Jonathan Matthew Wanagat

Title(s)HS Associate Clinical Professor, Medicine
SchoolMedicine
ORCID ORCID Icon0000-0002-8460-8616 Additional info
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    Collapse Research 
    Collapse Research Activities and Funding
    Quantitative imaging of the dystrophin-glycoprotein complex
    NIH R21AR072950Sep 6, 2019 - Aug 31, 2021
    Role: Principal Investigator
    Mitochondrial DNA Deletion Mutations: Biomarkers of Aging
    NIH R56AG060880Sep 30, 2018 - Aug 31, 2020
    Role: Principal Investigator
    Mitochondrial biogenesis, genetics and cell loss in mammalian aging
    NIH K02AG059847Sep 1, 2018 - May 31, 2023
    Role: Principal Investigator
    Mitochondrial biogenesis, genetics and cell loss in mammalian aging
    NIH R01AG055518Sep 30, 2017 - May 31, 2023
    Role: Principal Investigator
    Mitochondrial genetics in skeletal muscle aging
    NIH K08AG032873Sep 15, 2009 - Aug 31, 2015
    Role: Principal Investigator
    UCLA Medical Student Training in Aging Research (MSTAR) Program
    NIH T35AG026736Jun 1, 2005 - May 31, 2025
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria. Sci Adv. 2024 Apr 05; 10(14):eadl0389. Zhou Z, Ma A, Moore TM, Wolf DM, Yang N, Tran P, Segawa M, Strumwasser AR, Ren W, Fu K, Wanagat J, van der Bliek AM, Crosbie-Watson R, Liesa M, Stiles L, Acin-Perez R, Mahata S, Shirihai O, Goodarzi MO, Handzlik M, Metallo CM, Walker DW, Hevener AL. PMID: 38569044; PMCID: PMC10990287.
      View in: PubMed   Mentions:    Fields:    
    2. Immunolabelling perturbs the endogenous and antibody-conjugated elemental concentrations during immuno-mass spectrometry imaging. Anal Bioanal Chem. 2023 Oct 06. Mello MG, Westerhausen MT, Lockwood TE, Singh P, Wanagat J, Bishop DP. PMID: 37801117; PMCID: PMC10997740.
      View in: PubMed   Mentions:    Fields:    
    3. A Genetically Heterogeneous Rat Model with Divergent Mitochondrial Genomes. J Gerontol A Biol Sci Med Sci. 2023 05 11; 78(5):771-779. Sathiaseelan R, Ahn B, Stout MB, Logan S, Wanagat J, Nguyen HVM, Hord NG, Vandiver AR, Selvarani R, Ranjit R, Yarbrough H, Masingale A, Miller BF, Wolf RF, Austad SN, Richardson A. PMID: 36762848; PMCID: PMC10172978.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    4. Nanopore sequencing identifies a higher frequency and expanded spectrum of mitochondrial DNA deletion mutations in human aging. Aging Cell. 2023 06; 22(6):e13842. Vandiver AR, Hoang AN, Herbst A, Lee CC, Aiken JM, McKenzie D, Teitell MA, Timp W, Wanagat J. PMID: 37132288; PMCID: PMC10265159.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    5. Remdesivir does not affect mitochondrial DNA copy number or deletion mutation frequency in aged male rats: A short report. PLoS One. 2022; 17(10):e0271850. Herbst A, Choi S, Hoang AN, Kim C, Martinez Moreno D, McKenzie D, Aiken JM, Wanagat J. PMID: 36288327; PMCID: PMC9605030.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. Age- and time-dependent mitochondrial genotoxic and myopathic effects of beta-guanidinopropionic acid, a creatine analog, on rodent skeletal muscles. Geroscience. 2023 02; 45(1):555-567. Herbst A, Aiken JM, Kim C, Gushue D, McKenzie D, Moore TM, Zhou J, Hoang AN, Choi S, Wanagat J. PMID: 36178599; PMCID: PMC9886740.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    7. Long read mitochondrial genome sequencing using Cas9-guided adaptor ligation. Mitochondrion. 2022 07; 65:176-183. Vandiver AR, Pielstick B, Gilpatrick T, Hoang AN, Vernon HJ, Wanagat J, Timp W. PMID: 35787470; PMCID: PMC9399971.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    8. Metformin Treatment in Old Rats and Effects on Mitochondrial Integrity. Rejuvenation Res. 2021 Dec; 24(6):434-440. Herbst A, Hoang A, Kim C, Aiken JM, McKenzie D, Goldwater DS, Wanagat J. PMID: 34779265; PMCID: PMC8742278.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    9. Baseline pro-inflammatory gene expression in whole blood is related to adverse long-term outcomes after transcatheter aortic valve replacement: a case control study. BMC Cardiovasc Disord. 2021 08 02; 21(1):368. Goldwater DS, Leng M, Karlamangla A, Seeman T, Elashoff D, Wanagat JM, Reuben DB, Lindman BR, Cole S. PMID: 34340660; PMCID: PMC8327421.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. Assessing the reproducibility of labelled antibody binding in quantitative multiplexed immuno-mass spectrometry imaging. Anal Bioanal Chem. 2021 Sep; 413(21):5509-5516. Mello MG, Westerhausen MT, Singh P, Doble PA, Wanagat J, Bishop DP. PMID: 34304281; PMCID: PMC8493634.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    11. Skeletal muscle mitochondrial DNA copy number and mitochondrial DNA deletion mutation frequency as predictors of physical performance in older men and women. Geroscience. 2021 06; 43(3):1253-1264. Herbst A, Prior SJ, Lee CC, Aiken JM, McKenzie D, Hoang A, Liu N, Chen X, Xun P, Allison DB, Wanagat J. PMID: 33740224; PMCID: PMC8190323.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    12. Quantitative immuno-mass spectrometry imaging of skeletal muscle dystrophin. Sci Rep. 2021 01 13; 11(1):1128. Bishop DP, Westerhausen MT, Barthelemy F, Lockwood T, Cole N, Gibbs EM, Crosbie RH, Nelson SF, Miceli MC, Doble PA, Wanagat J. PMID: 33441839; PMCID: PMC7806610.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    13. Age-induced mitochondrial DNA point mutations are inadequate to alter metabolic homeostasis in response to nutrient challenge. Aging Cell. 2020 11; 19(11):e13166. Moore TM, Zhou Z, Strumwasser AR, Cohn W, Lin AJ, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Hoang AN, Widjaja K, Abrishami AD, Charugundla S, Stiles L, Whitelegge JP, Turcotte LP, Wanagat J, Hevener AL. PMID: 33049094; PMCID: PMC7681042.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    14. Mitochondrial DNA deletion mutations increase exponentially with age in human skeletal muscle. Aging Clin Exp Res. 2021 Jul; 33(7):1811-1820. Herbst A, Lee CC, Vandiver AR, Aiken JM, McKenzie D, Hoang A, Allison D, Liu N, Wanagat J. PMID: 32965609; PMCID: PMC7985047.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    15. A well-tolerated core needle muscle biopsy process suitable for children and adults. Muscle Nerve. 2020 12; 62(6):688-698. Barthelemy F, Woods JD, Nieves-Rodriguez S, Douine ED, Wang R, Wanagat J, Miceli MC, Nelson SF. PMID: 32820569; PMCID: PMC7756388.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    16. Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling. Sci Transl Med. 2020 08 05; 12(555). Zhou Z, Moore TM, Drew BG, Ribas V, Wanagat J, Civelek M, Segawa M, Wolf DM, Norheim F, Seldin MM, Strumwasser AR, Whitney KA, Lester E, Reddish BR, Vergnes L, Reue K, Rajbhandari P, Tontonoz P, Lee J, Mahata SK, Hewitt SC, Shirihai O, Gastonbury C, Small KS, Laakso M, Jensen J, Lee S, Drevon CA, Korach KS, Lusis AJ, Hevener AL. PMID: 32759275; PMCID: PMC8212422.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    17. Comment on: "Mitochondrial Mechanisms of Neuromuscular Junction Degeneration with Aging. Cells 2020, 9, 197". Cells. 2020 07 29; 9(8). Herbst A, Aiken JM, McKenzie D, Wanagat J. PMID: 32751058; PMCID: PMC7464736.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    18. Mitochondrial Dysfunction Is an Early Consequence of Partial or Complete Dystrophin Loss in mdx Mice. Front Physiol. 2020; 11:690. Moore TM, Lin AJ, Strumwasser AR, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Nguyen CQ, Yackly A, Mahata SK, Wanagat J, Stiles L, Turcotte LP, Crosbie RH, Zhou Z. PMID: 32636760; PMCID: PMC7317021.
      View in: PubMed   Mentions: 39  
    19. A novel approach to measure mitochondrial respiration in frozen biological samples. EMBO J. 2020 07 01; 39(13):e104073. Acin-Perez R, Benador IY, Petcherski A, Veliova M, Benavides GA, Lagarrigue S, Caudal A, Vergnes L, Murphy AN, Karamanlidis G, Tian R, Reue K, Wanagat J, Sacks H, Amati F, Darley-Usmar VM, Liesa M, Divakaruni AS, Stiles L, Shirihai OS. PMID: 32432379; PMCID: PMC7327496.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    20. Enhanced Methods for Needle Biopsy and Cryopreservation of Skeletal Muscle in Older Adults. J Cytol Histol. 2020; 11(2). Lee CC, Hoang A, Segovia D, Herbst A, Barthelemy F, Gibbs E, Crosbie R, Nelson SF, Miceli C, Wanagat J. PMID: 32566369; PMCID: PMC7304549.
      View in: PubMed   Mentions: 7  
    21. Super-Resolution Reconstruction for Two- and Three-Dimensional LA-ICP-MS Bioimaging. Anal Chem. 2019 12 03; 91(23):14879-14886. Westerhausen MT, Bishop DP, Dowd A, Wanagat J, Cole N, Doble PA. PMID: 31640341; PMCID: PMC7232986.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    22. Mitochondrial DNA alterations in aged macrophage migration inhibitory factor-knockout mice. Mech Ageing Dev. 2019 09; 182:111126. Herbst A, Hoang AN, Woo W, McKenzie D, Aiken JM, Miller RA, Allison DB, Liu N, Wanagat J. PMID: 31381889; PMCID: PMC6718337.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    23. Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice. Exp Gerontol. 2019 10 01; 125:110675. Kim MJ, Haroon S, Chen GD, Ding D, Wanagat J, Liu L, Zhang Y, White K, Park HJ, Han C, Boyd K, Caicedo I, Evans K, Linser PJ, Tanokura M, Prolla T, Salvi R, Vermulst M, Someya S. PMID: 31344454; PMCID: PMC6857812.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    24. Long term rapamycin treatment improves mitochondrial DNA quality in aging mice. Exp Gerontol. 2018 06; 106:125-131. Bielas J, Herbst A, Widjaja K, Hui J, Aiken JM, McKenzie D, Miller RA, Brooks SV, Wanagat J. PMID: 29486228; PMCID: PMC5911406.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    25. Digital PCR Quantitation of Muscle Mitochondrial DNA: Age, Fiber Type, and Mutation-Induced Changes. J Gerontol A Biol Sci Med Sci. 2017 Oct 01; 72(10):1327-1333. Herbst A, Widjaja K, Nguy B, Lushaj EB, Moore TM, Hevener AL, McKenzie D, Aiken JM, Wanagat J. PMID: 28460005; PMCID: PMC5861869.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    26. Latent mitochondrial DNA deletion mutations drive muscle fiber loss at old age. Aging Cell. 2016 Dec; 15(6):1132-1139. Herbst A, Wanagat J, Cheema N, Widjaja K, McKenzie D, Aiken JM. PMID: 27561813; PMCID: PMC5114866.
      View in: PubMed   Mentions: 35     Fields:    
    27. Mitochondrial quality control in insulin resistance and diabetes. Curr Opin Genet Dev. 2016 06; 38:118-126. Wanagat J, Hevener AL. PMID: 27318536; PMCID: PMC5067242.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    28. Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Sci Transl Med. 2016 Apr 13; 8(334):334ra54. Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, Beaven SW, Tontonoz P, Lusis AJ, Parks BW, Vergnes L, Reue K, Singh H, Bopassa JC, Toro L, Stefani E, Watt MJ, Schenk S, Akerstrom T, Kelly M, Pedersen BK, Hewitt SC, Korach KS, Hevener AL. PMID: 27075628; PMCID: PMC4934679.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    29. Skeletal muscle mitochondrial DNA deletions are not increased in CuZn-superoxide dismutase deficient mice. Exp Gerontol. 2015 Jan; 61:15-9. Wanagat J, Ahmadieh N, Bielas JH, Ericson NG, Van Remmen H. PMID: 25449857; PMCID: PMC4289650.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    30. Single Cell Multiplex Protein Measurements through Rare Earth Element Immunolabeling, Laser Capture Microdissection and Inductively Coupled Mass Spectrometry. J Cytol Histol. 2014 Nov; 5(6). Liba A, Wanagat J. PMID: 27239387; PMCID: PMC4880404.
      View in: PubMed   Mentions:
    31. HSP72 is a mitochondrial stress sensor critical for Parkin action, oxidative metabolism, and insulin sensitivity in skeletal muscle. Diabetes. 2014 May; 63(5):1488-505. Drew BG, Ribas V, Le JA, Henstridge DC, Phun J, Zhou Z, Soleymani T, Daraei P, Sitz D, Vergnes L, Wanagat J, Reue K, Febbraio MA, Hevener AL. PMID: 24379352; PMCID: PMC3994950.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    32. Divergent mitochondrial biogenesis responses in human cardiomyopathy. Circulation. 2013 May 14; 127(19):1957-67. Ahuja P, Wanagat J, Wang Z, Wang Y, Liem DA, Ping P, Antoshechkin IA, Margulies KB, Maclellan WR. PMID: 23589024; PMCID: PMC4236313.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    33. Mitochondrial oxidative stress and mammalian healthspan. Mech Ageing Dev. 2010 Jul-Aug; 131(7-8):527-35. Wanagat J, Dai DF, Rabinovitch P. PMID: 20566356; PMCID: PMC2933331.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    34. Generation, function, and prognostic utility of somatic mitochondrial DNA mutations in cancer. Environ Mol Mutagen. 2010 Jun; 51(5):427-39. Kulawiec M, Salk JJ, Ericson NG, Wanagat J, Bielas JH. PMID: 20544883.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    35. Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria. Aging Cell. 2010 Aug; 9(4):536-44. Dai DF, Chen T, Wanagat J, Laflamme M, Marcinek DJ, Emond MJ, Ngo CP, Prolla TA, Rabinovitch PS. PMID: 20456298; PMCID: PMC3265170.
      View in: PubMed   Mentions: 136     Fields:    Translation:AnimalsCells
    36. A mitochondrial view of aging, reactive oxygen species and metastatic cancer. Aging Cell. 2010 Aug; 9(4):462-5. Ladiges W, Wanagat J, Preston B, Loeb L, Rabinovitch P. PMID: 20456297.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    37. On mitochondria, mutations, and methodology. Cell Metab. 2009 Dec; 10(6):437. Vermulst M, Wanagat J, Loeb LA. PMID: 19945399.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    38. DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nat Genet. 2008 Apr; 40(4):392-4. Vermulst M, Wanagat J, Kujoth GC, Bielas JH, Rabinovitch PS, Prolla TA, Loeb LA. PMID: 18311139.
      View in: PubMed   Mentions: 206     Fields:    Translation:AnimalsCells
    39. Adult-onset calorie restriction delays the accumulation of mitochondrial enzyme abnormalities in aging rat kidney tubular epithelial cells. Am J Physiol Renal Physiol. 2007 Jun; 292(6):F1751-60. McKiernan SH, Tuen VC, Baldwin K, Wanagat J, Djamali A, Aiken JM. PMID: 17344189.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    40. Age-related changes in cardiac structure and function in Fischer 344 x Brown Norway hybrid rats. Am J Physiol Heart Circ Physiol. 2006 Jan; 290(1):H304-11. Hacker TA, McKiernan SH, Douglas PS, Wanagat J, Aiken JM. PMID: 16143657.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    41. Mitochondrial abnormalities are more frequent in muscles undergoing sarcopenia. J Appl Physiol (1985). 2002 Jun; 92(6):2617-24. Bua EA, McKiernan SH, Wanagat J, McKenzie D, Aiken JM. PMID: 12015381.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    42. Age-associated changes in function, structure and mitochondrial genetic and enzymatic abnormalities in the Fischer 344 x Brown Norway F(1) hybrid rat heart. J Mol Cell Cardiol. 2002 Jan; 34(1):17-28. Wanagat J, Wolff MR, Aiken JM. PMID: 11812161.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
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