Publications:
A selected list of publications:
Villanueva Claudio J, Vergnes Laurent, Wang Jiexin, Drew Brian G, Hong Cynthia, Tu Yiping, Hu Yan, Peng Xu, Xu Feng, Saez Enrique, Wroblewski Kevin, Hevener Andrea L, Reue Karen, Fong Loren G, Young Stephen G, Tontonoz Peter
Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ
specifies lipid storage versus thermogenic gene programs
Cell metabolism,
2013; 17(3):
423-35.
Williams Kevin J, Argus Joseph P, Zhu Yue, Wilks Moses Q, Marbois Beth N, York Autumn G, Kidani Yoko, Pourzia Alexandra L, Akhavan David, Lisiero Dominique N, Komisopoulou Evangelia, Henkin Amy H, Soto Horacio, Chamberlain Brian T, Vergnes Laurent, Jung Michael E, Torres Jorge Z, Liau Linda M, Christofk Heather R, Prins Robert M, Mischel Paul S, Reue Karen, Graeber Thomas G, Bensinger Steven J
An essential requirement for the SCAP/SREBP signaling axis to protect
cancer cells from lipotoxicity
Cancer research,
2013; 73(9):
2850-62.
Martin Lisa J, Lau Edward, Singh Harpreet, Vergnes Laurent, Tarling Elizabeth J, Mehrabian Margarete, Mungrue Imran, Xiao Sheila, Shih Diana, Castellani Lawrence, Ping Peipei, Reue Karen, Stefani Enrico, Drake Thomas A, Bostrom Kristina, Lusis Aldons J
Response to Pomozi et al's research commentary
Circulation research,
2013; 112(11):
e152-3.
Kidani Yoko, Elsaesser Heidi, Hock M Benjamin, Vergnes Laurent, Williams Kevin J, Argus Joseph P, Marbois Beth N, Komisopoulou Evangelia, Wilson Elizabeth B, Osborne Timothy F, Graeber Thomas G, Reue Karen, Brooks David G, Bensinger Steven J
Sterol regulatory element-binding proteins are essential for the
metabolic programming of effector T cells and adaptive immunity
Nature immunology,
2013; 14(5):
489-99.
Martin Lisa J, Lau Edward, Singh Harpreet, Vergnes Laurent, Tarling Elizabeth J, Mehrabian Margarete, Mungrue Imran, Xiao Sheila, Shih Diana, Castellani Lawrence, Ping Peipei, Reue Karen, Stefani Enrico, Drake Thomas A, Bostrom Kristina, Lusis Aldons J
ABCC6 localizes to the mitochondria-associated membrane
Circulation research,
2012; 111(5):
516-20.
Ghazalpour Anatole, Rau Christoph D, Farber Charles R, Bennett Brian J, Orozco Luz D, van Nas Atila, Pan Calvin, Allayee Hooman, Beaven Simon W, Civelek Mete, Davis Richard C, Drake Thomas A, Friedman Rick A, Furlotte Nick, Hui Simon T, Jentsch J David, Kostem Emrah, Kang Hyun Min, Kang Eun Yong, Joo Jong Wha, Korshunov Vyacheslav A, Laughlin Rick E, Martin Lisa J, Ohmen Jeffrey D, Parks Brian W, Pellegrini Matteo, Reue Karen, Smith Desmond J, Tetradis Sotirios, Wang Jessica, Wang Yibin, Weiss James N, Kirchgessner Todd, Gargalovic Peter S, Eskin Eleazar, Lusis Aldons J, LeBoeuf Renée C
Hybrid mouse diversity panel: a panel of inbred mouse strains suitable
for analysis of complex genetic traits
Mammalian genome : official journal of the International Mammalian Genome Society,
2012; 23(9-10):
680-92.
Dwyer Jennifer R, Donkor Jimmy, Zhang Peixiang, Csaki Lauren S, Vergnes Laurent, Lee Jessica M, Dewald Jay, Brindley David N, Atti Elisa, Tetradis Sotirios, Yoshinaga Yuko, De Jong Pieter J, Fong Loren G, Young Stephen G, Reue Karen
Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid
homeostasis in liver and aging cerebellum
Proceedings of the National Academy of Sciences of the United States of America,
2012; 109(37):
E2486-95.
Han Sungwon, Bahmanyar Shirin, Zhang Peixiang, Grishin Nick, Oegema Karen, Crooke Roseann, Graham Mark, Reue Karen, Dixon Jack E, Goodman Joel M
Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188)
is the metazoan Spo7p ortholog and functions in the lipin activation
pathway
The Journal of biological chemistry,
2012; 287(5):
3123-37.
Weinstein Michael M, Goulbourne Christopher N, Davies Brandon S J, Tu Yiping, Barnes Richard H, Watkins Steven M, Davis Ryan, Reue Karen, Tontonoz Peter, Beigneux Anne P, Fong Loren G, Young Stephen G
Reciprocal metabolic perturbations in the adipose tissue and liver of
GPIHBP1-deficient mice
Arteriosclerosis, thrombosis, and vascular biology,
2012; 32(2):
230-5.
Chao Lily C, Wroblewski Kevin, Ilkayeva Olga R, Stevens Robert D, Bain James, Meyer Gretchen A, Schenk Simon, Martinez Leonel, Vergnes Laurent, Narkar Vihang A, Drew Brian G, Hong Cynthia, Boyadjian Rima, Hevener Andrea L, Evans Ronald M, Reue Karen, Spencer Melissa J, Newgard Christopher B, Tontonoz Peter
Skeletal muscle Nur77 expression enhances oxidative metabolism and
substrate utilization
Journal of lipid research,
2012; 53(12):
2610-9.
Coffinier Catherine, Jung Hea-Jin, Nobumori Chika, Chang Sandy, Tu Yiping, Barnes Richard H, Yoshinaga Yuko, de Jong Pieter J, Vergnes Laurent, Reue Karen, Fong Loren G, Young Stephen G
Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects
and distinct nuclear shape abnormalities in neurons
Molecular biology of the cell,
2011; 22(23):
4683-93.
Young Stephen G, Davies Brandon S J, Voss Constance V, Gin Peter, Weinstein Michael M, Tontonoz Peter, Reue Karen, Bensadoun André, Fong Loren G, Beigneux Anne P
GPIHBP1, an endothelial cell transporter for lipoprotein lipase
Journal of lipid research,
2011; 52(11):
1869-84.
Vlashi Erina, Lagadec Chann, Vergnes Laurent, Matsutani Tomoo, Masui Kenta, Poulou Maria, Popescu Ruxandra, Della Donna Lorenza, Evers Patrick, Dekmezian Carmen, Reue Karen, Christofk Heather, Mischel Paul S, Pajonk Frank
Metabolic state of glioma stem cells and nontumorigenic cells
Proceedings of the National Academy of Sciences of the United States of America,
2011; 108(38):
16062-7.
Barajas Berenice, Che Nam, Yin Fen, Rowshanrad Amir, Orozco Luz D, Gong Ke Wei, Wang Xuping, Castellani Lawrence W, Reue Karen, Lusis Aldons J, Araujo Jesus A
NF-E2-related factor 2 promotes atherosclerosis by effects on plasma
lipoproteins and cholesterol transport that overshadow antioxidant
protection
Arteriosclerosis, thrombosis, and vascular biology,
2011; 31(1):
58-66.
Devarajan Asokan, Bourquard Noam, Hama Susan, Navab Mohamad, Grijalva Victor R, Morvardi Susan, Clarke Catherine F, Vergnes Laurent, Reue Karen, Teiber John F, Reddy Srinivasa T
Paraoxonase 2 deficiency alters mitochondrial function and exacerbates
the development of atherosclerosis
Antioxidants & redox signaling,
2011; 14(3):
341-51.
Zhang Jin, Khvorostov Ivan, Hong Jason S, Oktay Yavuz, Vergnes Laurent, Nuebel Esther, Wahjudi Paulin N, Setoguchi Kiyoko, Wang Geng, Do Anna, Jung Hea-Jin, McCaffery J Michael, Kurland Irwin J, Reue Karen, Lee Wai-Nang P, Koehler Carla M, Teitell Michael A
UCP2 regulates energy metabolism and differentiation potential of
human pluripotent stem cells
The EMBO journal,
2011; 30(24):
4860-73.
Weinstein Michael M, Tu Yiping, Beigneux Anne P, Davies Brandon S J, Gin Peter, Voss Constance, Walzem Rosemary L, Reue Karen, Tontonoz Peter, Bensadoun André, Fong Loren G, Young Stephen G
Cholesterol intake modulates plasma triglyceride levels in
glycosylphosphatidylinositol HDL-binding protein 1-deficient mice
Arteriosclerosis, thrombosis, and vascular biology,
2010; 30(11):
2106-13.
Péterfy M, Harris TE, Fujita N, Reue K
Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes,
J Biol Chem,
2010; Epub ahead of print Dec 2, 2009:
.
Donkor J, Zhang P, Wong S, O’Loughlin L, Kok B, Dewald J, Brindley DN, Reue K
A conserved serine residue is required for the phosphatidate phosphatase activity but not coactivator functions of lipin-1 and lipin-2,
J Biol Chem,
2009; 284:
29968-29978.
Phan J, Hickey M, Zhang P, Chesselet M, Reue K
Adipose tissue dysfunction tracks disease progression in two Huntington’s disease mouse models,
Hum Mol Genet,
2009; 18:
1006-1016.
Takeuchi K, Reue K
Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis,
Am J Physiol Endocrinol Metab,
2009; 296:
E1195-209.
Hegele RA, Reue K
Hoofbeats, zebras, and insights into insulin resistance,
J Clin Invest,
2009; 119:
249-251.
Chao LC, Wroblewski K, Zhang A, Pei L, Vergnes L, Ilkayeva OR, Ding S, Reue K, Watt MJ, Newgard CB, Pilch PF, Hevener AL, Tontonoz P
Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77,
Diabetes,
2009; 58:
2788-2796.
Chao Lily C, Wroblewski Kevin, Zhang Zidong, Pei Liming, Vergnes Laurent, Ilkayeva Olga R, Ding Shi Ying, Reue Karen, Watt Matthew J, Newgard Christopher B, Pilch Paul F, Hevener Andrea L, Tontonoz Peter
Insulin resistance and altered systemic glucose metabolism in mice
lacking Nur77
Diabetes,
2009; 58(12):
2788-96.
Reue K, Dwyer J
Lipin proteins and metabolic homeostasis,
J Lipid Res,
2009; 50:
Suppl: S109-114.
Brindley DN, Pilquil C, Sariahmetoglu M, Reue K
Phosphatidate degradation: Phosphatidate phosphatases (lipins) and lipid phosphate phosphatases,
Biochim Biophys Acta,
2009; 1791:
956-961.
Dean JT, Tran L, Beaven S, Tontonoz P, Reue K, Dipple KM, Liao JC
Resistance to diet-induced obesity in mice with synthetic glyoxylate shunt,
Cell Metab,
2009; 9:
525-536.
Bou Khalil M, Sundaram M, Zhang HY, Links PH, Raven JF, Manmontri B, Sariahmetoglu M, Tran K, Reue K, Brindley DN, Yao Z
The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic very low density lipoproteins,
J Lipid Res,
2009; 50:
47-58.
Bou Khalil Maroun, Sundaram Meenakshi, Zhang Hong-Yu, Links Philip H, Raven Jennifer F, Manmontri Boripont, Sariahmetoglu Meltem, Tran Khai, Reue Karen, Brindley David N, Yao Zemin
The level and compartmentalization of phosphatidate phosphatase-1
(lipin-1) control the assembly and secretion of hepatic VLDL
Journal of lipid research,
2009; 50(1):
47-58.
Reue K
The lipin protein family: mutations and metabolism,
Curr Opin Lipidol,
2009; 20:
165-170.
Donkor J, Sparks LM, Xie H, Smith SR, Reue K
Adipose tissue lipin-1 expression is correlated with PPARα gene expression and insulin sensitivity in healthy young men,
J Clin Endocrinol Metab,
2008; 93:
233-239.
Manmontri B, Sariahmetoglu M, Donkor J, Bou Khalil M, Yao Z, Reue K, Lehner R, Brindley DN
Glucocorticoids and cAMP selectively increase hepatic lipin-1 expression and insulin acts antagonistically,
J Lipid Res,
2008; 49:
1056-1067.
Manmontri Boripont, Sariahmetoglu Meltem, Donkor Jimmy, Bou Khalil Maroun, Sundaram Meenakshi, Yao Zemin, Reue Karen, Lehner Richard, Brindley David N
Glucocorticoids and cyclic AMP selectively increase hepatic lipin-1
expression, and insulin acts antagonistically
Journal of lipid research,
2008; 49(5):
1056-67.
Nagle CA, Vergnes L, Dejong H, Wang S, Lewin TM, Reue K, Coleman RA
Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6–/– mice,
J Lipid Res,
2008; 49:
823-831.
Lusis AJ, Attie AD, Reue K
Metabolic Syndrome: from epidemiology to gene networks,
Nat Rev Genet,
2008; 9:
819-830.
Reue K, Brindley DN
Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism,
J Lipid Res,
2008; 49:
2493-2503.
Zhang P, O’Loughlin L, Brindley, DN, Reue K
Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis,
J Lipid Res,
2008; 49:
1519-1528.
Reue K, Zhang P
The lipin protein family: dual roles in lipid biosynthesis and gene expression,
FEBS Lett,
2008; 582:
90-96.
Ji J, Lee RT, Vergnes L, Fong LG, Stewart CL, Reue K, Young SG, Zhang Q, Shanahan CM, Lammerding J
Cell nuclei spin in the absence of lamin B1,
J Biol Chem,
2007; 282:
20015-20026.
Ji Julie Y, Lee Richard T, Vergnes Laurent, Fong Loren G, Stewart Colin L, Reue Karen, Young Stephen G, Zhang Qiuping, Shanahan Catherine M, Lammerding Jan
Cell nuclei spin in the absence of lamin b1
The Journal of biological chemistry,
2007; 282(27):
20015-26.
Reue K, Donkor J
Genetic factors in type 2 diabetes: all in the (lipin) family,
Diabetes,
2007; 56:
2842-2843.
Péterfy M, Ben-Zeev O, Mao HZ, Weissglas-Volkov D. Aouizerat BE, Pullinger CR, Frost PH, Kane JP, Malloy MJ, Reue K, Pajukanta P, Doolittle MH
Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia,
Nat Genet,
2007; 39:
1483-1487.
Péterfy Miklós, Ben-Zeev Osnat, Mao Hui Z, Weissglas-Volkov Daphna, Aouizerat Bradley E, Pullinger Clive R, Frost Philip H, Kane John P, Malloy Mary J, Reue Karen, Pajukanta Päivi, Doolittle Mark H
Mutations in LMF1 cause combined lipase deficiency and severe
hypertriglyceridemia
Nature genetics,
2007; 39(12):
1483-7.
Donkor J, Sariahmetoglu M, Dewald J, Brindley DN, Reue K
Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns,
J Biol Chem,
2007; 282:
3450-3457.
Lindegaard, B., Larsen, L.F., Hansen, A.-B.E., Gerstoft, J., Pedersen, B.K., Reue, K
Adipose tissue lipin expression levels distinguish HIV patients with and without lipodystrophy,
Int. J. Obes,
2006; 31:
449-456.
Vergnes L
Beigneux AP
Davis R
Watkins SM
Young SG
Reue K
Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity,
J Lipid Res,
2006; 47:
745-754.
Beigneux AP
Vernes L
Qiao X
Quatela S
Davis R
Watkins SM
Coleman RA
Walzem RL
Philips M
Reue K
Young, SG
Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium,
J Lipid Res,
2006; 47:
734-744.
Beigneux Anne P, Vergnes Laurent, Qiao Xin, Quatela Steven, Davis Ryan, Watkins Steven M, Coleman Rosalind A, Walzem Rosemary L, Philips Mark, Reue Karen, Young Stephen G
Agpat6--a novel lipid biosynthetic gene required for triacylglycerol
production in mammary epithelium
Journal of lipid research,
2006; 47(4):
734-44.
Suviolahti E
Reue K
Cantor RM
Phan J
Gentile M
Naukkarinen J
Soro-Paavonen A
Oksanen L
Kaprio J
Rissanen A
Salomaa V
Kontula K
Taskinen MR
Pajukanta P
Peltonen L.
Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism,
Hum Mol Genet,
2006; 15:
377-386.
Suviolahti Elina, Reue Karen, Cantor Rita M, Phan Jack, Gentile Massimiliano, Naukkarinen Jussi, Soro-Paavonen Aino, Oksanen Laura, Kaprio Jaakko, Rissanen Aila, Salomaa Veikko, Kontula Kimmo, Taskinen Marja-Riitta, Pajukanta Päivi, Peltonen Leena
Cross-species analyses implicate Lipin 1 involvement in human glucose
metabolism
Human molecular genetics,
2006; 15(3):
377-86.
Lammerding J
Fong L
Ji JY
Reue K
Stewart CL
Young SG
Lee RT
Lamins A and C but not lamin B1 regulate nuclear mechanics,
J. Biol. Chem,
2006; 281:
25768-25780.
Xu J
Lee WN
Phan J
Saad MF
Reue K
Kurland IJ
Lipin deficiency impairs diurnal metabolic fuel switching,
Diabetes,
2006; 55:
3429-3438.
Yao-Borengasser A
Rasouli N
Varma V
Miles LM
Phanavanh B
Starks TN
Phan J
Spencer HJ 3rd
McGehee RE Jr
Reue K
Kern PA
Lipin expression is attenuated in adipose tissue of insulin-resistant human subjects and increases with peroxisome proliferator-activated receptor gamma activation,
Diabetes,
2006; 55:
2811-2818.
Yao-Borengasser Aiwei, Rasouli Neda, Varma Vijayalakshmi, Miles Leslie M, Phanavanh Bounleut, Starks Tasha N, Phan Jack, Spencer Horace J, McGehee Robert E, Reue Karen, Kern Philip A
Lipin expression is attenuated in adipose tissue of insulin-resistant
human subjects and increases with peroxisome proliferator-activated
receptor gamma activation
Diabetes,
2006; 55(10):
2811-8.
Reue K
Phan J
Metabolic consequences of lipodystrophy in mouse models,
Curr. Opin. Clin. Nutr. Metab. Care,
2006; 9:
436-441.
Reue K, Vergnes L
Systems biology approaches to metabolic and cardiovascular disorders. Approaches to lipid metabolism gene identification and characterization in the post-genomic era,
J Lipid Res,
2006; 47:
1891-1907.
Peterfy, M.
Phan, J.
Reue, K.
Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization and role in adipogenesis,
J. Biol. Chem,
2005; 280:
32883-32889.
Fong, LG Ng, JK Meta, M Coté, N Yang, SH Stewart, CL Sullivan, T Burghardt, A Majumdar, S Reue, K Bergo, MO Young, SG
Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice
Proceedings of the National Academy of Sciences of the United States of America. ,
2004; 101(52):
18111-6.
Fong Loren G, Ng Jennifer K, Meta Margarita, Coté Nathan, Yang Shao H, Stewart Colin L, Sullivan Terry, Burghardt Andrew, Majumdar Sharmila, Reue Karen, Bergo Martin O, Young Stephen G
Heterozygosity for Lmna deficiency eliminates the progeria-like
phenotypes in Zmpste24-deficient mice
Proceedings of the National Academy of Sciences of the United States of America,
2004; 101(52):
18111-6.
Vergnes, L., Peterfy, M., Bergo, M., Young, S.G., Reue, K.
Lamin B1 is required for mouse development and nuclear integrity,
Proc. Natl. Acad. Sci. USA,
2004; 101:
10428-10433.
Phan, J., Peterfy, M., Reue, K.
Lipin expression preceding PPAR-gamma is critical for adipogenesis in vivo and in vitro,
J. Biol. Chem,
2004; 279:
29558-29564.
Kast, HR Nguyen, CM Sinal, CJ Jones, SA Laffitte, BA Reue, K Gonzalez, FJ Willson, TM Edwards, PA
Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids
Molecular endocrinology (Baltimore, Md.) ,
2001; 15(10):
1720-8.
Peterfy, M., Phan, J., Xu, P., Reue, K.
Lipodystrophy in the fld mouse results from mutation in a novel nuclear protein, lipin,
Nature Genetics,
2001; 27:
121-124.
Mouzeyan, A., Choi, J., Allayee, H., Sinsheimer, J., Phan, J., Castellani, L.W., Reue, K., Lusis, A.J., Davis, R.C.
A gene conferring resistance to diet-induced hypercholesterolemia and atherosclerosis on mouse chromosome 2,
J. Lipid Res. ,
2000; 41:
573-582.
Harte, R.A., Hulten, L.M., Lindmark, H., Reue, K., Schotz, M.C., Khoo, J., Rosenfeld, M.E.
Low level expression of hormone-sensitive lipase in arterial macrophage-derived foam cells: potential explanation for low rates of cholesteryl ester hydrolysis,
Atherosclerosis,
2000; 149:
343-350.
Phan, J., Reue, K., Peterfy, M.
MS-IRS: PCR: A simple method for the isolation of microsatellites,
BioTechniques ,
2000; 28:
18-20.
Reue, K., Peterfy, M.
Mouse models of lipodystrophy,
Curr. Atherosclerosis Reports ,
2000; 2:
390-396.
