Theodore Friedman, M.D., Ph.D.

Work Titles
CTSI Member, CTSI Investigator, Workforce Development
Charles Drew University Chairman, Internal Medicine
UCLA Associate Professor, Medicine

Contact Information:

Work Email Address:

Work Phone Number:

(310) 668-5197


Office Address:

1731 E 120th St
Los Angeles, CA 90059

Detailed Biography:

Theodore C. Friedman, M.D., Ph.D. has a private practice specializing in treating patients with adrenal, pituitary, thyroid and fatigue disorders. His practice includes detecting and treating hormone imbalances, including hormone replacement therapy. Dr. Friedman is also an expert in diagnosing and treating pituitary disorders, including Cushings disease and syndrome. Dr. Friedman has privileges at Cedars-Sinai Medical Center and Martin Luther King Medical Center. Dr. Friedman's career reflects his ongoing quest to better understand and treat endocrine problems. With both medical and research doctoral degrees, he has conducted studies and cared for patients at some of the country's most prestigious institutions, including the University of Michigan, the NationaI Institutes of Health, Cedars-Sinai Medical Center, and UCLA's Charles Drew University of Medicine and Science.


A selected list of publications:

Mojtahedzadeh Mona, Lee Martin L, Friedman Theodore C   Continuation or discontinuation of pioglitazone when starting bedtime insulin in patients with poorly controlled type 2 diabetes in an inner-city population Journal of diabetes and its complications, ; 29(8): 1248-52.
Wang Ying, Yan Chaoying, Liu Limei, Wang Wei, Du Hanze, Fan Winnie, Lutfy Kabirullah, Jiang Meisheng, Friedman Theodore C, Liu Yanjun   11β-Hydroxysteroid dehydrogenase type 1 shRNA ameliorates glucocorticoid-induced insulin resistance and lipolysis in mouse abdominal adipose tissue American journal of physiology. Endocrinology and metabolism, 2015; 308(1): E84-95.
O'Dell Laura E, Natividad Luis A, Pipkin Joseph A, Roman Francisco, Torres Ivan, Jurado Jesus, Torres Oscar V, Friedman Theodore C, Tenayuca John M, Nazarian Arbi   Enhanced nicotine self-administration and suppressed dopaminergic systems in a rat model of diabetes Addiction biology, 2014; 19(6): 1006-19.
Sinha-Hikim Indrani, Friedman Theodore C, Shin Chang-Sung, Lee Desean, Ivey Rasheed, Sinha-Hikim Amiya P   Nicotine in combination with a high-fat diet causes intramyocellular mitochondrial abnormalities in male mice Endocrinology, 2014; 155(3): 865-72.
Wang Ying, Liu Limei, Du Hanze, Nagaoka Yoshiko, Fan Winnie, Lutfy Kabirullah, Friedman Theodore C, Jiang Meisheng, Liu Yanjun   Transgenic overexpression of hexose-6-phosphate dehydrogenase in adipose tissue causes local glucocorticoid amplification and lipolysis in male mice American journal of physiology. Endocrinology and metabolism, 2014; 306(5): E543-51.
Liu Limei, Nagashima Kazuaki, Yasuda Takao, Liu Yanjun, Hu Hai-Rong, He Guang, Feng Bo, Zhao Mingming, Zhuang Langen, Zheng Taishan, Friedman Theodore C, Xiang Kunsan   Mutations in KCNJ11 are associated with the development of autosomal dominant, early-onset type 2 diabetes Diabetologia, 2013; 56(12): 2609-18.
Natividad Luis A, Torres Oscar V, Friedman Theodore C, O'Dell Laura E   Adolescence is a period of development characterized by short- and long-term vulnerability to the rewarding effects of nicotine and reduced sensitivity to the anorectic effects of this drug Behavioural brain research, 2013; 257(12): 275-85.
Nie Ying, Ferrini Monica G, Liu Yanjun, Anghel Adrian, Espinosa Enma V Paez, Stuart Ronald C, Lutfy Kabirullah, Nillni Eduardo A, Friedman Theodore C   Morphine treatment selectively regulates expression of rat pituitary POMC and the prohormone convertases PC1/3 and PC2 Peptides, 2013; 47(12): 99-109.
Du Hanze, Liu Limei, Wang Ying, Nakagawa Yuichi, Lyzlov Alexei, Lutfy Kabirullah, Friedman Theodore C, Peng Xiaozhong, Liu Yanjun   Specific reduction of G6PT may contribute to downregulation of hepatic 11β-HSD1 in diabetic mice Journal of molecular endocrinology, 2013; 50(2): 167-78.
Teruya Stacey A, Bazargan-Hejazi Shahrzad, Mojtahedzadeh Mona, Doshi Megha, Russell Katherine, Parker-Kelly Darlene, Friedman Theodore C   A Review of Programs, Components and Outcomes in Biomedical Research Faculty Development International journal of university teaching and faculty development, 2013; 4(4): 223-236.
Ren Xiuhai, Lutfy Kabirullah, Mangubat Michael, Ferrini Monica G, Lee Martin L, Liu Yanjun, Friedman Theodore C   Alterations in phosphorylated CREB expression in different brain regions following short- and long-term morphine exposure: relationship to food intake Journal of obesity, 2013; 2013(4): 764742.
Davidson Mayer B, Duran Petra, Lee Martin L, Friedman Theodore C   High-dose vitamin D supplementation in people with prediabetes and hypovitaminosis D Diabetes care, 2013; 36(2): 260-6.
Friedman Theodore C, Sinha-Hikim Indrani, Parveen Meher, Najjar Sonia M, Liu Yanjun, Mangubat Michael, Shin Chang-Sung, Lyzlov Alexei, Ivey Rasheed, Shaheen Magda, French Samuel W, Sinha-Hikim Amiya P   Additive effects of nicotine and high-fat diet on hepatic steatosis in male mice Endocrinology, 2012; 153(12): 5809-20.
Tweed Jesse Oliver, Hsia Stanley H, Lutfy Kabirullah, Friedman Theodore C   The endocrine effects of nicotine and cigarette smoke Trends in endocrinology and metabolism: TEM, 2012; 23(7): 334-42.
Nguyen Alexander T, Marquez Paul, Hamid Abdul, Kieffer Brigitte, Friedman Theodore C, Lutfy Kabirullah   The rewarding action of acute cocaine is reduced in β-endorphin deficient but not in μ opioid receptor knockout mice European journal of pharmacology, 2012; 686(1-3): 50-4.
Rajavashisth Tripathi B, Shaheen Magda, Norris Keith C, Pan Deyu, Sinha Satyesh K, Ortega Juan, Friedman Theodore C   Decreased prevalence of diabetes in marijuana users: cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) III BMJ open, 2012; 2(6): e000494.
Mangubat Michael, Lutfy Kabirullah, Lee Martin L, Pulido Laura, Stout David, Davis Richard, Shin Chang-Sung, Shahbazian Meghdi, Seasholtz Stephen, Sinha-Hikim Amiya, Sinha-Hikim Indrani, O'Dell Laura E, Lyzlov Alexei, Liu Yanjun, Friedman Theodore C   Effect of nicotine on body composition in mice The Journal of endocrinology, 2012; 212(3): 317-26.
Lutfy Kabirullah, Aimiuwu Otaren, Mangubat Michael, Shin Chang-Sung, Nerio Namiko, Gomez Richard, Liu Yanjun, Friedman Theodore C   Nicotine stimulates secretion of corticosterone via both CRH and AVP receptors Journal of neurochemistry, 2012; 120(6): 1108-16.
Friedman Theodore C   Vitamin D supplementation to prevent the progression of prediabetes to diabetes: getting closer to a recommendation Translational research : the journal of laboratory and clinical medicine, 2011; 158(5): 273-5.
Kilimnik German, Kim Abraham, Steiner Donald F, Friedman Theodore C, Hara Manami   Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic α-cells in mouse models of ß-cell regeneration Islets, 2011; 2(3): 149-55.
Parikh Drupad, Hamid Abdul, Friedman Theodore C, Nguyen Khanh, Tseng Andy, Marquez Paul, Lutfy Kabirullah   Stress-induced analgesia and endogenous opioid peptides: the importance of stress duration European journal of pharmacology, 2011; 650(2-3): 563-7.
Chen John, Patel Roshni, Friedman Theodore C, Jones Kevin S   The Behavioral and Pharmacological Actions of NMDA Receptor Antagonism are Conserved in Zebrafish Larvae International journal of comparative psychology / ISCP ; sponsored by the International Society for Comparative Psychology and the University of Calabria, 2010; 23(1): 82-90.
Vuong Cassidy, Van Uum Stan H M, O'Dell Laura E, Lutfy Kabirullah, Friedman Theodore C   The effects of opioids and opioid analogs on animal and human endocrine systems Endocrine reviews, 2010; 31(1): 98-132.
Yuen Kevin C J, Cook David M, Sahasranam Prem, Patel Pragnesh, Ghods David E, Shahinian Hrayr K, Friedman Theodore C   Prevalence of GH and other anterior pituitary hormone deficiencies in adults with nonsecreting pituitary microadenomas and normal serum IGF-1 levels Clinical endocrinology, 2008; 69(2): 292-8.
Liu Yanjun, Nakagawa Yuichi, Wang Ying, Liu Limei, Du Hongwei, Wang Wei, Ren Xiuhai, Lutfy Kabirullah, Friedman Theodore C   Reduction of hepatic glucocorticoid receptor and hexose-6-phosphate dehydrogenase expression ameliorates diet-induced obesity and insulin resistance in mice Journal of molecular endocrinology, 2008; 41(2): 53-64.
Sahasranam Prem, Tran Michael T, Mohamed Hezla, Friedman Theodore C   Multiglandular parathyroid carcinoma: a case report and brief review Southern medical journal, 2007; 100(8): 841-4.
Espinosa Veronica Paez, Ferrini Monica, Shen Xiaoxiong, Lutfy Kabirullah, Nillni Eduardo A, Friedman Theodore C   Cellular colocalization and coregulation between hypothalamic pro-TRH and prohormone convertases in hypothyroidism American journal of physiology. Endocrinology and metabolism, 2007; 292(1): E175-86.
Lutfy Kabirullah, Brown Maria C, Nerio Namiko, Aimiuwu Otaren, Tran Benjamin, Anghel Adrian, Friedman Theodore C   Repeated stress alters the ability of nicotine to activate the hypothalamic-pituitary-adrenal axis Journal of neurochemistry, 2006; 99(5): 1321-7.
Liu Yanjun, Yan Chaoying, Wang Ying, Nakagawa Yuichi, Nerio Namiko, Anghel Adrian, Lutfy Kabirullah, Friedman Theodore C   Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice Endocrinology, 2006; 147(11): 5061-8.
Marquez Paul, Baliram Ramkumarie, Gajawada Nagaraju, Friedman Theodore C, Lutfy Kabirullah   Differential involvement of enkephalins in analgesic tolerance, locomotor sensitization, and conditioned place preference induced by morphine Behavioral neuroscience, 2006; 120(1): 10-5.
McGirr Rebecca, Ejbick Christina E, Carter David E, Andrews Joseph D, Nie Ying, Friedman Theodore C, Dhanvantari Savita   Glucose dependence of the regulated secretory pathway in alphaTC1-6 cells Endocrinology, 2005; 146(10): 4514-23.
Hardiman Atira, Friedman Theodore C, Grunwald William C, Furuta Machi, Zhu Ziaorong, Steiner Donald F, Cool David R   Endocrinomic profile of neurointermediate lobe pituitary prohormone processing in PC1/3- and PC2-Null mice using SELDI-TOF mass spectrometry Journal of molecular endocrinology, 2005; 34(3): 739-51.
Liu Yanjun, Nakagawa Yuichi, Wang Ying, Sakurai Reiko, Tripathi Pinky V, Lutfy Kabirullah, Friedman Theodore C   Increased glucocorticoid receptor and 11{beta}-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db/db mice Diabetes, 2005; 54(1): 32-40.
Shen Xiaoxiong, Li Qiao-Ling, Brent Gregory A, Friedman Theodore C   Regulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoter American journal of physiology. Endocrinology and metabolism, 2005; 288(1): E236-45.
Wang Christina, Swerdloff Ronald, Kipnes Mark, Matsumoto Alvin M, Dobs Adrian S, Cunningham Glenn, Katznelson Laurence, Weber Thomas J, Friedman Theodore C, Snyder Peter, Levine Howard L   New testosterone buccal system (Striant) delivers physiological testosterone levels: pharmacokinetics study in hypogonadal men The Journal of clinical endocrinology and metabolism, 2004; 89(8): 3821-9.
Sanchez Vanesa C, Goldstein Jorge, Stuart Ronald C, Hovanesian Virginia, Huo Lihong, Munzberg Heike, Friedman Theodore C, Bjorbaek Christian, Nillni Eduardo A   Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone The Journal of clinical investigation, 2004; 114(3): 357-69.
Choi Hoon-Ji Helen, Cornford Marcia, Wang Lina, Sun Julie, Friedman Theodore C   Acute chagas' disease presenting with a suprasellar mass and panhypopituitarism Pituitary, 2004; 7(2): 111-4.
Friedman Theodore C, Shahinian Hrayr   Bilateral cerebral aneurysms impinging on the pituitary Pituitary, 2004; 7(3): 193-4.
Friedman Theodore C   Prolactinomas The New England journal of medicine, 2004; 350(10): 1054-7; author reply 1054-7.
Liu Yanjun, Nakagawa Yuichi, Wang Ying, Li Renshan, Li Xiaojun, Ohzeki Takehiko, Friedman Theodore C   Leptin activation of corticosterone production in hepatocytes may contribute to the reversal of obesity and hyperglycemia in leptin-deficient ob/ob mice Diabetes, 2003; 52(6): 1409-16.
Li Qiao-Ling, Naqvi Syed, Shen Xiaoxiong, Liu Yan-Jun, Lindberg Iris, Friedman Theodore C   Prohormone convertase 2 enzymatic activity and its regulation in neuro-endocrine cells and tissues Regulatory peptides, 2003; 110(3): 197-205.
Friedman Theodore C, Norris Keith C   The role of vitamin D in mild to moderate chronic kidney disease Trends in endocrinology and metabolism: TEM, 2002; 13(5): 189-94.
Padero Maria Clara M, Bhasin Shalender, Friedman Theodore C   Androgen supplementation in older women: too much hype, not enough data Journal of the American Geriatrics Society, 2002; 50(6): 1131-40.

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