Bruce D. Teter, Ph.D.

A Short Biography:

Bruce Teter received a B.S. in marine biology and a minor in chemistry from Cal. State U., Long Beach in 1982. Dr. Teter received a Ph.D. degree in molecular biology from the University of Southern California in 1991 studying DNA structure in control of protein binding and gene expression. He then completed a postdoctoral fellowship in neurogerontology focusing on epigenetic control of gene expression changes with aging, working with Dr. Caleb Finch at the Andrus Gerontology Center in the School of Gerontology at USC. In 1996 he joined the lab of Dr. Greg Cole at UCLA and is currently Adjunct Associate Professor in the Department of Neurology, and Chief of the ApoE Research Laboratory, and Research Associate at GRECC, Veterans Administration, GLAHS. Dr. Teter's research focuses on the neurobiology of apolipoprotein E (apoE),and how the apoE4 isotype is the major genetic risk factor for sporadic AD.

Work Titles
UCLA Member, Brain Research Institute Associate Adjunct Professor, Neurology
Ph.D., USC

Contact Information:

Cell-phone Number:


Fax Number:


Work Phone Number:


Mailing Address:

VA Greater Los Angeles Healthcare System, West Los Angeles
11301 Wilshire Blvd
Bldg. 114, Rm. 114-1
Los Angeles, CA 90073

Work Address:

Bldg. 114, Rm. 114-1
11301 Wilshire Blvd
Los Angeles, CA 90073

VAMC, mc151
Bldg. 114, Rm. 115-5
11301 Wilshire Blvd
Los Angeles, CA 90073

Research Interest:

Dr. Teter's research focuses on the neurobiology of apolipoprotein E (apoE),and how the apoE4 isotype is the major genetic risk factor for sporadic AD. Dr. Teter has published seminal works showing how apoE4 inhibits neuroplasticity. His current research examines how apoE4 increases inflammation and modulates the innate immune system, both in the brain and in peripheral blood. These phenotypes are being examined for their role in pharmacogenetic effects of apoE4 on inhibiting the efficacy of therapeutic drugs, like the omega-3 fatty acid DHA found in fish oil, and the anti-inflammatory drug curcumin, a compound in curry spice. The goal is to find ways to overcome this apoE4 inhibition of drug efficacy, possibly through the addition of exercise.


A selected list of publications:

Teter Bruce, LaDu Mary Jo, Sullivan Patrick M, Frautschy Sally A, Cole Greg M   Apolipoprotein E isotype-dependent modulation of microRNA-146a in plasma and brain Neuroreport, 2016; 27(11): 791-5.
Teter, B.   Life-span influences of apoE4 on CNS function. Invited Peer Commentary on: Schonheit, B., Glockner, F., and Ohm, T.G. (2006) Apolipoprotein E polymorphism and dendritic shape. , Neurobiology of Aging, 2006; 28(5): 693-703; discussion 704-6..
Teter, B., Finch, C.E.   Caliban's Inheritance: Genetics of Neuronal Aging, Trends in Neuroscience , 2004; 10: 627-32.
Teter B, Xu P-T, Gilbert JR, Roses AD, Galasko D, Cole GM   Defective neuronal sprouting supported by human Apolipoprotein E4 represents a gain-of-deleterious function, J. Neurosci. Res, 2002; (687): 331-336.
Teter B, Ashford JW   Neuroplasticity in Alzheimer's Disease, Journal of Neuroscience Research, 2002; 70(Aging Brain and Alzheimer's Disease Special Issue): 402-437.
Teter B, Raber J, Nathan B, Crutcher KA   The presence of apoE4, not the absence of apoE3, contributes to AD pathology, J. Alzheimer's Disease, 2002; (4): 155-163.

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