Publications:
A selected list of publications:
Sene Abdoulaye, Khan Aslam A, Cox Douglas, Nakamura Rei E I, Santeford Andrea, Kim Bryan M, Sidhu Rohini, Onken Michael D, Harbour J William, Hagbi-Levi Shira, Chowers Itay, Edwards Peter A, Baldan Angel, Parks John S, Ory Daniel S, Apte Rajendra S
Impaired cholesterol efflux in senescent macrophages promotes
age-related macular degeneration
Cell metabolism,
2013; 17(4):
549-61.
Bennett Brian J, de Aguiar Vallim Thomas Q, Wang Zeneng, Shih Diana M, Meng Yonghong, Gregory Jill, Allayee Hooman, Lee Richard, Graham Mark, Crooke Rosanne, Edwards Peter A, Hazen Stanley L, Lusis Aldons J
Trimethylamine-N-oxide, a metabolite associated with atherosclerosis,
exhibits complex genetic and dietary regulation
Cell metabolism,
2013; 17(1):
49-60.
Zhang Yanqiao, Ge Xuemei, Heemstra Lydia A, Chen Wei-Dong, Xu Jiesi, Smith Joseph L, Ma Huiyan, Kasim Neda, Edwards Peter A, Novak Colleen M
Loss of FXR protects against diet-induced obesity and accelerates
liver carcinogenesis in ob/ob mice
Molecular endocrinology (Baltimore, Md.),
2012; 26(2):
272-80.
Bojanic Dragana D, Tarr Paul T, Gale Greg D, Smith Desmond J, Bok Dean, Chen Bryan, Nusinowitz Steven, Lövgren-Sandblom Anita, Björkhem Ingemar, Edwards Peter A
Differential expression and function of ABCG1 and ABCG4 during
development and aging
Journal of lipid research,
2010; 51(1):
169-81.
Tarling Elizabeth J, Bojanic Dragana D, Tangirala Rajendra K, Wang Xuping, Lovgren-Sandblom Anita, Lusis Aldons J, Bjorkhem Ingemar, Edwards Peter A
Impaired development of atherosclerosis in Abcg1-/- Apoe-/- mice:
identification of specific oxysterols that both accumulate in Abcg1-/-
Apoe-/- tissues and induce apoptosis
Arteriosclerosis, thrombosis, and vascular biology,
2010; 30(6):
1174-80.
Bensinger Steven J, Bradley Michelle N, Joseph Sean B, Zelcer Noam, Janssen Edith M, Hausner Mary Ann, Shih Roger, Parks John S, Edwards Peter A, Jamieson Beth D, Tontonoz Peter
LXR signaling couples sterol metabolism to proliferation in the
acquired immune response
Cell,
2008; 134(1):
97-111.
Hubbert M, Zhang Y, Lee FY, Edwards PA
Regulation of hepatic Insig-2 by the farnesoid X receptor,
Mol. Endo,
2007; 21:
1359-69.
Lee H, Hubbert ML, Osborne TF, Woodford K, Zerangue N, Edwards PA
Regulation of the sodium/sulfate co-transporter by farnesoid X receptor alpha,
J Biol. Chem,
2007; 282(30):
21653-61.
Shih DM, Kast-Woelbern HR, Wong J, Xia YR, Edwards PA, Lusis AJ.
A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids,
J Lipid Res,
2006; 47(2):
384-92.
Baldan A, Tarr P, Lee R, Edwards PA
ATP-binding cassette transporter G1 and lipid homeostasis,
Curr Opin Lipidol,
2006; 17(3):
227-32.
Zhang Y, Lee FY, Barrera G, Lee H, Vales C, Gonzalez FJ, Willson TM, Edwards PA.
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice,
Proc Natl Acad Sci U S A,
2006; 103(4):
1006-11.
Baldan A, Tarr P, Vales CS, Frank J, Shimotake TK, Hawgood S, Edwards PA
Deletion of the transmembrane transporter ABCG1 results in progressive pulmonary lipidosis,
J Biol Chem,
2006; 281(39):
29401-10.
Zhang Y, Wang X, Vales C, Lee FY, Lee H, Lusis AJ, Edwards PA
FXR deficiency causes reduced atherosclerosis in Ldlr-/- mice,
Arterioscler Thromb Vasc Biol,
2006; 26(10):
2316-21.
Lee H, Zhang Y, Lee FY, Nelson SF, Gonzalez FJ, Edwards PA
FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine,
J. Lipid Res,
2006; 47(1):
201-14.
Lee FY, Lee H, Hubbert ML, Edwards PA, Zhang Y.
FXR, a multipurpose nuclear receptor,
Trends Biochem Sci,
2006; 31(10):
572-80.
Baldan A, Pei L, Lee R, Tarr P, Tangirala RK, Weinstein MM, Frank J, Li AC, Tontonoz P, Edwards PA
Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow,
Arterioscler Thromb Vasc Biol,
2006; 26(10):
2301-7.
Baldán Angel, Pei Liming, Lee Richard, Tarr Paul, Tangirala Rajendra K, Weinstein Michael M, Frank Joy, Li Andrew C, Tontonoz Peter, Edwards Peter A
Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and
ApoE-/- mice transplanted with Abcg1-/- bone marrow
Arteriosclerosis, thrombosis, and vascular biology,
2006; 26(10):
2301-7.
Arai Satoko, Shelton John M, Chen Mingyi, Bradley Michelle N, Castrillo Antonio, Bookout Angie L, Mak Puiying A, Edwards Peter A, Mangelsdorf David J, Tontonoz Peter, Miyazaki Toru
A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in
atherosclerosis development
Cell metabolism,
2005; 1(3):
201-13.
Arai S, Shelton JM, Chen M, Bradley MN, Castrillo A, Bookout AL, Mak PA, Edwards PA, Mangelsdorf DJ, Tontonoz P, Miyazaki T
A role for the apoptosis inhibitory factor Aim/Sp alpha/Api6 in atherosclerosis development,
Cell Metabolism,
2005; 1:
201-213.
Lee FL, Kast-Woelbern HR, Chang J, Fishbein MC, Edwards PA
Alpha-A-crystallin is a target gene of the Farnesoid X-activated Receptor (FXR) in human livers,
J. Biol. Chem,
2005;
.
Zhang YQ, Castellani LW, Sinal CJ, Gonzalez FJ, Edwards PA
Peroxisome Proliferator-Activated Receptor-gamma Coactivator 1alpha (PGC-alpha) Regulates Triglyceride Metabolism by Activation of the Nuclear receptor FXR,
Genes and Development,
2004; 18:
157-169.
Downes Michael, Verdecia Mark A, Roecker A J, Hughes Robert, Hogenesch John B, Kast-Woelbern Heidi R, Bowman Marianne E, Ferrer Jean-Luc, Anisfeld Andrew M, Edwards Peter A, Rosenfeld John M, Alvarez Jacqueline G A, Noel Joseph P, Nicolaou K C, Evans Ronald M
A chemical, genetic, and structural analysis of the nuclear bile acid
receptor FXR
Molecular cell,
2003; 11(4):
1079-92.
Downes M, Verdecia MA, Roecker AJ, Hughes R, Hogenesch JB, Kast-Woelbern HR, Bowman ME, Ferrer JL, Anisfeld AM, Edwards PA, Rosenfeld JM, Alvarez JG, Noel JP, Nicolaou KC, Evans RM
A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR
Molecular cell. ,
2003; 11(4):
1079-92.
Mak PA, Bryan A, Laffitte BA, Desrumaux C, Linda K, Curtiss LK, Mangelsdorf DJ, Tontonoz P, Edwards PA
Regulated Expression of the ApoE/C-I/C-IV/C-II Gene Cluster in Murine and Human Macrophages; a Critical Role for the Nuclear Receptors LXRa and LXRb,
Journal of Biological Chemistry,
2002; 277:
31900-31908.
Kast Heidi R, Goodwin Bryan, Tarr Paul T, Jones Stacey A, Anisfeld Andrew M, Stoltz Catherine M, Tontonoz Peter, Kliewer Steve, Willson Timothy M, Edwards Peter A
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the
nuclear receptors pregnane X receptor, farnesoid X-activated receptor,
and constitutive androstane receptor
The Journal of biological chemistry,
2002; 277(4):
2908-15.
Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA
Regulation of multidrug resistance-associated protein 2 (MRP2;ABCC2) by the nuclear receptors PXR, FXR, and CAR,
J. Biol. Chem,
2002; 277:
2908-2915.
Chawla A, Boisvert WA, Lee C-H, Laffitte BA, Barak Y, Joseph SB, Liao D, Nagy L, Edwards PA, Curtiss LK, Evans RM, Tontonoz P
A PPARg-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis,
Molecular Cell,
2001; 7:
161-171.
Kast HR, Nguyen CM, Sinal CJ, Jones SA, Laffitte BA, Reue K, Gonzalez FJ, Willson TM, Edwards PA
Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids
Molecular endocrinology (Baltimore, Md.) ,
2001; 15(10):
1720-8.
Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA
Regulation of multidrug resistance-associated protein 2 (MRP2;ABCC2) by the nuclear receptors PXR, FXR, and CAR,
Journal of Biological Chemistry,
2001; 277:
2908-2915.
Venkateswaran A, Laffitte BA, Joseph SB, Mak PA, Wilpitz DC, Edwards PA, Tontonoz P
Control of Cellular Cholesterol Efflux by the Nuclear Receptor LXRa,
Proceedings of the National Academy of Sciences, USA ,
2000; 97:
12097-12102.