Laura Cobb, Ph.D.

A Short Biography:

Laura Cobb is a biochemist and molecular biologist who joined the faculty at UCLA in 2007. She obtained her BSc (Hons) in Biochemistry from the University of Newcastle upon Tyne, UK in 2001 and PhD in Cell Biology from The Babraham Institute/University of Cambridge, UK in 2005. Dr Cobb carried out post-doctoral studies in the Division of Pediatric Endocrinology at UCLA, studying the effects of the IGF system on human diseases including prostate cancer and diabetes.

Work Titles
UCLA Assistant Professor, Pediatrics Member, JCCC Genitourinary Oncology Program Area Visiting Assistant Professor, Pediatric Endocrinology
Ph.D., University of Cambridge
B.Sc., University of Newcastle-upon-Tyne

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A selected list of publications:

Muzumdar Radhika H, Huffman Derek M, Atzmon Gil, Buettner Christoph, Cobb Laura J, Fishman Sigal, Budagov Temuri, Cui Lingguang, Einstein Francine H, Poduval Aruna, Hwang David, Barzilai Nir, Cohen Pinchas   Humanin: a novel central regulator of peripheral insulin action PloS one, 2009; 4(7): e6334.
Tripathi Gyanendra, Salih Dervis A M, Drozd Anja C, Cosgrove Ruth A, Cobb Laura J, Pell Jennifer M   IGF-independent effects of insulin-like growth factor binding protein-5 (Igfbp5) in vivo The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2009; 23(8): 2616-26.
Carter, Cosgrove, Gonzalez, Eisemann, Lovett, Cobb, Pell   MEK5 and ERK5 are mediators of the pro-myogenic actions of IGF-2 Journal of cell science, 2009; .
Cobb Pinchas, Mehta Pinchas, Cohen Pinchas   Enhancing the Apoptotic Potential of Insulin-like Growth Factor-Binding Protein-3 in Prostate Cancer by modulation of CK2 Phosphorylation Molecular endocrinology (Baltimore, Md.), 2009; 4(7): .
Miyako Kenichi, Cobb Laura J, Francis Malik, Huang Alden, Peng Bonnie, Pintar John E, Ariga Hiroyoshi, Cohen Pinchas   PAPA-1 Is a nuclear binding partner of IGFBP-2 and modulates its growth-promoting actions Molecular endocrinology (Baltimore, Md.), 2009; 23(2): 169-75.
Anzo Makoto, Cobb Laura J, Hwang David L, Mehta Hemal, Said Jonathan W, Yakar Shoshana, LeRoith Derek, Cohen Pinchas   Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression Cancer research, 2008; 68(9): 3342-9.
Lee Kuk-Wha, Cobb Laura J, Paharkova-Vatchkova Vladislava, Liu Bingrong, Milbrandt Jeffrey, Cohen Pinchas   Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3 Carcinogenesis, 2007; 28(8): 1653-8.
Lovett Fiona A, Gonzalez Ivelisse, Salih Dervis A M, Cobb Laura J, Tripathi Gyanendra, Cosgrove Ruth A, Murrell Adele, Kilshaw Peter J, Pell Jennifer M   Convergence of Igf2 expression and adhesion signalling via RhoA and p38 MAPK enhances myogenic differentiation Journal of cell science, 2006; 119(Pt 23): 4828-40.
Cobb Laura J, Liu Bingrong, Lee Kuk-Wha, Cohen Pinchas   Phosphorylation by DNA-dependent protein kinase is critical for apoptosis induction by insulin-like growth factor binding protein-3 Cancer research, 2006; 66(22): 10878-84.
Cobb Laura M, Mychaleckyj Josyf C, Wozniak Daniel J, L√≥pez-Boado Yolanda S   Pseudomonas aeruginosa flagellin and alginate elicit very distinct gene expression patterns in airway epithelial cells: implications for cystic fibrosis disease Journal of immunology (Baltimore, Md. : 1950), 2004; 173(9): 5659-70.
Gonzalez Ivelisse, Tripathi Gyanendra, Carter Emma J, Cobb Laura J, Salih Dervis A M, Lovett Fiona A, Holding Cathy, Pell Jennifer M   Akt2, a novel functional link between p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways in myogenesis Molecular and cellular biology, 2004; 24(9): 3607-22.
Cobb Laura J, Salih Dervis A M, Gonzalez Ivelisse, Tripathi Gyanendra, Carter Emma J, Lovett Fiona, Holding Cathy, Pell Jennifer M   Partitioning of IGFBP-5 actions in myogenesis: IGF-independent anti-apoptotic function Journal of cell science, 2004; 117(Pt 9): 1737-46.
Salih Dervis A M, Tripathi Gyanendra, Holding Cathy, Szestak Tadge A M, Gonzalez M Ivelisse, Carter Emma J, Cobb Laura J, Eisemann Joan E, Pell Jennifer M   Insulin-like growth factor-binding protein 5 (Igfbp5) compromises survival, growth, muscle development, and fertility in mice Proceedings of the National Academy of Sciences of the United States of America, 2004; 101(12): 4314-9.

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