Yvette Taché, Ph.D.

A Short Biography:

Dr. Yvette Taché is a recognized leading expert in brain-gut interactions and the role of peptides in the underlying mechanisms of stress-related gut dysfunction. She and her research team reported some of the pioneer work on the central actions of peptides to influence digestive function and feeding behavior. Her laboratory provided the preclinical ground work showing potential benefit of blocking corticotropin releasing signaling pathways in experimental models of irritable bowel syndrome and postoperative ileus. Building on her initial work on the peptidergic regulation of vagal activity to the gut, she is investigating with Dr. P-Q Yuan their role in the modulation of the cholinergic anti-inflammatory reflex in the context of post operative ileus. In collaboration with Dr. Lixin Wang, they demonstrated the role of ghrelin agonists to alleviate gut motor dysfunction in models of Parkinson Disease. She is directing a consortium NIH SPARC grant on the structural and functional mapping of mammalian colonic nervous system.

Dr. Taché joined the Digestive Disease Division in 1982 and was appointed Professor-in-Residence in 1987 and Distinguished Professor since 2009.  Professor Taché developed this field of research through continued competitive grants obtained from the National Institute of Health (NIH) since 1982 as well as Veteran Administration (VA) Merit Award since 2000. She is director of the Animal Core within the NIHDDK Digestive Diseases Center and a co-director of the UCLA G. Oppenheimer Center for Neurobiology of Stress and Resilience (CNSR). She published 385 peer-reviewed articles, 175 reviews, 16 editorials and edited several books. Professor Taché has been the recipients of NIHDDK MERIT Award, the Distinguished Research Award in Gastrointestinal Physiology from the American Physiological Society, the Janssen Award for Basic Research in Gastrointestinal Motility, the Senior Investigator–Basic Science Award from the International Foundation for Functional Gastrointestinal Disorders, the Research Scientist Award from the Functional Brain-Gut Research Group, the Outstanding American Gastroenterology Association (AGA) Women in Sciences, the Research Mentor Award from the AGA Institute Council (Neurogastroenterology & Motility Section), and the Senior  Research Career Scientist Award and Middleton Award from the Veteran Administration and the Legion of Honor from the French Government. She served on NIH and VA grant application review panels and editorial boards of many peptides, integrative physiology, gastroenterology and stress-related journals and was an associated editor.


Work Titles
UCLA Director, Cure: Animal Models Core Professor, Vatche and Tamar Manoukian Division of Digestive Diseases Associate Director, CURE: Digestive Diseases Research Center Co-Director, UCLA Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress Director Animal Core, CURE: Digestive Diseases Research Center Member, Brain Research Institute Member, Molecular, Cellular & Integrative Physiology GPB Home Area
Education:
Degrees:
Ph.D.

Contact Information:

Fax Number:

(310) 268-4963

Work Phone Number:

(310) 312-9275

Work Address:

Laboratory
CURE:DDRC
11301 Wilshire Blvd.
VAGLAHS Bldg. 115
Los Angeles, CA 90073

Office
CURE Bldg. 115, Rm. 117, VA Greater LA Healthcare System
11301 Wilshire Blvd.
Los Angeles, CA 90073


Research Interest:

A better understanding of the brain-gut axis is of primary importance in the context of the bidirectional cross talk occurring through the autonomic nervous system and circulating hormones. There is a growing recognition that such interactions regulate digestive function, gut inflammation, and feeding behavior and can lead to the development and modulation of some gut pathophysiology. Our focus has been to delineate the signaling molecules in the brain that influence parasympathetic activity regulating gastric and colonic secretory motor function. We also assess the signaling to the brain occurring through capsaicin sensitive afferents activated by gut hormones and visceral pain. In particular, we investigate the brain and peripheral chemical coding involved under physiological conditions related to the cephalic phase and stress, and taking place in disease models of gastric erosions, postoperative ileus, irritable bowel syndrome

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