coming to the Buck Institute in 1998 as its founding President and CEO.

Work Titles
UCLA Instructor, Neurology
Education:
Degrees:
M.D.

Contact Information:

Email Address:

dbredesen@mednet.ucla.edu


Detailed Biography:

Dr. Bredesen is internationally recognized as an expert in the mechanisms of neurodegenerative diseases such as Alzheimer’s disease. He graduated from Caltech, then earned his MD from Duke University Medical Center in Durham, NC. He served as Chief Resident in Neurology at the University of California, San Francisco (UCSF) before joining Nobel laureate Stanley Prusiner’s laboratory at UCSF as an NIH Postdoctoral Fellow. He held faculty positions at UCSF, UCLA and the University of California, San Diego. Dr. Bredesen directed the Program on Aging at the Burnham Institute before coming to the Buck Institute in 1998 as its founding President and CEO. The uniform failure of recent drug trials in Alzheimer’s disease has highlighted the critical need for a more accurate understanding of the fundamental nature of Alzheimer’s disease. Dr. Bredesen’s research has led to new insight that explains the erosion of memory seen in Alzheimer’s disease, and has opened the door to a new therapeutic approach. He has found evidence that Alzheimer’s disease stems from an imbalance in nerve cell signaling: in the normal brain, specific signals foster nerve connections and memory making, while balancing signals support memory breaking, allowing irrelevant information to be forgotten. But in Alzheimer’s disease, the balance of these opposing signals is disturbed, nerve connections are suppressed, and memories are lost. This model is contrary to popular dogma that Alzheimer’s is a disease of toxicity, caused by the accumulation of sticky plaques in the brain. Bredesen believes the amyloid beta peptide, the source of the plaques, has a normal function in the brain -- promoting signals that allow some of the nerve connections to lapse. Thus the increase in the peptide that occurs in Alzheimer’s disease shifts the memory-making vs. memory-breaking balance in favor of memory loss. This work has led to the identification of several new therapeutic candidates that are currently in pre-clinical trials. Dr. Bredesen’s novel insights into the fundamental nature of Alzheimer’s disease recently attracted an investment of $3.5 million toward a $10 million goal for initial clinical trials of these new therapeutics. This generous support came from the private venture capitalist Douglas Rosenberg, who is helping to fund the Alzheimer’s Drug Discovery Network, centered at the Buck Institute. The unit is screening drug candidates to find those that can preserve a healthy balance in the signaling pathways that support memory. Dr. Bredesen’s work on nerve cell signaling is also the focus of a collaboration between the Buck Institute and BioMarin Pharmaceuticals, Inc., which is seeking treatments for a rare form of Alzheimer’s disease, early onset Familial Alzheimer’s Disease (eFAD), which may develop in people as young as 30 years of age.

Publications:

A selected list of publications:

Fiala Milan, Halder Ramesh C, Sagong Bien, Ross Olivia, Sayre James, Porter Verna, Bredesen Dale E   ω-3 Supplementation increases amyloid-β phagocytosis and resolvin D1 in patients with minor cognitive impairment FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015; .
Ellerby H Michael, Bredesen Dale E, Fujimura Satoshi, John Varghese   Correction to hunter-killer peptide (HKP) for targeted therapy Journal of medicinal chemistry, 2015; 58(4): 2045.
Bredesen Dale E   Reversal of cognitive decline: a novel therapeutic program Aging, 2014; 6(9): 707-17.
Zhang Qiang, Descamps Olivier, Hart Matthew J, Poksay Karen S, Spilman Patricia, Kane Darci J, Gorostiza Olivia, John Varghese, Bredesen Dale E   Paradoxical effect of TrkA inhibition in Alzheimer's disease models Journal of Alzheimer's disease : JAD, 2014; 40(3): 605-17.
Spilman Patricia, Descamps Olivier, Gorostiza Olivia, Peters-Libeu Clare, Poksay Karen S, Matalis Alexander, Campagna Jesus, Patent Alexander, Rao Rammohan, John Varghese, Bredesen Dale E   The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model Brain research, 2014; 1551(9): 25-44.
Theendakara Veena, Patent Alexander, Peters Libeu Clare A, Philpot Brittany, Flores Sonia, Descamps Olivier, Poksay Karen S, Zhang Qiang, Cailing Gabriellee, Hart Matthew, John Varghese, Rao Rammohan V, Bredesen Dale E   Neuroprotective Sirtuin ratio reversed by ApoE4 Proceedings of the National Academy of Sciences of the United States of America, 2013; 110(45): 18303-8.
Bredesen Dale E, John Varghese   Next generation therapeutics for Alzheimer's disease EMBO molecular medicine, 2013; 5(6): 795-8.
Descamps Olivier, Spilman Patricia, Zhang Qiang, Libeu Clare P, Poksay Karen, Gorostiza Olivia, Campagna Jesus, Jagodzinska Barbara, Bredesen Dale E, John Varghese   AβPP-selective BACE inhibitors (ASBI): novel class of therapeutic agents for alzheimer's disease Journal of Alzheimer's disease : JAD, 2013; 37(2): 343-55.
Zhang Junli, Spilman Patricia, Chen Sylvia, Gorostiza Olivia, Matalis Alex, Niazi Kayvan, Bredesen Dale E, Rao Rammohan V   The small co-chaperone p23 overexpressing transgenic mouse Journal of neuroscience methods, 2013; 212(2): 190-4.
Sultana Rukhsana, Robinson Renã A S, Lange Miranda Bader, Fiorini Ada, Galvan Veronica, Fombonne Joanna, Baker Austin, Gorostiza Olivia, Zhang Junli, Cai Jian, Pierce William M, Bredesen Dale E, Butterfield D Allan   Do proteomics analyses provide insights into reduced oxidative stress in the brain of an Alzheimer disease transgenic mouse model with an M631L amyloid precursor protein substitution and thereby the importance of amyloid-beta-resident methionine 35 in Alzheimer disease pathogenesis? Antioxidants & redox signaling, 2012; 17(11): 1507-14.
Rao Rammohan V, Descamps Olivier, John Varghese, Bredesen Dale E   Ayurvedic medicinal plants for Alzheimer's disease: a review Alzheimer's research & therapy, 2012; 4(3): 22.
Choi Sung W, Gerencser Akos A, Ng Ryan, Flynn James M, Melov Simon, Danielson Steven R, Gibson Bradford W, Nicholls David G, Bredesen Dale E, Brand Martin D   No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012; 32(47): 16775-84.
Bredesen Dale   mCiRNA-synaptic crystal ball? Aging, 2012; 4(11): 732-3.
Libeu Clare A Peters, Descamps Olivier, Zhang Qiang, John Varghese, Bredesen Dale E   Altering APP proteolysis: increasing sAPPalpha production by targeting dimerization of the APP ectodomain PloS one, 2012; 7(6): e40027.
Rodríguez Plaza Jonathan G, Villalón Rojas Amanda, Herrera Sur, Garza-Ramos Georgina, Torres Larios Alfredo, Amero Carlos, Zarraga Granados Gabriela, Gutiérrez Aguilar Manuel, Lara Ortiz María Teresa, Polanco Gonzalez Carlos, Uribe Carvajal Salvador, Coria Roberto, Peña Díaz Antonio, Bredesen Dale E, Castro-Obregon Susana, del Rio Gabriel   Moonlighting peptides with emerging function PloS one, 2012; 7(7): e40125.
Poksay Karen S, Banwait Surita, Crippen Danielle, Mao Xiao, Bredesen Dale E, Rao Rammohan V   The small chaperone protein p23 and its cleaved product p19 in cellular stress Journal of molecular neuroscience : MN, 2012; 46(2): 303-14.
Poksay Karen S, Madden David T, Peter Anna K, Niazi Kayvan, Banwait Surita, Crippen Danielle, Bredesen Dale E, Rao Rammohan V   Valosin-containing protein gene mutations: cellular phenotypes relevant to neurodegeneration Journal of molecular neuroscience : MN, 2011; 44(2): 91-102.
Mehlen Patrick, Bredesen Dale E   Dependence receptors: from basic research to drug development Science signaling, 2011; 4(157): mr2.
Zhang Junli, Rao Rammohan V, Spilman Patricia, Mangada Julie, Xie Lin, Vitelli Cathy, Gorostiza Olivia F, Madden David T, Zeng Xianmin, Jin Kunlin, Hart Matthew J, Bredesen Dale E, Galvan Veronica   Endogenously EGFP-Labeled Mouse Embryonic Stem Cells Aging and disease, 2011; 2(1): 18-29.
Madden David T, Davila-Kruger Diana, Melov Simon, Bredesen Dale E   Human embryonic stem cells express elevated levels of multiple pro-apoptotic BCL-2 family members PloS one, 2011; 6(12): e28530.
Descamps Olivier, Zhang Qiang, John Varghese, Bredesen Dale E   Induction of the C-terminal proteolytic cleavage of AβPP by statins Journal of Alzheimer's disease : JAD, 2011; 25(1): 51-7.
Orcholski Mark E, Zhang Qiang, Bredesen Dale E   Signaling via amyloid precursor-like proteins APLP1 and APLP2 Journal of Alzheimer's disease : JAD, 2011; 23(4): 689-99.
Libeu Clare Peters, Poksay Karen S, John Varghese, Bredesen Dale E   Structural and functional alterations in amyloid-β precursor protein induced by amyloid-β peptides Journal of Alzheimer's disease : JAD, 2011; 25(3): 547-66.
Sperandio Sabina, Poksay Karen S, Schilling Birgit, Crippen Danielle, Gibson Bradford W, Bredesen Dale E   Identification of new modulators and protein alterations in non-apoptotic programmed cell death Journal of cellular biochemistry, 2010; 111(6): 1401-12.
Spilman Patricia, Podlutskaya Natalia, Hart Matthew J, Debnath Jayanta, Gorostiza Olivia, Bredesen Dale, Richardson Arlan, Strong Randy, Galvan Veronica   Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease PloS one, 2010; 5(4): e9979.
Bredesen Dale E, John Varghese, Galvan Veronica   Importance of the caspase cleavage site in amyloid-β protein precursor Journal of Alzheimer's disease : JAD, 2010; 22(1): 57-63.
Butterfield D Allan, Galvan Veronica, Lange Miranda Bader, Tang Huidong, Sowell Renã A, Spilman Patricia, Fombonne Joanna, Gorostiza Olivia, Zhang Junli, Sultana Rukhsana, Bredesen Dale E   In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid beta-peptide of APP Free radical biology & medicine, 2010; 48(1): 136-44.
Harris Julie A, Devidze Nino, Halabisky Brian, Lo Iris, Thwin Myo T, Yu Gui-Qiu, Bredesen Dale E, Masliah Eliezer, Mucke Lennart   Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010; 30(1): 372-81.
Zhang Junli, Gorostiza Olivia F, Tang Huidong, Bredesen Dale E, Galvan Veronica   Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: a role for early experience Behavioural brain research, 2010; 206(2): 202-7.
Swistowski Andrzej, Zhang Qiang, Orcholski Mark E, Crippen Danielle, Vitelli Cathy, Kurakin Alexei, Bredesen Dale E   Novel mediators of amyloid precursor protein signaling The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009; 29(50): 15703-12.
Park Sun Ah, Shaked Gideon M, Bredesen Dale E, Koo Edward H   Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein Biochemical and biophysical research communications, 2009; 388(2): 450-5.
Chinta Shankar J, Poksay Karen S, Kaundinya Gaayatri, Hart Matthew, Bredesen Dale E, Andersen Julie K, Rao Rammohan V   Endoplasmic reticulum stress-induced cell death in dopaminergic cells: effect of resveratrol Journal of molecular neuroscience : MN, 2009; 39(1-2): 157-68.
Bredesen Dale E   Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence Molecular neurodegeneration, 2009; 4(1-2): 27.
Fombonne Joanna, Rabizadeh Shahrooz, Banwait Surita, Mehlen Patrick, Bredesen Dale E   Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction Annals of neurology, 2009; 65(3): 294-303.
Ellerby H Michael, Bredesen Dale E, Fujimura Satoshi, John Varghese   Hunter-killer peptide (HKP) for targeted therapy Journal of medicinal chemistry, 2008; 51(19): 5887-92.
Galvan Veronica, Zhang Junli, Gorostiza Olivia F, Banwait Surita, Huang Wei, Ataie Marina, Tang Huidong, Bredesen Dale E   Long-term prevention of Alzheimer's disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664 Behavioural brain research, 2008; 191(2): 246-55.
Bakhshi Jason, Weinstein Lee, Poksay Karen S, Nishinaga Brian, Bredesen Dale E, Rao Rammohan V   Coupling endoplasmic reticulum stress to the cell death program in mouse melanoma cells: effect of curcumin Apoptosis : an international journal on programmed cell death, 2008; 13(7): 904-14.
Bredesen Dale E   Programmed cell death mechanisms in neurological disease Current molecular medicine, 2008; 8(3): 173-86.
Banwait Surita, Galvan Veronica, Zhang Junli, Gorostiza Olivia F, Ataie Marina, Huang Wei, Crippen Danielle, Koo Edward H, Bredesen Dale E   C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's disease Journal of Alzheimer's disease : JAD, 2008; 13(1): 1-16.
Chinta Shankar J, Rane Anand, Poksay Karen S, Bredesen Dale E, Andersen Julie K, Rao Rammohan V   Coupling endoplasmic reticulum stress to the cell death program in dopaminergic cells: effect of paraquat Neuromolecular medicine, 2008; 10(4): 333-42.
Klionsky Daniel J, Abeliovich Hagai, Agostinis Patrizia, Agrawal Devendra K, Aliev Gjumrakch, Askew David S, Baba Misuzu, Baehrecke Eric H, Bahr Ben A, Ballabio Andrea, Bamber Bruce A, Bassham Diane C, Bergamini Ettore, Bi Xiaoning, Biard-Piechaczyk Martine, Blum Janice S, Bredesen Dale E, Brodsky Jeffrey L, Brumell John H, Brunk Ulf T, Bursch Wilfried, Camougrand Nadine, Cebollero Eduardo, Cecconi Francesco, Chen Yingyu, Chin Lih-Shen, Choi Augustine, Chu Charleen T, Chung Jongkyeong, Clarke Peter G H, Clark Robert S B, Clarke Steven G, Clavé Corinne, Cleveland John L, Codogno Patrice, Colombo María I, Coto-Montes Ana, Cregg James M, Cuervo Ana Maria, Debnath Jayanta, Demarchi Francesca, Dennis Patrick B, Dennis Phillip A, Deretic Vojo, Devenish Rodney J, Di Sano Federica, Dice J Fred, Difiglia Marian, Dinesh-Kumar Savithramma, Distelhorst Clark W, Djavaheri-Mergny Mojgan, Dorsey Frank C, Dröge Wulf, Dron Michel, Dunn William A, Duszenko Michael, Eissa N Tony, Elazar Zvulun, Esclatine Audrey, Eskelinen Eeva-Liisa, Fésüs László, Finley Kim D, Fuentes José M, Fueyo Juan, Fujisaki Kozo, Galliot Brigitte, Gao Fen-Biao, Gewirtz David A, Gibson Spencer B, Gohla Antje, Goldberg Alfred L, Gonzalez Ramon, González-Estévez Cristina, Gorski Sharon, Gottlieb Roberta A, Häussinger Dieter, He You-Wen, Heidenreich Kim, Hill Joseph A, Høyer-Hansen Maria, Hu Xun, Huang Wei-Pang, Iwasaki Akiko, Jäättelä Marja, Jackson William T, Jiang Xuejun, Jin Shengkan, Johansen Terje, Jung Jae U, Kadowaki Motoni, Kang Chanhee, Kelekar Ameeta, Kessel David H, Kiel Jan A K W, Kim Hong Pyo, Kimchi Adi, Kinsella Timothy J, Kiselyov Kirill, Kitamoto Katsuhiko, Knecht Erwin, Komatsu Masaaki, Kominami Eiki, Kondo Seiji, Kovács Attila L, Kroemer Guido, Kuan Chia-Yi, Kumar Rakesh, Kundu Mondira, Landry Jacques, Laporte Marianne, Le Weidong, Lei Huan-Yao, Lenardo Michael J, Levine Beth, Lieberman Andrew, Lim Kah-Leong, Lin Fu-Cheng, Liou Willisa, Liu Leroy F, Lopez-Berestein Gabriel, López-Otín Carlos, Lu Bo, Macleod Kay F, Malorni Walter, Martinet Wim, Matsuoka Ken, Mautner Josef, Meijer Alfred J, Meléndez Alicia, Michels Paul, Miotto Giovanni, Mistiaen Wilhelm P, Mizushima Noboru, Mograbi Baharia, Monastyrska Iryna, Moore Michael N, Moreira Paula I, Moriyasu Yuji, Motyl Tomasz, Münz Christian, Murphy Leon O, Naqvi Naweed I, Neufeld Thomas P, Nishino Ichizo, Nixon Ralph A, Noda Takeshi, Nürnberg Bernd, Ogawa Michinaga, Oleinick Nancy L, Olsen Laura J, Ozpolat Bulent, Paglin Shoshana, Palmer Glen E, Papassideri Issidora, Parkes Miles, Perlmutter David H, Perry George, Piacentini Mauro, Pinkas-Kramarski Ronit, Prescott Mark, Proikas-Cezanne Tassula, Raben Nina, Rami Abdelhaq, Reggiori Fulvio, Rohrer Bärbel, Rubinsztein David C, Ryan Kevin M, Sadoshima Junichi, Sakagami Hiroshi, Sakai Yasuyoshi, Sandri Marco, Sasakawa Chihiro, Sass Miklós, Schneider Claudio, Seglen Per O, Seleverstov Oleksandr, Settleman Jeffrey, Shacka John J, Shapiro Irving M, Sibirny Andrei, Silva-Zacarin Elaine C M, Simon Hans-Uwe, Simone Cristiano, Simonsen Anne, Smith Mark A, Spanel-Borowski Katharina, Srinivas Vickram, Steeves Meredith, Stenmark Harald, Stromhaug Per E, Subauste Carlos S, Sugimoto Seiichiro, Sulzer David, Suzuki Toshihiko, Swanson Michele S, Tabas Ira, Takeshita Fumihiko, Talbot Nicholas J, Tallóczy Zsolt, Tanaka Keiji, Tanaka Kozo, Tanida Isei, Taylor Graham S, Taylor J Paul, Terman Alexei, Tettamanti Gianluca, Thompson Craig B, Thumm Michael, Tolkovsky Aviva M, Tooze Sharon A, Truant Ray, Tumanovska Lesya V, Uchiyama Yasuo, Ueno Takashi, Uzcátegui Néstor L, van der Klei Ida, Vaquero Eva C, Vellai Tibor, Vogel Michael W, Wang Hong-Gang, Webster Paul, Wiley John W, Xi Zhijun, Xiao Gutian, Yahalom Joachim, Yang Jin-Ming, Yap George, Yin Xiao-Ming, Yoshimori Tamotsu, Yu Li, Yue Zhenyu, Yuzaki Michisuke, Zabirnyk Olga, Zheng Xiaoxiang, Zhu Xiongwei, Deter Russell L   Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes Autophagy, 2008; 4(2): 151-75.
Nguyen Thuy-Vi V, Galvan Veronica, Huang Wei, Banwait Surita, Tang Huidong, Zhang Junli, Bredesen Dale E   Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664 Journal of neurochemistry, 2008; 104(4): 1065-80.
Bredesen Dale E, Rabizadeh Shahrooz   APP-based neuroprotective strategies Current Alzheimer research, 2007; 4(5): 541-3.
Levy Robert M, Bredesen Dale E, Rosenblum Mark L   Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): experience at UCSF and review of the literature. 1985 Journal of neurosurgery, 2007; 107(6): 1253-73; discussion 1251.
Madden David T, Egger Lotti, Bredesen Dale E   A calpain-like protease inhibits autophagic cell death Autophagy, 2007; 3(5): 519-22.
del Rio Gabriel, Kane Darci J, Ball Keith D, Bredesen Dale E   A novel motif identified in dependence receptors PloS one, 2007; 2(5): e463.
Cusack Michael P, Thibert Boris, Bredesen Dale E, Del Rio Gabriel   Efficient identification of critical residues based only on protein structure by network analysis PloS one, 2007; 2(5): e421.
Galvan Veronica, Banwait Surita, Spilman Patricia, Gorostiza Olivia F, Peel Alyson, Ataie Marina, Crippen Danielle, Huang Wei, Sidhu Gurleen, Ichijo Hidenori, Bredesen Dale E   Interaction of ASK1 and the beta-amyloid precursor protein in a stress-signaling complex Neurobiology of disease, 2007; 28(1): 65-75.
Galvan Veronica, Bredesen Dale E   Neurogenesis in the adult brain: implications for Alzheimer's disease CNS & neurological disorders drug targets, 2007; 6(5): 303-10.
Young Jessica E, Gouw Launce, Propp Stephanie, Sopher Bryce L, Taylor Jillian, Lin Amy, Hermel Evan, Logvinova Anna, Chen Sylvia F, Chen Shiming, Bredesen Dale E, Truant Ray, Ptacek Louis J, La Spada Albert R, Ellerby Lisa M   Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation The Journal of biological chemistry, 2007; 282(41): 30150-60.
Kurakin Alexei, Swistowski Andrzej, Wu Susan C, Bredesen Dale E   The PDZ domain as a complex adaptive system PloS one, 2007; 2(9): e953.
Kurakin Alexei, Bredesen Dale E   An unconventional IAP-binding motif revealed by target-assisted iterative screening (TAIS) of the BIR3-cIAP1 domain Journal of molecular recognition : JMR, 2007; 20(1): 39-50.
Stoka Veronika, Turk Vito, Bredesen Dale E   Differential regulation of Smac/DIABLO and Hsp-70 during brain maturation Neuromolecular medicine, 2007; 9(3): 255-63.
Bredesen Dale E   Key note lecture: toward a mechanistic taxonomy for cell death programs Stroke; a journal of cerebral circulation, 2007; 38(2 Suppl): 652-60.
Saganich Michael J, Schroeder Brock E, Galvan Veronica, Bredesen Dale E, Koo Edward H, Heinemann Stephen F   Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006; 26(52): 13428-36.
Bredesen Dale E, Rao Rammohan V, Mehlen Patrick   Cell death in the nervous system Nature, 2006; 443(7113): 796-802.
Stoka Veronika, Turk Vito, Bredesen Dale E   Differential regulation of the intrinsic pathway of apoptosis in brain and liver during ageing FEBS letters, 2006; 580(15): 3739-45.
Galvan Veronica, Gorostiza Olivia F, Banwait Surita, Ataie Marina, Logvinova Anna V, Sitaraman Sandhya, Carlson Elaine, Sagi Sarah A, Chevallier Nathalie, Jin Kunlin, Greenberg David A, Bredesen Dale E   Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664 Proceedings of the National Academy of Sciences of the United States of America, 2006; 103(18): 7130-5.
Stoka Veronika, Chen Sylvia F, Turk Vito, Bredesen Dale E   Developmental shift in the apostat: comparison of neurones and astrocytes FEBS letters, 2005; 579(27): 6147-50.
Thibert Boris, Bredesen Dale E, del Rio Gabriel   Improved prediction of critical residues for protein function based on network and phylogenetic analyses BMC bioinformatics, 2005; 6(11): 213.
Warner Huber, Anderson Julie, Austad Steven, Bergamini Ettore, Bredesen Dale, Butler Robert, Carnes Bruce A, Clark Brian F C, Cristofalo Vincent, Faulkner John, Guarente Leonard, Harrison David E, Kirkwood Tom, Lithgow Gordon, Martin George, Masoro Ed, Melov Simon, Miller Richard A, Olshansky S Jay, Partridge Linda, Pereira-Smith Olivia, Perls Tom, Richardson Arlan, Smith James, von Zglinicki Thomas, Wang Eugenia, Wei Jeanne Y, Williams T Franklin   Science fact and the SENS agenda. What can we reasonably expect from ageing research? EMBO reports, 2005; 6(11): 1006-8.
Cottrell Barbara A, Galvan Veronica, Banwait Surita, Gorostiza Olivia, Lombardo Christian R, Williams Tristan, Schilling Birgit, Peel Alyson, Gibson Bradford, Koo Edward H, Link Christopher D, Bredesen Dale E   A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease Annals of neurology, 2005; 58(2): 277-89.
Rao Rammohan V, Bredesen Dale E   Misfolded proteins, endoplasmic reticulum stress and neurodegeneration Current opinion in cell biology, 2004; 16(6): 653-62.
Bredesen Dale E   Toward a mechanistic taxonomy of cell death programs Journal of Alzheimer's disease : JAD, 2004; 6(6 Suppl): S3-6.
Bredesen Dale E   Rebuttal to Austad: 'Is aging programmed? Aging cell, 2004; 3(5): 261-2.
Bredesen Dale E   The non-existent aging program: how does it work? Aging cell, 2004; 3(5): 255-9.
Jin Kunlin, Galvan Veronica, Xie Lin, Mao Xiao Ou, Gorostiza Olivia F, Bredesen Dale E, Greenberg David A   Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) mice Proceedings of the National Academy of Sciences of the United States of America, 2004; 101(36): 13363-7.
Mazelin Laetitia, Bernet Agnès, Bonod-Bidaud Christelle, Pays Laurent, Arnaud Ségolène, Gespach Christian, Bredesen Dale E, Scoazec Jean-Yves, Mehlen Patrick   Netrin-1 controls colorectal tumorigenesis by regulating apoptosis Nature, 2004; 431(7004): 80-4.
Hashimoto Yuichi, Kaneko Yuka, Tsukamoto Emi, Frankowski Harald, Kouyama Keisuke, Kita Yoshiko, Niikura Takako, Aiso Sadakazu, Bredesen Dale E, Matsuoka Masaaki, Nishimoto Ikuo   Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid-beta peptides via p75NTR/PLAIDD Journal of neurochemistry, 2004; 90(3): 549-58.
Castro-Obregón Susana, Rao Rammohan V, del Rio Gabriel, Chen Sylvia F, Poksay Karen S, Rabizadeh Shahrooz, Vesce Sabino, Zhang Xiao-Khun, Swanson Raymond A, Bredesen Dale E   Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77 The Journal of biological chemistry, 2004; 279(17): 17543-53.
Bredesen Dale E, Mehlen Patrick, Rabizadeh Shahrooz   Apoptosis and dependence receptors: a molecular basis for cellular addiction Physiological reviews, 2004; 84(2): 411-30.
Rao Rammohan V, Poksay Karen S, Castro-Obregon Susana, Schilling Birgit, Row Richard H, del Rio Gabriel, Gibson Bradford W, Ellerby H Michael, Bredesen Dale E   Molecular components of a cell death pathway activated by endoplasmic reticulum stress The Journal of biological chemistry, 2004; 279(1): 177-87.
Kurakin Alexei, Wu Susan, Bredesen Dale E   Target-assisted iterative screening of phage surface display cDNA libraries Methods in molecular biology (Clifton, N.J.), 2004; 264(1): 47-60.
Peel Alyson L, Sorscher Noah, Kim Joseph Y, Galvan Veronica, Chen Sylvia, Bredesen Dale E   Tau phosphorylation in Alzheimer's disease: potential involvement of an APP-MAP kinase complex Neuromolecular medicine, 2004; 5(3): 205-18.
Yokota Takanori, Miyagishi Makoto, Hino Taro, Matsumura Ryusuke, Tasinato Andrea, Urushitani Makoto, Rao Rammohan V, Takahashi Ryosuke, Bredesen Dale E, Taira Kazunari, Mizusawa Hidehiro, Andrea Tasinato   siRNA-based inhibition specific for mutant SOD1 with single nucleotide alternation in familial ALS, compared with ribozyme and DNA enzyme Biochemical and biophysical research communications, 2004; 314(1): 283-91.
Lu Daniel C, Shaked Gideon M, Masliah Eliezer, Bredesen Dale E, Koo Edward H   Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes Annals of neurology, 2003; 54(6): 781-9.
Mehlen Patrick, Bredesen Dale E   Meeting report: cellular dependence--old concept, new mechanisms Science's STKE : signal transduction knowledge environment, 2003; 2003(213): pe55.
Lu Daniel C, Soriano Salvador, Bredesen Dale E, Koo Edward H   Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity Journal of neurochemistry, 2003; 87(3): 733-41.
Peel Alyson L, Bredesen Dale E   Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice Neurobiology of disease, 2003; 14(1): 52-62.
Ellerby H Michael, Lee Sannamu, Ellerby Lisa M, Chen Sylvia, Kiyota Taira, del Rio Gabriel, Sugihara Gohsuke, Sun Yan, Bredesen Dale E, Arap Wadih, Pasqualini Renata   An artificially designed pore-forming protein with anti-tumor effects The Journal of biological chemistry, 2003; 278(37): 35311-6.
Kurakin Alexei V, Wu Susan, Bredesen Dale E   Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening The Journal of biological chemistry, 2003; 278(36): 34102-9.
Rabizadeh Shahrooz, Bredesen Dale E   Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR) Cytokine & growth factor reviews, 2003; 14(3-4): 225-39.
Galvan Veronica, Logvinova Anna, Sperandio Sabina, Ichijo Hidenori, Bredesen Dale E   Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1) The Journal of biological chemistry, 2003; 278(15): 13325-32.
Wellington Cheryl L, Ellerby Lisa M, Gutekunst Claire-Anne, Rogers Danny, Warby Simon, Graham Rona K, Loubser Odell, van Raamsdonk Jeremy, Singaraja Roshni, Yang Yu-Zhou, Gafni Juliette, Bredesen Dale, Hersch Steven M, Leavitt Blair R, Roy Sophie, Nicholson Donald W, Hayden Michael R   Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002; 22(18): 7862-72.
Galvan Veronica, Chen Sylvia, Lu Daniel, Logvinova Anna, Goldsmith Paul, Koo Edward H, Bredesen Dale E   Caspase cleavage of members of the amyloid precursor family of proteins Journal of neurochemistry, 2002; 82(2): 283-94.
Rao Rammohan V, Castro-Obregon Susana, Frankowski Harald, Schuler Martin, Stoka Veronica, del Rio Gabriel, Bredesen Dale E, Ellerby H Michael   Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway The Journal of biological chemistry, 2002; 277(24): 21836-42.
Kurakin Alexei, Bredesen Dale   Target-assisted iterative screening reveals novel interactors for PSD95, Nedd4, Src, Abl and Crk proteins Journal of biomolecular structure & dynamics, 2002; 19(6): 1015-29.
Rao Rammohan V, Peel Alyson, Logvinova Anna, del Rio Gabriel, Hermel Evan, Yokota Takanori, Goldsmith Paul C, Ellerby Lisa M, Ellerby H Michael, Bredesen Dale E   Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78 FEBS letters, 2002; 514(2-3): 122-8.
Frankowski Harald, Castro-Obregon Susana, del Rio Gabriel, Rao Rammohan V, Bredesen Dale E   PLAIDD, a type II death domain protein that interacts with p75 neurotrophin receptor Neuromolecular medicine, 2002; 1(3): 153-70.
Arap Wadih, Haedicke Wolfgang, Bernasconi Michele, Kain Renate, Rajotte Daniel, Krajewski Stanislaw, Ellerby H Michael, Bredesen Dale E, Pasqualini Renata, Ruoslahti Erkki   Targeting the prostate for destruction through a vascular address Proceedings of the National Academy of Sciences of the United States of America, 2002; 99(3): 1527-31.

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