Denson Fujikawa, M.D.

Work Titles
UCLA Health Sciences Clinical Professor, Neurology Member, Brain Research Institute

Contact Information:

Work Phone Number:


Mailing Address:

Mail code 151B4
16111 Plummer Street
North Hills, CA 91343

Work Address:

16111 Plummer Street
North Hills, CA 91343

Sepulveda VA ACC
16111 Plummer Street
North Hills, CA 91343

Detailed Biography:

Denson G. Fujikawa is a neurologist and neuroscientist who has been a member of the UCLA faculty since he joined the Department of Neurology in as a clinical instructor in 1981. Dr. Fujikawa is at the Sepulveda VA Ambulatory Care Center. He became an Adjunct Professor in 1996, and has been a Staff Neurologist at Sepulveda since 1983. Dr. Fujikawa earned his A.B. degree magna cum laude in psychology at Harvard University, and his M.D. degree at the University of Southern California School of Medicine. He did two years of general surgery residency at Columbia-Presbyterian Medical Center in New York, two years of of neurosurgery residency at UCLA Medical Center, then switched to neurology, completing his residency at Harbor-UCLA Medical Center in 1981. He then spent two years as a research fellow in Dr. Claude Wasterlain's Epilepsy Research Laboratory at Sepulveda. He spends half his time in clinical neurology, training UCLA neurology residents, with a subspecialty interest in epilepsy, and half his time doing basic research on in vivo mechanisms of naturally occurring apoptotic and pathologically induced necrotic neuronal death.


A selected list of publications:

Fujikawa, Denson G.   Starting ketamine for neuroprotection earlier than its current use as an anesthetic/antiepileptic drug late in refractory status epilepticus Epilepsia, 2019; 60(3): 373-380.
Fujikawa, Denson G.   The role of excitotoxic programmed necrosis in acute brain inury Computational and Structural Biotechnology Journal, 2015; 13: 213-221.
Fujikawa Denson G, Pais Emil S, Aviles Ernesto R, Hsieh Kung-Chiao, Bashir Muhammad Tariq   Methamphetamine-induced neuronal necrosis: the role of electrographic seizure discharges Neurotoxicology, 2016; 52: 84-8.
Fujikawa Denson G, Licht Eliot A, Jacobsen Rebecca H   Chronic epileptic encephalopathy in adult patients with bilaterally synchronous frequent and/or prolonged subclinical epileptiform discharges Epilepsy & behavior : E&B, 2012; 25(3): 442-8.
Fujikawa, D. G.   Chapter 17: Activation of caspase-independent programmed pathways in seizure-induced neuronal necrosis. In Fujikawa, D. G, ed. Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death, (New York Springer), 2010; 277-293.
Fujikawa, D. G.   Chapter 1: Introduction. In Fujikawa, D. G, ed. Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death, (New York Springer), 2010; 1-6.
Fujikawa, D. G.   Chapter 4: Age-dependence of neuronal apoptosis and of caspase activation. In Fujikawa, D. G, ed. Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death, (New York Springer), 2010; 67-77.
Fujikawa, D. G.   Concluding Remarks. In Fujikawa, D. G, ed. Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death , (New York Springer), 2010; 295-298.
Fujikawa, D. G., Zhao, S., Ke, X., Shinmei, S. S., Allen, S. G.   Mild as well as severe insults produce necrotic, not apoptotic, cells: Evidence from 60-min seizures Neurosci Lett, 2010; 469: 333-337.
Zhao Shuangping, Aviles Ernesto R, Fujikawa Denson G   Nuclear translocation of mitochondrial cytochrome c, lysosomal cathepsins B and D, and three other death-promoting proteins within the first 60 minutes of generalized seizures Journal of neuroscience research, 2010; 88(8): 1727-37.
Fujikawa Denson G, Shinmei Steve S, Zhao Shuangping, Aviles Ernesto R   Caspase-dependent programmed cell death pathways are not activated in generalized seizure-induced neuronal death Brain research, 2007; 1135(1): 206-18.
Fujikawa Denson G   Prolonged seizures and cellular injury: understanding the connection Epilepsy & behavior : E&B, 2005; 7 Suppl 3(1): S3-11.
Walker Matthew, Cross Helen, Smith Shelagh, Young Camilla, Aicardi Jean, Appleton Richard, Aylett Sarah, Besag Frank, Cock Hannah, DeLorenzo Robert, Drislane Franck, Duncan John, Ferrie Colin, Fujikawa Denson, Gray William, Kaplan Peter, Koutroumanidis Micheal, O'Regan Mary, Plouin Perrine, Sander Josemir, Scott Rod, Shorvon Simon, Treiman David, Wasterlain Claude, Wieshmann Udo   Nonconvulsive status epilepticus: Epilepsy Research Foundation workshop reports Epileptic disorders : international epilepsy journal with videotape, 2005; 7(3): 253-96.
Fujikawa Denson G   Neuronal death in mesial temporal sclerosis: separating morphology from mechanism Epilepsia, 2003; 44(12): 1607; author reply 1607-8.
Niquet Jerome, Baldwin Roger A, Allen Suni G, Fujikawa Denson G, Wasterlain Claude G   Hypoxic neuronal necrosis: protein synthesis-independent activation of a cell death program Proceedings of the National Academy of Sciences of the United States of America, 2003; 100(5): 2825-30.
Fujikawa Denson G, Ke Xingrao, Trinidad Rosen B, Shinmei Steve S, Wu Aiguo   Caspase-3 is not activated in seizure-induced neuronal necrosis with internucleosomal DNA cleavage Journal of neurochemistry, 2002; 83(1): 229-40.
Wu Aiguo, Fujikawa Denson G   Effects of AMPA-receptor and voltage-sensitive sodium channel blockade on high potassium-induced glutamate release and neuronal death in vivo Brain research, 2002; 946(1): 119-29.
Fujikawa Denson G   Apoptosis: ignoring morphology and focusing on biochemical mechanisms will not eliminate confusion Trends in pharmacological sciences, 2002; 23(7): 309-10; author reply 310.
Licht, E. A. Fujikawa, D. G.   Nonconvulsive status epilepticus with frontal features: quantitating severity of subclinical epileptiform discharges provides a marker for treatment efficacy, recurrence and outcome Epilepsy Res, 2002; 51(1-2): 13-21.
Licht Eliot A., Jacobsen Rebecca H., Fujikawa Denson G.   Chronically Impaired Frontal Lobe Function from Subclinical Epileptiform Discharges Epilepsy & behavior : E&B, 2002; 3(1): 96-100.
Fujikawa, D. G.   Confusion between neuronal apoptosis and activation of programmed cell death mechanisms in acute necrotic insults Trends Neurosci, 2000; 23(9): 410-1.
Fujikawa, D. G. Shinmei, S. S. Cai, B.   Kainic acid-induced seizures produce necrotic, not apoptotic, neurons with internucleosomal DNA cleavage: implications for programmed cell death mechanisms Neuroscience, 2000; 98(1): 41-53.
Fujikawa, D. G. Shinmei, S. S. Cai, B.   Seizure-induced neuronal necrosis: implications for programmed cell death mechanisms Epilepsia, 2000; 41 Suppl 6: S9-13.
Fujikawa, D. G. Itabashi, H. H. Wu, A. Shinmei, S. S.   Status epilepticus-induced neuronal loss in humans without systemic complications or epilepsy Epilepsia, 2000; 41(8): 981-91.
Fujikawa, D. G. Shinmei, S. S. Cai, B.   Lithium-pilocarpine-induced status epilepticus produces necrotic neurons with internucleosomal DNA fragmentation in adult rats Eur J Neurosci, 1999; 11(5): 1605-14.
Swarztrauber, K. Fujikawa, D. G.   An electroencephalographic study comparing maximum blink rates in schizophrenic and nonschizophrenic psychiatric patients and nonpsychiatric control subjects Biol Psychiatry, 1998; 43(4): 282-7.
Fujikawa, D. G.   Effects of N-methyl-D-aspartate-receptor blockade on high-potassium-induced neuronal death and glutamate release Neurosci Lett, 1997; 226(1): 25-8.
Fujikawa, D. G.   The temporal evolution of neuronal damage from pilocarpine-induced status epilepticus Brain Res, 1996; 725(1): 11-22.
Fujikawa, D. G. Kim, J. S. Daniels, A. H. Alcaraz, A. F. Sohn, T. B.   In vivo elevation of extracellular potassium in the rat amygdala increases extracellular glutamate and aspartate and damages neurons Neuroscience, 1996; 74(3): 695-706.
Fujikawa, D. G.   Anticonvulsants for eclampsia Lancet, 1995; 346(8973): 501-2.
Fujikawa, D. G.   Neuroprotective effect of ketamine administered after status epilepticus onset Epilepsia, 1995; 36(2): 186-95.
Fujikawa, D. G. Daniels, A. H. Kim, J. S.   The competitive NMDA receptor antagonist CGP 40116 protects against status epilepticus-induced neuronal damage Epilepsy Res, 1994; 17(3): 207-19.
Wasterlain, C. G. Fujikawa, D. G. Penix, L. Sankar, R.   Pathophysiological mechanisms of brain damage from status epilepticus Epilepsia, 1993; 34 Suppl 1: S37-53.
Fujikawa, D. G. Soderfeldt, B. Wasterlain, C. G.   Neuropathological changes during generalized seizures in newborn monkeys Epilepsy Res, 1992; 12(3): 243-51.
Fujikawa, D. G.   Single-dose phenytoin infusion Ann Intern Med, 1990; 112(3): 235-6.
Small, G. W. Kuhl, D. E. Riege, W. H. Fujikawa, D. G. Ashford, J. W. Metter, E. J. Mazziotta, J. C.   Cerebral glucose metabolic patterns in Alzheimer's disease. Effect of gender and age at dementia onset Arch Gen Psychiatry, 1989; 46(6): 527-32.
Fujikawa, D. G. Dwyer, B. E. Lake, R. R. Wasterlain, C. G.   Local cerebral glucose utilization during status epilepticus in newborn primates Am J Physiol, 1989; 256(6 Pt 1): C1160-7.
Hattori, H. Morin, A. M. Schwartz, P. H. Fujikawa, D. G. Wasterlain, C. G.   Posthypoxic treatment with MK-801 reduces hypoxic-ischemic damage in the neonatal rat Neurology, 1989; 39(5): 713-8.
Fujikawa, D. G. Vannucci, R. C. Dwyer, B. E. Wasterlain, C. G.   Generalized seizures deplete brain energy reserves in normoxemic newborn monkeys Brain Res, 1988; 454(1-2): 51-9.
Dwyer, B. E. Nishimura, R. N. Fujikawa, D. G.   Cerebral hypoxia-ischemia in immature rats: methodological considerations Exp Neurol, 1988; 99(3): 772-7.
Small, G. W. Kuhl, D. E. Fujikawa, D. G. Ashford, J. W.   Clinical characterization of Alzheimer's disease: reliability of 'age at onset' and a new descriptor, 'age at shift' J Geriatr Psychiatry Neurol, 1988; 1(4): 207-11.
Morin, A. M. Dwyer, B. E. Fujikawa, D. G. Wasterlain, C. G.   Low [3H]cytochalasin B binding in the cerebral cortex of newborn rat J Neurochem, 1988; 51(1): 206-11.
Steinman, J. L.Fujikawa, D. G.Wasterlain, C. G.Cherkin, A.Morley, J. E.   The effects of adrenergic, opioid and pancreatic polypeptidergic compounds on feeding and other behaviors in neonatal leghorn chicks Peptides, 1987; 8(4): 585-92.
Fujikawa, D. G. Dwyer, B. E. Wasterlain, C. G.   Preferential blood flow to brainstem during generalized seizures in the newborn marmoset monkey Brain Res, 1986; 397(1): 61-72.
Dwyer, B. E. Wasterlain, C. G. Fujikawa, D. G. Yamada, L.   Brain protein metabolism in epilepsy Adv Neurol, 1986; 44: 903-18.
Dwyer, B. E. Fujikawa, D. G. Wasterlain, C. G.   Metabolic anatomy of generalized bicuculline seizures in the newborn marmoset monkey Exp Neurol, 1986; 94(1): 213-27.
Yoshimori, R. N. Moore, R. A. Itabashi, H. H. Fujikawa, D. G.   Phaeohyphomycosis of brain: granulomatous encephalitis caused by Drechslera spicifera Am J Clin Pathol, 1982; 77(3): 363-70.
Fujikawa, D. G.   Letter: Treatment by vertebral manipulation Lancet, 1974; 2(7874): 228-9.

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