Alan Garfinkel, Ph.D.

Work Titles
UCLA Professor, Integrative Biology and Physiology Professor, Medicine Member, Molecular, Cellular & Integrative Physiology GPB Home Area Member, Neuroengineering Training Program Faculty, Cardiovascular Research Laboratory
Ph.D., Harvard University

Contact Information:

Work Address:

1121 Terasaki Life Science Bldg
Los Angeles, CA 90095

Detailed Biography:

Dr. Garfinkel graduated from Cornell and received his PhD from Harvard in philosophy and mathematics. He is particularly interested in nonlinear dynamics and its applications to medicine.




A selected list of publications:

Griffis Christopher G, Mistry Janki, Islam Kendall, Cutler Tamara, Colwell Christopher S, Garfinkel Alan   Circadian and ultradian rhythms in normal mice and in a mouse model of Huntington's disease Chronobiology international, 2022; 39(4): 513-524.
Qu Zhilin, Liu Michael B, Olcese Riccardo, Karagueuzian Hrayr, Garfinkel Alan, Chen Peng-Sheng, Weiss James N   R-on-T and the initiation of reentry revisited: Integrating old and new concepts Heart rhythm, 2022; 39(4): 513-524.
Garfinkel Alan, Bennoun Steve, Deeds Eric, Van Valkenburgh Blaire   Teaching Dynamics to Biology Undergraduates: the UCLA Experience Bulletin of mathematical biology, 2022; 84(3): 43.
O'Leary Erin Sanders, Sayson Hannah Whang, Shapiro Casey, Garfinkel Alan, Conley William J, Levis-Fitzgerald Marc, Eagan M Kevin, Van Valkenburgh Blaire   Reimagining the Introductory Math Curriculum for Life Sciences Students CBE life sciences education, 2021; 20(4): ar62.
Corazza Paolo, Maddison John, Bonetti Paolo, Guo Li, Luong Vy, Garfinkel Alan, Younis Saad, Cordeiro Maria Francesca   Predicting wet age-related macular degeneration (AMD) using DARC (detecting apoptosing retinal cells) AI (artificial intelligence) technology Expert review of molecular diagnostics, 2021; 21(1): 109-118.
Pham Bau N, Luo Jiangyuan, Anand Harnadar, Kola Olivia, Salcedo Pia, Nguyen Connie, Gaunt Sarah, Zhong Hui, Garfinkel Alan, Tillakaratne Niranjala, Edgerton V Reggie   Redundancy and multifunctionality among spinal locomotor networks Journal of neurophysiology, 2020; 124(5): 1469-1479.
Guihard Pierre J, Guo Yina, Wu Xiuju, Zhang Lily, Yao Jiayi, Jumabay Medet, Yao Yucheng, Garfinkel Alan, Boström Kristina I   Shaping Waves of Bone Morphogenetic Protein Inhibition During Vascular Growth Circulation research, 2020; 127(10): 1288-1305.
Ponnaluri Aditya V S, Verzhbinsky Ilya A, Eldredge Jeff D, Garfinkel Alan, Ennis Daniel B, Perotti Luigi E   Model of Left Ventricular Contraction: Validation Criteria and Boundary Conditions Functional imaging and modeling of the heart : ... International Workshop, FIMH ..., proceedings. FIMH, 2019; 11504(8): 294-303.
Kung Geoffrey L, Vaseghi Marmar, Gahm Jin K, Shevtsov Jane, Garfinkel Alan, Shivkumar Kalyanam, Ennis Daniel B   Microstructural Infarct Border Zone Remodeling in the Post-infarct Swine Heart Measured by Diffusion Tensor MRI Frontiers in physiology, 2018; 9(8): 826.
Landaw Julian, Garfinkel Alan, Weiss James N, Qu Zhilin   Memory-Induced Chaos in Cardiac Excitation Physical review letters, 2017; 118(13): 138101.
Liu Michael B, Ko Christopher Y, Song Zhen, Garfinkel Alan, Weiss James N, Qu Zhilin   A Dynamical Threshold for Cardiac Delayed Afterdepolarization-Mediated Triggered Activity Biophysical journal, 2016; 111(11): 2523-2533.
Ponnaluri Aditya V S, Perotti Luigi E, Liu Michael, Qu Zhilin, Weiss James N, Ennis Daniel B, Klug William S, Garfinkel Alan   Electrophysiology of Heart Failure Using a Rabbit Model: From the Failing Myocyte to Ventricular Fibrillation PLoS computational biology, 2016; 12(6): e1004968.
Prudat Yann, Madhvani Roshni V, Angelini Marina, Borgstom Nils P, Garfinkel Alan, Karagueuzian Hrayr S, Weiss James N, de Lange Enno, Olcese Riccardo, Kucera Jan P   Stochastic pacing reveals the propensity to cardiac action potential alternans and uncovers its underlying dynamics The Journal of physiology, 2016; 594(9): 2537-53.
Liu Michael B, de Lange Enno, Garfinkel Alan, Weiss James N, Qu Zhilin   Delayed afterdepolarizations generate both triggers and a vulnerable substrate promoting reentry in cardiac tissue Heart rhythm, 2015; 12(10): 2115-24.
Weiss James N, Garfinkel Alan, Karagueuzian Hrayr S, Nguyen Thao P, Olcese Riccardo, Chen Peng-Sheng, Qu Zhilin   Perspective: a dynamics-based classification of ventricular arrhythmias Journal of molecular and cellular cardiology, 2015; 82(5): 136-52.
Madhvani Roshni V, Angelini Marina, Xie Yuanfang, Pantazis Antonios, Suriany Silvie, Borgstrom Nils P, Garfinkel Alan, Qu Zhilin, Weiss James N, Olcese Riccardo   Targeting the late component of the cardiac L-type Ca2+ current to suppress early afterdepolarizations The Journal of general physiology, 2015; 145(5): 395-404.
Guo Yina, Sun Mingzhu, Garfinkel Alan, Zhao Xin   Mechanisms of side branching and tip splitting in a model of branching morphogenesis PloS one, 2014; 9(7): e102718.
Qu Zhilin, Hu Gang, Garfinkel Alan, Weiss James N   Nonlinear and Stochastic Dynamics in the Heart Physics reports, 2014; 543(2): 61-162.
Dolezal Brett Andrew, Chudzynski Joy, Dickerson Daniel, Mooney Larissa, Rawson Richard A, Garfinkel Alan, Cooper Christopher B   Exercise training improves heart rate variability after methamphetamine dependency Medicine and science in sports and exercise, 2014; 46(6): 1057-66.
Krishnamoorthi Shankarjee, Perotti Luigi E, Borgstrom Nils P, Ajijola Olujimi A, Frid Anna, Ponnaluri Aditya V, Weiss James N, Qu Zhilin, Klug William S, Ennis Daniel B, Garfinkel Alan   Simulation Methods and Validation Criteria for Modeling Cardiac Ventricular Electrophysiology PloS one, 2014; 9(12): e114494.
Guo Yina, Chen Ting-Hsuan, Zeng Xingjuan, Warburton David, Boström Kristina I, Ho Chih-Ming, Zhao Xin, Garfinkel Alan   Branching patterns emerge in a mathematical model of the dynamics of lung development The Journal of physiology, 2014; 592(2): 313-24.
Qu Zhilin, Xie Lai-Hua, Olcese Riccardo, Karagueuzian Hrayr S, Chen Peng-Sheng, Garfinkel Alan, Weiss James N   Early afterdepolarizations in cardiac myocytes: beyond reduced repolarization reserve Cardiovascular research, 2013; 99(1): 6-15.
Chang Marvin G, de Lange Enno, Calmettes Guillaume, Garfinkel Alan, Qu Zhilin, Weiss James N   Pro- and antiarrhythmic effects of ATP-sensitive potassium current activation on reentry during early afterdepolarization-mediated arrhythmias Heart rhythm : the official journal of the Heart Rhythm Society, 2013; 10(4): 575-82.
Chen Ting-Hsuan, Zhu Xiaolu, Pan Leiting, Zeng Xingjuan, Garfinkel Alan, Tintut Yin, Demer Linda L, Zhao Xin, Ho Chih-Ming   Directing tissue morphogenesis via self-assembly of vascular mesenchymal cells Biomaterials, 2012; 33(35): 9019-26.
Chen Ting-Hsuan, Guo Chunyan, Zhao Xin, Yao Yucheng, Boström Kristina I, Wong Margaret N, Tintut Yin, Demer Linda L, Ho Chih-Ming, Garfinkel Alan   Patterns of periodic holes created by increased cell motility Interface focus, 2012; 2(4): 457-64.
Chang Marvin G, Chang Connie Y, de Lange Enno, Xu Linmiao, O'Rourke Brian, Karagueuzian Hrayr S, Tung Leslie, Marbán Eduardo, Garfinkel Alan, Weiss James N, Qu Zhilin, Abraham M Roselle   Dynamics of early afterdepolarization-mediated triggered activity in cardiac monolayers Biophysical journal, 2012; 102(12): 2706-14.
Musienko Pavel, Courtine Gregoire, Tibbs Jameson E, Kilimnik Vyacheslav, Savochin Alexandr, Garfinkel Alan, Roy Roland R, Edgerton V Reggie, Gerasimenko Yury   Somatosensory control of balance during locomotion in decerebrated cat Journal of neurophysiology, 2012; 107(8): 2072-82.
Boström Kristina I, Garfinkel Alan, Yao Yucheng, Jumabay Medet   Concise review: applying stem cell biology to vascular structures Stem cells (Dayton, Ohio), 2012; 30(3): 386-91.
Nguyen Thao P, Xie Yuanfang, Garfinkel Alan, Qu Zhilin, Weiss James N   Arrhythmogenic consequences of myofibroblast-myocyte coupling Cardiovascular research, 2012; 93(2): 242-51.
Chen Ting-Hsuan, Hsu Jeffrey J, Zhao Xin, Guo Chunyan, Wong Margaret N, Huang Yi, Li Zongwei, Garfinkel Alan, Ho Chih-Ming, Tintut Yin, Demer Linda L   Left-right symmetry breaking in tissue morphogenesis via cytoskeletal mechanics Circulation research, 2012; 110(4): 551-9.
Chang Marvin G, Sato Daisuke, de Lange Enno, Lee Jong-Hwan, Karagueuzian Hrayr S, Garfinkel Alan, Weiss James N, Qu Zhilin   Bi-stable wave propagation and early afterdepolarization-mediated cardiac arrhythmias Heart rhythm : the official journal of the Heart Rhythm Society, 2012; 9(1): 115-22.
Cheng Henry, Reddy Aneela, Sage Andrew, Lu Jinxiu, Garfinkel Alan, Tintut Yin, Demer Linda L   Focal high cell density generates a gradient of patterns in self-organizing vascular mesenchymal cells Journal of vascular research, 2012; 49(5): 441-6.
Gahm Jin Kyu, Wisniewski Nicholas, Kindlmann Gordon, Kung Geoffrey L, Klug William S, Garfinkel Alan, Ennis Daniel B   Linear invariant tensor interpolation applied to cardiac diffusion tensor MRI Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, 2012; 15(Pt 2): 494-501.
Madhvani Roshni V, Xie Yuanfang, Pantazis Antonios, Garfinkel Alan, Qu Zhilin, Weiss James N, Olcese Riccardo   Shaping a new Ca²⁺ conductance to suppress early afterdepolarizations in cardiac myocytes The Journal of physiology, 2011; 589(Pt 24): 6081-92.
Tran Diana X, Sato Daisuke, Yochelis Arik, Weiss James N, Garfinkel Alan, Qu Zhilin   Bifurcation and chaos in a model of cardiac early afterdepolarizations Physical review letters, 2009; 102(25): 258103.
Sato Daisuke, Xie Lai-Hua, Sovari Ali A, Tran Diana X, Morita Norishige, Xie Fagen, Karagueuzian Hrayr, Garfinkel Alan, Weiss James N, Qu Zhilin   Synchronization of chaotic early afterdepolarizations in the genesis of cardiac arrhythmias Proceedings of the National Academy of Sciences of the United States of America, 2009; 106(9): 2983-8.
Garfinkel, A. Tintut, Y. Petrasek, D. Bostrom, K. Demer, L. L.   Pattern formation by vascular mesenchymal cells Proc Natl Acad Sci U S A, 2004; 101(25): 9247-50.
Xie, F Qu, Z Yang, J Baher, A Weiss, JN Garfinkel, A   A simulation study of the effects of cardiac anatomy in ventricular fibrillation The Journal of clinical investigation. , 2004; 113(5): 686-93.
S. Port, L. Demer, R. Jennrich, D. Walter and A. Garfinkel   Systolic blood pressure and mortality, The Lancet , 2000; 355: 175-80.
Garfinkel, A Kim, YH Voroshilovsky, O Qu, Z Kil, JR Lee, MH Karagueuzian, HS Weiss, JN Chen, PS   Preventing ventricular fibrillation by flattening cardiac restitution Proceedings of the National Academy of Sciences of the United States of America. , 2000; 97(11): 6061-6.
Krogstad, P Uittenbogaart, CH Dickover, R Bryson, YJ Plaeger, S Garfinkel, A   Primary HIV infection of infants: the effects of somatic growth on lymphocyte and virus dynamics Clinical immunology (Orlando, Fla.) , 1999; 92(1): 25-33.
Z. Qu, F. Xie, and A. Garfinkel   Diffusion-induced vortex filament instability in 3-Dimensional excitable media, Phys. Rev. Lett , 1999; 2668-2671.
Qu, Z Weiss, JN Garfinkel, A   Cardiac electrical restitution properties and stability of reentrant spiral waves: a simulation study The American journal of physiology. , 1999; 276(1 Pt 2): H269-83.
Garfinkel, A Chen, PS Walter, DO Karagueuzian, HS Kogan, B Evans, SJ Karpoukhin, M Hwang, C Uchida, T Gotoh, M Nwasokwa, O Sager, P Weiss, JN   Quasiperiodicity and chaos in cardiac fibrillation The Journal of clinical investigation. , 1997; 99(2): 305-14.
Garfinkel, A Spano, ML Ditto, WL Weiss, JN   Controlling cardiac chaos Science. , 1992; 257(5074): 1230-5.

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