Milan Fiala, M.D.

Work Titles
UCLA Research Professor, Orthopaedic Hospital Research Center

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Laboratory Address:

Department of Oral Biology and Medicine
10833 Le Conte
Westwood, CA 90095

Work Address:

Department of Oral Biology and Medicine
UCLA CHS 73-084
10833 Le Conte
Westwood, CA 90095

Detailed Biography:

Role of monocytes and monocyte migration across the blood-brain barrier in neurodegenerative disorders, specifically, the role of chemokines and apoptosis in Alzheimer's disease and AIDS dementia Research Description: Blood-brain barrier physiology and immunology: immune cell migration and virus penetration; immunomodulation by drugs of abuse: cytokines, lympho- proliferation and virus penetration; Alzheimer's disease: inflammatory pathogenesis.


A selected list of publications:

Mizwicki Mathew T, Liu Guanghao, Fiala Milan, Magpantay Larry, Sayre James, Siani Avi, Mahanian Michelle, Weitzman Rachel, Hayden Eric Y, Rosenthal Mark J, Nemere Ilka, Ringman John, Teplow David B   1α,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-β phagocytosis and inflammation in Alzheimer's disease patients Journal of Alzheimer's disease : JAD, 2013; 34(1): 155-70.
Mizwicki Mathew T, Menegaz Danusa, Zhang Jun, Barrientos-Durán Antonio, Tse Stephen, Cashman John R, Griffin Patrick R, Fiala Milan   Genomic and nongenomic signaling induced by 1α,25(OH)2-vitamin D3 promotes the recovery of amyloid-β phagocytosis by Alzheimer's disease macrophages Journal of Alzheimer's disease : JAD, 2012; 29(1): 51-62.
Liu Guanghao, Fiala Milan, Mizwicki Mathew T, Sayre James, Magpantay Larry, Siani Avi, Mahanian Michelle, Chattopadhyay Madhuri, La Cava Antonio, Wiedau-Pazos Martina   Neuronal phagocytosis by inflammatory macrophages in ALS spinal cord: inhibition of inflammation by resolvin D1 American journal of neurodegenerative disease, 2012; 1(1): 60-74.
Mizwicki Mathew T, Fiala Milan, Magpantay Larry, Aziz Najib, Sayre James, Liu Guanghao, Siani Avi, Chan Derrick, Martinez-Maza Otoniel, Chattopadhyay Madhuri, La Cava Antonio   Tocilizumab attenuates inflammation in ALS patients through inhibition of IL6 receptor signaling American journal of neurodegenerative disease, 2012; 1(3): 305-15.
Fiala Milan, Porter Verna   Delineating Alzheimer's disease progression with MGAT3, a biomarker for improved prognosis and personalized therapy Biomarkers in medicine, 2011; 5(5): 645-7.
Fiala Milan, Mahanian Michelle, Rosenthal Mark, Mizwicki Matthew T, Tse Eric, Cho Tiffany, Sayre James, Weitzman Rachel, Porter Verna   MGAT3 mRNA: a biomarker for prognosis and therapy of Alzheimer's disease by vitamin D and curcuminoids Journal of Alzheimer's disease : JAD, 2011; 25(1): 135-44.
Fiala Milan, Chattopadhay Madhuri, La Cava Antonio, Tse Eric, Liu Guanghao, Lourenco Elaine, Eskin Ascia, Liu Philip T, Magpantay Larry, Tse Stephen, Mahanian Michelle, Weitzman Rachel, Tong Jason, Nguyen Caroline, Cho Tiffany, Koo Patrick, Sayre James, Martinez-Maza Otoniel, Rosenthal Mark J, Wiedau-Pazos Martina   IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients Journal of neuroinflammation, 2010; 7(1): 76.
Fiala Milan   Re-balancing of inflammation and abeta immunity as a therapeutic for Alzheimer's disease-view from the bedside CNS & neurological disorders drug targets, 2010; 9(2): 192-6.
Fiala Milan, Veerhuis Robert   Biomarkers of inflammation and amyloid-beta phagocytosis in patients at risk of Alzheimer disease Experimental gerontology, 2010; 45(1): 57-63.
Avagyan Hripsime, Goldenson Ben, Tse Eric, Masoumi Ava, Porter Verna, Wiedau-Pazos Martina, Sayre James, Ong Reno, Mahanian Michelle, Koo Patrick, Bae Susan, Micic Miodrag, Liu Philip T, Rosenthal Mark J, Fiala Milan   Immune blood biomarkers of Alzheimer disease patients Journal of neuroimmunology, 2009; 210(1-2): 67-72.
Masoumi Ava, Goldenson Ben, Ghirmai Senait, Avagyan Hripsime, Zaghi Justin, Abel Ken, Zheng Xueying, Espinosa-Jeffrey Araceli, Mahanian Michelle, Liu Phillip T, Hewison Martin, Mizwickie Matthew, Cashman John, Fiala Milan   1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer's disease patients Journal of Alzheimer's disease : JAD, 2009; 17(3): 703-17.
Zaghi Justin, Goldenson Ben, Inayathullah Mohammed, Lossinsky Albert S, Masoumi Ava, Avagyan Hripsime, Mahanian Michelle, Bernas Michael, Weinand Martin, Rosenthal Mark J, Espinosa-Jeffrey Araceli, de Vellis Jean, Teplow David B, Fiala Milan   Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy Acta neuropathologica, 2009; 117(2): 111-24.
Fiala Milan, Singer Elyse J, Commins Deborah, Mirzapoiazova Tamara, Verin Alexander, Espinosa Araceli, Ugen Kenneth, Bernas Michael, Witte Marlys, Weinand Martin, Lossinsky Albert S   HIV-1 Antigens in Neurons of Cocaine-Abusing Patients The open virology journal, 2008; 2(3): 24-31.
Cashman John R, Ghirmai Senait, Abel Kenneth J, Fiala Milan   Immune defects in Alzheimer's disease: new medications development BMC neuroscience, 2008; 9 Suppl 2(3): S13.
Fiala Milan, Liu Philip T, Espinosa-Jeffrey Araceli, Rosenthal Mark J, Bernard George, Ringman John M, Sayre James, Zhang Laura, Zaghi Justin, Dejbakhsh Sheila, Chiang Ben, Hui James, Mahanian Michelle, Baghaee Anita, Hong Pamela, Cashman John   Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin Proceedings of the National Academy of Sciences of the United States of America, 2007; 104(31): 12849-54.
Fiala Milan, Cribbs David H, Rosenthal Mark, Bernard George   Phagocytosis of amyloid-beta and inflammation: two faces of innate immunity in Alzheimer's disease Journal of Alzheimer's disease : JAD, 2007; 11(4): 457-63.
Zhang Laura, Fiala Milan, Cashman John, Sayre James, Espinosa Araceli, Mahanian Michelle, Zaghi Justin, Badmaev Vladimir, Graves Michael C, Bernard George, Rosenthal Mark   Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patients Journal of Alzheimer's disease : JAD, 2006; 10(1): 1-7.
Chiappelli Francesco, Alwan Joseph, Prolo Paolo, Christensen Russell, Fiala Milan, Cajulis Olivia S, Bernard George   Neuro-immunity in stress-related oral ulcerations: a fractal analysis Frontiers in bioscience : a journal and virtual library, 2005; 10(1): 3034-41.
Fiala Milan, Lin Justin, Ringman John, Kermani-Arab Vali, Tsao George, Patel Amish, Lossinsky Albert S, Graves Michael C, Gustavson Andrew, Sayre James, Sofroni Emanuela, Suarez Tatiana, Chiappelli Francesco, Bernard George   Ineffective phagocytosis of amyloid-beta by macrophages of Alzheimer's disease patients Journal of Alzheimer's disease : JAD, 2005; 7(3): 221-32; discussion 255-62.
Graves Michael C, Fiala Milan, Dinglasan Lu Anne V, Liu Nancy Q, Sayre James, Chiappelli Francesco, van Kooten Cees, Vinters Harry V   Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cells Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases, 2004; 5(4): 213-9.
Fiala Milan, Popik Waldemar, Qiao Jian-Hua, Lossinsky Albert S, Alce Timothy, Tran Kenix, Yang Wendy, Roos Kenneth P, Arthos James   HIV-1 induces cardiomyopathyby cardiomyocyte invasion and gp120, Tat, and cytokine apoptotic signaling Cardiovascular toxicology, 2004; 4(2): 97-107.
Twu Cheryl, Liu Nancy Q, Popik Waldemar, Bukrinsky Michael, Sayre James, Roberts Jaclyn, Rania Shammas, Bramhandam Vishnu, Roos Kenneth P, MacLellan W Robb, Fiala Milan   Cardiomyocytes undergo apoptosis in human immunodeficiency virus cardiomyopathy through mitochondrion- and death receptor-controlled pathways Proceedings of the National Academy of Sciences of the United States of America, 2002; 99(22): 14386-91.
Liu Nancy Q, Lossinsky Albert S, Popik Waldemar, Li Xia, Gujuluva Chandrasekhar, Kriederman Benjamin, Roberts Jaclyn, Pushkarsky Tatania, Bukrinsky Michael, Witte Marlys, Weinand Martin, Fiala Milan   Human immunodeficiency virus type 1 enters brain microvascular endothelia by macropinocytosis dependent on lipid rafts and the mitogen-activated protein kinase signaling pathway Journal of virology, 2002; 76(13): 6689-700.

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