Alcino Jose Silva

Title(s)Professor, Neurobiology
SchoolMedicine
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    Other Positions
    Title(s)Professor, Psychiatry and Biobehavioral Sciences


    Collapse Overview 
    Collapse Overview
    The long-term goal of our laboratory is to understand the molecular, cellular, circuit and behavioral mechanisms of how we know what we know (check out our researchmaps.org!).
    Much of our work is focused on a crucial and exciting component of this question: memory. We are also leveraging our studies of memory and extraordinary cognition to develop treatments for cognitive disorders.

    Collapse Research 
    Collapse Research Activities and Funding
    CCR5 Activation and Cognitive Dysfunction Caused by HIV-Proteins
    NIH R01NS106969Sep 30, 2017 - May 31, 2022
    Role: Principal Investigator
    Molecular, Cellular and Circuit Mechnisms for Memory-linking deficits in Psychiatric Disorders
    NIH R01MH113071Jun 1, 2017 - May 31, 2022
    Role: Principal Investigator
    Building and sharing next generation open-source, wireless, multichannel miniaturized microscopes for imaging activity in freely behaving mice
    NIH U01NS094286Sep 30, 2015 - Jun 30, 2019
    Role: Co-Principal Investigator
    Forward Genetic Approaches to Mechanisms of Cortical Plasticity
    NIH P50MH077972Apr 1, 2007 - Aug 31, 2012
    Role: Principal Investigator
    Molecular and Cellular Cognition Meeting
    NIH R13MH073327Sep 22, 2004 - Jul 31, 2007
    Role: Principal Investigator
    AGE RELATED LEARNING AND MEMORY IMPROVEMENTS
    NIH R01AG017499Mar 1, 2000 - Feb 28, 2005
    Role: Principal Investigator
    PHENOTYPING THE MOUSE NERVOUS SYSTEM AND BEHAVIOR
    NIH R01MH061094Dec 6, 1999 - Nov 30, 2002
    Role: Principal Investigator
    Mechanisms for Cognitive Dysfunction in Noonan Syndrome
    NIH R01MH084315Sep 4, 1998 - Nov 30, 2020
    Role: Principal Investigator
    Mechanisms for Neurological Dysfunction in NF1
    NIH R01NS038480Sep 4, 1998 - Dec 31, 2008
    Role: Principal Investigator
    Molecular, cellular and circuit mechanisms for age-related deficits in memory-linking
    NIH RF1AG013622Jul 25, 1995 - Mar 31, 2022
    Role: Principal Investigator
    Gene Targeting Approaches to Learning and Memory Studies
    NIH R37AG013622Jul 25, 1995 - Jul 31, 2017
    Role: Principal Investigator
    Gene Targeting Approaches to Learning and Memory Studies
    NIH R01AG013622Jul 25, 1995 - Aug 31, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Intercellular Signaling Pathways as Therapeutic Targets for Vascular Dementia Repair. bioRxiv. 2024 Mar 27. Tian M, Kawaguchi R, Shen Y, Machnicki M, Villegas NG, Cooper DR, Montgomery N, Haring J, Lan R, Yuan AH, Williams CK, Magaki S, Vinters HV, Zhang Y, De Biase LM, Silva AJ, Carmichael ST. PMID: 38585718; PMCID: PMC10996514.
      View in: PubMed   Mentions:
    2. Control of feeding by a bottom-up midbrain-subthalamic pathway. Nat Commun. 2024 Mar 07; 15(1):2111. Reis FMCV, Maesta-Pereira S, Ollivier M, Schuette PJ, Sethi E, Miranda BA, Iniguez E, Chakerian M, Vaughn E, Sehgal M, Nguyen DCT, Yuan FTH, Torossian A, Ikebara JM, Kihara AH, Silva AJ, Kao JC, Khakh BS, Adhikari A. PMID: 38454000; PMCID: PMC10920831.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. Early Post-Natal Immune Activation Leads to Object Memory Deficits in Female Tsc2+/- Mice: The Importance of Including Both Sexes in Neuroscience Research. Biomedicines. 2024 Jan 17; 12(1). López-Aranda MF, Bach K, Bui R, Phan M, Lu O, Thadani C, Luchetti A, Mandanas R, Herrera I, López-Ávalos MD, Silva AJ. PMID: 38255309; PMCID: PMC10813674.
      View in: PubMed   Mentions:
    4. Behavioral and histological assessment of a novel treatment of neuroHIV in humanized mice. Res Sq. 2023 Dec 13. Levine AJ, Thadani C, Soontornniyomkij V, Lopez-Aranda MF, Mesa YG, Kitchen S, Rezek V, Silva A, Kolson DL. PMID: 38168407; PMCID: PMC10760308.
      View in: PubMed   Mentions:
    5. A dual-pathway architecture enables chronic stress to promote habit formation. bioRxiv. 2023 Oct 03. Giovanniello JR, Paredes N, Wiener A, Ramírez-Armenta K, Oragwam C, Uwadia HO, Lim K, Nnamdi G, Wang A, Sehgal M, Reis FM, Sias AC, Silva AJ, Adhikari A, Malvaez M, Wassum KM. PMID: 37873076; PMCID: PMC10592885.
      View in: PubMed   Mentions:
    6. Aversive experience drives offline ensemble reactivation to link memories across days. bioRxiv. 2023 Aug 19. Zaki Y, Pennington ZT, Morales-Rodriguez D, Francisco TR, LaBanca AR, Dong Z, Lamsifer S, Segura SC, Chen HT, Wick ZC, Silva AJ, van der Meer M, Shuman T, Fenton A, Rajan K, Cai DJ. PMID: 36993254; PMCID: PMC10054942.
      View in: PubMed   Mentions:
    7. Miniscope-LFOV: A large-field-of-view, single-cell-resolution, miniature microscope for wired and wire-free imaging of neural dynamics in freely behaving animals. Sci Adv. 2023 04 21; 9(16):eadg3918. Guo C, Blair GJ, Sehgal M, Sangiuliano Jimka FN, Bellafard A, Silva AJ, Golshani P, Basso MA, Blair HT, Aharoni D. PMID: 37083539; PMCID: PMC10121160.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    8. Local memory allocation recruits memory ensembles across brain regions. Neuron. 2023 02 15; 111(4):470-480.e5. Lavi A, Sehgal M, de Sousa AF, Ter-Mkrtchyan D, Sisan F, Luchetti A, Okabe A, Bear C, Silva AJ. PMID: 36563678; PMCID: PMC10548338.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    9. New research tools suggest a "levels-less" image of the behaving organism and dissolution of the reduction vs. anti-reduction dispute. Front Psychol. 2022; 13:990316. Bickle J, De Sousa AF, Silva AJ. PMID: 36110269; PMCID: PMC9470241.
      View in: PubMed   Mentions:
    10. A locus coeruleus-dorsal CA1 dopaminergic circuit modulates memory linking. Neuron. 2022 10 19; 110(20):3374-3388.e8. Chowdhury A, Luchetti A, Fernandes G, Filho DA, Kastellakis G, Tzilivaki A, Ramirez EM, Tran MY, Poirazi P, Silva AJ. PMID: 36041433; PMCID: PMC10508214.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    11. CCR5 closes the temporal window for memory linking. Nature. 2022 06; 606(7912):146-152. Shen Y, Zhou M, Cai D, Filho DA, Fernandes G, Cai Y, de Sousa AF, Tian M, Kim N, Lee J, Necula D, Zhou C, Li S, Salinas S, Liu A, Kang X, Kamata M, Lavi A, Huang S, Silva T, Do Heo W, Silva AJ. PMID: 35614219; PMCID: PMC9197199.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    12. Role of Type I Interferon Signaling and Microglia in the Abnormal Long-term Potentiation and Object Place Recognition Deficits of Male Mice With a Mutation of the Tuberous Sclerosis 2 Gene. Biol Psychiatry Glob Open Sci. 2023 Jul; 3(3):451-459. López-Aranda MF, Boxx GM, Phan M, Bach K, Mandanas R, Herrera I, Taloma S, Thadani C, Lu O, Bui R, Liu S, Li N, Zhou Y, Cheng G, Silva AJ. PMID: 37519458; PMCID: PMC10382699.
      View in: PubMed   Mentions:
    13. The emergence of molecular systems neuroscience. Mol Brain. 2022 01 04; 15(1):7. Shen Y, Luchetti A, Fernandes G, Do Heo W, Silva AJ. PMID: 34983613; PMCID: PMC8728933.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    14. Postnatal immune activation causes social deficits in a mouse model of tuberous sclerosis: Role of microglia and clinical implications. Sci Adv. 2021 Sep 17; 7(38):eabf2073. López-Aranda MF, Chattopadhyay I, Boxx GM, Fraley ER, Silva TK, Zhou M, Phan M, Herrera I, Taloma S, Mandanas R, Bach K, Gandal M, Geschwind DH, Cheng G, Rzhetsky A, White SA, Silva AJ. PMID: 34533985; PMCID: PMC8448451.
      View in: PubMed   Mentions: 8     Fields:    
    15. Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats. Elife. 2021 09 01; 10. Wang W, Schuette PJ, La-Vu MQ, Torossian A, Tobias BC, Ceko M, Kragel PA, Reis FM, Ji S, Sehgal M, Maesta-Pereira S, Chakerian M, Silva AJ, Canteras NS, Wager T, Kao JC, Adhikari A. PMID: 34468312; PMCID: PMC8457830.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    16. Dimensions and mechanisms of memory organization. Neuron. 2021 09 01; 109(17):2649-2662. de Sousa AF, Chowdhury A, Silva AJ. PMID: 34242564; PMCID: PMC8416710.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    17. Experiment Selection in Meta-Analytic Piecemeal Causal Discovery. IEEE Access. 2021; 9:97929-97941. Matiasz NJ, Wood J, Wang W, Silva AJ, Hsu W. PMID: 34532201; PMCID: PMC8442252.
      View in: PubMed   Mentions: 1  
    18. Chemokine Receptors CC Chemokine Receptor 5 and C-X-C Motif Chemokine Receptor 4 Are New Therapeutic Targets for Brain Recovery after Traumatic Brain Injury. J Neurotrauma. 2021 07 15; 38(14):2003-2017. Liraz-Zaltsman S, Friedman-Levi Y, Shabashov-Stone D, Gincberg G, Atrakcy-Baranes D, Joy MT, Carmichael ST, Silva AJ, Shohami E. PMID: 33256497.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    19. Pharmacological blockers of CCR5 and CXCR4 improve recovery after traumatic brain injury. Exp Neurol. 2021 04; 338:113604. Friedman-Levi Y, Liraz-Zaltsman S, Shemesh C, Rosenblatt K, Kesner EL, Gincberg G, Carmichael ST, Silva AJ, Shohami E. PMID: 33453212.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    20. Breakdown of spatial coding and interneuron synchronization in epileptic mice. Nat Neurosci. 2020 02; 23(2):229-238. Shuman T, Aharoni D, Cai DJ, Lee CR, Chavlis S, Page-Harley L, Vetere LM, Feng Y, Yang CY, Mollinedo-Gajate I, Chen L, Pennington ZT, Taxidis J, Flores SE, Cheng K, Javaherian M, Kaba CC, Rao N, La-Vu M, Pandi I, Shtrahman M, Bakhurin KI, Masmanidis SC, Khakh BS, Poirazi P, Silva AJ, Golshani P. PMID: 31907437; PMCID: PMC7259114.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    21. Human Memories Can Be Linked by Temporal Proximity. Front Hum Neurosci. 2019; 13:315. Yetton BD, Cai DJ, Spoormaker VI, Silva AJ, Mednick SC. PMID: 31572150; PMCID: PMC6753892.
      View in: PubMed   Mentions: 8  
    22. Getting the full picture. Elife. 2019 03 26; 8. Luchetti A, Chowdhury A, Silva AJ. PMID: 30912744; PMCID: PMC6435316.
      View in: PubMed   Mentions:    Fields:    
    23. Excitatory neuron-specific SHP2-ERK signaling network regulates synaptic plasticity and memory. Sci Signal. 2019 03 05; 12(571). Ryu HH, Kim T, Kim JW, Kang M, Park P, Kim YG, Kim H, Ha J, Choi JE, Lee J, Lim CS, Kim CH, Kim SJ, Silva AJ, Kaang BK, Lee YS. PMID: 30837304; PMCID: PMC6800025.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    24. CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury. Cell. 2019 02 21; 176(5):1143-1157.e13. Joy MT, Ben Assayag E, Shabashov-Stone D, Liraz-Zaltsman S, Mazzitelli J, Arenas M, Abduljawad N, Kliper E, Korczyn AD, Thareja NS, Kesner EL, Zhou M, Huang S, Silva TK, Katz N, Bornstein NM, Silva AJ, Shohami E, Carmichael ST. PMID: 30794775; PMCID: PMC7259116.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansAnimalsCells
    25. All the light that we can see: a new era in miniaturized microscopy. Nat Methods. 2019 Jan; 16(1):11-13. Aharoni D, Khakh BS, Silva AJ, Golshani P. PMID: 30573833; PMCID: PMC8320687.
      View in: PubMed   Mentions: 55     Fields:    Translation:Animals
    26. The mouse as a model for neuropsychiatric drug development. Curr Biol. 2018 09 10; 28(17):R909-R914. Howe JR, Bear MF, Golshani P, Klann E, Lipton SA, Mucke L, Sahin M, Silva AJ. PMID: 30205056; PMCID: PMC8163022.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    27. ResearchMaps.org for integrating and planning research. PLoS One. 2018; 13(5):e0195271. Matiasz NJ, Wood J, Doshi P, Speier W, Beckemeyer B, Wang W, Hsu W, Silva AJ. PMID: 29723213; PMCID: PMC5933701.
      View in: PubMed   Mentions: 2     Fields:    
    28. Enhancement of Brain d-Serine Mediates Recovery of Cognitive Function after Traumatic Brain Injury. J Neurotrauma. 2018 07 15; 35(14):1667-1680. Liraz-Zaltsman S, Slusher B, Atrakchi-Baranes D, Rosenblatt K, Friedman Levi Y, Kesner E, Silva AJ, Biegon A, Shohami E. PMID: 29648983.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    29. Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability. Cell. 2018 03 22; 173(1):166-180.e14. Hultman R, Ulrich K, Sachs BD, Blount C, Carlson DE, Ndubuizu N, Bagot RC, Parise EM, Vu MT, Gallagher NM, Wang J, Silva AJ, Deisseroth K, Mague SD, Caron MG, Nestler EJ, Carin L, Dzirasa K. PMID: 29502969; PMCID: PMC6005365.
      View in: PubMed   Mentions: 73     Fields:    Translation:Animals
    30. Randomised controlled trial of simvastatin treatment for autism in young children with neurofibromatosis type 1 (SANTA). Mol Autism. 2018; 9:12. Stivaros S, Garg S, Tziraki M, Cai Y, Thomas O, Mellor J, Morris AA, Jim C, Szumanska-Ryt K, Parkes LM, Haroon HA, Montaldi D, Webb N, Keane J, Castellanos FX, Silva AJ, Huson S, Williams S, Gareth Evans D, Emsley R, Green J, SANTA Consortium. PMID: 29484149; PMCID: PMC5824534.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    31. Memory formation depends on both synapse-specific modifications of synaptic strength and cell-specific increases in excitability. Nat Neurosci. 2018 03; 21(3):309-314. Lisman J, Cooper K, Sehgal M, Silva AJ. PMID: 29434376; PMCID: PMC5915620.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimalsCells
    32. Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory. Nat Commun. 2018 01 29; 9(1):422. Frank AC, Huang S, Zhou M, Gdalyahu A, Kastellakis G, Silva TK, Lu E, Wen X, Poirazi P, Trachtenberg JT, Silva AJ. PMID: 29379017; PMCID: PMC5789055.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    33. Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: in vivo neurospectroscopy and molecular evidence for regional phenotypes. Mol Autism. 2017; 8:47. Gonçalves J, Violante IR, Sereno J, Leitão RA, Cai Y, Abrunhosa A, Silva AP, Silva AJ, Castelo-Branco M. PMID: 28932379; PMCID: PMC5605987.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    34. Miniaturized two-photon microscope: seeing clearer and deeper into the brain. Light Sci Appl. 2017 Aug; 6(8):e17104. Silva AJ. PMID: 30167288; PMCID: PMC6062320.
      View in: PubMed   Mentions: 13  
    35. Spatial working memory in neurofibromatosis 1: Altered neural activity and functional connectivity. Neuroimage Clin. 2017; 15:801-811. Ibrahim AFA, Montojo CA, Haut KM, Karlsgodt KH, Hansen L, Congdon E, Rosser T, Bilder RM, Silva AJ, Bearden CE. PMID: 28725547; PMCID: PMC5501884.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    36. Memory's Intricate Web. Sci Am. 2017 Jun 20; 317(1):30-37. Silva AJ. PMID: 28632232; PMCID: PMC5915626.
      View in: PubMed   Mentions: 4     Fields:    
    37. Noonan syndrome-associated SHP2 mutation differentially modulates the expression of postsynaptic receptors according to developmental maturation. Neurosci Lett. 2017 05 10; 649:41-47. Oh JY, Rhee S, Silva AJ, Lee YS, Kim HK. PMID: 28366775; PMCID: PMC6844293.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    38. Risky Decision Making in Neurofibromatosis Type 1: An Exploratory Study. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Mar; 2(2):170-179. Jonas RK, Roh E, Montojo CA, Pacheco LA, Rosser T, Silva AJ, Bearden CE. PMID: 28736755; PMCID: PMC5518467.
      View in: PubMed   Mentions: 2     Fields:    
    39. Computer-Aided Experiment Planning toward Causal Discovery in Neuroscience. Front Neuroinform. 2017; 11:12. Matiasz NJ, Wood J, Wang W, Silva AJ, Hsu W. PMID: 28243197; PMCID: PMC5304468.
      View in: PubMed   Mentions: 3  
    40. CCR5 is a suppressor for cortical plasticity and hippocampal learning and memory. Elife. 2016 12 20; 5. Zhou M, Greenhill S, Huang S, Silva TK, Sano Y, Wu S, Cai Y, Nagaoka Y, Sehgal M, Cai DJ, Lee YS, Fox K, Silva AJ. PMID: 27996938; PMCID: PMC5213777.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    41. Randomized placebo-controlled study of lovastatin in children with neurofibromatosis type 1. Neurology. 2016 Dec 13; 87(24):2575-2584. Payne JM, Barton B, Ullrich NJ, Cantor A, Hearps SJ, Cutter G, Rosser T, Walsh KS, Gioia GA, Wolters PL, Tonsgard J, Schorry E, Viskochil D, Klesse L, Fisher M, Gutmann DH, Silva AJ, Hunter SJ, Rey-Casserly C, Cantor NL, Byars AW, Stavinoha PL, Ackerson JD, Armstrong CL, Isenberg J, O'Neil SH, Packer RJ, Korf B, Acosta MT, North KN, NF Clinical Trials Consortium. PMID: 27956565; PMCID: PMC5207004.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    42. Linking Memories across Time via Neuronal and Dendritic Overlaps in Model Neurons with Active Dendrites. Cell Rep. 2016 11 01; 17(6):1491-1504. Kastellakis G, Silva AJ, Poirazi P. PMID: 27806290; PMCID: PMC5149530.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    43. Corrigendum: The need for novel informatics tools for integrating and planning research in molecular and cellular cognition. Learn Mem. 2016 11; 23(11):668. Silva AJ, Müller KR. PMID: 27918288; PMCID: PMC5066599.
      View in: PubMed   Mentions:    Fields:    
    44. Molecular and Cellular Mechanisms for Trapping and Activating Emotional Memories. PLoS One. 2016; 11(8):e0161655. Rogerson T, Jayaprakash B, Cai DJ, Sano Y, Lee YS, Zhou Y, Bekal P, Deisseroth K, Silva AJ. PMID: 27579481; PMCID: PMC5007047.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    45. A shared neural ensemble links distinct contextual memories encoded close in time. Nature. 2016 06 02; 534(7605):115-8. Cai DJ, Aharoni D, Shuman T, Shobe J, Biane J, Song W, Wei B, Veshkini M, La-Vu M, Lou J, Flores SE, Kim I, Sano Y, Zhou M, Baumgaertel K, Lavi A, Kamata M, Tuszynski M, Mayford M, Golshani P, Silva AJ. PMID: 27251287; PMCID: PMC5063500.
      View in: PubMed   Mentions: 375     Fields:    Translation:AnimalsCells
    46. Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference. Pediatr Neurol. 2016 07; 60:1-12. Sahin M, Henske EP, Manning BD, Ess KC, Bissler JJ, Klann E, Kwiatkowski DJ, Roberds SL, Silva AJ, Hillaire-Clarke CS, Young LR, Zervas M, Mamounas LA, Tuberous Sclerosis Complex Working Group to Update the Research Plan. PMID: 27267556; PMCID: PMC4921275.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    47. Hijacking translation in addiction. Elife. 2016 Mar 01; 5. Izquierdo A, Silva AJ. PMID: 26929992; PMCID: PMC4786444.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    48. A randomized placebo-controlled lovastatin trial for neurobehavioral function in neurofibromatosis I. Ann Clin Transl Neurol. 2016 04; 3(4):266-79. Bearden CE, Hellemann GS, Rosser T, Montojo C, Jonas R, Enrique N, Pacheco L, Hussain SA, Wu JY, Ho JS, McGough JJ, Sugar CA, Silva AJ. PMID: 27081657; PMCID: PMC4818747.
      View in: PubMed   Mentions: 29     Fields:    
    49. Resting state functional MRI reveals abnormal network connectivity in neurofibromatosis 1. Hum Brain Mapp. 2015 Nov; 36(11):4566-81. Tomson SN, Schreiner MJ, Narayan M, Rosser T, Enrique N, Silva AJ, Allen GI, Bookheimer SY, Bearden CE. PMID: 26304096; PMCID: PMC4619152.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    50. The need for novel informatics tools for integrating and planning research in molecular and cellular cognition. Learn Mem. 2015 Sep; 22(9):494-8. Silva AJ, Müller KR. PMID: 26286658; PMCID: PMC4561409.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    51. The third international meeting on genetic disorders in the RAS/MAPK pathway: towards a therapeutic approach. Am J Med Genet A. 2015 Aug; 167A(8):1741-6. Korf B, Ahmadian R, Allanson J, Aoki Y, Bakker A, Wright EB, Denger B, Elgersma Y, Gelb BD, Gripp KW, Kerr B, Kontaridis M, Lazaro C, Linardic C, Lozano R, MacRae CA, Messiaen L, Mulero-Navarro S, Neel B, Plotkin S, Rauen KA, Roberts A, Silva AJ, Sittampalam SG, Zhang C, Schoyer L. PMID: 25900621; PMCID: PMC4515140.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    52. Synaptic clustering within dendrites: an emerging theory of memory formation. Prog Neurobiol. 2015 Mar; 126:19-35. Kastellakis G, Cai DJ, Mednick SC, Silva AJ, Poirazi P. PMID: 25576663; PMCID: PMC4361279.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    53. CREB regulates memory allocation in the insular cortex. Curr Biol. 2014 Dec 01; 24(23):2833-7. Sano Y, Shobe JL, Zhou M, Huang S, Shuman T, Cai DJ, Golshani P, Kamata M, Silva AJ. PMID: 25454591; PMCID: PMC4743759.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    54. Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome. Nat Neurosci. 2014 Dec; 17(12):1736-43. Lee YS, Ehninger D, Zhou M, Oh JY, Kang M, Kwak C, Ryu HH, Butz D, Araki T, Cai Y, Balaji J, Sano Y, Nam CI, Kim HK, Kaang BK, Burger C, Neel BG, Silva AJ. PMID: 25383899; PMCID: PMC4716736.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimals
    55. Maternal inflammation contributes to brain overgrowth and autism-associated behaviors through altered redox signaling in stem and progenitor cells. Stem Cell Reports. 2014 Nov 11; 3(5):725-34. Le Belle JE, Sperry J, Ngo A, Ghochani Y, Laks DR, López-Aranda M, Silva AJ, Kornblum HI. PMID: 25418720; PMCID: PMC4235743.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    56. Temporal and region-specific requirements of αCaMKII in spatial and contextual learning. J Neurosci. 2014 Aug 20; 34(34):11180-7. Achterberg KG, Buitendijk GH, Kool MJ, Goorden SM, Post L, Slump DE, Silva AJ, van Woerden GM, Kushner SA, Elgersma Y. PMID: 25143599; PMCID: PMC4340969.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    57. Encoding and storage of spatial information in the retrosplenial cortex. Proc Natl Acad Sci U S A. 2014 Jun 10; 111(23):8661-6. Czajkowski R, Jayaprakash B, Wiltgen B, Rogerson T, Guzman-Karlsson MC, Barth AL, Trachtenberg JT, Silva AJ. PMID: 24912150; PMCID: PMC4060653.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    58. Synaptic tagging during memory allocation. Nat Rev Neurosci. 2014 Mar; 15(3):157-69. Rogerson T, Cai DJ, Frank A, Sano Y, Shobe J, Lopez-Aranda MF, Silva AJ. PMID: 24496410; PMCID: PMC3992944.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
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    68. CaMKII binding to GluN2B is critical during memory consolidation. EMBO J. 2012 Mar 07; 31(5):1203-16. Halt AR, Dallapiazza RF, Zhou Y, Stein IS, Qian H, Juntti S, Wojcik S, Brose N, Silva AJ, Hell JW. PMID: 22234183; PMCID: PMC3297991.
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    72. Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders. Trends Mol Med. 2011 Feb; 17(2):78-87. Ehninger D, Silva AJ. PMID: 21115397; PMCID: PMC3075964.
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    96. The science of research: the principles underlying the discovery of cognitive and other biological mechanisms. J Physiol Paris. 2007 Jul-Nov; 101(4-6):203-13. Silva AJ. PMID: 18280120.
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    102. Memory for context becomes less specific with time. Learn Mem. 2007 Apr; 14(4):313-7. Wiltgen BJ, Silva AJ. PMID: 17522020.
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    103. Investigation of age-related cognitive decline using mice as a model system: behavioral correlates. Am J Geriatr Psychiatry. 2006 Dec; 14(12):1004-11. Murphy GG, Rahnama NP, Silva AJ. PMID: 17138807.
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    105. Stability of recent and remote contextual fear memory. Learn Mem. 2006 Jul-Aug; 13(4):451-7. Frankland PW, Ding HK, Takahashi E, Suzuki A, Kida S, Silva AJ. PMID: 16882861; PMCID: PMC1538922.
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    106. Differential effects of alphaCaMKII mutation on hippocampal learning and changes in intrinsic neuronal excitability. Eur J Neurosci. 2006 Apr; 23(8):2235-40. Ohno M, Sametsky EA, Silva AJ, Disterhoft JF. PMID: 16630070.
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    108. Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory. J Neurosci. 2006 Feb 15; 26(7):1923-34. Nagy V, Bozdagi O, Matynia A, Balcerzyk M, Okulski P, Dzwonek J, Costa RM, Silva AJ, Kaczmarek L, Huntley GW. PMID: 16481424; PMCID: PMC4428329.
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    112. Notch to remember. Trends Neurosci. 2005 Aug; 28(8):429-35. Costa RM, Drew C, Silva AJ. PMID: 15922461.
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    131. Central nervous system myelination in mice with deficient expression of Notch1 receptor. J Neurosci Res. 2002 Feb 01; 67(3):309-20. Givogri MI, Costa RM, Schonmann V, Silva AJ, Campagnoni AT, Bongarzone ER. PMID: 11813235.
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