Jim Lakes fundamental evolutionary discoveries, like the New-Animal-Phylogeny for which he received the 2011 Darwin-Wallace Medal, combine a deep understanding of biology with transformative genomic analyses. He is breaking new ground rooting the tree of life, reconstructing the eukaryotic rings of life, and providing genomic evidence for ancient prokaryotic endosymbioses. Research Interest: Evolution, Genomics and Bioinformatics, including the evolution and origin of genomes
Lake, J. A. Evidence for an early prokaryotic endosymbiosis. , Nature, 2009; 460: 967-971.
Lake, J. A., Skophammer, R. G., Herbold, C. W., and Servin, J. A. Genome beginnings: Rooting the tree of life. , Philosophical Transactions of the Royal Society, Section B, 2009; 364(1527): 2177-2185.
Ragan, M. A.; McInerney, J. O.; and Lake, J. A. The network of life: genome beginnings and evolution’, Philosophical Transactions of the Royal Society B, 2009; 364(1527): 2169-2289.
Lake, J. A. Reconstructing Evolutionary Graphs: 3D Parsimony. , Molecular Biology and Evolution, 2008; 25: 1677-1682.
Skophammer, R. G., Servin, J. A., Herbold, C. W., and Lake, J. A. Evidence for a Gram Positive, Eubacterial Root of the Tree of Life. , Molecular Biology and Evolution, 2007; 24: 1761-1768.
James A. Lake Disappearing Act, Nature, 2007; 446: 983.
James A. Lake Craig W. Herbold Marica C. Rivera Jacqueline A. Servin Ryan G. Skophammer Rooting the Tree of Life Using Nonubiquitous Genes, Molecular Biology and Evolution, 2006; 24(1): 130-6.
Simonson, AB Servin, JA Skophammer, RG Herbold, CW Rivera, MC Lake, JA Decoding the genomic tree of life Proceedings of the National Academy of Sciences of the United States of America. , 2005; 102 Suppl 1: 6608-13.
Rivera, MC Lake, JA The ring of life provides evidence for a genome fusion origin of eukaryotes Nature. , 2004; 431(7005): 152-5.
Jain, R Rivera, MC Moore, JE Lake, JA Horizontal gene transfer accelerates genome innovation and evolution Molecular biology and evolution. , 2003; 20(10): 1598-602.
Simonson, AB Lake, JA The transorientation hypothesis for codon recognition during protein synthesis Nature. , 2002; 416(6878): 281-5.
Lake, J Why Pauling didn't solve the structure of DNA Nature. , 2001; 409(6820): 558.
Lake, J.A., Jain, R., and Rivera, M.C. Mix and Match in the Tree of Life, Science, 1999; 283: 2927-2928.
Jain, R Rivera, MC Lake, JA Horizontal gene transfer among genomes: the complexity hypothesis Proceedings of the National Academy of Sciences of the United States of America. , 1999; 96(7): 3801-6.
Rivera, MC Jain, R Moore, JE Lake, JA Genomic evidence for two functionally distinct gene classes Proceedings of the National Academy of Sciences of the United States of America. , 1998; 95(11): 6239-44.
Aguinaldo, AM Turbeville, JM Linford, LS Rivera, MC Garey, JR Raff, RA Lake, JA Evidence for a clade of nematodes, arthropods and other moulting animals Nature. , 1997; 387(6632): 489-93.
Halanych, KM Bacheller, JD Aguinaldo, AM Liva, SM Hillis, DM Lake, JA Evidence from 18S ribosomal DNA that the lophophorates are protostome animals Science. , 1995; 267(5204): 1641-3.
Does this profile need updating? Contact Us