Thomas Vallim, Ph.D.

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A Short Biography:

Dr. Vallim is an Associate Professor in the Department of Biological Chemistry and in the Department of Medicine, Division of Cardiology at UCLA. Dr. Vallim was born in Brazil and emigrated to England as a teenager. In England, Dr. Vallim received his M.Sci and Ph.D from the University of Nottingham. As an undergraduate Ph.D student, Dr. Vallim’s research focused was on the transcriptional regulation of genes in lipid metabolism by dietary factors. Dr. Vallim came to UCLA for his post-doctoral studies in the laboratory of Peter Edwards, and later joined the faculty. Dr. Vallim is an Associate Professor in the David Geffen School of Medicine, Division of Cardiology and the Department of Biological Chemistry. Dr. Vallim's research involves the identification of molecular mechanisms that control lipid metabolism, with a focus on transcriptional regulation by nuclear receptors. 

Work Titles
CTSI Member, CTSI
UCLA Associate Professor, Cardiology Associate Professor, Biological Chemistry Member, Jonsson Comprehensive Cancer Center Member, Molecular Biology Institute Member, Molecular, Cellular & Integrative Physiology GPB Home Area
Education:
Degrees:
Ph.D.

Contact Information:

Email Address:

tvallim@mednet.ucla.edu


Website:

Lab website

Laboratory Address:

675 Charles E Young Drive South
MRL Receiving
Room 3240
Los Angeles, CA 90095


Mailing Address:

650 Charles E. Young Drive South
A2-237 CHS
Los Angeles, CA 90095


Publications:

A selected list of publications:

Clifford Bethan L, Sedgeman Leslie R, Williams Kevin J, Morand Pauline, Cheng Angela, Jarrett Kelsey E, Chan Alvin P, Brearley-Sholto Madelaine C, Wahlström Annika, Ashby Julianne W, Barshop William, Wohlschlegel James, Calkin Anna C, Liu Yingying, Thorell Anders, Meikle Peter J, Drew Brian G, Mack Julia J, Marschall Hanns-Ulrich, Tarling Elizabeth J, Edwards Peter A, de Aguiar Vallim Thomas Q   FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption Cell metabolism, 2021; 33(8): 1671-1684.e4.
von Scheidt Moritz, Zhao Yuqi, de Aguiar Vallim Thomas Q, Che Nam, Wierer Michael, Seldin Marcus M, Franzén Oscar, Kurt Zeyneb, Pang Shichao, Bongiovanni Dario, Yamamoto Masayuki, Edwards Peter A, Ruusalepp Arno, Kovacic Jason C, Mann Matthias, Björkegren Johan L M, Lusis Aldons J, Yang Xia, Schunkert Heribert   Transcription Factor MAFF (MAF Basic Leucine Zipper Transcription Factor F) Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism Circulation, 2021; 143(18): 1809-1823.
Cheng Joan, Cheng Angela, Clifford Bethan L, Wu Xiaohui, Hedin Ulf, Maegdefessel Lars, Pamir Nathalie, Sallam Tamer, Tarling Elizabeth J, de Aguiar Vallim Thomas Q   MicroRNA-144 Silencing Protects Against Atherosclerosis in Male, but Not Female Mice Arteriosclerosis, thrombosis, and vascular biology, 2020; 40(2): 412-425.
Parker Benjamin L, Calkin Anna C, Seldin Marcus M, Keating Michael F, Tarling Elizabeth J, Yang Pengyi, Moody Sarah C, Liu Yingying, Zerenturk Eser J, Needham Elise J, Miller Matthew L, Clifford Bethan L, Morand Pauline, Watt Matthew J, Meex Ruth C R, Peng Kang-Yu, Lee Richard, Jayawardana Kaushala, Pan Calvin, Mellett Natalie A, Weir Jacquelyn M, Lazarus Ross, Lusis Aldons J, Meikle Peter J, James David E, de Aguiar Vallim Thomas Q, Drew Brian G   An integrative systems genetic analysis of mammalian lipid metabolism Nature, 2019; 567(7747): 187-193.
Sullivan William J, Mullen Peter J, Schmid Ernst W, Flores Aimee, Momcilovic Milica, Sharpley Mark S, Jelinek David, Whiteley Andrew E, Maxwell Matthew B, Wilde Blake R, Banerjee Utpal, Coller Hilary A, Shackelford David B, Braas Daniel, Ayer Donald E, de Aguiar Vallim Thomas Q, Lowry William E, Christofk Heather R   Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization Cell, 2018; 175(1): 117-132.e21.
Rong Xin, Wang Bo, Palladino Elisa Nd, de Aguiar Vallim Thomas Q, Ford David A, Tontonoz Peter   ER phospholipid composition modulates lipogenesis during feeding and in obesity The Journal of clinical investigation, 2017; 127(10): 3640-3651.
Tarling Elizabeth J, Clifford Bethan L, Cheng Joan, Morand Pauline, Cheng Angela, Lester Ellen, Sallam Tamer, Turner Martin, de Aguiar Vallim Thomas Q   RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism The Journal of clinical investigation, 2017; 127(10): 3741-3754.
Mack Julia J, Mosqueiro Thiago S, Archer Brian J, Jones William M, Sunshine Hannah, Faas Guido C, Briot Anais, Aragón Raquel L, Su Trent, Romay Milagros C, McDonald Austin I, Kuo Cheng-Hsiang, Lizama Carlos O, Lane Timothy F, Zovein Ann C, Fang Yun, Tarling Elizabeth J, de Aguiar Vallim Thomas Q, Navab Mohamad, Fogelman Alan M, Bouchard Louis S, Iruela-Arispe M Luisa   NOTCH1 is a mechanosensor in adult arteries Nature communications, 2017; 8(1): 1620.
Sallam Tamer, Jones Marius C, Gilliland Thomas, Zhang Li, Wu Xiaohui, Eskin Ascia, Sandhu Jaspreet, Casero David, Vallim Thomas Q de Aguiar, Hong Cynthia, Katz Melanie, Lee Richard, Whitelegge Julian, Tontonoz Peter   Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis Nature, 2016; 534(7605): 124-8.
Wang Bo, Rong Xin, Duerr Mark A, Hermanson Daniel J, Hedde Per Niklas, Wong Jinny S, Vallim Thomas Q de Aguiar, Cravatt Benjamin F, Gratton Enrico, Ford David A, Tontonoz Peter   Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet Cell metabolism, 2016; 23(3): 492-504.
de Aguiar Vallim Thomas Q, Tarling Elizabeth J, Ahn Hannah, Hagey Lee R, Romanoski Casey E, Lee Richard G, Graham Mark J, Motohashi Hozumi, Yamamoto Masayuki, Edwards Peter A   MAFG is a transcriptional repressor of bile acid synthesis and metabolism Cell metabolism, 2015; 21(2): 298-310.
Tarling Elizabeth J, Ahn Hannah, de Aguiar Vallim Thomas Q   The Nuclear Receptor FXR Uncouples the Actions of miR-33 From SREBP-2 Arteriosclerosis, thrombosis, and vascular biology, 2015; .
de Aguiar Vallim Thomas Q, Tarling Elizabeth J, Kim Tammy, Civelek Mete, Baldan Angel, Esau Christine, Edwards Peter A   MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor Circulation research, 2013; 112(12): 1602-12.
de Aguiar Vallim Thomas Q, Tarling Elizabeth J, Edwards Peter A   Pleiotropic roles of bile acids in metabolism Cell metabolism, 2013; 17(5): 657-69.
Tarling Elizabeth J, de Aguiar Vallim Thomas Q, Edwards Peter A   Role of ABC transporters in lipid transport and human disease Trends in endocrinology and metabolism: TEM, 2013; 24(7): 342-50.
Bennett Brian J, de Aguiar Vallim Thomas Q, Wang Zeneng, Shih Diana M, Meng Yonghong, Gregory Jill, Allayee Hooman, Lee Richard, Graham Mark, Crooke Rosanne, Edwards Peter A, Hazen Stanley L, Lusis Aldons J   Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation Cell metabolism, 2013; 17(1): 49-60.
Lee Florence Ying, de Aguiar Vallim Thomas Quad, Chong Hansook Kim, Zhang Yanqiao, Liu Yaping, Jones Stacey A, Osborne Timothy F, Edwards Peter A   Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity Molecular endocrinology (Baltimore, Md.), 2010; 24(8): 1626-36.

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