Carla Marie Koehler

Title(s)Professor, Chemistry and Biochemistry
SchoolCollege of Letters and Science
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    Collapse Research 
    Collapse Research Activities and Funding
    Control of calcium flux and mitochondrial fission by the Charcot Marie Tooth disease protein Mfn2.
    NIH R01NS120690Jan 1, 2020 - Nov 30, 2025
    Role: Co-Principal Investigator
    Small Molecule Probes to Correct AGT Mistargeting in Primary Hyperoxaluria 1
    NIH R01DK101780Aug 21, 2015 - Mar 31, 2020
    Role: Principal Investigator
    Mitochondrial Assembly and Dynamics in Health and Disease
    NIH R13NS066552Jul 1, 2009 - Jun 30, 2010
    Role: Principal Investigator
    Small molecule modulators for mitochondrial protein import
    NIH R03DA027714Jun 1, 2009 - May 31, 2010
    Role: Principal Investigator
    Small Molecule Modulators for Redox Regulation in the Mitochondrial Intermembrane
    NIH R03MH085683Sep 30, 2008 - Aug 31, 2009
    Role: Principal Investigator
    Multi-user fermentation facility upgrade
    NIH S10RR023749May 1, 2008 - Apr 30, 2010
    Role: Principal Investigator
    2007 Protein Transport Across Membranes Gordon Conference
    NIH R13GM080876Apr 1, 2007 - Mar 31, 2008
    Role: Principal Investigator
    Cardiolipin remodeling and its role in mitochondrial function in Barth Syndrome
    NIH R21HL082801May 1, 2006 - Oct 31, 2009
    Role: Principal Investigator
    RNA trafficking in mitochondria
    NIH R01GM073981Jan 1, 2006 - Jun 30, 2025
    Role: Principal Investigator
    Fluorescent microscope and imaging system
    NIH S10RR019009Apr 15, 2004 - Apr 14, 2005
    Role: Principal Investigator
    Mitochondrial biogenesis &neurodegenerative disorders
    NIH R21DC006663Apr 1, 2004 - Mar 31, 2006
    Role: Principal Investigator
    PROTEIN AND NUCLEIC ACID DETECTION/QUANTITATION SYSTEM
    NIH S10RR015955Apr 1, 2001 - Mar 31, 2002
    Role: Principal Investigator
    BIOGENESIS OF THE MITOCHONDRIAL INNER MEMBRANE
    NIH R01GM061721Sep 1, 2000 - Jul 31, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Spatial mapping of mitochondrial networks and bioenergetics in lung cancer. Nature. 2023 03; 615(7953):712-719. Han M, Bushong EA, Segawa M, Tiard A, Wong A, Brady MR, Momcilovic M, Wolf DM, Zhang R, Petcherski A, Madany M, Xu S, Lee JT, Poyurovsky MV, Olszewski K, Holloway T, Gomez A, John MS, Dubinett SM, Koehler CM, Shirihai OS, Stiles L, Lisberg A, Soatto S, Sadeghi S, Ellisman MH, Shackelford DB. PMID: 36922590; PMCID: PMC10033418.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    2. Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition. Nat Commun. 2022 04 05; 13(1):1833. Liang WG, Wijaya J, Wei H, Noble AJ, Mancl JM, Mo S, Lee D, Lin King JV, Pan M, Liu C, Koehler CM, Zhao M, Potter CS, Carragher B, Li S, Tang WJ. PMID: 35383169; PMCID: PMC8983764.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. Aim32 is a dual-localized 2Fe-2S mitochondrial protein that functions in redox quality control. J Biol Chem. 2021 10; 297(4):101135. Zhang D, Dailey OR, Simon DJ, Roca-Datzer K, Jami-Alahmadi Y, Hennen MS, Wohlschlegel JA, Koehler CM, Dabir DV. PMID: 34461091; PMCID: PMC8482512.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Mitochondrial Calcium Uniporter Deficiency in Zebrafish Causes Cardiomyopathy With Arrhythmia. Front Physiol. 2020; 11:617492. Langenbacher AD, Shimizu H, Hsu W, Zhao Y, Borges A, Koehler C, Chen JN. PMID: 33424641; PMCID: PMC7785991.
      View in: PubMed   Mentions: 8  
    5. Reply to: In vivo quantification of mitochondrial membrane potential. Nature. 2020 07; 583(7815):E19-E20. Momcilovic M, Shirihai O, Murphy MP, Koehler CM, Sadeghi S, Shackelford DB. PMID: 32641810.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    6. Publisher Correction: In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature. 2020 01; 577(7791):E7. Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB. PMID: 31896820.
      View in: PubMed   Mentions:    Fields:    
    7. In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature. 2019 11; 575(7782):380-384. Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB. PMID: 31666695; PMCID: PMC7328016.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    8. FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity. J Biol Chem. 2018 12 21; 293(51):19797-19811. Yien YY, Shi J, Chen C, Cheung JTM, Grillo AS, Shrestha R, Li L, Zhang X, Kafina MD, Kingsley PD, King MJ, Ablain J, Li H, Zon LI, Palis J, Burke MD, Bauer DE, Orkin SH, Koehler CM, Phillips JD, Kaplan J, Ward DM, Lodish HF, Paw BH. PMID: 30366982; PMCID: PMC6314115.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    9. A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B). ACS Chem Biol. 2018 10 19; 13(10):3000-3010. François-Moutal L, Jahanbakhsh S, Nelson ADL, Ray D, Scott DD, Hennefarth MR, Moutal A, Perez-Miller S, Ambrose AJ, Al-Shamari A, Coursodon P, Meechoovet B, Reiman R, Lyons E, Beilstein M, Chapman E, Morris QD, Van Keuren-Jensen K, Hughes TR, Khanna R, Koehler C, Jen J, Gokhale V, Khanna M. PMID: 30141626; PMCID: PMC6504997.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    10. PNPase knockout results in mtDNA loss and an altered metabolic gene expression program. PLoS One. 2018; 13(7):e0200925. Shimada E, Ahsan FM, Nili M, Huang D, Atamdede S, TeSlaa T, Case D, Yu X, Gregory BD, Perrin BJ, Koehler CM, Teitell MA. PMID: 30024931; PMCID: PMC6053217.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    11. ER-mitochondria contacts: Actin dynamics at the ER control mitochondrial fission via calcium release. J Cell Biol. 2018 01 02; 217(1):15-17. Steffen J, Koehler CM. PMID: 29259094; PMCID: PMC5748997.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    12. Stendomycin selectively inhibits TIM23-dependent mitochondrial protein import. Nat Chem Biol. 2017 Dec; 13(12):1239-1244. Filipuzzi I, Steffen J, Germain M, Goepfert L, Conti MA, Potting C, Cerino R, Pfeifer M, Krastel P, Hoepfner D, Bastien J, Koehler CM, Helliwell SB. PMID: 28991239; PMCID: PMC5945950.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    13. Osm1 facilitates the transfer of electrons from Erv1 to fumarate in the redox-regulated import pathway in the mitochondrial intermembrane space. Mol Biol Cell. 2017 Oct 15; 28(21):2773-2785. Neal SE, Dabir DV, Wijaya J, Boon C, Koehler CM. PMID: 28814504; PMCID: PMC5638582.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    14. Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS). Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8770-8775. Sangwan S, Zhao A, Adams KL, Jayson CK, Sawaya MR, Guenther EL, Pan AC, Ngo J, Moore DM, Soriaga AB, Do TD, Goldschmidt L, Nelson R, Bowers MT, Koehler CM, Shaw DE, Novitch BG, Eisenberg DS. PMID: 28760994; PMCID: PMC5565441.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    15. Adaptation of a Genetic Screen Reveals an Inhibitor for Mitochondrial Protein Import Component Tim44. J Biol Chem. 2017 Mar 31; 292(13):5429-5442. Miyata N, Tang Z, Conti MA, Johnson ME, Douglas CJ, Hasson SA, Damoiseaux R, Chang CA, Koehler CM. PMID: 28167535; PMCID: PMC5392686.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    16. Repurposing Approach Identifies Auranofin with Broad Spectrum Antifungal Activity That Targets Mia40-Erv1 Pathway. Front Cell Infect Microbiol. 2017; 7:4. Thangamani S, Maland M, Mohammad H, Pascuzzi PE, Avramova L, Koehler CM, Hazbun TR, Seleem MN. PMID: 28149831; PMCID: PMC5241286.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    17. Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria. Mol Biol Cell. 2017 Mar 01; 28(5):600-612. Steffen J, Vashisht AA, Wan J, Jen JC, Claypool SM, Wohlschlegel JA, Koehler CM. PMID: 28057766; PMCID: PMC5328619.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    18. Loss of function of SLC25A46 causes lethal congenital pontocerebellar hypoplasia. Brain. 2016 11 01; 139(11):2877-2890. Wan J, Steffen J, Yourshaw M, Mamsa H, Andersen E, Rudnik-Schöneborn S, Pope K, Howell KB, McLean CA, Kornberg AJ, Joseph J, Lockhart PJ, Zerres K, Ryan MM, Nelson SF, Koehler CM, Jen JC. PMID: 27543974; PMCID: PMC5840878.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    19. Mitochondrial Transfer by Photothermal Nanoblade Restores Metabolite Profile in Mammalian Cells. Cell Metab. 2016 05 10; 23(5):921-9. Wu TH, Sagullo E, Case D, Zheng X, Li Y, Hong JS, TeSlaa T, Patananan AN, McCaffery JM, Niazi K, Braas D, Koehler CM, Graeber TG, Chiou PY, Teitell MA. PMID: 27166949; PMCID: PMC5062745.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    20. UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells. EMBO J. 2016 Apr 15; 35(8):899. Zhang J, Khvorostov I, Hong JS, Oktay Y, Vergnes L, Nuebel E, Wahjudi PN, Setoguchi K, Wang G, Do A, Jung HJ, McCaffery JM, Kurland IJ, Reue K, Lee WN, Koehler CM, Teitell MA. PMID: 27084758; PMCID: PMC4972131.
      View in: PubMed   Mentions: 11     Fields:    
    21. Defining functional classes of Barth syndrome mutation in humans. Hum Mol Genet. 2016 05 01; 25(9):1754-70. Lu YW, Galbraith L, Herndon JD, Lu YL, Pras-Raves M, Vervaart M, Van Kampen A, Luyf A, Koehler CM, McCaffery JM, Gottlieb E, Vaz FM, Claypool SM. PMID: 26908608; PMCID: PMC4986330.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    22. P53 Regulates Rapid Apoptosis in Human Pluripotent Stem Cells. J Mol Biol. 2016 Apr 10; 428(7):1465-75. Setoguchi K, TeSlaa T, Koehler CM, Teitell MA. PMID: 26239243; PMCID: PMC4733597.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    23. Mia40 Protein Serves as an Electron Sink in the Mia40-Erv1 Import Pathway. J Biol Chem. 2015 Aug 21; 290(34):20804-20814. Neal SE, Dabir DV, Tienson HL, Horn DM, Glaeser K, Ogozalek Loo RR, Barrientos A, Koehler CM. PMID: 26085103; PMCID: PMC4543643.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    24. Mitochondria-targeted RNA import. Methods Mol Biol. 2015; 1264:107-16. Wang G, Shimada E, Nili M, Koehler CM, Teitell MA. PMID: 25631008; PMCID: PMC4439183.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    25. The great escape: Mgr2 of the mitochondrial TIM23 translocon is a gatekeeper Tasked with releasing membrane proteins. Mol Cell. 2014 Dec 04; 56(5):613-4. Steffen J, Koehler CM. PMID: 25479635.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    26. Defining the role of oxygen tension in human neural progenitor fate. Stem Cell Reports. 2014 Nov 11; 3(5):743-57. Xie Y, Zhang J, Lin Y, Gaeta X, Meng X, Wisidagama DR, Cinkornpumin J, Koehler CM, Malone CS, Teitell MA, Lowry WE. PMID: 25418722; PMCID: PMC4235163.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    27. Pharmacologic rescue of an enzyme-trafficking defect in primary hyperoxaluria 1. Proc Natl Acad Sci U S A. 2014 Oct 07; 111(40):14406-11. Miyata N, Steffen J, Johnson ME, Fargue S, Danpure CJ, Koehler CM. PMID: 25237136; PMCID: PMC4210028.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    28. TMEM14C is required for erythroid mitochondrial heme metabolism. J Clin Invest. 2014 Oct; 124(10):4294-304. Yien YY, Robledo RF, Schultz IJ, Takahashi-Makise N, Gwynn B, Bauer DE, Dass A, Yi G, Li L, Hildick-Smith GJ, Cooney JD, Pierce EL, Mohler K, Dailey TA, Miyata N, Kingsley PD, Garone C, Hattangadi SM, Huang H, Chen W, Keenan EM, Shah DI, Schlaeger TM, DiMauro S, Orkin SH, Cantor AB, Palis J, Koehler CM, Lodish HF, Kaplan J, Ward DM, Dailey HA, Phillips JD, Peters LL, Paw BH. PMID: 25157825; PMCID: PMC4191016.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    29. Macrocytic anemia and mitochondriopathy resulting from a defect in sideroflexin 4. Am J Hum Genet. 2013 Nov 07; 93(5):906-14. Hildick-Smith GJ, Cooney JD, Garone C, Kremer LS, Haack TB, Thon JN, Miyata N, Lieber DS, Calvo SE, Akman HO, Yien YY, Huston NC, Branco DS, Shah DI, Freedman ML, Koehler CM, Italiano JE, Merkenschlager A, Beblo S, Strom TM, Meitinger T, Freisinger P, Donati MA, Prokisch H, Mootha VK, DiMauro S, Paw BH. PMID: 24119684; PMCID: PMC3824126.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimals
    30. The Taz1p transacylase is imported and sorted into the outer mitochondrial membrane via a membrane anchor domain. Eukaryot Cell. 2013 Dec; 12(12):1600-8. Herndon JD, Claypool SM, Koehler CM. PMID: 24078306; PMCID: PMC3889572.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    31. Carla Koehler: Small TIMs are a big deal. Interviewed by Caitlin Sedwick. J Cell Biol. 2013 Apr 29; 201(3):358-9. Koehler C. PMID: 23629962; PMCID: PMC3639390.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    32. A small molecule inhibitor of redox-regulated protein translocation into mitochondria. Dev Cell. 2013 Apr 15; 25(1):81-92. Dabir DV, Hasson SA, Setoguchi K, Johnson ME, Wongkongkathep P, Douglas CJ, Zimmerman J, Damoiseaux R, Teitell MA, Koehler CM. PMID: 23597483; PMCID: PMC3726224.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    33. Meiosis I arrest abnormalities lead to severe oligozoospermia in meiosis 1 arresting protein (M1ap)-deficient mice. Biol Reprod. 2013 Mar; 88(3):76. Arango NA, Li L, Dabir D, Nicolau F, Pieretti-Vanmarcke R, Koehler C, McCarrey JR, Lu N, Donahoe PK. PMID: 23269666; PMCID: PMC4013860.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    34. New tools for the identification of developmentally regulated enhancer regions in embryonic and adult zebrafish. Zebrafish. 2013 Mar; 10(1):21-9. Levesque MP, Krauss J, Koehler C, Boden C, Harris MP. PMID: 23461416; PMCID: PMC3670562.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    35. Metabolic regulation in pluripotent stem cells during reprogramming and self-renewal. Cell Stem Cell. 2012 Nov 02; 11(5):589-95. Zhang J, Nuebel E, Daley GQ, Koehler CM, Teitell MA. PMID: 23122286; PMCID: PMC3492890.
      View in: PubMed   Mentions: 242     Fields:    Translation:HumansCells
    36. A mutation in PNPT1, encoding mitochondrial-RNA-import protein PNPase, causes hereditary hearing loss. Am J Hum Genet. 2012 Nov 02; 91(5):919-27. von Ameln S, Wang G, Boulouiz R, Rutherford MA, Smith GM, Li Y, Pogoda HM, Nürnberg G, Stiller B, Volk AE, Borck G, Hong JS, Goodyear RJ, Abidi O, Nürnberg P, Hofmann K, Richardson GP, Hammerschmidt M, Moser T, Wollnik B, Koehler CM, Teitell MA, Barakat A, Kubisch C. PMID: 23084290; PMCID: PMC3487123.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    37. Role of twin Cys-Xaa9-Cys motif cysteines in mitochondrial import of the cytochrome C oxidase biogenesis factor Cmc1. J Biol Chem. 2012 Sep 07; 287(37):31258-69. Bourens M, Dabir DV, Tienson HL, Sorokina I, Koehler CM, Barrientos A. PMID: 22767599; PMCID: PMC3438957.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    38. Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells. Nat Protoc. 2012 May 10; 7(6):1068-85. Zhang J, Nuebel E, Wisidagama DR, Setoguchi K, Hong JS, Van Horn CM, Imam SS, Vergnes L, Malone CS, Koehler CM, Teitell MA. PMID: 22576106; PMCID: PMC3819135.
      View in: PubMed   Mentions: 148     Fields:    Translation:HumansCells
    39. Correcting human mitochondrial mutations with targeted RNA import. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):4840-5. Wang G, Shimada E, Zhang J, Hong JS, Smith GM, Teitell MA, Koehler CM. PMID: 22411789; PMCID: PMC3323963.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    40. UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells. EMBO J. 2011 Nov 15; 30(24):4860-73. Zhang J, Khvorostov I, Hong JS, Oktay Y, Vergnes L, Nuebel E, Wahjudi PN, Setoguchi K, Wang G, Do A, Jung HJ, McCaffery JM, Kurland IJ, Reue K, Lee WN, Koehler CM, Teitell MA. PMID: 22085932; PMCID: PMC3243621.
      View in: PubMed   Mentions: 254     Fields:    Translation:HumansCells
    41. The complexity of cardiolipin in health and disease. Trends Biochem Sci. 2012 Jan; 37(1):32-41. Claypool SM, Koehler CM. PMID: 22014644; PMCID: PMC3259273.
      View in: PubMed   Mentions: 174     Fields:    Translation:Humans
    42. PNPASE and RNA trafficking into mitochondria. Biochim Biophys Acta. 2012 Sep-Oct; 1819(9-10):998-1007. Wang G, Shimada E, Koehler CM, Teitell MA. PMID: 22023881; PMCID: PMC3267854.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    43. Barth syndrome mutations that cause tafazzin complex lability. J Cell Biol. 2011 Feb 07; 192(3):447-62. Claypool SM, Whited K, Srijumnong S, Han X, Koehler CM. PMID: 21300850; PMCID: PMC3101092.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    44. PNPASE regulates RNA import into mitochondria. Cell. 2010 Aug 06; 142(3):456-67. Wang G, Chen HW, Oktay Y, Zhang J, Allen EL, Smith GM, Fan KC, Hong JS, French SW, McCaffery JM, Lightowlers RN, Morse HC, Koehler CM, Teitell MA. PMID: 20691904; PMCID: PMC2921675.
      View in: PubMed   Mentions: 164     Fields:    Translation:HumansAnimalsCells
    45. The mitochondrial import gene tomm22 is specifically required for hepatocyte survival and provides a liver regeneration model. Dis Model Mech. 2010 Jul-Aug; 3(7-8):486-95. Curado S, Ober EA, Walsh S, Cortes-Hernandez P, Verkade H, Koehler CM, Stainier DY. PMID: 20483998; PMCID: PMC2898538.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    46. Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9578-83. Hasson SA, Damoiseaux R, Glavin JD, Dabir DV, Walker SS, Koehler CM. PMID: 20457929; PMCID: PMC2906835.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    47. MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria. Nat Cell Biol. 2010 Jun; 12(6):553-562. Zaltsman Y, Shachnai L, Yivgi-Ohana N, Schwarz M, Maryanovich M, Houtkooper RH, Vaz FM, De Leonardis F, Fiermonte G, Palmieri F, Gillissen B, Daniel PT, Jimenez E, Walsh S, Koehler CM, Roy SS, Walter L, Hajnóczky G, Gross A. PMID: 20436477; PMCID: PMC4070879.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    48. Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria. Am J Pathol. 2009 Nov; 175(5):1810-6. Area-Gomez E, de Groof AJ, Boldogh I, Bird TD, Gibson GE, Koehler CM, Yu WH, Duff KE, Yaffe MP, Pon LA, Schon EA. PMID: 19834068; PMCID: PMC2774047.
      View in: PubMed   Mentions: 170     Fields:    Translation:HumansAnimalsCells
    49. Importing mitochondrial proteins: machineries and mechanisms. Cell. 2009 Aug 21; 138(4):628-44. Chacinska A, Koehler CM, Milenkovic D, Lithgow T, Pfanner N. PMID: 19703392; PMCID: PMC4099469.
      View in: PubMed   Mentions: 624     Fields:    Translation:HumansAnimalsCells
    50. Reconstitution of the mia40-erv1 oxidative folding pathway for the small tim proteins. Mol Biol Cell. 2009 Aug; 20(15):3481-90. Tienson HL, Dabir DV, Neal SE, Loo R, Hasson SA, Boontheung P, Kim SK, Loo JA, Koehler CM. PMID: 19477928; PMCID: PMC2719566.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    51. Functional characterization of a mitochondrial Ser/Thr protein phosphatase in cell death regulation. Methods Enzymol. 2009; 457:255-73. Lu G, Sun H, Korge P, Koehler CM, Weiss JN, Wang Y. PMID: 19426872; PMCID: PMC3705213.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    52. The cardiolipin transacylase, tafazzin, associates with two distinct respiratory components providing insight into Barth syndrome. Mol Biol Cell. 2008 Dec; 19(12):5143-55. Claypool SM, Boontheung P, McCaffery JM, Loo JA, Koehler CM. PMID: 18799610; PMCID: PMC2592642.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    53. Cardiolipin defines the interactome of the major ADP/ATP carrier protein of the mitochondrial inner membrane. J Cell Biol. 2008 Sep 08; 182(5):937-50. Claypool SM, Oktay Y, Boontheung P, Loo JA, Koehler CM. PMID: 18779372; PMCID: PMC2528576.
      View in: PubMed   Mentions: 158     Fields:    Translation:AnimalsCells
    54. Redox regulation of protein folding in the mitochondrial intermembrane space. Biochim Biophys Acta. 2009 Jan; 1793(1):139-45. Koehler CM, Tienson HL. PMID: 18761382; PMCID: PMC4099470.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    55. Gazing at translocation in the mitochondrion. Cell. 2008 Aug 08; 134(3):382-3. Walsh S, Koehler CM. PMID: 18692459.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    56. The Tim8-Tim13 complex has multiple substrate binding sites and binds cooperatively to Tim23. J Mol Biol. 2008 Oct 24; 382(5):1144-56. Beverly KN, Sawaya MR, Schmid E, Koehler CM. PMID: 18706423; PMCID: PMC2651516.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    57. Assembly of the three small Tim proteins precedes docking to the mitochondrial carrier translocase. EMBO Rep. 2008 Jun; 9(6):548-54. Gebert N, Chacinska A, Wagner K, Guiard B, Koehler CM, Rehling P, Pfanner N, Wiedemann N. PMID: 18421298; PMCID: PMC2427372.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    58. Human polynucleotide phosphorylase: location matters. Trends Cell Biol. 2007 Dec; 17(12):600-8. Chen HW, Koehler CM, Teitell MA. PMID: 17983748.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    59. A role for cytochrome c and cytochrome c peroxidase in electron shuttling from Erv1. EMBO J. 2007 Nov 28; 26(23):4801-11. Dabir DV, Leverich EP, Kim SK, Tsai FD, Hirasawa M, Knaff DB, Koehler CM. PMID: 17972915; PMCID: PMC2099471.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    60. Tim54p connects inner membrane assembly and proteolytic pathways in the mitochondrion. J Cell Biol. 2007 Sep 24; 178(7):1161-75. Hwang DK, Claypool SM, Leuenberger D, Tienson HL, Koehler CM. PMID: 17893242; PMCID: PMC2064651.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    61. Contiguous X-chromosome deletion syndrome encompassing the BTK, TIMM8A, TAF7L, and DRP2 genes. J Clin Immunol. 2007 Nov; 27(6):640-6. Sedivá A, Smith CI, Asplund AC, Hadac J, Janda A, Zeman J, Hansíková H, Dvoráková L, Mrázová L, Velbri S, Koehler C, Roesch K, Sullivan KE, Futatani T, Ochs HD. PMID: 17851739.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    62. A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development. Genes Dev. 2007 Apr 01; 21(7):784-96. Lu G, Ren S, Korge P, Choi J, Dong Y, Weiss J, Koehler C, Chen JN, Wang Y. PMID: 17374715; PMCID: PMC1838530.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    63. In vitro analysis of yeast mitochondrial protein import. Curr Protoc Cell Biol. 2007 Mar; Chapter 11:Unit 11.19. Stuart RA, Koehler CM. PMID: 18228496.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    64. Mammalian polynucleotide phosphorylase is an intermembrane space RNase that maintains mitochondrial homeostasis. Mol Cell Biol. 2006 Nov; 26(22):8475-87. Chen HW, Rainey RN, Balatoni CE, Dawson DW, Troke JJ, Wasiak S, Hong JS, McBride HM, Koehler CM, Teitell MA, French SW. PMID: 16966381; PMCID: PMC1636764.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    65. A new function in translocation for the mitochondrial i-AAA protease Yme1: import of polynucleotide phosphorylase into the intermembrane space. Mol Cell Biol. 2006 Nov; 26(22):8488-97. Rainey RN, Glavin JD, Chen HW, French SW, Teitell MA, Koehler CM. PMID: 16966379; PMCID: PMC1636789.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    66. The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity. Cancer Lett. 2007 Apr 18; 248(2):198-210. French SW, Dawson DW, Chen HW, Rainey RN, Sievers SA, Balatoni CE, Wong L, Troke JJ, Nguyen MT, Koehler CM, Teitell MA. PMID: 16934922.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    67. Mitochondrial mislocalization and altered assembly of a cluster of Barth syndrome mutant tafazzins. J Cell Biol. 2006 Jul 31; 174(3):379-90. Claypool SM, McCaffery JM, Koehler CM. PMID: 16880272; PMCID: PMC2064234.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    68. Redox pathways of the mitochondrion. Antioxid Redox Signal. 2006 May-Jun; 8(5-6):813-22. Koehler CM, Beverly KN, Leverich EP. PMID: 16771672.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    69. Hereditary spastic paraplegia: respiratory choke or unactivated substrate? Cell. 2005 Oct 21; 123(2):183-5. Claypool SM, Koehler CM. PMID: 16239134.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    70. Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20. J Mol Biol. 2005 Mar 18; 347(1):81-93. Likic VA, Perry A, Hulett J, Derby M, Traven A, Waller RF, Keeling PJ, Koehler CM, Curran SP, Gooley PR, Lithgow T. PMID: 15733919.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    71. Defective mitochondrial protein translocation precludes normal Caenorhabditis elegans development. J Biol Chem. 2004 Dec 24; 279(52):54655-62. Curran SP, Leverich EP, Koehler CM, Larsen PL. PMID: 15485840.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    72. The role of Hot13p and redox chemistry in the mitochondrial TIM22 import pathway. J Biol Chem. 2004 Oct 15; 279(42):43744-51. Curran SP, Leuenberger D, Leverich EP, Hwang DK, Beverly KN, Koehler CM. PMID: 15294910.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    73. The calcium-binding aspartate/glutamate carriers, citrin and aralar1, are new substrates for the DDP1/TIMM8a-TIMM13 complex. Hum Mol Genet. 2004 Sep 15; 13(18):2101-11. Roesch K, Hynds PJ, Varga R, Tranebjaerg L, Koehler CM. PMID: 15254020.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    74. The small Tim proteins and the twin Cx3C motif. Trends Biochem Sci. 2004 Jan; 29(1):1-4. Koehler CM. PMID: 14729324.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    75. New developments in mitochondrial assembly. Annu Rev Cell Dev Biol. 2004; 20:309-35. Koehler CM. PMID: 15473843.
      View in: PubMed   Mentions: 106     Fields:    Translation:Cells
    76. A mitochondrial rhomboid protease. Dev Cell. 2003 Jun; 4(6):769-70. van der Bliek AM, Koehler CM. PMID: 12791261.
      View in: PubMed   Mentions: 11     Fields:    
    77. Trichomonas vaginalis Hmp35, a putative pore-forming hydrogenosomal membrane protein, can form a complex in yeast mitochondria. J Biol Chem. 2003 Aug 15; 278(33):30548-61. Dyall SD, Lester DC, Schneider RE, Delgadillo-Correa MG, Plümper E, Martinez A, Koehler CM, Johnson PJ. PMID: 12766161.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    78. The role of Tim9p in the assembly of the TIM22 import complexes. Traffic. 2003 Mar; 4(3):144-52. Leuenberger D, Curran SP, Wong D, Koehler CM. PMID: 12656987.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    79. The role of the Tim8p-Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins. J Cell Biol. 2002 Sep 16; 158(6):1017-27. Curran SP, Leuenberger D, Schmidt E, Koehler CM. PMID: 12221072; PMCID: PMC2173223.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    80. Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex. Hum Mol Genet. 2002 Mar 01; 11(5):477-86. Roesch K, Curran SP, Tranebjaerg L, Koehler CM. PMID: 11875042.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    81. The Tim9p-Tim10p complex binds to the transmembrane domains of the ADP/ATP carrier. EMBO J. 2002 Mar 01; 21(5):942-53. Curran SP, Leuenberger D, Oppliger W, Koehler CM. PMID: 11867522; PMCID: PMC125908.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    82. Protein translocation pathways of the mitochondrion. FEBS Lett. 2000 Jun 30; 476(1-2):27-31. Koehler CM. PMID: 10878244.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
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