Dr. Marvizón is a neuroscientist who investigates the basic mechanisms of chronic pain using animal, cellular and molecular methods. His projects are funded by the Department of Veteran Affairs and the National Institutes of Health. He is also a blogger and aspiring popular science writer.
Dr. Marvizón’s research field is pain neurophysiology. He investigates chronic pain disorders at the physiological, cellular and molecular levels using the Latent Sensitization animal model. Latent Sensitization is triggered by injuries that cause long-term inflammation or nerve damage, such as skin incision, injection of inflammatory agents or nerve transection. This is followed by a period of increased sensitivity to mechanical (for example, poking with nylon filaments known as von Frey filaments) or thermal (focusing a hot light on the paw) stimuli. The key part of the Latent Sensitization model is that when that period of hypersensitivity has ended it can be reinstated temporarily by an injection of an antagonist of opioid receptors (mu, delta or kappa) or of alpha-2 adrenergic receptors. This reveals that the neural pathways that process pain remain sensitized but at the same time are suppressed by the activation of these opioid or adrenergic receptors. It is likely that similar process occur in chronic pain patients. Another important characteristic of Latent Sensitization is that pain can also be reinstated by stress (like making a rat swim in a bucket of water or exposing it to a new environment). Again, this happen to chronic pain patients. The research group led by Dr. Marvizón is currently using novel transgenic mouse techniques like conditional knock-out and chemogenetics (DREADD) to study the pathways linking stress to pain. Dr. Marvizón writes in defense of animal research for the organization Speaking of Research (https://speakingofresearch.com/). For more information about his projects and his general view on science, please visit his blog Pain, Brain & Science http://pain-brain-science.blogspot.com/
Office
VA Greater Los Angeles Healthcare System
11301 Wilshire Blvd.
Los Angeles, CA 90073
Latent Sensitization is triggered by injuries that cause long-term inflammation or nerve damage, such as skin incision, injection of inflammatory agents or nerve transection. This is followed by a period of increased sensitivity to mechanical (for example, poking with nylon filaments known as von Frey filaments) or thermal (focusing a hot light on the paw) stimuli. The key part of the Latent Sensitization model is that when that period of hypersensitivity has ended it can be reinstated temporarily by an injection of an antagonist of opioid receptors (mu, delta or kappa) or of alpha-2 adrenergic receptors. This reveals that the neural pathways that process pain remain sensitized but at the same time are suppressed by the activation of these opioid or adrenergic receptors. It is likely that similar process occur in chronic pain patients. Another important characteristic of Latent Sensitization is that pain can also be reinstated by stress (like making a rat swim in a bucket of water or exposing it to a new environment). Again, this happen to chronic pain patients.
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