Ana J. Coito, Ph.D.


Work Titles
UCLA Professor, Surgery Member, Liver and Pancreas Transplantation
Education:
Degrees:
Ph.D.

Contact Information:

Email Address:

acoito@mednet.ucla.edu

Work Email Address:

acoito@mednet.ucla.edu


Office Phone Number:

310-794-9480

Work Phone Number:

310-825-3887

Mailing Address:

The Dumont-UCLA Transplant Center
77-120 CHS
Box 957054
Los Angeles, CA 90095


Office Address:

Office
MRL 2726
Los Angeles, CA 90095


Work Address:

Laboratory
MRL 2230
Los Angeles, CA 90095


Detailed Biography:

Liver ischemia/reperfusion (I/R) injury is a pathophysiological process in which the hypoxic insult is further accentuated by restoration of blood flow to the compromised organ. Liver I/R injury is linked to leukocyte infiltration, release of free radicals and of cytokines. The mechanisms involved in leukocyte recruitment to inflammatory sites in liver are poorly understood. Overall, leukocytes circulate continuously in the blood, and their migration across endothelial barriers or extracellular matrix (ECM) proteins to inflamed tissues is a complex process dependent on the coordination of cellular adhesion-release steps and focal matrix degradation. While adhesion molecules are critical to the successful promotion of leukocyte transmigration by providing leukocyte attachment to the vascular endothelium, matrix metalloproteinases (MMPs) are important for facilitating leukocyte movement across vascular barriers. Our research is primarily focused in dissecting the function of key ECM proteins and MMPs upon leukocyte migration and activation in hepatic I/R injury.

Publications:

A selected list of publications:

Duarte Sergio, Baber John, Fujii Takehiro, Coito Ana J   Matrix metalloproteinases in liver injury, repair and fibrosis Matrix biology : journal of the International Society for Matrix Biology, 2015; .
Kato Hiroyuki, Kuriyama Naohisa, Duarte Sergio, Clavien Pierre-Alain, Busuttil Ronald W, Coito Ana J   MMP-9 deficiency shelters endothelial PECAM-1 expression and enhances regeneration of steatotic livers after ischemia and reperfusion injury Journal of hepatology, 2014; 60(5): 1032-9.
Duarte Sergio, Kato Hiroyuki, Kuriyama Naohisa, Suko Kathryn, Ishikawa Tomo-O, Busuttil Ronald W, Herschman Harvey R, Coito Ana J   Hepatic ischemia and reperfusion injury in the absence of myeloid cell-derived COX-2 in mice PloS one, 2014; 9(5): e96913.
Duarte S, Shen X-D, Fondevila C, Busuttil R W, Coito A J   Fibronectin-α4β1 interactions in hepatic cold ischemia and reperfusion injury: regulation of MMP-9 and MT1-MMP via the p38 MAPK pathway American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2012; 12(10): 2689-99.
Duarte Sergio, Hamada Takashi, Kuriyama Naohisa, Busuttil Ronald W, Coito Ana J   TIMP-1 deficiency leads to lethal partial hepatic ischemia and reperfusion injury Hepatology (Baltimore, Md.), 2012; 56(3): 1074-85.
Coito AJ.   Leukocyte transmigration across endothelial and extracellular matrix protein barriers in liver ischemia/reperfusion injury, Curr Opin Organ Transplant, 2011; 16(1): 34-40.
Kuriyama N, Duarte S, Hamada T, Busuttil RW, Coito AJ.   Tenascin-C: a novel mediator of hepatic ischemia and reperfusion injury, Hepatology, 2011; 54(6): 2125-36.
Fondevila C, Shen XD, Duarte S, Busuttil RW, Coito AJ.   Cytoprotective effects of a cyclic RGD peptide in steatotic liver cold ischemia and reperfusion injury, Am J Transplant. , 2009; 9(10): 2240-50.
Hamada T, Duarte S, Tsuchihashi S, Busuttil RW, Coito AJ   Inducible nitric oxide synthase deficiency impairs matrix metalloproteinase-9 activity and disrupts leukocyte migration in hepatic ischemia/reperfusion injury, Am J Pathol, 2009; 174(6): 2265-77.
Hamada T, Tsuchihashi S, Avanesyan A, Duarte S, Moore C, Busuttil RW, Coito AJ   Cyclooxygenase-2 deficiency enhances Th2 immune responses and impairs neutrophil recruitment in hepatic ischemia/reperfusion injury, J Immunol , 2008; 180: 1843-53.
Hamada T, Fondevila F, Busuttil RW, Coito AJ   Metalloproteinase-9 deficiency protects against hepatic ischemia/reperfusion injury, Hepatology, 2008; 47: 186-98.
Coito AJ   Immunology of Transplantation, Fundamentals of Immunology, 2007; Book Chapter: 249-256.
Moore C, Shen XD, Gao F, Busuttil RW, Coito AJ   Fibronectin-alpha4beta1 integrin interactions regulate metalloproteinase-9 expression in steatotic liver ischemia and reperfusion injury, American Journal of Pathology, 2007; 170: 567-77.
Coito AJ, Kupiec-Weglinski JW, Busuttil RW   Extracellular Matrix and Organ Transplantation, Immunobiology of Organ Transplantation, 2004; Book Chapter: 576-589.
Amersi F, Shen X-D, Moore C, Melinek J, Busuttil RW, Kupiec-Weglinski JW, Coito AJ   Fibronectin-a4b1 integrin interactions mediated blockade protects genetically fat zucker rat livers from ischemia/ reperfusion injury, Am. J. Pathol, 2003; 162: 1229-1239.

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