Detailed Biography:
The long-term goal of our research is to elucidate how genomic and environmental variation of RNA regulatory networks impacts phenotypic traits and diseases. We are a hybrid computational and experimental lab. We combine genomic, bioinformatic, molecular, and network approaches to study mRNA processing and post-transcriptional gene regulation in mammalian cells. We develop novel computational and statistical methods for analysis of massive genome and transcriptome data. We integrate computational studies with high-throughput and experimental research to systematically investigate the variation and dynamics of RNA regulatory networks between species, within human populations, and in response to developmental and disease signals.
Publications:
A selected list of publications:
Molinie Benoit, Wang Jinkai, Lim Kok Seong, Hillebrand Roman, Lu Zhi-Xiang, Van Wittenberghe Nicholas, Howard Benjamin D, Daneshvar Kaveh, Mullen Alan C, Dedon Peter, Xing Yi, Giallourakis Cosmas C
m(6)A-LAIC-seq reveals the census and complexity of the m(6)A
epitranscriptome
Nature methods,
2016; 13(8):
692-8.
Batista Pedro J, Molinie Benoit, Wang Jinkai, Qu Kun, Zhang Jiajing, Li Lingjie, Bouley Donna M, Lujan Ernesto, Haddad Bahareh, Daneshvar Kaveh, Carter Ava C, Flynn Ryan A, Zhou Chan, Lim Kok-Seong, Dedon Peter, Wernig Marius, Mullen Alan C, Xing Yi, Giallourakis Cosmas C, Chang Howard Y
m(6)A RNA modification controls cell fate transition in mammalian
embryonic stem cells
Cell stem cell,
2014; 15(6):
707-19.
Guo Rui, Zheng Lijuan, Park Juw Won, Lv Ruitu, Chen Hao, Jiao Fangfang, Xu Wenqi, Mu Shirong, Wen Hong, Qiu Jinsong, Wang Zhentian, Yang Pengyuan, Wu Feizhen, Hui Jingyi, Fu Xiangdong, Shi Xiaobing, Shi Yujiang Geno, Xing Yi, Lan Fei, Shi Yang
BS69/ZMYND11 reads and connects histone H3.3 lysine 36
trimethylation-decorated chromatin to regulated pre-mRNA processing
Molecular cell,
2014; 56(2):
298-310.