Luisa Iruela-Arispe, Ph.D.

Edit your Faculty Profile
Work Titles
CTSI Member, CTSI
UCLA Chair, Molecular Biology Interdepartmental Program Director, Molecular Biology Institute Professor, Vice Chair, Molecular, Cell, and Developmental Biology Member, Cell & Developmental Biology GPB Home Area Member, Genetics & Genomics GPB Home Area Member, Molecular, Cellular & Integrative Physiology GPB Home Area
Education:
Degrees:
Ph.D., University fo Washington, Seattle, 1986 - 1989
M.S., Federal University of Rio De Janeiro, Brazil, 1983 - 1986
B.S., University of Game Filho, Rio de Janerio, Brazil, 1987 - 1983
Academic Experience:
1989 - 1993 University fo Washington, Seattle, Cell and Molecular Biology

Contact Information:

Work Email Address:

arispe@mbi.ucla.edu


Website:

http://www.mcdb.ucla.edu/Research/Arispe/arispe.mainpage.html

Work Phone Number:

(310) 794-5763

(310) 794-5785

Mailing Address:

UCLA Mol, Cell & Dvlmt Bio
BOX 951606, 621 Charles E. Young Dr. S,
Los Angeles, CA 90095


Work Address:

Office
611 Charles E. Young Drive East
Paul Boyer 559
Los Angeles, CA 90095


Detailed Biography:

Luisa Iruela-Arispe is a cell and developmental biologist and professor in the Department of Molecular, Cell and Developmental Biology. She earned her Ph.D. degree from the University of Sao Paulo in Brazil in 1989 and received post-doctoral training at the Universtity of Washington in Seattle. She was appointed Assistant Professor at the Department of Pathology at Harvard Medical School in 1994 where she stayed for four years. In 1998, Dr. Iruela-Arispe joined the faculty of the Department of Molecular, Cell and Developmental Biology at UCLA. Her research centers in understanding the molecular regulation of endothelial cell commitment and differentiation, patterning of the vasculature and homeostatic vascular function. This information has provided the basis to develop strategies to control vascular growth during disease, particularly in cancer. Dr. Iruela-Arispe is strongly committed to education. She is currently the Vice-Chair for teaching in her Department and provides instruction to both undergraduates and graduate students. She is actively involved in her field of research and has organized several meetings including two Gordon Conferences, one on Angiogenesis and a second on Vascular Biology. She is the founder and director of the Vascular Biology Training Program at UCLA.

Publications:

A selected list of publications:

Youssef, K., Jarenwattananon, N., Archer, B., Mack, J., Iruela-Arispe, L., Bouchard, L.   R-D flow control in porous scaffolds: Toward a next generation of bioreactors, IEEE Trans Biomed Eng, 2016; .
Download
Rodri­guez-Manzaneque Juan Carlos, Fernandez-Rodriguez R., Rodriguez-Baena Francisco Javier, Iruela-Arispe M Luisa   ADAMTS proteases in vascular biology Matrix biology : journal of the International Society for Matrix Biology, 2015; 44-46(11): 38-45.
Domigan Courtney K, Warren Carmen M, Antanesian Vaspour, Happel Katharina, Ziyad Safiyyah, Lee Sunyoung, Krall Abigail, Duan Lewei, Torres-Collado Antoni X, Castellani Lawrence W, Elashoff David, Christofk Heather R, van der Bliek Alexander M, Potente Michael, Iruela-Arispe M Luisa   Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy Journal of cell science, 2015; 128(12): 2236-48.
Download
Domigan CK, Warren CM, Antanesian V, Happel K, Ziyad S, Lee S, Krall A, Duan L, Torres-Collado AX, Castellani LW, Elashoff D, Christofk HR, van der Bliek AM, Potente M, Iruela-Arispe ML.   Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy, J Cell Sci, 2015; 128(12): 2236-48.
Download
Briot Anais, Iruela-Arispe M Luisa   Blockade of specific NOTCH ligands: a new promising approach in cancer therapy Cancer discovery, 2015; 5(2): 112-4.
Domigan Courtney K, Ziyad Safiyyah, Iruela-Arispe M Luisa   Canonical and noncanonical vascular endothelial growth factor pathways: new developments in biology and signal transduction Arteriosclerosis, thrombosis, and vascular biology, 2015; 35(1): 30-9.
Briot, A., Civelek, M., Seki, A., Hoi, K., Mack, J.J., Lee, S.D., Kim, J., Hong, C., Yu, J., Fishbein, G.A., Vakili, L., Fogelman, A.M., Fishbein M.C., Lusis, A.J., Tontonoz, P., Navab, M., Berliner, J.A., Iruela-Arispe, M.L.   Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis, J Exp Med, 2015; 212(12): 2147-63.
Download
Hernandez-Garci­a Ricardo, Iruela-Arispe M Luisa, Reyes-Cruz Guadalupe, Vazquez-Prado Jose©   Endothelial RhoGEFs: A systematic analysis of their expression profiles in VEGF-stimulated and tumor endothelial cells Vascular pharmacology, 2015; .
Hernandez-Garcia, R., Iruela-Arispe, M.L., Reyes-Cruz, G., Vazquez-Prado, J.   Endothelial RhoGEFs: A systematic analysis of their expression profiles in VEGF-stimulated and tumor endothelial cells, Vascul Pharmacol, 2015; 74: 60-72.
Download
McDonald Austin I, Iruela-Arispe M Luisa   Healing arterial ulcers: Endothelial lining regeneration upon vascular denudation injury Vascular pharmacology, 2015; 72: 9-15.
McDonald, A., Iruela-Arispe, M.L.   Healing arterial ulcers: Endothelial lining regeneration upon vascular denudation injury, Vascul Pharmacol, 2015; 72: 9-15.
Download
Rannou, E., Francois, A., Toullec, A., Guipaud, O., Buard, V., Tarlet, G., Mintet, E., Jaillet, C., Iruela-Arispe, M.L., Benderitter, M., Sabourin, J.C., Milliat, F.   In vivo evidence for an endothelium-dependent mechanism in radiation-induced normal tissue injury, Sci Rep, 2015; 5: 15738.
Download
Moughon Diana, He Huanhuan, Schokrpur Shiruyeh, Jiang Ziyue Karen, Yaqoob Madeeha, David John, Lin Crystal, Iruela-Arispe M Luisa, Dorigo Oliver, Wu Lily   Macrophage Blockade Using CSF1R Inhibitors Reverses The Vascular Leakage Underlying Malignant Ascites In Late-Stage Epithelial Ovarian Cancer Cancer research, 2015; .
Moughon, D.L., He, H., Schokrpur, S., Jiang, Z.K., Yaqoob, M., David, J., Lin, C., Iruela-Arispe, M.L., Dorigo, O., Wu, L.   Macrophage blockade using CSF1R inhibitors reverses the vascular leakage underlying malignant ascites in late-stage epithelial ovarian cancer, Cancer Res, 2015; 75(22): 4742-52.
Download
Simons Michael, Alitalo Kari, Annex Brian H, Augustin Hellmut G, Beam Craig, Berk Bradford C, Byzova Tatiana, Carmeliet Peter, Chilian William, Cooke John P, Davis George E, Eichmann Anne, Iruela-Arispe M Luisa, Keshet Eli, Sinusas Albert J, Ruhrberg Christiana, Woo Y Joseph, Dimmeler Stefanie, Dimmeler Stefanie   State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A Scientific Statement From the American Heart Association Circulation research, 2015; 116(11): e99-132.
Warren, C.M., Ziyad, S., Briot, A., Der, A., Iruela-Arispe, M.L.   A Ligand-Independent VEGFR2 Signaling Pathway Limits Angiogenic Responses in Diabetes, Science Signaling, 2014; 7(307): .
Download
Griffin, D.R., Borrajo, J., Soon, A., Acosta-Velez, G.F., Oshita, V., Darling, N., Mack, J., Barker, T., Iruela-Arispe, M.L., Segura, T.   Hybrid Photopatterned Enzymatic Reaction (HyPER) for in Situ Cell Manipulation, Chemobiochem, 2014; 15(2): 233-242.
Download
Michael Iacovos P, Westenskow Peter D, Hacibekiroglu Sabiha, Greenwald Alissa Cohen, Ballios Brian G, Kurihara Toshihide, Li Zhijie, Warren Carmen M, Zhang Puzheng, Aguilar Edith, Donaldson Laura, Marchetti Valentina, Baba Takeshi, Hussein Samer M, Sung Hoon-Ki, Iruela-Arispe M Luisa, Rini James M, van der Kooy Derek, Friedlander Martin, Nagy Andras   Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye EMBO molecular medicine, 2014; 6(5): 604-23.
Warren Carmen M, Iruela-Arispe M Luisa   Podosome rosettes precede vascular sprouts in tumour angiogenesis Nature cell biology, 2014; 16(10): 928-30.
Goddard, L.M., Murphy, J.T., Org, T., Enciso, J.M., Hashimoto-Partyka, M.K., Warren, C.M., Domigan, C.K., McDonald, A.I., He, H., Sanchez, L.A., Allen, N.C., Orsenigo, F., Chao, L.C., Dejana, E., Tontonoz, P., Mikkola, H.K.A., Iruela-Arispe, M.L.   Progesterone receptor in the vascular endothelium triggers physiological uterine permeability pre-implantation, Cell, 2014; 156(3): 549-562.
Download
Briot Anais, Jaroszewicz Artur, Warren Carmen M, Lu Jing, Touma Marlin, Rudat Carsten, Hofmann Jennifer J, Airik Rannar, Weinmaster Gerry, Lyons Karen, Wang Yibin, Kispert Andreas, Pellegrini Matteo, Iruela-Arispe M Luisa   Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells Developmental cell, 2014; 31(6): 707-21.
Domigan Courtney K, Iruela-Arispe M Luisa   Stealing VEGF from thy neighbor Cell, 2014; 159(3): 473-4.
Nowak-Sliwinska Patrycja, Segura Tatiana, Iruela-Arispe M Luisa   The chicken chorioallantoic membrane model in biology, medicine and bioengineering Angiogenesis, 2014; 17(4): 779-804.
Goddard Lauren M, Iruela-Arispe M Luisa   Cellular and molecular regulation of vascular permeability Thrombosis and haemostasis, 2013; 109(3): 407-15.
Cristofaro Brunella, Shi Yu, Faria Marcella, Suchting Steven, Leroyer Aurelie S, Trindade Alexandre, Duarte Antonio, Zovein Ann C, Iruela-Arispe M Luisa, Nih Lina R, Kubis Nathalie, Henrion Daniel, Loufrani Laurent, Todiras Mihail, Schleifenbaum Johanna, Gollasch Maik, Zhuang Zhen W, Simons Michael, Eichmann Anne, le Noble Ferdinand   Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models Development (Cambridge, England), 2013; 140(8): 1720-9.
Roodhart Jeanine M L, He Huanhuan, Daenen Laura G M, Monvoisin Arnaud, Barber Chad, Amersfoort Miranda van, Hofmann Jennifer J, Radtke Freddy, Lane Timothy F, Voest Emile E, Iruela-Arispe M Luisa   Notch1 regulates angio-supportive bone marrow-derived cells: relevance to chemoresistance Blood, 2013; .
Janzen Deanna M, Rosales Miguel A, Paik Daniel Y, Lee Daniel S, Smith Daniel A, Witte Owen N, Iruela-Arispe M Luisa, Memarzadeh Sanaz   Progesterone receptor signaling in the microenvironment of endometrial cancer influences its response to hormonal therapy Cancer research, 2013; .
Mack Julia J, Youssef Khalid, Noel Onika D V, Lake Michael P, Wu Ashley, Iruela-Arispe M Luisa, Bouchard Louis-S   Real-time maps of fluid flow fields in porous biomaterials Biomaterials, 2013; 34(8): 1980-6.
Baer Caroline, Squadrito Mario Leonardo, Iruela-Arispe M Luisa, De Palma Michele   Reciprocal interactions between endothelial cells and macrophages in angiogenic vascular niches Experimental cell research, 2013; 140(8): .
Goddard Lauren M, Ton Amy N, Org Tõnis, Mikkola Hanna K A, Iruela-Arispe M Luisa   Selective suppression of endothelial cytokine production by progesterone receptor Vascular pharmacology, 2013; .
Corada, M., Orsenigo, F., Morini, M.F., Pitulescu, M. Bhat, G., Nyqvist, D., Breviario, F., Conti, V., Briot, A., Iruela-Arispe, M.L., Adams, R.H., Dejana, E.   Sox17 is indispensable for acquisition and maintenance of arterial identity, Nature Commun, 2013; 4: .
Defalco Tony, Saraswathula Anirudh, Briot Anais, Iruela-Arispe M Luisa, Capel Blanche   Testosterone levels influence mouse fetal leydig cell progenitors through notch signaling Biology of reproduction, 2013; 88(4): 91.
Milde, F., Iruela-Arispe, M.L., Koumoutsakos, P.   The Mouse Retina in 3D: Quantification of vascular growth and remodeling, Integrative Biol, 2013; 5(12): 1426-1438.
Download
Iruela-Arispe M Luisa, Beitel Greg J   Tubulogenesis Development (Cambridge, England), 2013; 140(14): 2851-5.
Turlo Kirsten A, Scapa Jason, Bagher Pooneh, Jones Allan W, Feil Robert, Korthuis Ronald J, Segal Steven S, Iruela-Arispe M Luisa   β1-integrin is essential for vasoregulation and smooth muscle survival in vivo Arteriosclerosis, thrombosis, and vascular biology, 2013; 33(10): 2325-35.
Turlo Kirsten A, Noel Onika D V, Vora Roshni, LaRussa Marie, Fassler Reinhard, Hall-Glenn Faith, Iruela-Arispe M Luisa   An essential requirement for β1 integrin in the assembly of extracellular matrix proteins within the vascular wall Developmental biology, 2012; 365(1): 23-35.
Avraham-Davidi Inbal, Ely Yona, Pham Van N, Castranova Daniel, Grunspan Moshe, Malkinson Guy, Gibbs-Bar Liron, Mayseless Oded, Allmog Gabriella, Lo Brigid, Warren Carmen M, Chen Tom T, Ungos Josette, Kidd Kameha, Shaw Kenna, Rogachev Ilana, Wan Wuzhou, Murphy Philip M, Farber Steven A, Carmel Liran, Shelness Gregory S, Iruela-Arispe M Luisa, Weinstein Brant M, Yaniv Karina   ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1 Nature medicine, 2012; 18(6): 967-73.
Hall-Glenn Faith, De Young R Andrea, Huang Bau-Lin, van Handel Ben, Hofmann Jennifer J, Chen Tom T, Choi Aaron, Ong Jessica R, Benya Paul D, Mikkola Hanna, Iruela-Arispe M Luisa, Lyons Karen M   CCN2/connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis PloS one, 2012; 7(2): e30562.
He Huanhuan, Xu Jingying, Warren Carmen M, Duan Dan, Li Xinmin, Wu Lily, Iruela-Arispe M Luisa   Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages Blood, 2012; 120(15): 3152-62.
Hofmann Jennifer J, Briot Anais, Enciso Josephine, Zovein Ann C, Ren Shuxun, Zhang Zhen W, Radtke Freddy, Simons Michael, Wang Yibin, Iruela-Arispe M Luisa   Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome Development (Cambridge, England), 2012; 139(23): 4449-60.
Cooley Marion A, Fresco Victor M, Dorlon Margaret E, Twal Waleed O, Lee Nathan V, Barth Jeremy L, Kern Christine B, Iruela-Arispe M Luisa, Argraves W Scott   Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation Developmental dynamics : an official publication of the American Association of Anatomists, 2012; 241(2): 303-14.
Scheppke Lea, Murphy Eric A, Zarpellon Alessandro, Hofmann Jennifer J, Merkulova Alona, Shields David J, Weis Sara M, Byzova Tatiana V, Ruggeri Zaverio M, Iruela-Arispe M Luisa, Cheresh David A   Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane Blood, 2012; 119(9): 2149-58.
Domigan Courtney K, Iruela-Arispe M Luisa   Recent advances in vascular development Current opinion in hematology, 2012; 19(3): 176-83.
Howell Matthew D, Torres-Collado Antoni X, Iruela-Arispe M Luisa, Gottschall Paul E   Selective decline of synaptic protein levels in the frontal cortex of female mice deficient in the extracellular metalloproteinase ADAMTS1 PloS one, 2012; 7(10): e47226.
Chhabra Akanksha, Lechner Andrew J, Ueno Masaya, Acharya Asha, Van Handel Ben, Wang Yanling, Iruela-Arispe M Luisa, Tallquist Michelle D, Mikkola Hanna K A   Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling Developmental cell, 2012; 22(3): 651-9.
Iruela-Arispe M Luisa   LUMENating blood vessels Developmental cell, 2011; 20(4): 412-4.
Ziyad Safiyyah, Iruela-Arispe M Luisa   Molecular mechanisms of tumor angiogenesis Genes & cancer, 2011; 2(12): 1085-96.
Anderson Sean M, Shergill Bhupinder, Barry Zachary T, Manousiouthakis Eleana, Chen Tom T, Botvinick Elliot, Platt Manu O, Iruela-Arispe M Luisa, Segura Tatiana   VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF Integrative biology : quantitative biosciences from nano to macro, 2011; 3(9): 887-96.
Chen, T.T., Luque, A., Lee, S., Anderson, S.M., Segura, T., Iruela-Arispe, M.L.   Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells. , J Cell Biol, 2010; 188(4): 595-609.
Chen Tom T, Luque Alfonso, Lee Sunyoung, Anderson Sean M, Segura Tatiana, Iruela-Arispe M Luisa   Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells The Journal of cell biology, 2010; 188(4): 595-609.
Zovein Ann C, Luque Alfonso, Turlo Kirsten A, Hofmann Jennifer J, Yee Kathleen M, Becker Michael S, Fassler Reinhard, Mellman Ira, Lane Timothy F, Iruela-Arispe M Luisa   Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism Developmental cell, 2010; 18(1): 39-51.
da Silva Rita Graça, Tavora Bernardo, Robinson Stephen D, Reynolds Louise E, Szekeres Charles, Lamar John, Batista Sílvia, Kostourou Vassiliki, Germain Mitchel A, Reynolds Andrew R, Jones Dylan T, Watson Alan R, Jones Janet L, Harris Adrian, Hart Ian R, Iruela-Arispe M Luisa, Dipersio C Michael, Kreidberg Jordan A, Hodivala-Dilke Kairbaan M   Endothelial alpha3beta1-integrin represses pathological angiogenesis and sustains endothelial-VEGF The American journal of pathology, 2010; 177(3): 1534-48.
Arroyo Alicia G, Iruela-Arispe M Luisa   Extracellular matrix, inflammation, and the angiogenic response Cardiovascular research, 2010; 86(2): 226-35.
Hofmann, J.J., Zovein, A.C., Koh, H., Radtke, R., Weinmaster, G., and Iruela-Arispe, M.L.   Instructive role of the vasculature in bile duct development revealed through deletion of Jagged1: Insights into Alagile Syndrome, Development, 2010; .
Hofmann Jennifer J, Zovein Ann C, Koh Huilin, Radtke Freddy, Weinmaster Gerry, Iruela-Arispe M Luisa   Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome Development (Cambridge, England), 2010; 137(23): 4061-72.
Stockmann Christian, Kerdiles Yann, Nomaksteinsky Marc, Weidemann Alexander, Takeda Norihiko, Doedens Andrew, Torres-Collado Antonio X, Iruela-Arispe Luisa, Nizet Victor, Johnson Randall S   Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(9): 4329-34.
Warren Carmen M, Iruela-Arispe M Luisa   Signaling circuitry in vascular morphogenesis Current opinion in hematology, 2010; 17(3): 213-8.
Priceman Saul J, Sung James L, Shaposhnik Zory, Burton Jeremy B, Torres-Collado Antoni X, Moughon Diana L, Johnson Mai, Lusis Aldons J, Cohen Donald A, Iruela-Arispe M Luisa, Wu Lily   Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy Blood, 2010; 115(7): 1461-71.
Corada Monica, Nyqvist Daniel, Orsenigo Fabrizio, Caprini Andrea, Giampietro Costanza, Taketo Makoto M, Iruela-Arispe M Luisa, Adams Ralf H, Dejana Elisabetta   The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling Developmental cell, 2010; 18(6): 938-49.
Lee Yoon-Jin, Koch Moritz, Karl Daniel, Torres-Collado Antoni X, Fernando Namali T, Rothrock Courtney, Kuruppu Darshini, Ryeom Sandra, Iruela-Arispe M Luisa, Yoon Sam S   Variable inhibition of thrombospondin 1 against liver and lung metastases through differential activation of metalloproteinase ADAMTS1 Cancer research, 2010; 70(3): 948-56.
Zovein Ann C, Turlo Kirsten A, Ponec Ryan M, Lynch Maureen R, Chen Kevin C, Hofmann Jennifer J, Cox Timothy C, Gasson Judith C, Iruela-Arispe M Luisa   Vascular remodeling of the vitelline artery initiates extravascular emergence of hematopoietic clusters Blood, 2010; 116(18): 3435-44.
Turlo Kirsten A, Gallaher Sean D, Vora Roshni, Laski Frank A, Iruela-Arispe M Luisa   When Cre-mediated recombination in mice does not result in protein loss Genetics, 2010; 186(3): 959-67.
Iruela-Arispe M Luisa, Davis George E   Cellular and molecular mechanisms of vascular lumen formation Developmental cell, 2009; 16(2): 222-31.
Rodríguez-Manzaneque Juan Carlos, Carpizo Darren, Plaza-Calonge María del Carmen, Torres-Collado Antoni Xavier, Thai Shelley N-M, Simons Michael, Horowitz Arie, Iruela-Arispe M Luisa   Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion The international journal of biochemistry & cell biology, 2009; 41(4): 800-10.
Speck, N.A. and Iruela-Arispe, M.L.   Conditional Cre/LoxP Strategies for the Study of Hematopoietic Stem Cell Formation, Blood Cells Mol. Dis, 2009; 43: 6-11.
Speck Nancy A, Iruela-Arispe M Luisa   Conditional Cre/LoxP strategies for the study of hematopoietic stem cell formation Blood cells, molecules & diseases, 2009; 43(1): 6-11.
Torres-Collado, A.X. Iruela-Arispe, M.L.   Contributions of ADAMS and ADAMTSs during tumor expansion and metastasis, Cancer Genome and Tumor Microenvironment, 2009; 293-314.
Skuli Nicolas, Liu Liping, Runge Anja, Wang Tao, Yuan Lijun, Patel Sunny, Iruela-Arispe Luisa, Simon M Celeste, Keith Brian   Endothelial deletion of hypoxia-inducible factor-2alpha (HIF-2alpha) alters vascular function and tumor angiogenesis Blood, 2009; 114(2): 469-77.
Iruela-Arispe, M.L. and Lee, S.   Mechanisms Underlying Contex-Dependent VEGF Signaling for Distinct Biological Responses. , Handbook of Cell Signaling, 2nd Edition, 2009; 1919-1925.
Anderson Sean M, Chen Tom T, Iruela-Arispe M Luisa, Segura Tatiana   The phosphorylation of vascular endothelial growth factor receptor-2 (VEGFR-2) by engineered surfaces with electrostatically or covalently immobilized VEGF Biomaterials, 2009; 30(27): 4618-28.
Zovein Ann C, Iruela-Arispe M Luisa   Time to cut the cord: placental HSCs grow up Cell stem cell, 2009; 5(4): 351-2.
Suárez Yajaira, Fernández-Hernando Carlos, Yu Jun, Gerber Scott A, Harrison Kenneth D, Pober Jordan S, Iruela-Arispe M Luisa, Merkenschlager Matthias, Sessa William C   Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis Proceedings of the National Academy of Sciences of the United States of America, 2008; 105(37): 14082-7.
Stankunas Kryn, Hang Calvin T, Tsun Zhi-Yang, Chen Hanying, Lee Nathan V, Wu Jiang I, Shang Ching, Bayle J Henri, Shou Weinian, Iruela-Arispe M Luisa, Chang Ching-Pin   Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis Developmental cell, 2008; 14(2): 298-311.
Iruela-Arispe, M.L.   Endothelial Cell Activation, Angiogenesis: An Integrative Approach from Science to Medicine, 2008; 35-43.
Zovein Ann C, Hofmann Jennifer J, Lynch Maureen, French Wendy J, Turlo Kirsten A, Yang Yanan, Becker Michael S, Zanetta Lucia, Dejana Elisabetta, Gasson Judith C, Tallquist Michelle D, Iruela-Arispe M Luisa   Fate tracing reveals the endothelial origin of hematopoietic stem cells Cell stem cell, 2008; 3(6): 625-36.
Misra Sanjay, Lee Nathan, Fu Alex A, Raghavakaimal Sreekumar, Mandrekar Jaywant, Bjarnason Haraldur, McKusick Michael A, Iruela-Arispe Luisa, Mukhopadhyay Debabrata   Increased expression of a disintegrin and metalloproteinase thrombospondin 1 in thrombosed hemodialysis grafts Journal of vascular and interventional radiology : JVIR, 2008; 19(1): 111-9.
Guo Wei, Lasky Joseph L, Chang Chun-Ju, Mosessian Sherly, Lewis Xiaoman, Xiao Yun, Yeh Jennifer E, Chen James Y, Iruela-Arispe M Luisa, Varella-Garcia Marileila, Wu Hong   Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation Nature, 2008; 453(7194): 529-33.
Guo, W., Lasky, J.L., Chang, C.J., Mosessian, S., Lewis, X., Xiao, Y., Yeh, J.E., Chen, J.Y., Iruela-Arispe, M.L., Varella-Garcia, M., and Wu, H.   Multiple genetic and molecular alterations cooperatively contribute LSC formation in a Pten-deficient leukemia model. , Nature, 2008; 453: 529-533.
Iruela-Arispe M Luisa   Regulation of thrombospondin1 by extracellular proteases Current drug targets, 2008; 9(10): 863-8.
Lee Sunyoung, Chen Tom T, Barber Chad L, Jordan Maria C, Murdock Jared, Desai Sharina, Ferrara Napoleone, Nagy Andras, Roos Kenneth P, Iruela-Arispe M Luisa   Autocrine VEGF signaling is required for vascular homeostasis Cell, 2007; 130(4): 691-703.
Hellström Mats, Phng Li-Kun, Hofmann Jennifer J, Wallgard Elisabet, Coultas Leigh, Lindblom Per, Alva Jackelyn, Nilsson Ann-Katrin, Karlsson Linda, Gaiano Nicholas, Yoon Keejung, Rossant Janet, Iruela-Arispe M Luisa, Kalén Mattias, Gerhardt Holger, Betsholtz Christer   Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis Nature, 2007; 445(7129): 776-80.
Hellstrom, M., Phng, L.K., Hofmann, J.J., Wallgard, El., Coultas, L., Limdblom, P., Alva, J., Nilsson, L., Gaiano, N., Yoon, K., Rossant, J., Iruela-Arispe, M.L., Kalen, M., Gerhardt, H., and Betsholtz, C.   Dll4/Notch1 signaling is required for selection of single endothelial tip cells. , Nature, 2007; 445: 776-780.
Lundkvist Andrea, Lee Sunyoung, Iruela-Arispe Luisa, Betsholtz Christer, Gerhardt Holger   Growth factor gradients in vascular patterning Novartis Foundation symposium, 2007; 283(7129): 194-201; discussion 201-6, 238-41.
Lee Min, Chen Tom T, Iruela-Arispe M Luisa, Wu Benjamin M, Dunn James C Y   Modulation of protein delivery from modular polymer scaffolds Biomaterials, 2007; 28(10): 1862-70.
Hofmann Jennifer J, Luisa Iruela-Arispe M   Notch expression patterns in the retina: An eye on receptor-ligand distribution during angiogenesis Gene expression patterns : GEP, 2007; 7(4): 461-70.
Hofmann Jennifer J, Iruela-Arispe M Luisa   Notch signaling in blood vessels: who is talking to whom about what? Circulation research, 2007; 100(11): 1556-68.
Lee, S. and Iruela-Arispe, M.L.   The Extracellular Matrix and VEGF Processing. , Anti-Angiogenesis, 2nd Edition, 2007; .
Lee, N.V. and Iruela-Arispe, M.L.   Thrombospondins and Angiogenesis. , Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy. , 2007; 233-245.
Yang Li V, Radu Caius G, Roy Meenakshi, Lee Sunyoung, McLaughlin Jami, Teitell Michael A, Iruela-Arispe M Luisa, Witte Owen N   Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor Molecular and cellular biology, 2007; 27(4): 1334-47.
Torres-Collado, A.X., Kisiel, W., Iruela-Arispe, M.L., Rodriguez-Manzaneque, J.C.   . ADAMTS1 interacts with, cleaves and modifies the extracellular location of the matrix inhibitor tissue factor pathway inhibitor-2 (TFPI-2), J Biol Chem, 2006; 281: 17827-17837.
Lee Nathan V, Sato Makoto, Annis Douglas S, Loo Joseph A, Wu Lily, Mosher Deane F, Iruela-Arispe M Luisa   ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2 The EMBO journal, 2006; 25(22): 5270-83.
Hashimoto-Partyka Minako K, Lydon John P, Iruela-Arispe M Luisa   Generation of a mouse for conditional excision of progesterone receptor Genesis (New York, N.Y. : 2000), 2006; 44(8): 391-5.
Zovein Ann C, Iruela-Arispe M Luisa   My O'Myeloid, a tale of two lineages Proceedings of the National Academy of Sciences of the United States of America, 2006; 103(35): 12959-60.
Kern Christine B, Twal Waleed O, Mjaatvedt Corey H, Fairey Sarah E, Toole Bryan P, Iruela-Arispe M Luisa, Argraves W Scott   Proteolytic cleavage of versican during cardiac cushion morphogenesis Developmental dynamics : an official publication of the American Association of Anatomists, 2006; 235(8): 2238-47.
Barber, C.L. and Iruela-Arispe, M.L.   The Ever-Elusive Endothelial Progenitor Cell: Identities, Functions and Clinical Implications. , Pediatric Res, 2006; 59: 26R-32R.
Alva Jackelyn A, Zovein Ann C, Monvoisin Arnaud, Murphy Thomas, Salazar Anthony, Harvey Natasha L, Carmeliet Peter, Iruela-Arispe M Luisa   VE-Cadherin-Cre-recombinase transgenic mouse: a tool for lineage analysis and gene deletion in endothelial cells Developmental dynamics : an official publication of the American Association of Anatomists, 2006; 235(3): 759-67.
Monvoisin, A., Alva, J.A., Hofmann, J.J., Zovein, A.C., Lane, T.F., and Iruela-Arispe, M.L.   VE-cadherin-CreER(T2) transgenic mice: A model for inducible recombination in the endothelium, Dev Dyn, 2006; 235: 3413-3422.
Monvoisin Arnaud, Alva Jackelyn A, Hofmann Jennifer J, Zovein Ann C, Lane Timothy F, Iruela-Arispe M Luisa   VE-cadherin-CreERT2 transgenic mouse: a model for inducible recombination in the endothelium Developmental dynamics : an official publication of the American Association of Anatomists, 2006; 235(12): 3413-22.
Iruela-Arispe M Luisa   When it comes to blocking lymphatics, it is all a question of time The American journal of pathology, 2006; 169(2): 347-50.
Krampert Monika, Kuenzle Sandra, Thai Shelley N-M, Lee Nathan, Iruela-Arispe M Luisa, Werner Sabine   ADAMTS1 proteinase is up-regulated in wounded skin and regulates migration of fibroblasts and endothelial cells The Journal of biological chemistry, 2005; 280(25): 23844-52.
Cho Hyun-Mi, Rosenblatt Joseph D, Kang Young-Sook, Iruela-Arispe M Luisa, Morrison Sherie L, Penichet Manuel L, Kwon Young-Guen, Kim Tae-Woong, Webster Keith A, Nechustan Hovav, Shin Seung-Uon   Enhanced inhibition of murine tumor and human breast tumor xenografts using targeted delivery of an antibody-endostatin fusion protein Molecular cancer therapeutics, 2005; 4(6): 956-67.
Lee Nathan V, Rodriguez-Manzaneque Juan Carlos, Thai Shelley N-M, Twal Waleed O, Luque Alfonso, Lyons Karen M, Argraves W Scott, Iruela-Arispe M Luisa   Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1 The Journal of biological chemistry, 2005; 280(41): 34796-804.
Lee Sunyoung, Jilani Shahla M, Nikolova Ganka V, Carpizo Darren, Iruela-Arispe M Luisa   Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors The Journal of cell biology, 2005; 169(4): 681-91.
Iruela-Arispe ML   Vascular Development and Angiogenesis, Encyclopedia of Molecular Cell Biology and Molecular Medicine, 2005; .
Calzada Maria J, Zhou Longen, Sipes John M, Zhang Jane, Krutzsch Henry C, Iruela-Arispe M Luisa, Annis Douglas S, Mosher Deane F, Roberts David D   Alpha4beta1 integrin mediates selective endothelial cell responses to thrombospondins 1 and 2 in vitro and modulates angiogenesis in vivo Circulation research, 2004; 94(4): 462-70.
Iruela-Arispe Luisa   Angiogenesis: novel and basic science insights and human therapy - keystone symposium IDrugs : the investigational drugs journal, 2004; 7(2): 111-3.
Fiala Milan, Murphy Thomas, MacDougall James, Yang Wendy, Luque Alfonso, Iruela-Arispe Luisa, Cashman John, Buga Georgette, Byrns Russel E, Barbaro Giuseppe, Arthos James   HAART drugs induce mitochondrial damage and intercellular gaps and gp120 causes apoptosis Cardiovascular toxicology, 2004; 4(4): 327-37.
Alva Jackelyn A, Iruela-Arispe M Luisa   Notch signaling in vascular morphogenesis Current opinion in hematology, 2004; 11(4): 278-83.
Iruela-Arispe M Luisa, Luque Alfonso, Lee Nathan   Thrombospondin modules and angiogenesis The international journal of biochemistry & cell biology, 2004; 36(6): 1070-8.
Thomas-Tikhonenko Andrei, Iruela-Arispe M Luisa   Whence thrombospondin? Cancer biology & therapy, 2004; 3(4): 406-7.
Luque Alfonso, Carpizo Darren R, Iruela-Arispe M Luisa   ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165 The Journal of biological chemistry, 2003; 278(26): 23656-65.
Iruela-Arispe M Luisa, Carpizo Darren, Luque Alfonso   ADAMTS1: a matrix metalloprotease with angioinhibitory properties Annals of the New York Academy of Sciences, 2003; 995(26): 183-90.
Ellwood-Yen Katharine, Graeber Thomas G, Wongvipat John, Iruela-Arispe M Luisa, Zhang JianFeng, Matusik Robert, Thomas George V, Sawyers Charles L   Myc-driven murine prostate cancer shares molecular features with human prostate tumors Cancer cell, 2003; 4(3): 223-38.
Jilani Shahla M, Murphy Thomas J, Thai Shelley N M, Eichmann Anne, Alva Jackelyn A, Iruela-Arispe M Luisa   Selective binding of lectins to embryonic chicken vasculature The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2003; 51(5): 597-604.
Park Ho-Jin, Kong Dequan, Iruela-Arispe Luisa, Begley Ulrike, Tang Dongjiang, Galper Jonas B   3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA Circulation research, 2002; 91(2): 143-50.
Rodríguez-Manzaneque Juan Carlos, Westling Jennifer, Thai Shelley N-M, Luque Alfonso, Knauper Vera, Murphy Gillian, Sandy John D, Iruela-Arispe M Luisa   ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors Biochemical and biophysical research communications, 2002; 293(1): 501-8.
Murayama Yuichi, Viñuela Fernando, Tateshima Satoshi, Gonzalez Nestor R, Song Joon K, Mahdavieh Haleh, Iruela-Arispe Luisa   Cellular responses of bioabsorbable polymeric material and Guglielmi detachable coil in experimental aneurysms Stroke; a journal of cerebral circulation, 2002; 33(4): 1120-8.
Thai Shelley N-M, Iruela-Arispe M Luisa   Expression of ADAMTS1 during murine development Mechanisms of development, 2002; 115(1-2): 181-5.
Gaspar John, Thai Shelley, Voland Carole, Dube Antoinise, Libermann Towia A, Iruela-Arispe M Luisa, Oettgen Peter   Opposing functions of the Ets factors NERF and ELF-1 during chicken blood vessel development Arteriosclerosis, thrombosis, and vascular biology, 2002; 22(7): 1106-12.
Adams Jason Y, Johnson Mai, Sato Makoto, Berger Frank, Gambhir Sanjiv S, Carey Michael, Iruela-Arispe M Luisa, Wu Lily   Visualization of advanced human prostate cancer lesions in living mice by a targeted gene transfer vector and optical imaging Nature medicine, 2002; 8(8): 891-7.
Dube A, Thai S, Gaspar J, Rudders S, Libermann TA, Iruela-Arispe L, Oettgen P   Elf-1 is a transcriptional regulator of the Tie2 gene during vascular development Circulation research. , 2001; 88(2): 237-44.
Saaristo A, Karkkainen MJ, Alitalo K, Montesano R, Iruela-Arispe ML, Pepper MS   Growth factor regulation of physiological angiogenesis in the mammary gland, Vascular Morphogenesis in the Female Reproductive System, 2001; Eds: Augustin, H.G., Iruela-Arispe, M.L., Rogers, : 25-40.
Rodriguez-Manzaneque JC, Lane TF, Ortega MA, Hynes RO, Lawler J and Iruela-Arispe ML   Thrombospondin-1 suppresses tumor growth by a novel mechanism that includes blockade of matrix metalloproteinase-9 activation PNAS, 2001; 22: 12485-12490.
Villa N, Walker L, Lindsell CE, Gasson J, Iruela-Arispe ML, Weinmaster G   Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels Mechanisms of development. , 2001; 108(1-2): 161-4.
Iruela-Arispe ML, Ortega MA, Oikemus S and Pepper MS   Vascular morphogenesis in the mammary gland - introduction and overview, Vascular Morphogenesis in the Female Reproductive System, 2001; Eds: Augustin, H.G., Iruela-Arispe, M.L., Rogers, : 3-24.
Graubert MD, Ortega MA, Kessel B, Mortola JF and Iruela-Arispe ML   Vascular repair after menstruation involves regulation of vascular endothelial growthfactor-receptor phosphorylation by sFLT-1 Am J Pathol, 2001; 158(4): 1399-410.
Sandy JD, Westling J, Kenagy RD, Iruela-Arispe ML, Verscharen C, Rodriguez-Mazaneque JC, Zimmermann DR, Lemire JM, Fischer JW, Wight TN, Clowes AW   Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4 The Journal of biological chemistry. , 2001; 276(16): 13372-8.
Iruela-Arispe ML, Vazquez F, and Ortega MA   Antiangiogenic domains shared by thrombospondins and metallospondins, a new family of angiogenic inhibitors, Ann. N.Y. Acad. Sci, 2000; 886: 58-66.
Chandrasekaran L, He ZC, Al-Barazi H, Krutzch HC, Iruela-Arispe ML and Roberts DD   Cell contact-dependent activation of a3?1 integrin modulates endothelial cell responses to thrombospondin-1, Mol. Biol. Cell, 2000; 11: 2885-2900.
Rodriguez-Manzaneque JC, Milchanowski AB, Dufour EK, Leduc R and Iruela-Arispe ML   Characterization of Meth-1/Adamts-1 Processing Reveals Two Distinct Active Forms, J. Biol. Chem, 2000; 275: 33471-33479.
Carpizo D, Iruela-Arispe ML   Endogenous regulators of angiogenesis--emphasis on proteins with thrombospondin--type I motifs Cancer metastasis reviews. , 2000; 19(1-2): 159-65.
Rodriguez-Manzaneque JC, Graubert M and Iruela-Arispe ML   Endothelial cell dysfunction following prolonged activation of progesterone receptor, Human Reproduction, 2000; 15: 39-47.
Lee SW, Reimer CL, Fang L, Iruela-Arispe ML, Aaronson SA   Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression Molecular and cellular biology. , 2000; 20(5): 1723-32.
Pepper MS, Baetens D, Mandriota SJ, Di Sanza C, Oikemus S, Lane TF, Soriano JV, Montesano R, Iruela-Arispe ML   Regulation of VEGF and VEGF receptor expression in the rodent mammary gland during pregnancy, lactation, and involution Developmental dynamics : an official publication of the American Association of Anatomists. , 2000; 218(3): 507-24.
Pal S, Iruela-Arispe ML, Harvey VS, Zeng H, Nagy JA, Dvorak HF, Mukhopadhyay D   Retinoic acid selectively inhibits the vascular permeabilizing effect of VPF/VEGF, an early step in the angiogenic cascade Microvascular research. , 2000; 60(2): 112-20.
Streit M, Velasco P, Riccardi L, Spencer L, Brown LF, Janes L, Lange-Asschenfeldt B, Yano K, Hawighorst T, Iruela-Arispe L, Detmar M   Thrombospondin-1 suppresses wound healing and granulation tissue formation in the skin of transgenic mice The EMBO journal. , 2000; 19(13): 3272-82.
Iruela-Arispe ML, Ortega MA and Vazquez F   Anti-angiogenic domain of thrombospondin, Angiogenesis in Health and Disease: Basic Mechanisms and Clinical Applications, 1999; .
Iruela-Arispe ML, Vazquez F and Ortega MA   Anti-angiogenic domains shared by thrombospondins and ADAM/TS proteins, Anti-Cancer Proteins & Drugs: Structure, Function & Design, 1999; 886: 58-66.
Iruela-Arispe ML, Rodriguez-Manzaneque JC, Abu-Jawdeh G   Endometrial endothelial cells express estrogen and progesterone receptors and exhibit a tissue specific response to angiogenic growth factors Microcirculation (New York, N.Y. : 1994) , 1999; 6(2): 127-40.
Dhanabal M, Ramchandran R, Volk R, Stillman IE, Lombardo M, Iruela-Arispe ML, Simons M and Sukhatme VP   Endostatin: yeast production, mutants, and anti-tumor effect in renal cell carcinoma, Cancer Res, 1999; 59: 189-197.
Wu H, Lee SH, Gao J, Liu X, Iruela-Arispe ML   Inactivation of erythropoietin leads to defects in cardiac morphogenesis Development (Cambridge, England) , 1999; 126(16): 3597-605.
Zhai Y, Yu J, Iruela-Arispe L, Huang WQ, Wang Z, Hayes AJ, Lu J, Jiang G, Rojas L, Lippman ME, Ni J, Yu GL, Li LY   Inhibition of angiogenesis and breast cancer xenograft tumor growth by VEGI, a novel cytokine of the TNF superfamily International journal of cancer. Journal international du cancer. , 1999; 82(1): 131-6.
Iruela-Arispe ML, Lombardo M, Krutzsch HC, Lawler J and Roberts DD   Inhibition of angiogenesis by thrombospondin-1 is mediated by two independent regions within the type 1 repeats, Circulation, 1999; 100: 1423-1431.
Vazquez F, Hastings G, Ortega MA, Lane TF, Oikemus S, Lombardo M and Iruela-Arispe ML   METH1, a human ortholog of ADAMTS, and METH2 are members of a new family of proteins with angio-inhibitory activity, J. Biol. Chem, 1999; 274: 23349-23357.
Vazquez F, Rodriguez-Manzaneque JC, Lydon JP, Edwards DP, OMalley BW and Iruela-Arispe ML   Progesterone regulates proliferation of endothelial cells, J. Biol. Chem, 1999; 274: 2185-2192.
Brown LF, Guidi AJ, Schnitt SJ, Van De Water L, Iruela-Arispe ML, Yeo TK, Tognazzi K, Dvorak HF   Vascular stroma formation in carcinoma in situ, invasive carcinoma, and metastatic carcinoma of the breast Clinical cancer research : an official journal of the American Association for Cancer Research. , 1999; 5(5): 1041-56.
Uebelhoer, M., Iruela-Arispe, M.L.   Cross-talk between signaling and metabolism in the vasculature. , Vascular Pharm, 2016; 83: 4-9.
Download
Briot, A., Bouloumie, A., Iruela-Arispe, M.L.   Notch, lipids, and endothelial cells, Current Opin Lipidol, 2016; 27(5): 513-20.
He, H., Mack, J.J., Guc E., Warren, C.M., Squadrito, M.L., Kilarski, W.M., Baer, C., Freshman, R.D., McDonald, A.I., Ziyad, S., Swartz, M.A., De Palma, M., Iruela-Arispe, M.L.   Perivascular macrophages limit permeability, ATVB, 2016; 36: 2203-2212.
Download
Inkeles, M.S., Teles, R.M., Pouldar, D., Andrade, P.R., Madigan, C.A., Lopez, D., Ambrose, M., Noursadeghi, M., Sarno E.N., Rea, T.H., Ochoa, M.T., Iruela-Arispe, M.L., Swindell, W.R., Ottenhoff, T.H., Geluk, A., Bloom, B.R., Pellegrini, M., Modlin, R.L.   Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy, JCI Insight, 2016; 1(15): e88843.
Download
Shirali, A.S., McDonald, A.I., Mack, J.J., Iruela-Arispe, M.L.   Reproducible arterial denudation injury by infrarenal abdominal aortic clamping in a murine model, J Vis Exp, 2016; (117): e54755.
Download
Guihard, P.J., Yao, J., Blazquez-Medela, A.M., Iruela-Arispe, M.L., Bostrom, K.I., Yao, Y.   Endothelial-Mesenchymal transition in vascular calcification of Ins2 Akita/+ Mice. , PLoS One, 2016; 11(12): e54755.
Download

Does this profile need updating? Contact Us