Stephen Smale, Ph.D.

A Short Biography:

Stephen T. Smale is a molecular immunologist and biochemist who arrived at UCLA in 1990 as an Assistant Professor in the Department of Microbiology and Immunology within the UCLA School of Medicine. In 1999, he was promoted to Professor and, in 2014, to Distinguished Professor, in the Department of Microbiology, Immunology, and Molecular Genetics, which spans the UCLA College of Letters and Science and the David Geffen School of Medicine. From 1990 to 2007, he was also a Howard Hughes Medical Institute Investigator. Dr. Smale graduated Magna Cum Laude from Cornell University, with Honors and Distinction in Chemistry. He received his Ph.D. in Biochemistry from the University of California, Berkeley under the mentorship of Dr. Robert Tjian. He then was a Helen Hay Whitney Foundation postdoctoral fellow with Nobelist Dr. David Baltimore at the Whitehead Institute, MIT. At UCLA, Dr. Smale previously served as Vice Chair of the Department of Microbiology, Immunology, and Molecular Genetics, Director of Basic and Translational Research for the UCLA Jonsson Comprehensive Cancer Center, Director of the Howard Hughes Medical Institute Science Education Program, Co-Director of the UCLA-Caltech Medical Scientist Training Program, founding Chair of the School of Medicine's Research Initiative in Immunity, Inflammation, infection, and Transplantation (I3T), and Vice Dean for Research in the David Geffen School of Medicine. The research in Dr. Smale's laboratory focuses on gene regulation during inflammatory and innate immune responses and during lymphocyte development and leukemogenesis.

Work Titles
UCLA Distinguished Professor, Microbiology, Immunology & Molecular Genetics Sherie L. and Donald G. Morrison Chair, Molecular Immunology

Contact Information:

Email Address:

Lab Number:

(310) 206-4946

Office Phone Number:

(310) 206-4777

Laboratory Address:

6-535 MRL
675 Charles E. Young Drive South
Los Angeles, CA 90095

Mailing Address:

Box 951489
Los Angeles, CA 90095

Office Address:

6-730 MRL
675 Charles E. Young Drive South
Los Angeles, CA 90095


A selected list of publications:

Langerman Justin, Lopez David, Pellegrini Matteo, Smale Stephen T   Species-Specific Relationships between DNA and Chromatin Properties of CpG Islands in Embryonic Stem Cells and Differentiated Cells Stem cell reports, 2021; 16(4): 899-912.
Hsieh Wei-Yuan, Zhou Quan D, York Autumn G, Williams Kevin J, Scumpia Philip O, Kronenberger Eliza B, Hoi Xen Ping, Su Baolong, Chi Xun, Bui Viet L, Khialeeva Elvira, Kaplan Amber, Son Young Min, Divakaruni Ajit S, Sun Jie, Smale Stephen T, Flavell Richard A, Bensinger Steven J   Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome Cell metabolism, 2020; 32(1): 128-143.e5.
Zhou Quan D, Chi Xun, Lee Min Sub, Hsieh Wei Yuan, Mkrtchyan Jonathan J, Feng An-Chieh, He Cuiwen, York Autumn G, Bui Viet L, Kronenberger Eliza B, Ferrari Alessandra, Xiao Xu, Daly Allison E, Tarling Elizabeth J, Damoiseaux Robert, Scumpia Philip O, Smale Stephen T, Williams Kevin J, Tontonoz Peter, Bensinger Steven J   Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins Nature immunology, 2020; 21(7): 746-755.
Weinmann Amy S, Youngblood Ben A, Smale Stephen T, Brink Robert, Schatz David G, McHeyzer-Williams Michael   A Future Outlook on Molecular Mechanisms of Immunity Trends in immunology, 2020; 41(7): 549-555.
Sallam Tamer, Jones Marius, Thomas Brandon J, Wu Xiaohui, Gilliland Thomas, Qian Kevin, Eskin Ascia, Casero David, Zhang Zhengyi, Sandhu Jaspreet, Salisbury David, Rajbhandari Prashant, Civelek Mete, Hong Cynthia, Ito Ayaka, Liu Xin, Daniel Bence, Lusis Aldons J, Whitelegge Julian, Nagy Laszlo, Castrillo Antonio, Smale Stephen, Tontonoz Peter   Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA Nature medicine, 2018; 24(3): 304-312.
Rajbhandari Prashant, Thomas Brandon J, Feng An-Chieh, Hong Cynthia, Wang Jiexin, Vergnes Laurent, Sallam Tamer, Wang Bo, Sandhu Jaspreet, Seldin Marcus M, Lusis Aldons J, Fong Loren G, Katz Melanie, Lee Richard, Young Stephen G, Reue Karen, Smale Stephen T, Tontonoz Peter   IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure Cell, 2018; 172(1-2): 218-233.e17.
Scumpia Philip O, Botten Giovanni A, Norman Joshua S, Kelly-Scumpia Kindra M, Spreafico Roberto, Ruccia Amber R, Purbey Prabhat K, Thomas Brandon J, Modlin Robert L, Smale Stephen T   Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense PLoS pathogens, 2017; 13(7): e1006496.
Purbey Prabhat K, Scumpia Philip O, Kim Peter J, Tong Ann-Jay, Iwamoto Keisuke S, McBride William H, Smale Stephen T   Defined Sensing Mechanisms and Signaling Pathways Contribute to the Global Inflammatory Gene Expression Output Elicited by Ionizing Radiation Immunity, 2017; 47(3): 421-434.e3.
Tong AJ, Liu X, Thomas BJ, Lissner MM, Baker MR, Senagolage MD, Allred AL, Barish GD, Smale ST   A stringent systems approach uncovers gene-specific mechanisms regulating inflammation Cell, 2016; 165: 165-179.
Arenzana TL, Schjerven H, Smale ST   Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor Genes & Dev, 2015; 29: 1801-1816.
Smale ST, Tarakhovsky A, Natoli G   Chromatin contributions to the regulation of innate immunity Annual Review of Immunology, 2014; 32: 489-911.
Schjerven H, McLaughlin J, Arenzana TL, Frietze S, Cheng D, Wadsworth SE, Lawson GW, Bensinger SJ, Farnham PJ, Witte ON, Smale ST   Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros Nature Immunol, 2013; 14: 1073-1083.
Smale ST, Plevy SE, Weinmann AS, Zhou L, Ramirez-Carrozzi VR, Pope SD, Bhatt DM, Tong AJ   Toward an understanding of the gene-specific and global logic of inducible gene transcription Cold Spring Harb Symp Quant Biol, 2013; 78: 61-68.
Bhatt DM, Pandya-Jones A, Tong AJ, Barozzi I, Lissner MM, Natoli G, Black DL, Smale ST   Transcript dynamics of pro inflammatory genes revealed by sequence analysis of subcellular RNA fractions Cell, 2012; 150: 279-290.
Xu J, Smale ST   Designing an enhancer landscape Cell, 2012; 151: 929-931.
Murray PJ, Smale ST   Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways Nature Immunol, 2012; 13: 916-924.
Negishi H, Yanai H, Nakajima A, Koshiba R, Atarashi K, Matsuda A, Matsuki K, Miki S, Doi T, Aderem A, Nishio J, Smale ST, Honda K, Taniguchi T   Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses Nature Immunol, 2012; 13: 659-666.
Siggers T, Chang AB, Teixeira A, Wong D, Williams KJ, Ahmed B, Ragoussis J, Udalova IA, Smale ST, Bulyk ML   Principles of dimer-specific gene regulation revealed by a comprehensive characterization of NF-kB family DNA binding Nature Immunol, 2011; 13: 95-102.
Smale ST   Hierarchies of NF-kB target-gene regulation Nature Immunol, 2011; 12: 689-694.
Smale ST   Selective transcription in response to an inflammatory stimulus Cell, 2010; 140: 833-844.
Smale ST   Seq-ing LPS-induced enhancers, Immunity, 2010; 32: 296-297.
Ramirez-Carrozzi VR, Braas D, Bhatt DM, Cheng CS, Hong C, Doty KR, Black JC, Hoffmann A, Carey M, Smale ST   A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling Cell, 2009; 138: 114-128.
Xu J, Watts JA, Pope SD, Gadue P, Kamps M, Plath K, Zaret KS, Smale ST   Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells Genes & Dev, 2009; 23: 2824-2838.
Carey M, Peterson CL, and Smale ST   Transcriptional regulation in eukaryotes: Concepts, strategies, and techniques, Second edition, , 2009; Cold Spring Harbor Laboratory Press: .
Smale ST, Dorshkind K   Hematopoiesis flies high with Ikaros Nature Immunol, 2006; 7: 367-369.
Li CC, Ramirez-Carrozzi VR, Smale ST   Pursuing global gene regulation "logic" via RNA interference and chromatin immunoprecipitation Nature Immunol, 2006; 7: 692-697.
Ramirez-Carrozzi VR, Nazarian AA, Li CC, Gore SL, Sridharan R, Imbalzano AN, Smale ST   Selective and antagonistic functions of SWI/SNF and Mi-2b nucleosome remodeling complexes during an inflammatory response Genes & Dev, 2006; 20: 282-296.
Sanjabi S, Williams KJ, Saccani S, Zhou L, Hoffmann A, Ghosh G, Gerondakis S, Natoli G, Smale ST   A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation Genes & Dev, 2005; 19: 2138-2151.
Su RC, Brown KE, Saaber S, Fisher AG, Merkenschlager M, Smale ST   Dynamic assembly of silent chromatin during thymocyte maturation Nature Genetics, 2004; 36: 502-506.
Smale ST   A Th2 cytokine LCR. Adding a new piece to the regulatory puzzle Immunity, 2003; 19: 1-2.
Smale ST   The establishment and maintenance of lymphocyte identity through gene silencing Nature Immunol, 2003; 4: 607-615.
Papathanasiou P, Perkins AC, Cobb BS, Ferrini R, Sridharan R, Hoyne GF, Nelms KA, Smale ST, Goodnow CC   Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor Immunity, 2003; 19: 131-144.
Smale ST, Kadonaga JT   The RNA polymerase II core promoter Annual Review of Biochemistry, 2003; 72: 449-479.
McCarty AS, Kleiger G, Eisenberg D, Smale ST   Selective dimerization of a C2H2 zinc finger subfamily Molecular Cell, 2003; 11: 459-470.
Dovat S, Ronni T, Russell D, Ferrini R, Cobb BS, Smale ST   A common mechanism for mitotic inactivation of C2H2 zinc finger DNA-binding domains Genes & Dev, 2002; 16: 2985-2990.
Smale ST and Fisher AG   Chromatin structure and gene regulation in the immune system Annual Review of Immunology, 2002; 20: 427-462.
Smale ST   Core promoters: active contributors to combinatorial gene regulation Genes & Dev, 2001; 15: 2503-2508.
Trinh LA, Ferrini R, Cobb BS, Weinmann AS, Hahm K, Ernst P, Garraway IP, Merkenschlager M, Smale ST   Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator Genes & Dev, 2001; 15: 1817-1832.
Weinmann AS, Mitchell DM, Sanjabi S, Bradley MN, Hoffmann A, Liou HC, Smale ST   Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event Nature Immunol, 2001; 2: 51-57.
Cobb BS, Morales-Alcelay S, Kleiger G, Brown KE, Fisher AG, Smale ST   Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding Genes & Dev, 2000; 14: 2146-2160.
Carey M and Smale ST   Transcriptional regulation in eukaryotes: Concepts, strategies, and techniques, , 2000; Cold Spring Harbor Laboratory Press: .
Weinmann AS, Plevy SE, Smale ST   Rapid and selective remodeling of a positioned nucleosome during the induction of IL-12 p40 transcription Immunity, 1999; 11: 665-675.
Brightbill HD, Libraty DH, Krutzik SR, Yang RB, Belisle JT, Bleharski JR, Maitland M, Norgard MV, Plevy SE, Smale ST, Brennan PJ, Bloom BR, Godowski PJ, Modlin RL   Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors Science, 1999; 285: 732-736.
Ernst P, Hahm K, Cobb BS, Brown KE, Trinh LA, McCarty AS, Merkenschlager M, Klug CA, Fisher AG, Smale ST   Mechanisms of transcriptional regulation in lymphocyte progenitors: insight from an analysis of the terminal transferase promoter Cold Spr Harb Symp Quant Biol, 1999; 64: 87-97.
Hahm K, Cobb BS, McCarty AS, Brown KE, Klug CA, Lee R, Akashi K, Weissman IL, Fisher AG, and Smale ST   Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin Genes & Dev, 1998; 12: 782-796.
Smale ST, Jain A, Kaufmann J, Emami KH, Lo K, Garraway IP   The initiator element: a paradigm for core promoter heterogeneity within metazoan protein-coding genes Cold Spr Harb Symp Quant Biol, 1998; 63: 21-31.
Brown KE, Guest SS, Smale ST, Hahm K, Merkenschlager M, Fisher AG   Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin Cell, 1997; 91: 845-854.
Emami KH, Jain A, Smale ST   Mechanism of synergy between TATA and initiator: synergistic binding of TFIID following a putative TFIIA-induced isomerization Genes & Dev, 1997; 11: 3007-3019.
Kaufmann J, Verrijzer CP, Shao J, Smale ST   CIF, an essential cofactor for TFIID-dependent initiator function Genes & Dev, 1996; 10: 873-886.
Ernst P, Smale ST   Combinatorial regulation of transcription II: The immunoglobulin mu heavy chain gene Immunity, 1995; 2: 427-438.
Ernst P, Smale ST   Combinatorial regulation of transcription. I: General aspects of transcriptional control Immunity, 1995; 2: 311-319.
Kaufmann J, Smale ST   Direct recognition of initiator elements by a component of the transcription factor IID complex Genes & Dev, 1994; 8: 821-829.

Does this profile need updating? Contact Us